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Questions and Answers
What is the generic name for Vasotec?
What is the generic name for Vasotec?
- captopril
- lisinopril
- enalapril (correct)
- benazepril
What is the action of Vasotec?
What is the action of Vasotec?
Angiotensin-converting enzyme (ACE) inhibitors block the conversion of angiotensin I to angiotensin II.
Which of the following are brand names for enalapril?
Which of the following are brand names for enalapril?
- Captopril
- Vasotec (correct)
- Lisinopril
- Epaned (correct)
What are the therapeutic effects of Vasotec?
What are the therapeutic effects of Vasotec?
Vasotec is classified as an _____ and an ACE inhibitor.
Vasotec is classified as an _____ and an ACE inhibitor.
What are the indications for using Vasotec?
What are the indications for using Vasotec?
Vasotec can only be prescribed to adults.
Vasotec can only be prescribed to adults.
What is a major contraindication for Vasotec?
What is a major contraindication for Vasotec?
The primary mechanism of action (MOA) of Vasotec involves inhibition of _____ activity.
The primary mechanism of action (MOA) of Vasotec involves inhibition of _____ activity.
What is the prescribed route and the onset for enalapril?
What is the prescribed route and the onset for enalapril?
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Study Notes
Vasotec Overview
- Generic Name: Enalapril, pronounced e-NAL-a-pril
- Brand Names: Epaned, Vasotec
Pharmacological Action
- Class: ACE inhibitor (Angiotensin-converting enzyme inhibitor)
- Mechanism: Inhibits conversion of angiotensin I to angiotensin II, reduces vasoconstriction, and prevents bradykinin degradation.
- Results in systemic vasodilation and lowered blood pressure (BP).
Therapeutic Effects
- Lowers BP in hypertensive patients.
- Increases survival rates and alleviates symptoms in symptomatic heart failure.
- Slows progression from asymptomatic left ventricular dysfunction to overt heart failure.
Indications for Use
- Management of hypertension, alone or with other antihypertensives.
- Treatment of symptomatic heart failure.
- Slowing down the progression of left ventricular dysfunction.
- Unlabeled use includes treatment of proteinuria in steroid-resistant nephrotic syndrome.
Classification
- Therapeutic class: Antihypertensives.
- Pharmacologic class: ACE inhibitor.
Administration Details
- Route: Oral (PO), Intravenous (IV)
- Onset/Peak/Duration:
- Enalapril PO: Onset 1 hr, Peak 4-8 hr, Duration 12-24 hr.
- Enalaprilat IV: Onset 15 min, Peak 1-4 hr, Duration 4-6 hr.
Contraindications and Precautions
- Contraindicated in hypersensitivity, history of angioedema, concurrent use with aliskiren in specific renal conditions.
- Caution is advised in patients with renal impairment, hypovolemia, lactation, and during surgery/anesthesia.
Use Cases
- Treats high blood pressure in adults and children (≥1 month old).
- Addresses congestive heart failure in adults.
- Manages ventricular disorders affecting blood pumping capability.
Allergies and Interactions
- Not suitable for individuals allergic to other ACE inhibitors (e.g., benazepril, lisinopril).
- Avoid concurrent use with aliskiren in diabetic patients.
Description and Composition
- VASOTEC® is the maleate salt of enalapril, chemically defined as (S)-1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline, (Z)-2-butenedioate salt.
Mechanism of Action
- Two isoforms of ACE: somatic and testicular, with distinct physiological roles.
- Somatic ACE primarily regulates blood pressure, while the testicular isoform is associated with sperm functions.
- Enalaprilat competes with angiotensin I for ACE binding, decreasing levels of angiotensin II, reducing blood pressure, while increasing plasma renin activity due to loss of feedback inhibition.
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