β Thalassemia Major Study

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Questions and Answers

Which physiological abnormalities are associated with beta thalassemia major?

  • High calcium levels, reduced oxidative stress, and abnormal hemoglobin structure
  • Iron overload, oxidative stress, and aggregated β-globin proteins (correct)
  • Low iron levels, reduced oxidative stress, and aggregated α-globin proteins
  • High cholesterol levels, increased oxidative stress, and abnormal RBC size

What is the main role of acetylcholinesterase (AChE) in RBCs of beta thalassemia patients?

  • Producing amyloid β (Aβ) peptides
  • Regulating calcium levels
  • Participating in reactive oxygen species (ROS) production (correct)
  • Preventing inflammatory stress

Which membrane bound proteins show increased contents in RBCs of beta thalassemia patients?

  • ATP synthase and cytochrome c
  • Hemoglobin and myoglobin
  • Glutathione peroxidase and catalase
  • Cyclooxygenase-2 (COX-2) and CD38 (correct)

Which factor is implicated in the upregulation of cyclooxygenase-2 (COX-2) and CD38 in RBCs of beta thalassemia patients?

<p>Iron overload (A)</p> Signup and view all the answers

What is the main cause of oxidative stress in beta thalassemia major?

<p>Iron overload and increased amyloid β (Aβ) peptides (A)</p> Signup and view all the answers

Which process is induced by the overproduction of amyloid β (Aβ) peptides in RBCs?

<p>Cell death, named eryptosis (D)</p> Signup and view all the answers

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