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Questions and Answers
What is the approximate number of molecules found in cannabis?
What is the primary concern when prescribing THC-containing cannabis products to individuals?
What is the role of endocannabinoids in the brain?
What is the effect of CBD on GABA receptors?
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What is the primary mechanism of action of CBD?
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What was the outcome of the post-marketing surveillance of Rimonabant?
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What is the role of paracetamol in the endocannabinoid system?
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What is the primary difference between THC and CBD?
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Study Notes
Cannabinoids and Cannabis
- Cannabis contains approximately 500 molecules, including over 100 cannabinoids, terpenoids, and flavonoids.
- Different cannabis strains have unique cannabinoid profiles.
Rimonabant (CB1 Receptor Agonist)
- Approved as a treatment for obesity in 2005, reducing body weight, waist circumference, and improving metabolic syndrome and insulin sensitivity.
- Withdrawn from the market in 2008 due to increased risk of psychiatric side effects, including depression.
Medicinal Cannabis Safety
- Generally well tolerated when dosed appropriately, but requires consideration of THC and/or CBD content.
- CBD is non-intoxicating and has fewer safety concerns than THC.
- THC-containing products should not be prescribed to individuals with a history of psychosis.
How Cannabis Works
- Affects the body's natural cannabis system, influencing:
- Sleep
- Positive mood
- Appetite and metabolism
- Stress coping
- Analgesia
- THC is a partial agonist at CB1 and CB2 receptors.
Endocannabinoids
- Cannabis-like molecules naturally produced in the brain and body.
- Boosted by paracetamol, endocannabinoids act as retrograde messengers, regulating glutamate and GABA release via CB1, maintaining equilibrium.
How CBD Works
- Exhibits diverse pharmacological effects, including:
- Endocannabinoid booster
- 5-HT1A agonist
- GPR55 antagonist
- Pro-drug for an active metabolite
- CBD increases inhibition via GABAA receptors, decreasing neuron excitability, a target of known anxiety and epilepsy drugs.
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