Vaccination Protocols and Guidelines

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Questions and Answers

What is the recommended interval between doses for the Rotarix vaccine?

  • 2 weeks
  • 8 weeks
  • 6 weeks
  • 4 weeks (correct)

Which of the following populations should avoid the polysaccharide vaccine?

  • Patients with chronic lung disease
  • Children under 2 years
  • Asymptomatic HIV patients
  • Children in need of chemotherapy (correct)

What condition is a contraindication for the administration of the rotavirus vaccine?

  • Uncorrected congenital gastrointestinal malformation (correct)
  • History of asthma
  • Temporary flu virus
  • Mild allergy to dairy

Which vaccine has a protective efficacy of 88-91% against rotavirus gastroenteritis episodes?

<p>Rotateq (C)</p> Signup and view all the answers

At what age should the second dose of the Rotarix vaccine be given?

<p>24 weeks (B)</p> Signup and view all the answers

Which side effect is commonly associated with the oral live-attenuated rotavirus vaccine?

<p>Diarrhea (A)</p> Signup and view all the answers

What is the duration recommended for starting chemotherapy after receiving the polysaccharide vaccine?

<p>Less than 10 days prior to commencement (D)</p> Signup and view all the answers

Which of the following is not a possible high-risk condition for the receipt of the polysaccharide vaccine?

<p>Normal immune system (C)</p> Signup and view all the answers

What major change was introduced in the fourth edition of the national protocol book for Paediatrics?

<p>The content and colour scheme were updated. (D)</p> Signup and view all the answers

Which group primarily benefits from the fourth edition of the national protocol book for Paediatrics?

<p>Young doctors with limited paediatric exposure. (C)</p> Signup and view all the answers

What has been retained from the previous editions in the fourth edition?

<p>The layout of the current version. (B)</p> Signup and view all the answers

What future plans are mentioned for the protocol book beyond its current printed form?

<p>Release as an iOS and Android app. (B)</p> Signup and view all the answers

What is the primary reason for the production of the fourth edition of the protocol book?

<p>To help young doctors fill in knowledge gaps. (C)</p> Signup and view all the answers

Who provided a foreword for the fourth edition?

<p>Datuk Dr Noor Hisham bin Abdullah. (B)</p> Signup and view all the answers

What significant updates were made in the 2nd Print of the 4th Edition?

<p>Corrections for errors found in previous prints. (D)</p> Signup and view all the answers

What is the recommended interval for the primary series of the PCV vaccine in children under 2 years?

<p>1 month apart (C)</p> Signup and view all the answers

Which notable resource was incorporated into the fourth edition?

<p>The latest edition of a drug dosages handbook. (A)</p> Signup and view all the answers

Which group of children is recommended to receive the PCV vaccine at the ages of 12-15 months?

<p>High risk children (B)</p> Signup and view all the answers

What is NOT a side effect of the pneumococcal vaccine?

<p>Nausea (B)</p> Signup and view all the answers

Which of the following is NOT a contraindication for the pneumococcal vaccine?

<p>Recent travel (C)</p> Signup and view all the answers

What is the recommended schedule for unvaccinated high risk children aged 2-5 years for the pneumococcal vaccine?

<p>2 doses 6-8 weeks apart (A)</p> Signup and view all the answers

Which condition qualifies a child as high risk for receiving the pneumococcal vaccine?

<p>Nephrotic syndrome (B)</p> Signup and view all the answers

How many doses should unvaccinated infants aged 7-11 months receive for the pneumococcal vaccine?

<p>2 doses 1 month apart (D)</p> Signup and view all the answers

Which age group is NOT eligible for the single dose of the pneumococcal vaccine?

<p>Healthy children under 6 years (A)</p> Signup and view all the answers

What is the recommended interval for the second dose of Varicella for children aged 12 months and above?

<p>4 weeks apart (D)</p> Signup and view all the answers

Which fluid therapy is primarily used for circulatory support in the case of vascular collapse?

<p>Intravenous fluid therapy (A)</p> Signup and view all the answers

When should intravenous fluids be prescribed to a well child?

<p>When experiencing severe dehydration with ongoing losses (D)</p> Signup and view all the answers

Which vaccination requires consulting a doctor for the schedule based on the age of the child receiving the first dose?

<p>Meningococcal (A)</p> Signup and view all the answers

According to the guidelines, which calculation is used to determine an individual’s maintenance fluid requirements?

<p>Holliday and Segar formula (C)</p> Signup and view all the answers

What is a possible consequence of incorrectly prescribed or administered intravenous fluids?

<p>Potential hazards to the patient (D)</p> Signup and view all the answers

What is the primary reason for intravenous fluids to be given in the case of severe dehydration?

<p>To replace fluid and electrolyte deficit (C)</p> Signup and view all the answers

What is one of the important factors to monitor when administering intravenous fluids?

<p>Fluid balance (C)</p> Signup and view all the answers

What is the maintenance fluid requirement for a child weighing 29 kg according to the Holliday-Segar calculator?

<p>1680 mls (B)</p> Signup and view all the answers

In cases of sepsis, what is a critical factor to determine before starting intravenous fluid therapy?

<p>Plasma electrolytes (B)</p> Signup and view all the answers

For the first 10 kg of body weight, how much fluid is allocated per kg in the Holliday-Segar calculator?

<p>100 ml/kg (C)</p> Signup and view all the answers

Which condition is least likely to require increased fluid administration in children?

<p>Routine hydration (A)</p> Signup and view all the answers

What is the infusion rate per hour for a child weighing 21 kg after calculating total fluid requirements?

<p>70 mls/hour (A)</p> Signup and view all the answers

What is an acceptable estimation for insensible losses per square meter in a 24-hour period?

<p>300-400 mls/m2/24 hours (B)</p> Signup and view all the answers

Children requiring fluid replacement for ongoing losses often have which of the following conditions?

<p>Cystic fibrosis (C)</p> Signup and view all the answers

What category of weight in the Holliday-Segar calculation contributes 1 ml/kg/hour to the infusion rate?

<p>All additional kg (D)</p> Signup and view all the answers

What is the recommended maximum rate at which serum sodium should decrease during rehydration in hypernatremic states?

<p>0.5 mmol/l per hour (A)</p> Signup and view all the answers

Which fluid is recommended for replacing ongoing losses due to profuse diarrhea?

<p>0.9% Normal Saline (D)</p> Signup and view all the answers

In the case of severe hypernatremia, which serum sodium level is considered severe?

<blockquote> <p>160 mmol/l (B)</p> </blockquote> Signup and view all the answers

Which clinical sign is NOT commonly associated with hypernatremic dehydration?

<p>Increased urination (D)</p> Signup and view all the answers

When replacing fluid losses, if a patient has lost 200ml over the previous 4 hours, what replacement rate is recommended for the next 4 hours?

<p>50ml/hr (C)</p> Signup and view all the answers

What is the daily sodium requirement for children?

<p>2-3 mmol/kg/day (C)</p> Signup and view all the answers

What condition can result in hypernatremia due to water deficit?

<p>Diabetes insipidus (D)</p> Signup and view all the answers

What is a common misconception regarding the appearance of children with hypernatremic dehydration?

<p>They may appear sicker than expected for their degree of dehydration (C)</p> Signup and view all the answers

Flashcards

Paediatric Protocols Book

The book was first created in 2005 and is a standard reference for medical professionals who work with children.

Paediatrics Protocol Book - 3rd Edition

The 3rd edition of the book was extremely popular among doctors.

Suboptimal Paediatrics Exposure

Doctors who work with children often don't have enough training in the subject in their undergraduate years.

Target Audience of Paediatrics Protocols

The book is intended for doctors working with children in different medical settings like hospitals and clinics.

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Paediatrics Protocols Accessibility

The book is made available for free download online and is being designed to be downloaded on mobile devices.

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Paediatrics Protocols Book Updates

The book is updated regularly and is available in both print and digital formats.

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Paediatrics Protocols Collaboration

The book is a collaborative effort, with many doctors contributing to its content.

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Frank Shann - Drug Doses Book

The book has drug dosages from a well-known handbook by Professor Frank Shann and can be purchased or downloaded.

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PCV13

A vaccine that protects against 13 strains of Streptococcus pneumoniae, a bacterium that causes pneumonia, ear infections, meningitis, and other illnesses.

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PCV7

A vaccine that protects against 7 strains of Streptococcus pneumoniae, a bacterium that causes pneumonia, ear infections, meningitis, and other illnesses.

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3-Dose Primary Series for PCV

A primary series of vaccines given to infants and young children to protect against Streptococcus pneumoniae. The series typically involves 3 doses given at least 1 month apart.

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PCV Booster Dose

A booster dose of the pneumococcal vaccine given to children between 12-15 months of age to strengthen their immunity against Streptococcus pneumoniae. This dose is usually given after the primary series is completed.

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Hypersensitivity Reaction to PCV

An allergic reaction to a previous pneumococcal vaccine. Symptoms may include irritability, drowsiness, restless sleep, fever, redness, swelling or pain at the injection site, and rash.

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Immunosuppression

A condition where a person's immune system is weakened, making them more susceptible to infections. This can be due to various factors, including HIV infection, certain medical conditions, or medications.

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High-Risk Children for Pneumococcal Infections

Children who are at increased risk of severe disease from pneumococcal infections, such as those with certain medical conditions, infants under 2 years of age, and those with weakened immune systems.

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Injection Routes for PCV

The preferred route of administration for pneumococcal vaccines is intramuscular, meaning the vaccine is injected into a muscle. In some cases, it can also be given subcutaneously, meaning it is injected under the skin.

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Pneumococcal Vaccine

A vaccine that protects against 23 strains of pneumococcal bacteria, which can cause serious infections like pneumonia, meningitis, and ear infections.

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Pneumococcal Polysaccharide Vaccine for High-Risk Adults

This vaccine is given in a single dose and is recommended for adults who are at high risk of pneumococcal infections, such as those with weakened immune systems, chronic lung disease, or other health conditions increasing their susceptibility to infections.

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Rotavirus Vaccine

A vaccine that protects against rotavirus, a common cause of severe diarrhea and dehydration in infants and young children.

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Varicella Vaccine

A vaccine that protects against chickenpox, a highly contagious viral disease that causes a rash and fever.

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Asplenia

A condition in which the spleen is absent or not functioning properly.

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Nephrotic Syndrome

A condition characterized by swelling in the body due to fluid buildup, often affecting the kidneys and other organs.

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Chronic Lung Disease

A chronic lung disease that can cause a person to be more susceptible to infections, including pneumococcal infections.

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Oral Rehydration in Well Children

Oral (given by mouth) fluids are the preferred method for rehydration in well children, as they provide adequate hydration and are safer than IV fluids.

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Holliday and Segar Formula

When IV fluids are necessary, the Holliday and Segar formula is a starting point for calculating fluid requirements based on weight.

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Uses of Intravenous Fluids

Intravenous fluids are used to support circulation, replace fluid deficits, provide daily fluid needs, replace ongoing losses, and manage severe dehydration when oral methods fail.

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Safe Use of IV Fluids

The correct use of IV fluids requires careful calculation and monitoring to ensure safety and prevent complications. Incorrectly prescribed or administered IV fluids can be harmful.

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Rotavirus Vaccination Schedule

The first dose of the Rotavirus vaccine should be given after the child is 6 weeks old. Follow the manufacturer’s instructions to determine the number and timing of subsequent doses.

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Meningococcal Vaccine for Travelers

Children travelling to high-risk areas should receive a single dose of the Meningococcal vaccine. This provides immunity for up to three years.

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Varicella Vaccination Schedule

Children 12 months and older require two doses of the Varicella (chickenpox) vaccine, spaced more than 4 weeks apart.

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Hepatitis A Vaccination Schedule

Children above 1 year old require two doses of the Hepatitis A vaccine, given 6-12 months apart.

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Who needs fluid management?

Children with specific needs like surgical recovery, fluid imbalances, infections, or chronic illnesses may need specific fluid management.

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How does the Holliday-Segar formula work?

The Holliday-Segar formula calculates the fluid requirements based on body weight, dividing it into three categories: the first 10 kg, the next 10 kg, and any additional weight, with different fluid amounts for each category.

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How is the hourly fluid rate calculated?

The Holliday-Segar formula calculates the total daily fluid requirement, then divides it by 24 hours to determine the hourly fluid infusion rate.

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What lab monitoring is needed for IV fluids?

Children requiring maintenance IV fluids should have their blood sugar and electrolytes checked when starting IV therapy and again after 24 hours.

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What is the process for calculating fluids using the Holliday-Segar formula?

Calculate the daily fluid requirement based on the Holliday-Segar formula and then divide it into hourly doses.

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How do we estimate insensible fluid loss?

The estimated insensible fluid loss in children is between 300-400 ml/m²/24 hours plus the urine output.

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How do we calculate the total fluid requirement?

The total fluid requirement is the sum of the calculated maintenance fluid and the estimated insensible losses plus urine output.

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What is the Body Surface Area (BSA) method?

The Body Surface Area (BSA) method can be used to calculate fluid needs, but it's important to understand the basics of the Holliday-Segar weight-based method.

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Daily Sodium Requirement for Children

The daily sodium requirement for a child is between 2 and 3 mmol/kg/day.

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Hypernatremia Definition

Hypernatremia is a condition where the serum sodium level is above 150 mmol/l.

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Moderate Hypernatremia

Moderate hypernatremia occurs when serum sodium levels are between 150-160 mmol/l.

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Severe Hypernatremia

Severe hypernatremia occurs when serum sodium levels are above 160 mmol/l.

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Causes of Hypernatremia

Causes of hypernatremia include water loss that exceeds sodium loss (e.g., diarrhea), water deficit (e.g., diabetes insipidus), and excessive sodium gain (e.g., large amounts of NaHCO3 infusion or salt poisoning).

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Clinical Appearance in Hypernatremic Dehydration

Children with hypernatremic dehydration may appear sicker than expected for the degree of dehydration they have.

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Symptoms of Hypernatremic Dehydration

Symptoms of hypernatremic dehydration predominantly relate to intracellular dehydration and neurological dysfunction.

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Management of Central Diabetes Insipidus in Hypernatremia

In cases of hypernatremia due to central diabetes insipidus, consult an endocrinologist.

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Study Notes

Paediatric Protocols (Malaysia)

  • Fourth edition, second printing of national protocol book for paediatrics, inspired by Sarawak Paediatric Protocols.
  • Main target audience: Young doctors preparing for district hospitals and health clinics.
  • Updated content and colour scheme maintains layout of previous edition.

Vaccine Schedules and Considerations

  • Pneumococcal (Polysaccharide): Recommended for high-risk children (under 2 and over 2 yrs.) Single dose for high risk over 2 years, revaccination within 3 years. Intramuscular or subcutaneous. Immunogenic in children ≥2 yrs, against 23 serotypes, booster at 3-5yrs in the healthy children; high risk children (immunosuppression, HIV, asplenia, nephrotic syndrome, chronic lung disease). Avoid during chemotherapy/radiotherapy.
  • Rotavirus: First dose for infants ≥6 weeks old (Rotateq – 3 doses, Rotarix – 2 doses; doses dependent of infant age: different schedule). Contraindications include prior hypersensitivity to vaccine components or uncorrected congenital GIT malformation. Side effects often include loss of appetite, irritability, fever, and diarrhoea. Live-attenuated vaccine; protective efficacies range from 63 – 91%.
  • Varicella (Chickenpox): For children 12 months to 12 years, scheduled dosing dependent on patient age & first vaccination. Live attenuated vaccine; pregnant patients contraindicated.
  • Meningococcal: Recommended for children travelling to high-risk areas; single dose, providing immunity for up to 3 years.
  • Hepatitis A: For children above 1 year; 2 doses, 6-12 months apart.

Paediatric Fluid and Electrolyte Guidelines

  • IV fluids used for circulatory support, deficit replacement, maintenance, and ongoing losses.
  • Holliday-Segar formula for calculating maintenance fluid requirements based on weight.
  • Close monitoring through clinical observation, fluid balance, weight, and daily electrolyte profiles is crucial.
  • Fluid losses >0.5ml/kg/hr require replacement.
  • Calculation can be based on previous hour or 4 hour period. For example, a 200ml loss over 4 hours will be replaced at a rate of 50ml/hr for the next 4 hours.
  • Ongoing losses replaced with normal saline or Hartmann’s solution; protein-rich losses/low albumin leads to 5% human albumin.
  • Fluid therapy is crucial to calculating maintenance rates, including insensible losses (300-400ml/m2/24 hours) + urine output.

Sodium Disorders

  • Normal serum sodium (135-145mmol/l)
  • Hypernatremia (serum Na+>150mmol/l) defined as moderate (150-160mmol/l) or severe (>160mmol/l): can be due to water loss or deficit, or sodium gain.
  • Symptoms include irritability, doughy skin, ataxia, tremor, hyperreflexia, seizures, reduced awareness, and coma.
  • Consult Endocrinology for hypernatremia due to central diabetes insipidus.

Drug Dosages

  • Frank Shann-Drug Doses Book (17th edition) incorporated.
  • Available through [email protected], iOS/Android stores, and www.drugdoses.com (printed versions available to MOH facilities only).

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