5 Questions
What type of neoplasia invades neighboring tissues and metastasizes to distant sites?
Malignant neoplasia
Which gene mutations are directly involved in the development of cancer?
Driver gene mutations
Which mechanism is involved in repairing single-strand DNA breaks?
Mismatch repair
Which proteins are involved in double-strand DNA repair through homologous recombination?
BRCA1, BRCA2
What is the most common cause of DNA damage from extrinsic factors?
UV radiation
Study Notes
Neoplasia and Cancer Development
- Malignant neoplasia invades neighboring tissues and metastasizes to distant sites.
Genetic Mutations in Cancer Development
- Tumor suppressor genes (e.g., TP53) and oncogenes (e.g., RAS) are directly involved in the development of cancer.
DNA Repair Mechanisms
- Base excision repair is the mechanism involved in repairing single-strand DNA breaks.
Double-Strand DNA Repair
- BRCA1, BRCA2, and RAD51 proteins are involved in double-strand DNA repair through homologous recombination.
DNA Damage Causes
- Ultraviolet (UV) radiation is the most common cause of DNA damage from extrinsic factors.
Test your knowledge of the upper limb skeletal structure, pectoral region, arm, forearm, and hand anatomy. Explore the osseofascial compartments of the forearm, identify muscles, and understand their attachments, innervation, and actions.
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