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Questions and Answers

What is the primary component of the filtration barrier in the kidneys?

  • Fenestrated endothelial capillaries
  • Mesangial cells
  • Filtration slits with diaphragms
  • Thick continuous basement membrane (correct)

Which part of the juxtaglomerular apparatus is responsible for detecting sodium concentration?

  • Glomerular capillaries
  • Macula Densa (correct)
  • Juxtaglomerular cells
  • Lacis cells

What is the main function of the proximal convoluted tubule (PCT)?

  • Active reabsorption of glucose and amino acids (correct)
  • Active secretion of urea
  • Excretion of potassium ions
  • Filtration of blood

What is the primary epithelial type found lining the distal convoluted tubule (DCT)?

<p>Simple cuboidal epithelium (C)</p> Signup and view all the answers

Which of the following layers in the urinary passage is composed of transitional epithelium?

<p>Mucosa (A)</p> Signup and view all the answers

Flashcards

Filtration Barrier Components

The filtration barrier in the glomerulus, separating blood from urine, consists of fenestrated endothelial capillaries, a thick basement membrane, and filtration slits with diaphragms.

Juxtaglomerular Apparatus (JGA)

The JGA is a structure at the vascular pole of the renal corpuscle, involved in blood pressure regulation. It contains the macula densa, juxtaglomerular cells and lacis cells.

Macula Densa Function

The macula densa cells in the JGA are osmoreceptors, detecting changes in sodium concentration to regulate the kidney's response to blood pressure.

Juxtaglomerular (JG) Cells Function

JG cells, modified smooth muscle cells in the afferent arteriole, secrete renin to help control blood pressure.

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Proximal Convoluted Tubule (PCT) Function

The PCT actively reabsorbs glucose, amino acids, and important ions like Na+, Cl-, and K+, and water from the filtrate.

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Urinary system function

Maintains homeostasis, forms urine, and secretes hormones like erythropoietin and renin.

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Kidney structure

Bean-shaped organ composed of stroma (capsule, and renal interstitium) and parenchyma (cortex and medulla).

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Uriniferous tubule

Structural unit of the kidney, consisting of a nephron and a collecting tubule; produces and concentrates urine.

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Nephron

Basic functional unit of the kidney, responsible for filtering blood and producing urine.

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Renal corpuscle

The initial filtering unit of the nephron, containing a glomerulus (capillary network) and Bowman's capsule.

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Glomerulus

A network of capillaries within the renal corpuscle.

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Bowman's capsule

Double-walled structure surrounding the glomerulus, collecting the filtered fluid.

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Renal Cortex

Outer region of the kidney containing the renal corpuscles and proximal/distal convoluted tubules.

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Kidney Stroma

The supportive framework of the kidney, consisting of the capsule (dense connective tissue) and the renal interstitium (minimal connective tissue between parenchyma).

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Kidney Parenchyma

The functional tissue of the kidney, responsible for urine production and filtration. It comprises the outer cortex and inner medulla.

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Uriniferous Tubule Function

The uriniferous tubule is responsible for urine production (nephron) and concentrating urine (collecting tubule).

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What are the types of absorption involved in urine formation?

Urine formation involves both active and passive absorption. Active absorption requires energy to move substances against their concentration gradient, while passive absorption relies on diffusion.

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Nephron Components

The nephron, the functional unit of the kidney, consists of the renal corpuscle (for filtration), the proximal convoluted tubule, the loop of Henle, and the distal convoluted tubule.

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What is the Renal Corpuscle?

The renal corpuscle is the initial filtering unit of the nephron, consisting of a glomerulus (network of capillaries) and Bowman's capsule (double-walled structure surrounding the glomerulus).

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What is the Bowman's Capsule?

The Bowman's capsule is a double-walled structure that surrounds the glomerulus. Its inner visceral layer is composed of podocytes and the outer parietal layer is lined by simple squamous epithelium.

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What is the Glomerulus?

The glomerulus is a network of capillaries within the renal corpuscle. It's responsible for filtering blood.

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Filtration Barrier

The barrier that separates blood in the glomerulus from the urine in Bowman's capsule. It is made of three layers: fenestrated endothelial capillaries, the basement membrane, and filtration slits with diaphragms.

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What is the Macula Densa?

A part of the distal convoluted tubule (DCT) that faces the glomerulus. It detects changes in sodium concentration in the filtrate.

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Juxtaglomerular Cells

Modified smooth muscle cells in the afferent arteriole. They produce and secrete renin, a hormone that regulates blood pressure.

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Distal Convoluted Tubule (DCT) Function

Maintains the balance of sodium, potassium, and water in the urine. It reabsorbs these ions under the influence of hormones like aldosterone and ADH.

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Macula Densa

A group of specialized cells in the distal convoluted tubule (DCT) that sense sodium concentration in the filtrate and send signals to regulate blood pressure.

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What is the brush border?

The microvilli lining the luminal surfaces of the proximal convoluted tubule (PCT) cells. It increases the surface area for reabsorption of nutrients and water.

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Proximal Convoluted Tubule (PCT)

The first part of the renal tubule where most of the reabsorption of essential nutrients, water, and ions occurs.

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Distal Convoluted Tubule (DCT)

The section of the renal tubule after the loop of Henle, where fine-tuning of water and electrolyte balance takes place under the influence of hormones.

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Urinary Passages

The structures that carry urine from the kidneys to the outside of the body. They include the calyces, pelvis, ureter, bladder, and urethra.

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Transitional Epithelium (Urothelium)

A specialized type of epithelium that lines the urinary passages, allowing for stretching and accommodating changes in urine volume.

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Detrusor Muscle

The smooth muscle layer in the bladder wall that contracts to expel urine.

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Layers of Urinary Passage

The urinary passages have three layers: mucosa (lining), muscular layer (smooth muscle), and adventitia (connective tissue).

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What are the main functions of the urinary system?

These include maintaining homeostasis through filtration, absorption, and secretion; forming urine to eliminate metabolic wastes; and secreting hormones such as erythropoietin and renin.

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Loop of Henle

A U-shaped structure in the nephron responsible for creating a concentration gradient in the medulla, allowing for water reabsorption and urine concentration.

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Kidney Cortex

The outer region of the kidney containing the renal corpuscles, proximal and distal convoluted tubules. It's like the outer layer of the kidney where most of the filtration and reabsorption takes place.

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Study Notes

Urinary System Histology

  • The urinary system comprises paired kidneys, ureters, urinary bladder, and urethra.

Kidney Structure

  • The kidney is a bean-shaped retroperitoneal organ.
  • It's composed of:
    • Stroma:
      • Capsule: Dense connective tissue surrounded by adipose tissue (peri-renal fat).
      • Renal interstitium: Intertubular, extraglomerular, extravascular space within the kidney.
      • Minimal connective tissue between parenchymal cells.
    • Parenchyma: Functional tissue of the kidney, distinct from connective tissue.
      • Outer Cortex
      • Inner Medulla
  • The kidney's histological structure includes calyces, renal pelvis, minor and major calyces.

Uriniferous Tubule

  • The structural unit of the kidney is the nephron and a collecting tubule.
  • The nephron produces urine.
  • The collecting tubules concentrate urine and transport it to the calyces.

Nephron

  • The basic functional unit of the kidney is the nephron.
  • Each kidney contains millions of nephrons (1-4 million).
  • Nephron components:
    • Renal (Malpighian) corpuscle
    • Proximal convoluted tubule
    • Loop of Henle
    • Distal convoluted tubule

Renal Corpuscle

  • The renal corpuscle is composed of:
    • Glomerulus: A vascular ball (approximately 200 µm in diameter) covered by Bowman's capsule.
    • Bowman's capsule: A double-walled epithelial cup-shaped structure surrounding the glomerulus.
      • Visceral layer: Modified simple squamous epithelium (podocytes).
      • Parietal layer: Simple squamous epithelium.

Filtration Barrier

  • The filtration barrier separates blood within glomerular capillaries from the urinary space of Bowman's capsule.
  • Components:
    • Fenestrated endothelial capillaries
    • Thick continuous basement membrane
    • Filtration slits covered with diaphragms

Mesangial Cells

  • Stellate-shaped cells located among glomerular capillaries.
  • Functions:
    • Structural support
    • Phagocytic function

Juxtaglomerular Apparatus

  • Located at the vascular pole of the renal corpuscle.
  • Components:
    • Macula densa: Part of the distal convoluted tubule (DCT) facing the glomerulus. Acts as osmoreceptors sensitive to Na+ concentration.
    • Juxtaglomerular (JG) cells: Renin-producing cells in the wall of the afferent arteriole, respond to changes in blood pressure and Na+ levels.
    • Lacis cells (extraglomerular mesangial cells): Small, pale cells with pale nuclei.

Proximal Convoluted Tubule (PCT)

  • Lined by simple cuboidal epithelium.
  • Tubule cells have microvilli (brush border) on their luminal surfaces.
  • Function:
    • Active reabsorption of glucose and amino acids
    • Reabsorption of Na+, Cl−, K+, and water (H₂O)

Distal Convoluted Tubule (DCT)

  • Wide lumen, lined with cuboidal cells.
  • Lacks a brush border.
  • Function:
    • Reabsorption of Na+, K+, and water under the influence of aldosterone and ADH.
    • Excretion of H₂O and NH₃.

Urinary Passages

  • Calyces
  • Pelvis
  • Ureter
  • Bladder
  • Urethra

Layers of Urinary Passage

  • Mucosa: Transitional epithelium (urothelium)
  • Muscular layer: Smooth muscle fibers (detrusor muscle)
  • Adventitia: Loose connective tissue

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