Dopamine Drugs

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Paris (correct)
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Berlin
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A patient presents to you with Parkinson's disease and you wish to provide them with a drug that gets converted to DA in the CNS. Which drug are you thinking of?

L-Dopa

What does Carbidopa achieve?

Carbidopa - used in adjunct with L-Dopa to prevent the conversion of L-Dopa to DA early in the periphery. Carbidopa is the gatekeeper of L-Dopa ensuring the drug gets to the CNS without being converted so that there in the brain it can then become DA

What class of drug is Entacapone and what does it achieve?

COMT inhibitor --> inhibits the breakdown of L-Dopa in the periphery since COMT likes to break down L-Dopa before the poor drug reaches the CNS and converts into DA. Thus, Entacapone is used as an adjunct with L-Dopa to ensure effectiveness

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What type of drug is Selegine and what is it's MOA?

Selegine is an MAO inhibitor - it works by inhibiting the breakdown of residual DA from the CNS thus ensuring DA stays in the CNS a while --> used as adjunct

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