10 Questions
Which element in the heme moiety of hemoglobin binds to oxygen?
Iron
What is the molecular weight of hemoglobin?
64,450
In normal adult human hemoglobin (hemoglobin A), how many pairs of polypeptides are there in each molecule?
2
What causes a decrease in the affinity of hemoglobin for oxygen?
An increase in the concentration of 2,3-BPG
When blood is exposed to oxidizing agents, what change occurs to the iron in hemoglobin?
It is converted to ferric iron (Fe3+)
What happens when methemoglobin is present in large quantities in the circulation?
Causes a dusky discoloration of the skin resembling cyanosis
What enzyme system in red cells converts methemoglobin back to hemoglobin?
NADH-methemoglobin reductase system
What is the consequence of carbon monoxide reacting with hemoglobin?
Forms carboxyhemoglobin which displaces O2 on hemoglobin
Where is most of the biliverdin converted in humans and excreted?
Converted to bilirubin and excreted in the bile
For what condition can phototherapy be used effectively according to the text?
Jaundice due to hemolysis in infants
Learn about the structure of hemoglobin, the red, oxygen-carrying pigment in vertebrate red blood cells, which is composed of four subunits containing heme moieties conjugated to polypeptides. Explore the role of globin in the hemoglobin molecule and the significance of heme as an iron-containing porphyrin derivative.
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