Vaginal Squamous Cell Carcinoma in Female Reproductive System
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Questions and Answers

What is the typical age range for women to experience breast fibrocystic changes?

  • 50-70 years
  • Over 70 years
  • 25-50 years (correct)
  • 15-25 years
  • Which protein is the immature teratoma component positive for?

  • Glial fibrillary acidic protein (GFAP) (correct)
  • Estrogen receptor
  • Progesterone receptor
  • Androgen receptor
  • What is the main cause of gynecomastia in elderly men?

  • Puberty
  • Chemotherapy
  • Endogenous hormonal imbalance (correct)
  • Liver failure
  • What type of cells typically line type 1 breast cysts in fibrocystic changes?

    <p>Metaplastic apocrine cells</p> Signup and view all the answers

    What is the microscopic feature of 'florid type' gynecomastia?

    <p>Increased ducts with cellular periductal stroma</p> Signup and view all the answers

    What is the defining feature of adenososis?

    <p>Increased ductules and lobular expansion with epithelial proliferation</p> Signup and view all the answers

    Which histologic type is the most common in primary vaginal squamous cell carcinoma?

    <p>Usual nonkeratinizing</p> Signup and view all the answers

    What defines a primary vaginal squamous cell carcinoma?

    <p>No history of invasive SCC of the cervix or vulva diagnosed for at least 10 years</p> Signup and view all the answers

    What are the three independent prognostic factors for primary vaginal squamous cell carcinoma?

    <p>Old age, tumor size &gt;4 cm, advanced stage</p> Signup and view all the answers

    Where does sarcoma botryoides (embryonal rhabdomyosarcoma) most commonly occur in the female genital tract?

    <p>Vagina</p> Signup and view all the answers

    At what age group does sarcoma botryoides (embryonal rhabdomyosarcoma) typically occur?

    <p>Young girls less than 10 years of age</p> Signup and view all the answers

    How does sarcoma botryoides (embryonal rhabdomyosarcoma) typically present?

    <p>With a characteristic appearance of a 'bunch of grapes'</p> Signup and view all the answers

    What is the size threshold that differentiates a benign serous tumor from a cortical inclusion cyst?

    <p>1 cm</p> Signup and view all the answers

    In what percentage of cases are benign serous tumors bilateral?

    <p>20%</p> Signup and view all the answers

    What may be apparent in the cyst wall of benign serous tumors that does not necessarily indicate low malignant potential?

    <p>Nodularity/papillary structures</p> Signup and view all the answers

    Which type of epithelium lines serous cystadenomas?

    <p>Flat epithelium</p> Signup and view all the answers

    What differentiates serous cystadenomas from serous cystadenofibromas regarding architecture?

    <p>Presence of broad fibrous stromal cores</p> Signup and view all the answers

    What term is used to describe foci of epithelial changes in serous cystadenomas involving less than 10% of the neoplasm?

    <p>Serous cystadenoma with focal epithelial proliferation</p> Signup and view all the answers

    What is a characteristic feature of infiltrating lobular carcinoma that makes it difficult to detect on mammography?

    <p>Permeative growth pattern</p> Signup and view all the answers

    Which type of breast carcinoma has a predilection for metastasizing to viscera, bone marrow, and meninges?

    <p>Lobular carcinoma</p> Signup and view all the answers

    What is a common histologic feature of the classic form of infiltrating lobular carcinoma?

    <p>Desmoplastic stroma with basophilic appearance</p> Signup and view all the answers

    Which age group is more commonly affected by carcinoma of the male breast compared to women?

    <p>60+ years</p> Signup and view all the answers

    What type of breast carcinoma may have both clinically inflammatory features without lymphatic plugging?

    <p>Inflammatory carcinoma</p> Signup and view all the answers

    What is a distinguishing feature of lobular neoplasia in infiltrating lobular carcinoma cases?

    <p>Often arranged in targetoid patterns around ducts</p> Signup and view all the answers

    Which type of endometrial carcinoma is typically high-grade and has early dissemination to the pelvis and abdomen?

    <p>Serous carcinoma</p> Signup and view all the answers

    What is the most common uterine neoplasm, typically presenting with symptoms like pain, pressure sensation, and abnormal uterine bleeding?

    <p>Leiomyoma</p> Signup and view all the answers

    In serous carcinoma, what factor has been reported to be over-expressed and/or amplified in a significant proportion of cases, suggesting it may be a therapeutic target?

    <p>HER2</p> Signup and view all the answers

    Which type of carcinoma is characterized by a papillary pattern with broad fibrovascular cores, high-grade nuclei, and frequent mitotic figures along with necrotic foci?

    <p>Serous carcinoma</p> Signup and view all the answers

    Which uterine tumor usually has a white to tan cut surface with a whorled trabecular pattern, and may be submucosal, intramural, or subserosal?

    <p>Leiomyoma</p> Signup and view all the answers

    Which uterine sarcoma is the most common pure uterine sarcoma, typically occurring in postmenopausal women and diagnosed with caution due to its rarity?

    <p>Leiomyosarcoma</p> Signup and view all the answers

    Which type of tumor is considered a potential precursor lesion of pelvic high-grade serous carcinoma, including ovarian, tubal, and primary peritoneal carcinomas?

    <p>STIC</p> Signup and view all the answers

    What is the characteristic microscopic appearance of leiomyomas?

    <p>'Cigar-shaped' nuclei with small nucleoli</p> Signup and view all the answers

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