Podcast
Questions and Answers
What is the primary component of the filtration barrier in the kidneys?
What is the primary component of the filtration barrier in the kidneys?
- Fenestrated endothelial capillaries
- Mesangial cells
- Filtration slits with diaphragms
- Thick continuous basement membrane (correct)
Which part of the juxtaglomerular apparatus is responsible for detecting sodium concentration?
Which part of the juxtaglomerular apparatus is responsible for detecting sodium concentration?
- Glomerular capillaries
- Macula Densa (correct)
- Juxtaglomerular cells
- Lacis cells
What is the main function of the proximal convoluted tubule (PCT)?
What is the main function of the proximal convoluted tubule (PCT)?
- Active reabsorption of glucose and amino acids (correct)
- Active secretion of urea
- Excretion of potassium ions
- Filtration of blood
What is the primary epithelial type found lining the distal convoluted tubule (DCT)?
What is the primary epithelial type found lining the distal convoluted tubule (DCT)?
Which of the following layers in the urinary passage is composed of transitional epithelium?
Which of the following layers in the urinary passage is composed of transitional epithelium?
Flashcards
Filtration Barrier Components
Filtration Barrier Components
The filtration barrier in the glomerulus, separating blood from urine, consists of fenestrated endothelial capillaries, a thick basement membrane, and filtration slits with diaphragms.
Juxtaglomerular Apparatus (JGA)
Juxtaglomerular Apparatus (JGA)
The JGA is a structure at the vascular pole of the renal corpuscle, involved in blood pressure regulation. It contains the macula densa, juxtaglomerular cells and lacis cells.
Macula Densa Function
Macula Densa Function
The macula densa cells in the JGA are osmoreceptors, detecting changes in sodium concentration to regulate the kidney's response to blood pressure.
Juxtaglomerular (JG) Cells Function
Juxtaglomerular (JG) Cells Function
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Proximal Convoluted Tubule (PCT) Function
Proximal Convoluted Tubule (PCT) Function
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Urinary system function
Urinary system function
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Kidney structure
Kidney structure
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Uriniferous tubule
Uriniferous tubule
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Nephron
Nephron
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Renal corpuscle
Renal corpuscle
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Glomerulus
Glomerulus
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Bowman's capsule
Bowman's capsule
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Renal Cortex
Renal Cortex
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Kidney Stroma
Kidney Stroma
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Kidney Parenchyma
Kidney Parenchyma
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Uriniferous Tubule Function
Uriniferous Tubule Function
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What are the types of absorption involved in urine formation?
What are the types of absorption involved in urine formation?
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Nephron Components
Nephron Components
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What is the Renal Corpuscle?
What is the Renal Corpuscle?
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What is the Bowman's Capsule?
What is the Bowman's Capsule?
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What is the Glomerulus?
What is the Glomerulus?
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Filtration Barrier
Filtration Barrier
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What is the Macula Densa?
What is the Macula Densa?
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Juxtaglomerular Cells
Juxtaglomerular Cells
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Distal Convoluted Tubule (DCT) Function
Distal Convoluted Tubule (DCT) Function
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Macula Densa
Macula Densa
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What is the brush border?
What is the brush border?
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Proximal Convoluted Tubule (PCT)
Proximal Convoluted Tubule (PCT)
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Distal Convoluted Tubule (DCT)
Distal Convoluted Tubule (DCT)
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Urinary Passages
Urinary Passages
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Transitional Epithelium (Urothelium)
Transitional Epithelium (Urothelium)
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Detrusor Muscle
Detrusor Muscle
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Layers of Urinary Passage
Layers of Urinary Passage
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What are the main functions of the urinary system?
What are the main functions of the urinary system?
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Loop of Henle
Loop of Henle
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Kidney Cortex
Kidney Cortex
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Study Notes
Urinary System Histology
- The urinary system comprises paired kidneys, ureters, urinary bladder, and urethra.
Kidney Structure
- The kidney is a bean-shaped retroperitoneal organ.
- It's composed of:
- Stroma:
- Capsule: Dense connective tissue surrounded by adipose tissue (peri-renal fat).
- Renal interstitium: Intertubular, extraglomerular, extravascular space within the kidney.
- Minimal connective tissue between parenchymal cells.
- Parenchyma: Functional tissue of the kidney, distinct from connective tissue.
- Outer Cortex
- Inner Medulla
- Stroma:
- The kidney's histological structure includes calyces, renal pelvis, minor and major calyces.
Uriniferous Tubule
- The structural unit of the kidney is the nephron and a collecting tubule.
- The nephron produces urine.
- The collecting tubules concentrate urine and transport it to the calyces.
Nephron
- The basic functional unit of the kidney is the nephron.
- Each kidney contains millions of nephrons (1-4 million).
- Nephron components:
- Renal (Malpighian) corpuscle
- Proximal convoluted tubule
- Loop of Henle
- Distal convoluted tubule
Renal Corpuscle
- The renal corpuscle is composed of:
- Glomerulus: A vascular ball (approximately 200 µm in diameter) covered by Bowman's capsule.
- Bowman's capsule: A double-walled epithelial cup-shaped structure surrounding the glomerulus.
- Visceral layer: Modified simple squamous epithelium (podocytes).
- Parietal layer: Simple squamous epithelium.
Filtration Barrier
- The filtration barrier separates blood within glomerular capillaries from the urinary space of Bowman's capsule.
- Components:
- Fenestrated endothelial capillaries
- Thick continuous basement membrane
- Filtration slits covered with diaphragms
Mesangial Cells
- Stellate-shaped cells located among glomerular capillaries.
- Functions:
- Structural support
- Phagocytic function
Juxtaglomerular Apparatus
- Located at the vascular pole of the renal corpuscle.
- Components:
- Macula densa: Part of the distal convoluted tubule (DCT) facing the glomerulus. Acts as osmoreceptors sensitive to Na+ concentration.
- Juxtaglomerular (JG) cells: Renin-producing cells in the wall of the afferent arteriole, respond to changes in blood pressure and Na+ levels.
- Lacis cells (extraglomerular mesangial cells): Small, pale cells with pale nuclei.
Proximal Convoluted Tubule (PCT)
- Lined by simple cuboidal epithelium.
- Tubule cells have microvilli (brush border) on their luminal surfaces.
- Function:
- Active reabsorption of glucose and amino acids
- Reabsorption of Na+, Cl−, K+, and water (H₂O)
Distal Convoluted Tubule (DCT)
- Wide lumen, lined with cuboidal cells.
- Lacks a brush border.
- Function:
- Reabsorption of Na+, K+, and water under the influence of aldosterone and ADH.
- Excretion of H₂O and NH₃.
Urinary Passages
- Calyces
- Pelvis
- Ureter
- Bladder
- Urethra
Layers of Urinary Passage
- Mucosa: Transitional epithelium (urothelium)
- Muscular layer: Smooth muscle fibers (detrusor muscle)
- Adventitia: Loose connective tissue
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