Urinary System and Kidney Function Quiz M 3.1

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Questions and Answers

What happens to the number of nephrons as a person ages?

  • The number of nephrons remains constant.
  • The number of nephrons doubles after age 40.
  • The number of nephrons increases significantly.
  • The number of nephrons gradually decreases. (correct)

Which statement best describes the function of the glomerulus?

  • It converts filtered fluid into urine.
  • It filters large amounts of fluid. (correct)
  • It encases the renal pelvis.
  • It reabsorbs nutrients back into the bloodstream.

What distinguishes cortical nephrons from juxtamedullary nephrons?

  • Cortical nephrons are located in the inner medulla.
  • Cortical nephrons are more numerous than juxtamedullary nephrons.
  • Cortical nephrons have short loops of Henle. (correct)
  • Cortical nephrons have longer loops of Henle.

What occurs after fluid flows into Bowman's capsule?

<p>It enters the proximal tubule. (C)</p> Signup and view all the answers

How is hydrostatic pressure in glomerular capillaries characterized?

<p>It is high compared to other capillaries. (A)</p> Signup and view all the answers

Which of the following structures is the last component before the renal pelvis?

<p>Cortical collecting tubule. (A)</p> Signup and view all the answers

At what age does the decline in nephron number typically begin?

<p>40 years (A)</p> Signup and view all the answers

What is the role of the macula densa in the nephron?

<p>To monitor sodium concentration. (D)</p> Signup and view all the answers

What is the primary structure through which blood enters the kidneys?

<p>Hilum (A)</p> Signup and view all the answers

Which two major regions are found within the kidney?

<p>Cortex and medulla (D)</p> Signup and view all the answers

How much blood flow do the kidneys receive as a percentage of cardiac output?

<p>22% (B)</p> Signup and view all the answers

What is the role of the glomerular capillaries?

<p>Filter large amounts of fluid and solutes (A)</p> Signup and view all the answers

What is unique about renal circulation compared to other circulatory systems?

<p>It has two capillary beds (A)</p> Signup and view all the answers

Where do the renal pyramids meet within the kidney?

<p>At the papilla (B)</p> Signup and view all the answers

What causes rapid fluid filtration in the glomerular capillaries?

<p>High hydrostatic pressure (A)</p> Signup and view all the answers

What benefit does low hydrostatic pressure in tubular capillaries provide?

<p>Allows for fluid reabsorption (A)</p> Signup and view all the answers

What happens to substances that are freely filtered at the glomerulus but neither reabsorbed nor secreted?

<p>They remain unchanged in concentration in the urine. (A)</p> Signup and view all the answers

Which of the following substances is likely to be partially reabsorbed after being filtered?

<p>Sodium ions (A)</p> Signup and view all the answers

What characterizes substances that are filtered at the glomerulus but not present in the urine?

<p>They are completely reabsorbed back into the bloodstream. (B)</p> Signup and view all the answers

Which statement best describes the handling of acids in the nephron?

<p>They can be filtered and additional quantities can be secreted. (A)</p> Signup and view all the answers

What is the primary formula that illustrates how substances are handled by the nephron?

<p>Excretion = Filtration - Reabsorption + Secretion (C)</p> Signup and view all the answers

Which of the following substances is highly reabsorbed, resulting in a small amount appearing in the urine?

<p>Electrolytes (A)</p> Signup and view all the answers

How does tubular reabsorption compare to tubular secretion in the process of urine formation?

<p>Reabsorption is generally more important than secretion. (A)</p> Signup and view all the answers

Which best describes the fate of waste products like creatinine in the nephron?

<p>They are filtered without any reabsorption or secretion. (A)</p> Signup and view all the answers

What initiates peristaltic contractions in the ureters?

<p>Inherent pacemaker activity (C)</p> Signup and view all the answers

How does the sympathetic nervous system affect peristaltic contractions in the ureters?

<p>Inhibits the contractions (A)</p> Signup and view all the answers

What occurs when the stretch reflex in the bladder is activated?

<p>Stimulation of bladder contraction (A)</p> Signup and view all the answers

What is the primary role of the higher centers in the cerebral cortex related to urination?

<p>To help inhibit the external sphincter (D)</p> Signup and view all the answers

What is the result of voluntary urination?

<p>Contraction of the abdominal muscles (C)</p> Signup and view all the answers

What is NOT a process involved in urine excretion?

<p>Absorption (D)</p> Signup and view all the answers

What happens to urine composition after it enters the renal pelvis?

<p>It remains unchanged (A)</p> Signup and view all the answers

How much urine typically remains in the bladder after complete emptying?

<p>5 to 10 ml (D)</p> Signup and view all the answers

What is the primary function of the vasa recta in the kidney?

<p>Formation of concentrated urine (C)</p> Signup and view all the answers

What initiates the attrition reflex in the urinary bladder?

<p>Full bladder causing tension in the walls (A)</p> Signup and view all the answers

Which part of the bladder is primarily responsible for collecting urine?

<p>Body (A)</p> Signup and view all the answers

What allows action potentials to spread quickly throughout the smooth muscle of the bladder?

<p>Low resistance electrical pathways created by fused cells (C)</p> Signup and view all the answers

What role does the internal sphincter play in bladder function?

<p>Prevents emptying of the bladder until a threshold pressure is met (C)</p> Signup and view all the answers

Which nerves are primarily responsible for the innervation of the bladder?

<p>Pelvic nerves (B)</p> Signup and view all the answers

What type of muscle is the external sphincter of the bladder?

<p>Voluntary skeletal muscle (D)</p> Signup and view all the answers

How do sympathetic fibers affect the bladder?

<p>Connect primarily to blood vessels with little effect on bladder contraction (C)</p> Signup and view all the answers

Which of the following waste products are eliminated from the body primarily by the kidneys?

<p>Urea, creatine, uric acid, bilirubin (B)</p> Signup and view all the answers

What is the primary stimulus for erythropoietin secretion in individuals with severe kidney disease?

<p>Hypoxia (D)</p> Signup and view all the answers

What is the primary role of the kidneys in regulating arterial blood pressure?

<p>Regulating sodium and water reabsorption (D)</p> Signup and view all the answers

Which of the following hormones is produced by the kidneys and is essential for calcium absorption from the gastrointestinal tract?

<p>1,25-dihydroxyvitamin D3 (B)</p> Signup and view all the answers

What is the role of the kidneys in maintaining acid-base balance?

<p>Excrete excess hydrogen ions through urine (A)</p> Signup and view all the answers

Why does an increase in sodium intake lead to a temporary increase in cellular fluid volume?

<p>Sodium attracts water, causing an increase in fluid volume. (A)</p> Signup and view all the answers

Which of the following is NOT a function of the kidneys?

<p>Regulation of blood glucose levels (B)</p> Signup and view all the answers

What is the primary function of the kidneys?

<p>To filter the blood and eliminate waste products (A)</p> Signup and view all the answers

Flashcards

Functions of Kidneys

The kidneys filter plasma, remove waste, and regulate body fluids.

Waste Products

Includes urea, creatinine, uric acid, bilirubin, and hormone metabolites.

Homeostasis

The kidneys adjust excretion rates to match fluid and electrolyte intake.

Erythropoietin

Hormone secreted by kidneys to stimulate red blood cell production.

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Acid-Base Regulation

Kidneys help manage pH balance alongside lungs and buffers.

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Vitamin D Activation

Kidneys produce 1,25-dihydroxyvitamin D, essential for calcium metabolism.

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Gluconeogenesis

Process of synthesizing glucose from amino acids during fasting.

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Electrolyte Regulation

Kidneys regulate sodium, chloride, potassium, calcium, and more.

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Vasa Recta

Specialized blood vessels in the kidney loops aiding urine concentration.

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Attrition Reflex

Nervous reflex triggering bladder emptying or desire to urinate.

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Bladder Body

Main part of the bladder where urine collects.

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Bladder Neck

Connects the bladder to the urethra, regulates urine release.

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Internal Sphincter

Smooth muscle preventing bladder emptying until pressure rises.

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External Sphincter

Voluntary skeletal muscle controlling urination.

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Pelvic Nerves

Nerves involved in bladder sensation and contraction.

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Parasympathetic Innovation

Nerve signals that stimulate bladder contraction.

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Kidney Structure

The kidneys are bean-shaped organs located on the posterior abdomen.

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Hilum

The hilum is the medial part of the kidney where blood vessels and nerves enter.

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Cortex and Medulla

The kidney has an outer cortex and inner medulla, where functions occur.

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Renal Pyramids

The medulla is divided into 8-10 renal pyramids that collect urine.

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Renal Pelvis

The renal pelvis collects urine from the major calyces to direct it to the ureters.

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Blood Flow to Kidneys

Kidneys receive about 22% of cardiac output, roughly 1100 mL per minute.

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Glomerular Filtration

The glomerulus filters large amounts of fluid and solutes to begin urine formation.

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Peritubular Capillaries

These capillaries surround renal tubules and are involved in fluid reabsorption.

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Ureters

Muscular tubes that transport urine from kidneys to bladder, 25-35 cm long.

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Peristaltic contractions

Involuntary muscle contractions that move urine through the ureters.

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Stretch reflex in bladder

Reflex that triggers bladder contractions when filled, amplifying signals.

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Positive feedback loop

A cycle where an initial action leads to an increase in the same action.

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Urine excretion calculation

Urine excretion equals filtration minus reabsorption plus secretion.

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Bowman's capsule

Structure where protein-free fluid first enters during filtration in kidneys.

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Smooth muscle innervation

Ureters controlled by sympathetic and parasympathetic nerves for contraction regulation.

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Hydrostatic Pressure

The pressure exerted by a fluid at equilibrium due to gravity, affecting filtration rates in kidneys.

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Nephrons

The functional filtration units of the kidneys, approximately 1 million per kidney.

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Glomerulus

A network of capillaries that filters blood into Bowman's capsule to start urine formation.

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Loop of Henle

A U-shaped part of the nephron that reabsorbs water and salt, consisting of descending and ascending limbs.

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Macula Densa

Specialized epithelial cells at the thick ascending limb of the Loop of Henle, involved in regulating blood pressure.

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Cortical Nephrons

Nephrons located in the outer cortex of the kidney with short loops of Henle.

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Juxtamedullary Nephrons

Nephrons with long loops of Henle that extend deep into the medulla, enhancing water reabsorption.

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Nephron function

The nephron modifies fluid through reabsorption and secretion of substances.

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Excretion rate

The amount of substance excreted equals the filtration rate when not reabsorbed or secreted.

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Creatinine handling

Creatinine is filtered but not reabsorbed or secreted, showing direct filtration relation.

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Partial reabsorption

Substances filtered and partially reabsorbed change concentration in urine.

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Glucose reabsorption

Glucose is filtered and completely reabsorbed back into the blood, not in urine.

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Secretion in nephron

Some filtered substances are not reabsorbed and additional quantities are secreted into the renal tubules.

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Excretion formula

The formula for excretion is: excretion = filtration - reabsorption + secretion.

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Importance of reabsorption

Tubular reabsorption is crucial for urine formation, exceeding the role of secretion for most substances.

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Study Notes

Urinary System and Kidney Function

  • Kidneys filter plasma, removing waste and regulating: water balance, electrolyte balance, body fluid osmolality, electrolyte concentrations, arterial pressure, acid-base balance, erythrocyte production, hormone secretion, metabolism, and excretion, and gluconeogenesis.
  • Kidneys eliminate metabolic wastes (urea, creatine, uric acid, bilirubin, hormones).
  • Water and electrolyte excretion rates adjust to match intake for homeostasis.
  • Kidneys regulate sodium, chloride, potassium, calcium, hydrogen, magnesium, and phosphate.
  • Kidneys are critical for long-term arterial blood pressure regulation.
  • Kidneys help regulate acid-base balance, alongside lungs and buffer system.
  • Kidneys produce erythropoietin to stimulate red blood cell production. Hypoxia is a main stimulus.
  • Kidneys produce 1-5 hydroxyvitamin D3 (active form of vitamin D) essential for calcium deposition in bone and calcium reabsorption.
  • Kidneys perform gluconeogenesis (glucose synthesis from amino acids) during prolonged fasting.

Kidney Anatomy and Structure

  • Kidneys lie on posterior abdominal wall, weighing ~150g each.
  • Size of a clenched fist, medial side has hilum (where renal artery, vein, lymphatics, nerve supply pass).
  • Two main regions: outer cortex, inner medulla, divided into pyramids.
  • Pyramid bases at cortex-medulla border, tips (papillae) collect urine.
  • Urine collected by minor calices, then major calices, forming renal pelvis.
  • Urine travels to bladder via ureters.

Renal Blood Flow and Filtration

  • ~22% cardiac output flows to kidneys (~1100 ml/min).
  • Renal artery branches, forming interlobar, arcuate, and interlobular arteries, leading afferent arterioles and glomerular capillaries.
  • Glomeruli filter large amounts of fluid and solutes, starting urine formation.
  • Filtered fluid flows to peri-tubular capillaries, surrounding renal tubules.
  • High glomerular hydrostatic pressure drives rapid filtration.
  • Adjustments to afferent and efferent arterioles regulate hydrostatic pressure for tubular reabsorption.

Nephron Structure and Function

  • Each kidney has ~800,000-1,000,000 nephrons.
  • Nephron consists of glomerulus (capillary network) and a long tubule.
  • Bowman's capsule surrounds glomerulus, collecting filtered fluid.
  • Filtered fluid moves into proximal tubule, then loop of Henle (descending/ascending limbs), distal tubule, and collecting duct.
  • Loop of Henle includes specialized cells (macula densa) for regulating reabsorption/secretion.

Urine Formation

  • Glomerular filtration, tubular reabsorption, and tubular secretion.
  • Substances can be freely filtered, reabsorbed, or secreted.
  • Kidney functions to make urine and maintaining homeostasis by filtering, regulating, or excreting substances to maintain healthy levels.
  • Urinary excretion = filtration - reabsorption + secretion.

Kidney Function Summary

  • Important in removing waste products from the body, maintaining fluid and electrolyte balance, and regulating blood pressure.
  • Filtration rate (180L/day) allows processing plasma ~60 times daily

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