Podcast
Questions and Answers
What is the approximate number of molecules found in cannabis?
What is the approximate number of molecules found in cannabis?
What is the primary concern when prescribing THC-containing cannabis products to individuals?
What is the primary concern when prescribing THC-containing cannabis products to individuals?
What is the role of endocannabinoids in the brain?
What is the role of endocannabinoids in the brain?
What is the effect of CBD on GABA receptors?
What is the effect of CBD on GABA receptors?
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What is the primary mechanism of action of CBD?
What is the primary mechanism of action of CBD?
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What was the outcome of the post-marketing surveillance of Rimonabant?
What was the outcome of the post-marketing surveillance of Rimonabant?
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What is the role of paracetamol in the endocannabinoid system?
What is the role of paracetamol in the endocannabinoid system?
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What is the primary difference between THC and CBD?
What is the primary difference between THC and CBD?
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Study Notes
Cannabinoids and Cannabis
- Cannabis contains approximately 500 molecules, including over 100 cannabinoids, terpenoids, and flavonoids.
- Different cannabis strains have unique cannabinoid profiles.
Rimonabant (CB1 Receptor Agonist)
- Approved as a treatment for obesity in 2005, reducing body weight, waist circumference, and improving metabolic syndrome and insulin sensitivity.
- Withdrawn from the market in 2008 due to increased risk of psychiatric side effects, including depression.
Medicinal Cannabis Safety
- Generally well tolerated when dosed appropriately, but requires consideration of THC and/or CBD content.
- CBD is non-intoxicating and has fewer safety concerns than THC.
- THC-containing products should not be prescribed to individuals with a history of psychosis.
How Cannabis Works
- Affects the body's natural cannabis system, influencing:
- Sleep
- Positive mood
- Appetite and metabolism
- Stress coping
- Analgesia
- THC is a partial agonist at CB1 and CB2 receptors.
Endocannabinoids
- Cannabis-like molecules naturally produced in the brain and body.
- Boosted by paracetamol, endocannabinoids act as retrograde messengers, regulating glutamate and GABA release via CB1, maintaining equilibrium.
How CBD Works
- Exhibits diverse pharmacological effects, including:
- Endocannabinoid booster
- 5-HT1A agonist
- GPR55 antagonist
- Pro-drug for an active metabolite
- CBD increases inhibition via GABAA receptors, decreasing neuron excitability, a target of known anxiety and epilepsy drugs.
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