Podcast
Questions and Answers
In which clinical condition is ammonia level within normal range, while urea level increases in the blood?
In which clinical condition is ammonia level within normal range, while urea level increases in the blood?
- Hyperammonemia
- Hepatic failure
- Renal failure (correct)
- Portal hypertension
What is the consequence of ammonia accumulation in the brain on the TCA cycle?
What is the consequence of ammonia accumulation in the brain on the TCA cycle?
- Stimulation of the urea cycle
- Debilitation of energy production (correct)
- Increase in energy production
- No effect on energy production
What is the role of glutamate dehydrogenase enzyme in the brain?
What is the role of glutamate dehydrogenase enzyme in the brain?
- Regulating the urea cycle
- Activating N-acetyl glutamate
- Converting glutamate to α-ketoglutarate acid
- Reacting ammonia with α-ketoglutarate acid to form glutamate (correct)
What is the consequence of collateral circulation in liver cirrhosis?
What is the consequence of collateral circulation in liver cirrhosis?
What is the primary source of energy for the brain?
What is the primary source of energy for the brain?
What is the primary location where ammonia is converted into non-toxic urea?
What is the primary location where ammonia is converted into non-toxic urea?
Which enzyme requires N-acetyl glutamate as an activator in the urea cycle?
Which enzyme requires N-acetyl glutamate as an activator in the urea cycle?
What is the immediate product of the reaction between CO2 and ammonia in the urea cycle?
What is the immediate product of the reaction between CO2 and ammonia in the urea cycle?
What is the rate-limiting enzyme in the urea cycle that is allosterically activated by N-acetyl glutamate?
What is the rate-limiting enzyme in the urea cycle that is allosterically activated by N-acetyl glutamate?
What is a potential cause of hyperammonemia?
What is a potential cause of hyperammonemia?
What is the source of CO2 needed for the first step of the urea cycle?
What is the source of CO2 needed for the first step of the urea cycle?
What is the TCA cycle intermediate produced in the urea cycle after the deamination of glutamate?
What is the TCA cycle intermediate produced in the urea cycle after the deamination of glutamate?
What is the result of a defect in the ornithine transporter in the urea cycle?
What is the result of a defect in the ornithine transporter in the urea cycle?
How many ATP molecules are required for the first step of the urea cycle, catalyzed by carbamoyl phosphate synthase I?
How many ATP molecules are required for the first step of the urea cycle, catalyzed by carbamoyl phosphate synthase I?
What is the role of N-acetyl glutamate in the urea cycle?
What is the role of N-acetyl glutamate in the urea cycle?
What is the consequence of liver cell dysfunction on the urea cycle?
What is the consequence of liver cell dysfunction on the urea cycle?
What is the relationship between the urea cycle and the TCA cycle?
What is the relationship between the urea cycle and the TCA cycle?
