Podcast
Questions and Answers
What is the FDA approval status of valproate in the treatment of mania?
What is the FDA approval status of valproate in the treatment of mania?
- Approved in 1995 (correct)
- Not approved for mania
- Still pending approval
- Approved in the 1960s
How does valproate affect GABA function?
How does valproate affect GABA function?
- Does not impact GABA function
- Blocks GABA receptors
- Reduces GABA function
- Enhances GABA function (correct)
Which enzyme is involved in the metabolism of valproate?
Which enzyme is involved in the metabolism of valproate?
- P450 2C9 (correct)
- P450 1A2
- P450 2D6
- P450 3A4
What is the bioavailability of valproate when administered orally?
What is the bioavailability of valproate when administered orally?
What contributes to toxic side effects related to valproate use?
What contributes to toxic side effects related to valproate use?
What is the peak time for valproate levels after administration?
What is the peak time for valproate levels after administration?
What is the typical range for peak plasma levels of valproate?
What is the typical range for peak plasma levels of valproate?
What is the primary concern with using valproate during the first trimester of pregnancy?
What is the primary concern with using valproate during the first trimester of pregnancy?
What is the Pregnancy Category for valproate?
What is the Pregnancy Category for valproate?
What is the potential effect of valproate on platelet aggregation?
What is the potential effect of valproate on platelet aggregation?
What is the primary concern with using valproate in children younger than 2 years old?
What is the primary concern with using valproate in children younger than 2 years old?
What is the typical adult dosage range for valproate?
What is the typical adult dosage range for valproate?
What is the maximum daily dosage of valproate?
What is the maximum daily dosage of valproate?
What is a potential adverse effect of valproate that may occur during long-term use?
What is a potential adverse effect of valproate that may occur during long-term use?
What is a potential drug interaction that can occur with the combination of valproate and tricyclic antidepressants (TCAs)?
What is a potential drug interaction that can occur with the combination of valproate and tricyclic antidepressants (TCAs)?
What is a potential concern with using valproate in patients with diabetes?
What is a potential concern with using valproate in patients with diabetes?
What is the recommended trough concentration range for monitoring plasma levels of the drug?
What is the recommended trough concentration range for monitoring plasma levels of the drug?
What type of monitoring is recommended for patients taking this drug?
What type of monitoring is recommended for patients taking this drug?
What should patients be advised about when taking this drug?
What should patients be advised about when taking this drug?
What is the mechanism of action of lamotrigine?
What is the mechanism of action of lamotrigine?
Which drug is the only one of the 'nonclassified mood stabilizers' that has been approved by the FDA for treating bipolar disorder?
Which drug is the only one of the 'nonclassified mood stabilizers' that has been approved by the FDA for treating bipolar disorder?
What is the mechanism of action of gabapentin?
What is the mechanism of action of gabapentin?
What is the recommended initial daily dosage of valproic acid for adults?
What is the recommended initial daily dosage of valproic acid for adults?
What is the recommended dosage form for valproic acid?
What is the recommended dosage form for valproic acid?
Which of the following drug interactions with valproic acid can result in increased sedation and disorientation?
Which of the following drug interactions with valproic acid can result in increased sedation and disorientation?
What is the recommended maximum daily dosage of valproic acid for acute mania?
What is the recommended maximum daily dosage of valproic acid for acute mania?
Which of the following muscle relaxants is known to cause significant CNS and respiratory depression?
Which of the following muscle relaxants is known to cause significant CNS and respiratory depression?
Which of these adverse effects is NOT associated with Tizanidine use?
Which of these adverse effects is NOT associated with Tizanidine use?
Why should the use of Methocarbamol be cautious in patients taking anticholinesterase medications?
Why should the use of Methocarbamol be cautious in patients taking anticholinesterase medications?
Which of the following is a contraindicated drug interaction for Tizanidine?
Which of the following is a contraindicated drug interaction for Tizanidine?
What is the maximum daily dose of Baclofen recommended for adult patients?
What is the maximum daily dose of Baclofen recommended for adult patients?
Which of the following adverse effects is NOT associated with Cyclobenzaprine?
Which of the following adverse effects is NOT associated with Cyclobenzaprine?
What is the maximum recommended duration of Carisoprodol treatment?
What is the maximum recommended duration of Carisoprodol treatment?
Which of the following muscle relaxants is known to cause hepatotoxicity?
Which of the following muscle relaxants is known to cause hepatotoxicity?
Which of the following muscle relaxants has a potentially life-threatening interaction with MAOIs?
Which of the following muscle relaxants has a potentially life-threatening interaction with MAOIs?
Which of these muscle relaxants is NOT associated with leukopenia or hematologic abnormalities?
Which of these muscle relaxants is NOT associated with leukopenia or hematologic abnormalities?
What is the known effect of carisoprodol on the fetus during pregnancy?
What is the known effect of carisoprodol on the fetus during pregnancy?
What is the primary safety concern with the use of cyclobenzaprine?
What is the primary safety concern with the use of cyclobenzaprine?
What is the primary safety concern with the use of metaxalone?
What is the primary safety concern with the use of metaxalone?
What is the primary safety concern with the use of methocarbamol?
What is the primary safety concern with the use of methocarbamol?
What is the primary safety concern with the use of orphenadrine?
What is the primary safety concern with the use of orphenadrine?
What is the primary safety concern with the use of tizanidine?
What is the primary safety concern with the use of tizanidine?
Which muscle relaxant is known to cause hepatotoxicity?
Which muscle relaxant is known to cause hepatotoxicity?
Which muscle relaxant is contraindicated in the acute recovery phase of a myocardial infarction?
Which muscle relaxant is contraindicated in the acute recovery phase of a myocardial infarction?
Which muscle relaxant is known to cause serotonin syndrome?
Which muscle relaxant is known to cause serotonin syndrome?
Which muscle relaxant is not approved for use in children younger than 16 years old?
Which muscle relaxant is not approved for use in children younger than 16 years old?
What is the main difference between centrally acting muscle relaxants and direct-acting antispasmodics?
What is the main difference between centrally acting muscle relaxants and direct-acting antispasmodics?
Which of the following is NOT a centrally acting muscle relaxant?
Which of the following is NOT a centrally acting muscle relaxant?
How do centrally acting muscle relaxants affect skeletal muscle spasms?
How do centrally acting muscle relaxants affect skeletal muscle spasms?
Which centrally acting muscle relaxant is metabolized via CYP1A2?
Which centrally acting muscle relaxant is metabolized via CYP1A2?
What precaution should be taken when prescribing baclofen to patients with a seizure disorder?
What precaution should be taken when prescribing baclofen to patients with a seizure disorder?
Why should carisoprodol be avoided in patients with porphyria?
Why should carisoprodol be avoided in patients with porphyria?
Which condition should caution be exercised when prescribing baclofen?
Which condition should caution be exercised when prescribing baclofen?
How do centrally acting muscle relaxants relieve muscle spasms?
How do centrally acting muscle relaxants relieve muscle spasms?
What is a common side effect of centrally acting muscle relaxants?
What is a common side effect of centrally acting muscle relaxants?
How are most of the centrally acting muscle relaxants eliminated from the body?
How are most of the centrally acting muscle relaxants eliminated from the body?
Which drug has the longest half-life among lamotrigine, topiramate, and gabapentin?
Which drug has the longest half-life among lamotrigine, topiramate, and gabapentin?
What is the primary method of excretion for lamotrigine, topiramate, and gabapentin?
What is the primary method of excretion for lamotrigine, topiramate, and gabapentin?
Which drug is associated with weight gain among the three discussed medications?
Which drug is associated with weight gain among the three discussed medications?
Which side effect is commonly associated with all three drugs?
Which side effect is commonly associated with all three drugs?
What pregnancy category are lamotrigine, topiramate, and gabapentin classified under?
What pregnancy category are lamotrigine, topiramate, and gabapentin classified under?
Which drug decreases the effectiveness of oral contraceptives?
Which drug decreases the effectiveness of oral contraceptives?
Which adverse reaction has a rare occurrence with lamotrigine and topiramate within the first 2 to 8 weeks of therapy?
Which adverse reaction has a rare occurrence with lamotrigine and topiramate within the first 2 to 8 weeks of therapy?
What is advised for patients taking topiramate due to the risk of kidney stones?
What is advised for patients taking topiramate due to the risk of kidney stones?
What is the recommended initial dose of cyclobenzaprine for the short-term treatment of painful muscle spasms?
What is the recommended initial dose of cyclobenzaprine for the short-term treatment of painful muscle spasms?
What action should be taken with the dose of cyclobenzaprine once improvement occurs?
What action should be taken with the dose of cyclobenzaprine once improvement occurs?
Which muscle relaxant is less sedating and suitable for daytime use to minimize the risk of impaired driving?
Which muscle relaxant is less sedating and suitable for daytime use to minimize the risk of impaired driving?
For which patient population are lower doses of muscle relaxants recommended due to potential impairments?
For which patient population are lower doses of muscle relaxants recommended due to potential impairments?
What is the maximum recommended daily dose of tizanidine for spasticity?
What is the maximum recommended daily dose of tizanidine for spasticity?
