Stuff for LAB animal
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Questions and Answers

Missions

AALAS = to advance “responsible laboratory animal care and use to benefit people and animals.” LAMA = “enhancing the quality of management and care of laboratory animals throughout the world” by “promoting education, knowledge exchange and professional development” of facility managers and supervisors ILAR = “to evaluate and to report on scientific, technological, and ethical use of animals and related biological resources, and of non‐ animal alternatives in non food settings, such as research, testing, ‐ education, and production of pharmaceuticals.” ACLAM = to “encourage education, training and research in laboratory animal medicine, establish standards, and recognized qualified persons

ORGS

AALAS = Serves as the principal means of communication between individuals and organizations within the field of laboratory animal and administers certificate program. LAMA = Promotes education, knowledge exchange and professional development ASLAP = Professional organization to exchange ideas, experiences, and knowledge among veterinarians and veterinary students NABR = Advocates for sound pubic policy in support of ethical and essential animal use in biomedical research. Nonprofit

ORGS

NABR = Advocates for sound pubic policy in support of ethical and essential animal use in biomedical research FBR = Nonprofit organization dedicated to improving the quality of human and animal health ILAR = Advisor to the federal government, the biomedical research community, science educators and students, and the public ASLAP = Acts as spokesperson for laboratory animal practitioners within the AVMA House of Delegates

ORGS

<p>NABR = Serves as a unified voice in Washington, DC, for the scientific community on legislative and regulatory matters affecting laboratory animal research FBR = Promotes public understanding and support for humane and responsible use of animals in scientific and medical research ILAR = Develops guidelines and disseminates information on scientific, technological, and ethical use of animals ACLAM = Specialty board recognized by the AVMA</p> Signup and view all the answers

ORGS

<p>NABR = “that now, and for the foreseeable future, it is not possible to completely replace the use of animals in biomedical research, ETC&quot; FBR = Provides educational materials (brochures, posters, reference papers, discussion papers, videos) to teachers, students, the media and the general public ILAR = Publishes the ILAR Journal, a quarterly peer reviewed publication on ‐ a variety of topics pertinent to the biomedical research community IACUC = Approves protocol amendments and conducts semi annual inspections</p> Signup and view all the answers

<p>Refinement = Use of less invasive procedures, provision of pain relief, provision of environmental enrichment and decreased restraint time Replacement = Use of a less “sentient” species (fish instead of mouse for example) Reduction = Using one control group with multiple study groups are examples of reduction methods</p> <ul> <li>= -</li> </ul> Signup and view all the answers

Grants provide money for the primary investigator’s (PI) and research team salaries, supplies, equipment and purchase & care of animals for a __________ period.

<p>3 year</p> Signup and view all the answers

Primary public granting agencies are the National Institute of Health (NIH) and the National Science Foundation (NSF)

<p>True</p> Signup and view all the answers

Primary public granting agencies are the National Institute of Health (NIH), the National Science Foundation (NSF), and the United Stated Department of Agriculture

<p>False</p> Signup and view all the answers

USDA-APHIS inspectors perform unannounced visits at least ______ a year.

<p>Once</p> Signup and view all the answers

AAALAC site visits occur ________

<p>Once every 3 years</p> Signup and view all the answers

<p>AALAC = Encourages high standards of animal care, use, and well-being through use of voluntary accreditation and assessment programs AWIC = Provides specific information on employee training and identification of improved research methods that could reduce or replace animal use and minimize pain and distress to animals GLP = Provide framework for performing high-quality, well-documented, and repeatable safety studies</p> <ul> <li>= -</li> </ul> Signup and view all the answers

IACUC must conduct de novo (anew) review of animal use protocols at least once every 3 years

<p>True</p> Signup and view all the answers

IACUC must conduct de novo (anew) review of animal use protocols at least once every year

<p>False</p> Signup and view all the answers

Governmental body, organizationally positioned within the National Institutes of Health (NIH), that is responsible for interpreting and implementing the PHS Policy and evaluating whether institutions are in compliance

<p>OLAW</p> Signup and view all the answers

A USDA veterinary medical officer performs unannounced compliance inspections at least ________

<p>Annually</p> Signup and view all the answers

Match

<p>Cleaning = removes excessive amounts of excrement, dirt and debris Sanitation = - maintenance of environmental conditions conducive to health and well being; ‐ washing away (reducing) microbes Disinfection = reduces or eliminates unacceptable concentrations of microorganisms; destroy (-cidal) or inhibit (static) microbial growth Sterilization = validated process used to render a product free of all forms of viable microorganisms</p> Signup and view all the answers

Rodent cage changes (movement of animals from soiled to clean cages) are performed within laminar flow hoods (LFHs) designed to protect animals from potential airborne contaminants present in the room

<p>True</p> Signup and view all the answers

Rodent cage changes (movement of animals from soiled to clean cages) are performed within biological safety cabinets (BSCs) designed to protect animals from potential airborne contaminants present in the room

<p>False</p> Signup and view all the answers

LFHs are not comparable to biological safety cabinets (BSCs) in the level of protection they provide to animals or personnel and are not appropriate to contain hazards or provide a sterile work area

<p>True</p> Signup and view all the answers

Biological Safety Cabinet (BSC) protect personnel, the environment and items within the qwork area

<p>True</p> Signup and view all the answers

Laminar Flow Change Stations (LFHs) protect personnel, the environment and items within the qwork area

<p>False</p> Signup and view all the answers

Study Notes

Grants and Funding

  • Grants provide money for the primary investigator's (PI) and research team salaries, supplies, equipment, and purchase & care of animals for a specified period.

Primary Public Granting Agencies

  • Primary public granting agencies include the National Institute of Health (NIH), the National Science Foundation (NSF), and the United States Department of Agriculture (USDA).

Inspections and Site Visits

  • USDA-APHIS inspectors perform unannounced visits at least once a year.
  • AAALAC site visits occur periodically.

IACUC Review

  • IACUC must conduct de novo review of animal use protocols at least once every 3 years.

Governmental Body

  • The Office of Laboratory Animal Welfare (OLAW) is a governmental body, organizationally positioned within the National Institutes of Health (NIH), responsible for interpreting and implementing the PHS Policy and evaluating whether institutions are in compliance.

Compliance Inspections

  • A USDA veterinary medical officer performs unannounced compliance inspections at least once a year.

Rodent Cage Changes

  • Rodent cage changes (movement of animals from soiled to clean cages) are performed within biological safety cabinets (BSCs) designed to protect animals from potential airborne contaminants present in the room.

Laminar Flow Hoods (LFHs) vs. Biological Safety Cabinets (BSCs)

  • LFHs are not comparable to BSCs in the level of protection they provide to animals or personnel and are not appropriate to contain hazards or provide a sterile work area.
  • BSCs protect personnel, the environment, and items within the work area.

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