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What is a carrier in the context of infectious diseases?
What is a carrier in the context of infectious diseases?
What is the primary difference between an incubatory carrier and a convalescent carrier?
What is the primary difference between an incubatory carrier and a convalescent carrier?
What is a contact carrier?
What is a contact carrier?
What is the primary characteristic of a healthy carrier?
What is the primary characteristic of a healthy carrier?
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How long can an untreated case remain infectious?
How long can an untreated case remain infectious?
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What is the main difference between an untreated case and a carrier?
What is the main difference between an untreated case and a carrier?
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What is a common example of an acute, self-limited disease?
What is a common example of an acute, self-limited disease?
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What is the importance of carriers?
What is the importance of carriers?
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What is the primary reason for excluding susceptible contacts from school in the early days of highly infectious diseases?
What is the primary reason for excluding susceptible contacts from school in the early days of highly infectious diseases?
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What is the goal of eradication of infectious diseases?
What is the goal of eradication of infectious diseases?
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What is the purpose of bacteriological examination of contacts of enterica and diphtheria?
What is the purpose of bacteriological examination of contacts of enterica and diphtheria?
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What is the primary mechanism of transmission in Inutero Infection?
What is the primary mechanism of transmission in Inutero Infection?
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What is the purpose of isolating contacts of certain diseases?
What is the purpose of isolating contacts of certain diseases?
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What is the goal of health education in community control measures?
What is the goal of health education in community control measures?
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What is the outcome of Lethal Inutero Infection?
What is the outcome of Lethal Inutero Infection?
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What is the third way of Vertical Infection transmission?
What is the third way of Vertical Infection transmission?
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What is the measure of control of environment in community control measures?
What is the measure of control of environment in community control measures?
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What is the purpose of super chlorination of water supply?
What is the purpose of super chlorination of water supply?
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What is the role of host factors in the infectious cycle?
What is the role of host factors in the infectious cycle?
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What is the purpose of epidemiologic study and investigation?
What is the purpose of epidemiologic study and investigation?
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What is the primary function of natural barriers of infection?
What is the primary function of natural barriers of infection?
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What is the bactericidal effect of sweat related to?
What is the bactericidal effect of sweat related to?
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What is the golden rule of treating others?
What is the golden rule of treating others?
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What is the role of cilia of epithelial lining in the respiratory tract?
What is the role of cilia of epithelial lining in the respiratory tract?
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What is a key aspect of effective speaking?
What is a key aspect of effective speaking?
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What is essential for effective listening?
What is essential for effective listening?
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What is the result of stimulation of the immune system?
What is the result of stimulation of the immune system?
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What is important for effective communication?
What is important for effective communication?
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Why is it important to manage your facial expressions?
Why is it important to manage your facial expressions?
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What is the term for infection transmitted through contaminated food or water?
What is the term for infection transmitted through contaminated food or water?
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What is a key aspect of an effective attitude for communication?
What is a key aspect of an effective attitude for communication?
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Which of the following infections can be transmitted through more than one mode?
Which of the following infections can be transmitted through more than one mode?
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What is the route of entry for arthropod-borne infection?
What is the route of entry for arthropod-borne infection?
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What is the term for infection transmitted from mother to fetus during pregnancy?
What is the term for infection transmitted from mother to fetus during pregnancy?
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What is the primary mode of transmission for tetanus?
What is the primary mode of transmission for tetanus?
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What is the term for infection transmitted through direct inhalation of droplet spray?
What is the term for infection transmitted through direct inhalation of droplet spray?
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What is a predisposing factor for direct droplet infection?
What is a predisposing factor for direct droplet infection?
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What is the route of entry for in-utero infection?
What is the route of entry for in-utero infection?
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Study Notes
Types of Infection
- Cases show manifestations of disease and are infectious for a varied period of time depending on the nature of the disease and whether specific therapy is available and properly given or not.
- Untreated cases are usually infectious throughout the clinical course of the disease, which varies in different diseases.
Carriers
- A carrier is an apparently healthy person who is infected and harbors a pathogenic organism in their body, without showing manifestations of disease, but is infectious and can spread infection.
- Importance of carriers: they are clinically healthy, not known, move freely, are a large number, and are a dangerous group.
- Types of carriers:
- Incubatory carrier: infectious during the incubation period.
- Convalescent carrier: a certain percentage of convalescents (recovered cases) continue to harbor the causative organism in particular foci for a varied period of time.
- Contact carrier: contacts of cases or carriers of some infectious diseases may be infected but not diseased.
- Healthy carrier: inhabitants of endemic areas of infectious diseases may get infected from a polluted environment.
Modes of Transmission
- Ingestion infection (food-borne infection)
- Arthropod-borne infection (insect-borne infection, vector-borne infection)
- Contact infection (including percutaneous infection)
- Occasional modes of transmission:
- Injection infection: a form of contact infection
- In-utero infection: congenital infection, vertical infection (including transplacental infection)
Entry of Infection
- Respiratory tract: for respiratory (droplet) infection
- Gastrointestinal tract: for ingestion infection
- Percutaneous route: for arthropod-borne infection, wound infection, and injection infection
- Skin and mucous membranes: for other contact infections
- Fetal circulation: for in-utero infection
Droplet Infection
- Modes of transmission:
- Direct droplet infection: both the reservoir of infection and the new host are found together within the same place
- Indirect droplet infection: reservoirs and hosts do not come together, infection is transmitted by airborne infection, contaminated articles, and fomites
In-Utero Infection
- It is infection transmitted from the pregnant to the fetus either:
- Early infection in the first trimester, before formation of the placenta
- Trans-placental infection, after formation of the placenta
- Hazards of in-utero infection: unfavorable outcome of pregnancy that may be either:
- Lethal: abortion, stillbirth, or neonatal mortality
- Sublethal: congenital anomalies and malformations (deformities)
Vertical Infection
- Mother to infant infection, called “vertical infection”
- Vertical infection is transmitted in three ways:
- In-utero infection
- Perinatal infection: infection acquired from the infected birth canal during childbirth
- Breast-feeding: infection through nursing (lactation of) the baby (CMV-HIV-HBV& HCV)
Exposed Host
- The host is the third link of the infectious cycle
- When infected, infection either passes unnoticed or is followed by disease, according to certain agent and host factors
- Host factors are related to body resistance (nonspecific) and immunity (specific) factors
Defense Mechanism of the Body
- Defense mechanism is made of two components:
- Natural barriers of infection:
- Healthy epithelial surfaces (skin and mucous membranes) form the first line of defense that prevents invasion of the body by organisms
- Skin: intact surface is a natural barrier (undamaged), bactericidal effect of sweat
- Respiratory tract: defense is due to hair, cilia of epithelial lining, sneezing, and coughing help elimination of infection
- Natural barriers of infection:
Community Control Measures
- Applied preventive measures: measures of primary prevention related to particular disease involving a group or community are applied
- Control of environment: control of vehicles and vectors, e.g., adequate ventilation and spacing, super chlorination of water supply, and sanitary collection and disposal of community
- Health education: specific prevention
- Control measures:
- Case-finding and control of cases and contacts
- Epidemiologic study and investigation to trace sources and channels of infection
- Drastic control measures: to be taken if necessary, e.g., closing schools, and food markets
Eradication of Infectious Disease
- It is getting rid of the causative organism, and consequently of the disease, in a certain area, country, or worldwide: no reported cases, nor reservoirs of infection
- Eradication, however, has been achieved for a limited number of infections, otherwise it is practically difficult to fulfill, especially in developing countries
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