Vasotec Flashcards
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Questions and Answers

What is the generic name for Vasotec?

  • captopril
  • lisinopril
  • enalapril (correct)
  • benazepril
  • What is the action of Vasotec?

    Angiotensin-converting enzyme (ACE) inhibitors block the conversion of angiotensin I to angiotensin II.

    Which of the following are brand names for enalapril?

  • Captopril
  • Vasotec (correct)
  • Lisinopril
  • Epaned (correct)
  • What are the therapeutic effects of Vasotec?

    <p>Lowering of blood pressure in hypertension and increased survival in symptomatic heart failure.</p> Signup and view all the answers

    Vasotec is classified as an _____ and an ACE inhibitor.

    <p>antihypertensive</p> Signup and view all the answers

    What are the indications for using Vasotec?

    <p>Management of hypertension and symptomatic heart failure.</p> Signup and view all the answers

    Vasotec can only be prescribed to adults.

    <p>False</p> Signup and view all the answers

    What is a major contraindication for Vasotec?

    <p>Hypersensitivity and history of angioedema.</p> Signup and view all the answers

    The primary mechanism of action (MOA) of Vasotec involves inhibition of _____ activity.

    <p>angiotensin-converting enzyme</p> Signup and view all the answers

    What is the prescribed route and the onset for enalapril?

    <p>Enalapril PO 1 hr onset.</p> Signup and view all the answers

    Study Notes

    Vasotec Overview

    • Generic Name: Enalapril, pronounced e-NAL-a-pril
    • Brand Names: Epaned, Vasotec

    Pharmacological Action

    • Class: ACE inhibitor (Angiotensin-converting enzyme inhibitor)
    • Mechanism: Inhibits conversion of angiotensin I to angiotensin II, reduces vasoconstriction, and prevents bradykinin degradation.
    • Results in systemic vasodilation and lowered blood pressure (BP).

    Therapeutic Effects

    • Lowers BP in hypertensive patients.
    • Increases survival rates and alleviates symptoms in symptomatic heart failure.
    • Slows progression from asymptomatic left ventricular dysfunction to overt heart failure.

    Indications for Use

    • Management of hypertension, alone or with other antihypertensives.
    • Treatment of symptomatic heart failure.
    • Slowing down the progression of left ventricular dysfunction.
    • Unlabeled use includes treatment of proteinuria in steroid-resistant nephrotic syndrome.

    Classification

    • Therapeutic class: Antihypertensives.
    • Pharmacologic class: ACE inhibitor.

    Administration Details

    • Route: Oral (PO), Intravenous (IV)
    • Onset/Peak/Duration:
      • Enalapril PO: Onset 1 hr, Peak 4-8 hr, Duration 12-24 hr.
      • Enalaprilat IV: Onset 15 min, Peak 1-4 hr, Duration 4-6 hr.

    Contraindications and Precautions

    • Contraindicated in hypersensitivity, history of angioedema, concurrent use with aliskiren in specific renal conditions.
    • Caution is advised in patients with renal impairment, hypovolemia, lactation, and during surgery/anesthesia.

    Use Cases

    • Treats high blood pressure in adults and children (≥1 month old).
    • Addresses congestive heart failure in adults.
    • Manages ventricular disorders affecting blood pumping capability.

    Allergies and Interactions

    • Not suitable for individuals allergic to other ACE inhibitors (e.g., benazepril, lisinopril).
    • Avoid concurrent use with aliskiren in diabetic patients.

    Description and Composition

    • VASOTEC® is the maleate salt of enalapril, chemically defined as (S)-1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline, (Z)-2-butenedioate salt.

    Mechanism of Action

    • Two isoforms of ACE: somatic and testicular, with distinct physiological roles.
    • Somatic ACE primarily regulates blood pressure, while the testicular isoform is associated with sperm functions.
    • Enalaprilat competes with angiotensin I for ACE binding, decreasing levels of angiotensin II, reducing blood pressure, while increasing plasma renin activity due to loss of feedback inhibition.

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    Test your knowledge about Vasotec, including its generic name, brand names, and mechanism of action. These flashcards will help reinforce your understanding of this ACE inhibitor and its pharmacological properties.

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