Podcast
Questions and Answers
What is the maximum duration for which vaccines can be stored at the regional level?
What is the maximum duration for which vaccines can be stored at the regional level?
- 1 month
- 3 months (correct)
- 6 months
- 2 months
At which temperature should OPV, Measles, and Mumps vaccines be stored at the district level?
At which temperature should OPV, Measles, and Mumps vaccines be stored at the district level?
- 0 to +8⁰ C
- -10 to -20⁰ C
- -15 to -25⁰ C (correct)
- 0 to +5⁰ C
What is the maximum duration for which vaccines can be stored at health facility level?
What is the maximum duration for which vaccines can be stored at health facility level?
- 3 months
- 2 months
- 1 month (correct)
- 4 months
What temperature range is appropriate for storing Hepatitis B, DPT, DT, Td, TT, and BCG vaccines at the regional level?
What temperature range is appropriate for storing Hepatitis B, DPT, DT, Td, TT, and BCG vaccines at the regional level?
What is the primary purpose of insulated containers in the vaccine distribution process?
What is the primary purpose of insulated containers in the vaccine distribution process?
Which type of vaccine is produced from inactivated toxins?
Which type of vaccine is produced from inactivated toxins?
What is a critical component of the cold chain system?
What is a critical component of the cold chain system?
Which of the following vaccines uses genetic engineering technologies?
Which of the following vaccines uses genetic engineering technologies?
What does the term 'cold chain' refer to in the context of vaccines?
What does the term 'cold chain' refer to in the context of vaccines?
What type of vaccine is a DPT vaccine primarily based on?
What type of vaccine is a DPT vaccine primarily based on?
What is one primary function of walk-in cold rooms?
What is one primary function of walk-in cold rooms?
Which of the following is a characteristic of ice-lined refrigerators?
Which of the following is a characteristic of ice-lined refrigerators?
Which equipment is primarily used for long-term storage of OPV/Measles/MMR vaccines?
Which equipment is primarily used for long-term storage of OPV/Measles/MMR vaccines?
What type of refrigerator is typically found at the health facility level?
What type of refrigerator is typically found at the health facility level?
For vaccine storage, what equipment is considered mobile?
For vaccine storage, what equipment is considered mobile?
What is a common feature of walk-in freezers?
What is a common feature of walk-in freezers?
What is a primary benefit of using large top-opening refrigerator/freezers at the district level?
What is a primary benefit of using large top-opening refrigerator/freezers at the district level?
Which of the following statements is true about deep freezers?
Which of the following statements is true about deep freezers?
What is essential for an effective cold chain system?
What is essential for an effective cold chain system?
Which team member is responsible at the central level of the cold chain system?
Which team member is responsible at the central level of the cold chain system?
What type of equipment is specifically used for vaccine transport?
What type of equipment is specifically used for vaccine transport?
What is a consequence of exposing vaccines to unsuitable temperatures?
What is a consequence of exposing vaccines to unsuitable temperatures?
Which of the following is NOT considered basic cold chain equipment for vaccine storage?
Which of the following is NOT considered basic cold chain equipment for vaccine storage?
At the divisional level, which team member is involved in maintaining the cold chain?
At the divisional level, which team member is involved in maintaining the cold chain?
What is the role of thermometers in the cold chain system?
What is the role of thermometers in the cold chain system?
What critical aspect contributes to maintaining vaccine stability?
What critical aspect contributes to maintaining vaccine stability?
What is the required thickness of the walls of the thermocol box to keep vaccines for longer durations?
What is the required thickness of the walls of the thermocol box to keep vaccines for longer durations?
Which of the following is NOT recommended for maintaining temperature in cold boxes?
Which of the following is NOT recommended for maintaining temperature in cold boxes?
Why is it important to regularly measure and record temperatures for vaccine storage?
Why is it important to regularly measure and record temperatures for vaccine storage?
What does a blue window D indicate on a cold chain monitor card?
What does a blue window D indicate on a cold chain monitor card?
Which thermometer type is NOT listed as a device for monitoring temperatures?
Which thermometer type is NOT listed as a device for monitoring temperatures?
If all windows A, B, C, and D are white on a cold chain monitor card, what should you do with the vaccines?
If all windows A, B, C, and D are white on a cold chain monitor card, what should you do with the vaccines?
What is indicated if windows A, B, or C are completely blue while D remains white?
What is indicated if windows A, B, or C are completely blue while D remains white?
What is the function of a cold chain monitor card?
What is the function of a cold chain monitor card?
What does a vaccine vial monitor (VVM) indicate about the vaccine?
What does a vaccine vial monitor (VVM) indicate about the vaccine?
When the inner square of the VVM is darker than the surrounding disk, what should be done?
When the inner square of the VVM is darker than the surrounding disk, what should be done?
What does the VVM use to indicate heat exposure?
What does the VVM use to indicate heat exposure?
How does a VVM function when exposed to freezing temperatures?
How does a VVM function when exposed to freezing temperatures?
In what way is the VVM used in conjunction with other monitoring devices?
In what way is the VVM used in conjunction with other monitoring devices?
What color is the inner square of the VVM when the vaccine can still be used?
What color is the inner square of the VVM when the vaccine can still be used?
Which of the following statements is true regarding the VVM?
Which of the following statements is true regarding the VVM?
What is a key feature of the VVM that distinguishes it from other monitoring devices?
What is a key feature of the VVM that distinguishes it from other monitoring devices?
Flashcards
Vaccines
Vaccines
Vaccines are biological preparations that provide immunity to specific diseases. They contain weakened or inactive forms of the disease-causing organism or its toxins.
Vaccine Cold Chain
Vaccine Cold Chain
A system that maintains the potency of vaccines during transportation, storage, and distribution from the manufacturer to the point of use.
What are the main substances used in vaccine production?
What are the main substances used in vaccine production?
Live microorganisms, killed microorganisms, and toxoids.
Live and Killed Vaccines
Live and Killed Vaccines
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Toxoid Vaccines
Toxoid Vaccines
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Vaccine Storage Time
Vaccine Storage Time
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What is the 'cold chain' for vaccines?
What is the 'cold chain' for vaccines?
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Why are different vaccine storage equipment needed?
Why are different vaccine storage equipment needed?
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What temperatures are vaccines stored at?
What temperatures are vaccines stored at?
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What are insulated containers used for?
What are insulated containers used for?
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What is the cold chain system?
What is the cold chain system?
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Why are competent personnel and procedures important in the cold chain?
Why are competent personnel and procedures important in the cold chain?
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Who are the key personnel involved in the cold chain at different levels?
Who are the key personnel involved in the cold chain at different levels?
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What are the different levels of the cold chain system?
What are the different levels of the cold chain system?
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What equipment is used in the cold chain system?
What equipment is used in the cold chain system?
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How do temperature changes affect vaccines?
How do temperature changes affect vaccines?
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What happens to vaccine potency when exposed to inappropriate temperatures?
What happens to vaccine potency when exposed to inappropriate temperatures?
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Why is temperature control essential for vaccines?
Why is temperature control essential for vaccines?
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Thermocol box wall thickness
Thermocol box wall thickness
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Why is temperature control important for vaccines?
Why is temperature control important for vaccines?
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What is a Cold Chain Monitor Card (CCM)?
What is a Cold Chain Monitor Card (CCM)?
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How does a CCM work?
How does a CCM work?
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What does it mean if all CCM windows are white?
What does it mean if all CCM windows are white?
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What does it mean if some CCM windows are blue?
What does it mean if some CCM windows are blue?
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What is a serious issue indicated on a CCM?
What is a serious issue indicated on a CCM?
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Why is regular temperature monitoring important?
Why is regular temperature monitoring important?
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What are walk-in cold rooms (WIC) and walk-in freezers (WIF) used for?
What are walk-in cold rooms (WIC) and walk-in freezers (WIF) used for?
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What is the purpose of deep freezers in the vaccine cold chain?
What is the purpose of deep freezers in the vaccine cold chain?
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Why are ice-lined refrigerators (ILR) crucial in the vaccine cold chain?
Why are ice-lined refrigerators (ILR) crucial in the vaccine cold chain?
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What are two-compartment refrigerators/freezers used for in the vaccine cold chain?
What are two-compartment refrigerators/freezers used for in the vaccine cold chain?
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What are small "ice-lined" refrigerators used for in the vaccine cold chain?
What are small "ice-lined" refrigerators used for in the vaccine cold chain?
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What are the two main aspects of the vaccine cold chain system?
What are the two main aspects of the vaccine cold chain system?
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What is "cold chain equipment" in the context of vaccines?
What is "cold chain equipment" in the context of vaccines?
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How does the level of the cold chain influence the type of equipment used?
How does the level of the cold chain influence the type of equipment used?
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What is a Vaccine Vial Monitor (VVM)?
What is a Vaccine Vial Monitor (VVM)?
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Can a VVM detect if a vaccine has been frozen?
Can a VVM detect if a vaccine has been frozen?
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What is the role of VVMs in the cold chain?
What is the role of VVMs in the cold chain?
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How can you tell if a vaccine is safe to use based on a VVM?
How can you tell if a vaccine is safe to use based on a VVM?
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When should you NOT use a vaccine based on a VVM?
When should you NOT use a vaccine based on a VVM?
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What is the purpose of a Vaccine Vial Monitor?
What is the purpose of a Vaccine Vial Monitor?
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Where are VVMs typically located on a vaccine vial?
Where are VVMs typically located on a vaccine vial?
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Study Notes
Cold Chain Management
- A system for transporting, storing, and distributing vaccines at the correct temperature.
- Aims to maintain vaccine potency throughout the process.
- Essential components include personnel, appropriate equipment (refrigerators, freezers, cold rooms, cold boxes, vaccine carriers, etc.), transport facilities, maintenance of equipment, and monitoring.
Vaccine Production
- Vaccines are produced from disease-causing microorganisms or toxins.
- Three types are used:
- Live microorganisms (weakened): Measles, polio, tuberculosis.
- Killed microorganisms: Pertussis (used in DPT).
- Toxoids (inactivated toxins): Tetanus, diphtheria.
- Genetic engineering (recombinant DNA) is also used in vaccine production (e.g., Hepatitis B).
Vaccine Storage
- All vaccines need specific storage conditions to maintain potency.
- Storage temperatures vary by vaccine type, with some requiring extreme cold (e.g., -15 to -25°C).
- OPV, Measles, and Mumps -DT, Td, TT, and BCG.
- Vaccines are kept in refrigerators, freezers, and cold rooms.
Vaccine Storage Temperatures
- National level: up to 6 months storage (-15°C to -25°C) for some vaccines, 0 to +8°C for others.
- Regional level: up to 3 months storage, similar temperature ranges as above.
- District level: up to 1 month, similar temperature ranges as above.
- Health Facility level: up to 1 month, similar temperature ranges as above.
Vaccine Stability
- Vaccines are sensitive biological substances that lose potency over time.
- Loss of potency occurs faster when exposure is outside the recommended temperature ranges.
- This loss of potency is permanent and irreversible.
- The correct temperature is crucial for vaccine potency.
- Specific vaccines are highly sensitive to heat and light, requiring darker containers and storage in the dark if necessary.
- Live oral polio vaccine, measles (lyophilized), pertussis and mumps (lyophilized), Hepatitis B, DPT, DT and Td, BCG (lyophilized) and tetanus toxoid (all more sensitive to heat).
Vaccine Stability - Freezing
- Some vaccines are damaged by freezing (examples: DPT, DT, TD, Tetanus, Hep B)
- Other vaccines are not affected by freezing (e.g BCG, OPV (live attenuated vaccine), measles, mumps).
Vaccine Stability (Light)
- Certain vaccines (e.g., lyophilized Measles, BCG) are sensitive to light and should be kept in dark containers.
- Loss of potency due to light exposure is also permanent and irreversible.
Equipment
-
Storage: Refrigerators, freezers, walk-in cold rooms
-
Transport: Cold boxes, vaccine carriers, insulated containers
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Monitoring: Thermometers, cold chain monitors, vaccine vial monitors, freeze watch monitors
Cold Chain Monitoring
- Temperature monitoring is crucial to maintain potency.
- Different types of devices exist (alcohol/mercury thermometers, dials, liquid crystal thermometers, recording thermometers).
- A cold chain monitoring card (CCM) tracks temperatures throughout the cold chain.
Vaccine Vial Monitors (VVM)
- A new type of monitor applied directly to vaccine vials at the manufacturers.
- Monitors for heat exposure
- Changes color to indicate temperature exposure.
- VVMs provide a visual indication of exposure to heat damage and are an additional monitoring tool.
Vaccine Shipping Indicators
- Indicators that travel with vaccines.
- Some are temperature-sensitive dots that irreversibly change color (silver-gray to black) above a specific temperature (+48°C).
Freeze Indicators
- Devices used to measure the freezing temperatures.
- For freeze sensitive vaccines.
- Freeze tags, freeze watch monitors (temp. sensitive indicator)
Shake Test
- Used to detect if a vaccine vial has been frozen.
- Detects if sediments settle at a slower rate in frozen vials.
Domestic Refrigerators
- Maintaining correct temperatures is necessary, especially in locations with potential power outages and maintaining a constant supply of vaccines/supplies and diluents.
- Proper arrangement of vials and proper storage with protective ice packs to prevent cold injury
- Proper use of refrigerators.
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