Vasoconstriction and Endothelins

Which protein is a key mediator of vasoconstriction in response to endothelial damage?

What is the first line of defense against bleeding?

In which condition are endothelin receptor blockers commonly used?

True or false: Vasoconstriction is the first line of defense against bleeding?

True or false: Endothelins are proteins released by endothelial cells near the site of damage?

True or false: Endothelin receptor blockers are commonly used in the treatment of pulmonary hypertension?

Which organ synthesizes coagulation factors?

Where do coagulation factors become activated?

What forms an insoluble protein to prevent blood loss?

Which of the following is true about the coagulation cascade?

What happens during the coagulation cascade?

What is the role of endothelial damage in the coagulation cascade?

Which factor converts prothrombin to thrombin?

What is the role of fibrin in the coagulation cascade?

What is the result of the activation of Factor X?

Which of the following is a direct thrombin inhibitor?

Which factor is decreased by Xa inhibitors?

Which of the following is an oral anticoagulant?

Which cells express Tissue Factor Thromboplastin Glycoprotein?

Which of the following is true about Tissue Factor Thromboplastin Glycoprotein?

What is the basis for Prothrombin Time (PT) and International Normalized Ratio (INR) tests?

Which factor is produced in endothelial cells and circulates bound to von Willebrand Factor?

Which factor is activated by TF:VIIa complex?

Which protein is released from von Willebrand Factor in response to vascular injury?

Which substance binds calcium in blood samples to prevent clotting?

What is the role of calcium in clot formation?

What is the function of Activated platelets in the coagulation cascade?

Which factor is responsible for crosslinking fibrin and stabilizing the fibrin plug?

What happens if Factor XIII is absent?

Which co-factor is required for Factor XIII activation?

Which of the following is an important deactivator of coagulation?

Which proteins are involved in deactivating coagulation?

Which of the following is NOT an important deactivator of coagulation?

Which of the following is a serine protease inhibited by Antithrombin III?

Where is Antithrombin III produced?

What is the basis for the role of heparin drug therapy?

Which protein primarily inactivates factors Va and VIIIa?

Where are proteins C and S synthesized?

What is the active form of protein C?

Which protein is activated by thrombomodulin on endothelial cells?

Where is thrombomodulin found?

What complex activates protein C to APC?

Which protein is required as a co-factor for protein C and protein S to activate protein C?

In what form does protein S circulate in the body?

Which protein is required as a co-factor for activated protein C (APC) to function?

Which of the following is the mechanism by which TFPI inactivates Xa?

What happens to plasma levels of TFPI with heparin administration?

What is the potential contribution of TFPI to the antithrombotic effect?