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Questions and Answers
What percentage of congenital heart diseases are caused by chromosomal genetic defects?
What percentage of congenital heart diseases are caused by chromosomal genetic defects?
What type of lesion is characterized by a blockage or narrowing of a blood vessel?
What type of lesion is characterized by a blockage or narrowing of a blood vessel?
What is the name of the defect in which there is a hole in the wall separating the two upper chambers of the heart?
What is the name of the defect in which there is a hole in the wall separating the two upper chambers of the heart?
What is the term for a heart defect in which the pulmonary artery and aorta are reversed?
What is the term for a heart defect in which the pulmonary artery and aorta are reversed?
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What is the term for a heart defect in which there is a hole in the wall separating the two lower chambers of the heart?
What is the term for a heart defect in which there is a hole in the wall separating the two lower chambers of the heart?
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What is the primary purpose of an echocardiogram in the diagnosis of a congenital heart defect?
What is the primary purpose of an echocardiogram in the diagnosis of a congenital heart defect?
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What is the benefit of early use of indomethacin to close a PDA soon after birth?
What is the benefit of early use of indomethacin to close a PDA soon after birth?
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Where is the incision made during PDA surgery?
Where is the incision made during PDA surgery?
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What is the normal course of development for the hole between the two atria in infants?
What is the normal course of development for the hole between the two atria in infants?
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What is the result of oxygen-rich blood flowing through the hole in the septum into the right ventricle?
What is the result of oxygen-rich blood flowing through the hole in the septum into the right ventricle?
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What is the term for the extra noise created by blood flowing through the hole in the septum?
What is the term for the extra noise created by blood flowing through the hole in the septum?
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What is the treatment for a child with a small VSD that causes no symptoms?
What is the treatment for a child with a small VSD that causes no symptoms?
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What is a common lung problem associated with Tetralogy of Fallot?
What is a common lung problem associated with Tetralogy of Fallot?
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What is the purpose of a prostaglandin infusion in Tetralogy of Fallot treatment?
What is the purpose of a prostaglandin infusion in Tetralogy of Fallot treatment?
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What is the term for the sudden drop in arterial blood gases in Tetralogy of Fallot?
What is the term for the sudden drop in arterial blood gases in Tetralogy of Fallot?
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What is the purpose of a synthetic Dacron patch in Tetralogy of Fallot surgery?
What is the purpose of a synthetic Dacron patch in Tetralogy of Fallot surgery?
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What is the term for the narrowing of the pulmonary valve and outflow tract in Tetralogy of Fallot?
What is the term for the narrowing of the pulmonary valve and outflow tract in Tetralogy of Fallot?
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What is the result of right ventricular hypertrophy in Tetralogy of Fallot?
What is the result of right ventricular hypertrophy in Tetralogy of Fallot?
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What is the term for the loud murmur or blue lips and skin in Tetralogy of Fallot?
What is the term for the loud murmur or blue lips and skin in Tetralogy of Fallot?
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What is the primary goal of corrective repair of Tetralogy of Fallot?
What is the primary goal of corrective repair of Tetralogy of Fallot?
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What is a common symptom of mitral valve prolapse?
What is a common symptom of mitral valve prolapse?
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What is a risk factor for mitral valve prolapse?
What is a risk factor for mitral valve prolapse?
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What is the purpose of beta blockers in managing mitral valve prolapse?
What is the purpose of beta blockers in managing mitral valve prolapse?
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What is the name of the diagnostic test that uses X-rays to produce images of the chest?
What is the name of the diagnostic test that uses X-rays to produce images of the chest?
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What is the purpose of diuretics in managing mitral valve prolapse?
What is the purpose of diuretics in managing mitral valve prolapse?
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What is the name of the procedure that involves repairing or replacing the mitral valve?
What is the name of the procedure that involves repairing or replacing the mitral valve?
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What is myocarditis?
What is myocarditis?
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What is the purpose of aspirin in managing mitral valve prolapse?
What is the purpose of aspirin in managing mitral valve prolapse?
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What is the primary site of attachment for the organisms involved in GABHS infection?
What is the primary site of attachment for the organisms involved in GABHS infection?
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What is the typical duration of an incubation period in GABHS infection?
What is the typical duration of an incubation period in GABHS infection?
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What is the term for the inflammation of the pericardium, myocardium, or endocardium?
What is the term for the inflammation of the pericardium, myocardium, or endocardium?
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What is the characteristic of subcutaneous nodules?
What is the characteristic of subcutaneous nodules?
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What is the term for a neurological disorder characterized by spasmodic involuntary movements of the limbs or facial muscles?
What is the term for a neurological disorder characterized by spasmodic involuntary movements of the limbs or facial muscles?
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What is the characteristic of erythema marginatum?
What is the characteristic of erythema marginatum?
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What is the term for joint pain affecting five or more joints?
What is the term for joint pain affecting five or more joints?
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What is the effect of molecular mimicry in GABHS infection?
What is the effect of molecular mimicry in GABHS infection?
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Study Notes
Fetal Circulation
- Before birth, the fetus receives oxygenated blood from the mother's placenta
- The oxygenated blood flows through the umbilical vein to the heart, where it bypasses the lungs and goes directly to the body
Fetal Circulation Right After Birth
- After birth, the infant's lungs expand and begin to breathe in oxygen
- The bypasses that were present in the fetal circulation now close, and the lungs take over the oxygenation of blood
Causes of Congenital Heart Diseases
- Chromosomal/genetic: 10%-12% (e.g., Down syndrome)
- Maternal or environmental: 1%-2% (e.g., maternal alcohol consumption, maternal illness)
- Infections: CMV, toxoplasmosis, other viral illnesses
- Infants of Diabetic Mothers (IDMs): 10% risk of CHD (e.g., VSD, cardiomyopathy, TGA)
- Multifactorial: 85%
Etiology of Congenital Heart Disease
- Lesions: obstructive, acyanotic, and cyanotic
- Obstructive lesions: Coarctation of aorta, pulmonary stenosis
- Acyanotic lesions: Ventricular septal defect, atrial septal defect, patent ductus arteriosus
- Cyanotic lesions: Tetralogy of Fallot, transposition of great arteries, truncus arteriosus, total anomalous pulmonary venous return
Increased Pulmonary Blood Flow Defects
- Abnormal connection between two sides of the heart
- Increased blood volume on the right side of the heart
- Increased pulmonary blood flow: atrial septal defect, ventricular septal defect
- Diagnostic tests: echocardiogram, chest X-ray, electrocardiogram, cardiac catheterization
Management of Congenital Heart Diseases
- Watchful waiting
- Medications: indomethacin to close PDA soon after birth
- Surgical closure: PDA surgery is done on the blood vessel, not the heart
Ventricular Septal Defect (VSD)
- A hole between the two ventricles
- Oxygen-rich blood from the left ventricle flows into the right ventricle
- Creates a heart murmur
- Treatment: depends on the size, location, and severity of the VSD
Tetralogy of Fallot
- Four defects: VSD, overriding aorta, pulmonary stenosis, right ventricular hypertrophy
- Signs and symptoms: loud murmur, cyanosis, rapid breathing, sudden drop in arterial blood gases
- Treatment: prostaglandin infusion, surgery (corrective repair of tetralogy of Fallot)
Diagnostic Tests
- Chest X-ray
- Electrocardiogram
- Stress test
- Coronary angiogram
Management of Heart Disease
- Medications: beta blockers, diuretics, heart rhythm medication, aspirin
- Surgery: valve repair and replacement, minimally invasive surgery
Myocarditis
- Inflammation of the heart muscle
- Causes: GABHS infection, molecular mimicry, streptococcal antigens, decrease in regulatory T-cells
- Signs and symptoms: rapid or abnormal heart rhythms, fever, malaise, headache, elevated leukocyte count
Rheumatic Fever
- Causes: GABHS infection, molecular mimicry
- Signs and symptoms: carditis, polyarthritis, chorea, subcutaneous nodules, erythema marginatum
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