Filovirus
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Questions and Answers

What is the primary site of replication for filoviruses?

  • Nucleus
  • Cytoplasm (correct)
  • Endoplasmic reticulum
  • Golgi apparatus
  • What is the primary mechanism of transmission for filoviruses?

  • Airborne transmission
  • Contaminated food and water
  • Vector-borne transmission
  • Direct contact and bodily secretions (correct)
  • What is the primary effect of TLR4 activation in the context of filovirus infection?

  • Increased viral replication
  • Induction of apoptosis
  • Inflammation and hemorrhagic fever (correct)
  • Immune system suppression
  • Which of the following groups is most likely to be infected with filoviruses?

    <p>Healthcare workers</p> Signup and view all the answers

    What are the primary examples of filoviruses?

    <p>Ebola and Marburg</p> Signup and view all the answers

    Study Notes

    Filovirus Characteristics

    • Filoviruses are helical RNA viruses with a negative-sense genome.
    • They have a helical orange wrapping around the genome, indicating their helical structure.
    • Replication occurs in the cytoplasm, like all RNA viruses (excluding orthomyxovirus).

    Filovirus Structure

    • Filoviruses are enveloped, having a lipid bilayer derived from the host cell membrane.

    Examples of Filoviruses

    • Ebola virus
    • Marburg virus

    Filovirus Infection

    • Filoviruses cause hemorrhagic fever, demonstrated by petechial rash, hemorrhage, and shock.
    • The infection can lead to end-organ failure, specifically affecting the kidneys and liver.
    • Fatal outcome is common, characterized by severe blood loss and shock.

    Transmission and Vectors

    • Filoviruses can be spread through direct contact with infected bodily fluids, such as blood and secretions.
    • Vectors of filoviruses include monkeys and fruit bats.
    • Healthcare workers are at a higher risk of getting infected due to their occupational exposure.

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