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Questions and Answers
What type of cartilage is initially present in endochondral formation?
What type of cartilage is initially present in endochondral formation?
What is the primary function of cells that erode bone?
What is the primary function of cells that erode bone?
What is the role of osteoblasts in endochondral formation?
What is the role of osteoblasts in endochondral formation?
What is the function of parathyroid hormone (PTH) in bone physiology?
What is the function of parathyroid hormone (PTH) in bone physiology?
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What is the main component of bone that provides flexibility?
What is the main component of bone that provides flexibility?
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What is the purpose of bone lining cells?
What is the purpose of bone lining cells?
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What is the effect of calcitriol on bone physiology?
What is the effect of calcitriol on bone physiology?
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What is the term for the process of bone change throughout an animal's life?
What is the term for the process of bone change throughout an animal's life?
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What is the function of calcitonin in bone physiology?
What is the function of calcitonin in bone physiology?
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What is the characteristic of intramembranous formation?
What is the characteristic of intramembranous formation?
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What type of bone is evident in the adult skeleton?
What type of bone is evident in the adult skeleton?
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What is the function of gap junctions in bone lining cells?
What is the function of gap junctions in bone lining cells?
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What is the purpose of the epiphyseal plate in long bone growth?
What is the purpose of the epiphyseal plate in long bone growth?
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What is the final outcome of bone healing?
What is the final outcome of bone healing?
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What is the primary component of bone that provides strength?
What is the primary component of bone that provides strength?
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What is the function of cells that extract calcium from bones?
What is the function of cells that extract calcium from bones?
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What is the role of calcitriol in calcium absorption?
What is the role of calcitriol in calcium absorption?
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What is the term for the process of bone formation and resorption?
What is the term for the process of bone formation and resorption?
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What is unique about the roots of the cheek teeth in the Hystricomorpha suborder?
What is unique about the roots of the cheek teeth in the Hystricomorpha suborder?
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What is the primary function of the beak shape variation in birds?
What is the primary function of the beak shape variation in birds?
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What is the term for the joint present between the maxillary beak and skull in birds?
What is the term for the joint present between the maxillary beak and skull in birds?
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What is unique about the teeth of Chelonians?
What is unique about the teeth of Chelonians?
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What is the function of the vertebral discs in the spinal column?
What is the function of the vertebral discs in the spinal column?
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What is a characteristic of the incisors of Myomorph rodents?
What is a characteristic of the incisors of Myomorph rodents?
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What is a unique feature of the teeth of snakes?
What is a unique feature of the teeth of snakes?
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What is the term for the gap between the incisors and cheek teeth in rodents?
What is the term for the gap between the incisors and cheek teeth in rodents?
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What is a characteristic of the teeth of Lizards?
What is a characteristic of the teeth of Lizards?
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What is the primary function of the annulus fibrosus in the vertebral column?
What is the primary function of the annulus fibrosus in the vertebral column?
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Which cervical vertebra is responsible for a nodding movement?
Which cervical vertebra is responsible for a nodding movement?
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How many thoracic vertebrae are present in dogs and cats?
How many thoracic vertebrae are present in dogs and cats?
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What is the name of the joint formed by the atlas and the axis?
What is the name of the joint formed by the atlas and the axis?
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What is the characteristic of the spinous processes in the thoracic region?
What is the characteristic of the spinous processes in the thoracic region?
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What is the function of the lateral part of the thoracic vertebrae?
What is the function of the lateral part of the thoracic vertebrae?
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How many vertebrae are present in the lumbar region of dogs and cats?
How many vertebrae are present in the lumbar region of dogs and cats?
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What is the characteristic of the sacral region?
What is the characteristic of the sacral region?
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What is the joint that connects the sacrum to the pelvis?
What is the joint that connects the sacrum to the pelvis?
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Which of the following bones is responsible for supporting the shoulder joint and shell in chelonians?
Which of the following bones is responsible for supporting the shoulder joint and shell in chelonians?
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What is the term for the ventral joint that connects the two halves of the pelvis?
What is the term for the ventral joint that connects the two halves of the pelvis?
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Which of the following bones is the largest sesamoid bone in the body?
Which of the following bones is the largest sesamoid bone in the body?
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What is the term for the hole on either side of the pelvic symphysis that makes the pelvis lighter?
What is the term for the hole on either side of the pelvic symphysis that makes the pelvis lighter?
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Which of the following bones is fused with the proximal row of tarsal bones in birds?
Which of the following bones is fused with the proximal row of tarsal bones in birds?
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What is the term for the intertarsal joint in birds that is equivalent to the hock joint in other animals?
What is the term for the intertarsal joint in birds that is equivalent to the hock joint in other animals?
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Which of the following bones is rotated in chelonians?
Which of the following bones is rotated in chelonians?
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What is the term for the separate bone that forms the structure of the hip joint in rabbits?
What is the term for the separate bone that forms the structure of the hip joint in rabbits?
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Which of the following bones is fused with the distal row of tarsal bones in birds?
Which of the following bones is fused with the distal row of tarsal bones in birds?
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Study Notes
Bone Structure
- Bone is a living organ that undergoes changes throughout an animal's life.
- It consists of cells, collagen, glycoproteins, and calcium hydroxyapatite.
- There are two types of bone formation: endochondral and intramembranous.
Bone Cells
- Osteoclasts: cells that erode bone, used to remodel bone not needed, and extract calcium from bones.
- Bone Lining Cells (BLCs): cover inactive bone surfaces, prevalent in the adult skeleton, and connect to other BLCs via gap junctions.
Endochondral Formation
- All bones, except for the skull, undergo endochondral formation.
- Bones begin as cartilage during fetal development, which is replaced by osteocytes and calcium hydroxyapatite.
- Formation begins in the primary growth center in the diaphysis and expands outwards.
- Cartilage is gradually removed as bone is created, and secondary growth begins in the epiphysis.
Bone Healing
- Bones are one of the best healing tissues.
- Fractures are most common in long bones.
- The healing process involves haemorrhaging, hematoma, calluses, and remodelling.
- Remodelling occurs after the callus has formed, and three factors influence healing.
Parathyroid Hormone (PTH)
- Released by cells in the parathyroid gland.
- Increases osteoclast activity, releasing calcium into blood circulation.
- Inhibits osteoblast activity, reducing calcium deposition.
- Increases the rate of excretion of inorganic phosphate by kidneys.
Vitamin D3 and Calcitriol
- Vitamin D3 is an inactive precursor of calcitriol.
- Calcitriol promotes intestinal absorption of calcium.
- Stimulates osteoclast activity.
Calcitonin
- Has the opposite effect to PTH and calcitriol.
- Decreases osteoclast activity, reducing calcium release from bone.
- Increases osteoblast activity, resulting in calcium deposition.
Spinal Column
- Consists of vertebrae, which have bodies, arches, transverse and spinous processes, and vertebral foramina.
- Between each vertebra are vertebral discs, which act as shock absorbers and allow for flexibility.
- Processes are sites for muscle attachment and provide leverage for movement.
Regions of the Spinal Column
- Cervical (C1-C7): atlas (C1) holds up the head and allows for nodding movement.
- Thoracic (T1-T13): dorsal to the thorax, has the same number of vertebrae as ribs present.
- Lumbar (L1-L7): dorsal to the abdomen, has large bodies to support abdominal organs.
- Sacral (S1-S3): dorsal to the pelvic region, three vertebrae fused together to form the sacrum.
Pelvic Limb
- Consists of the pelvis, femur, patella, fabellae, tibia, fibula, tarsus, metatarsus, and phalanges.
- The pelvis develops as six bones that ossify into a complete structure.
- The two halves of the pelvis are joined ventrally by the pelvic symphysis.
- The pelvis joins the axial skeleton via the sacroiliac joints.
Pelvis
- Hind limbs attach to the spinal column via the pelvis.
- Functions: weight-bearing from hind limbs, protects and supports the intestines, bladder, and internal sex organs.
- Notable structures: pelvic/pubic symphysis, acetabulum, obturator foramina.
Femur
- Long bone of the thigh.
- Proximal end: head of femur, large processes.
- Straight shaft.
- Distal end: forms the stifle joint with the patella and tibia.
Patella
- Sesamoid bone, formed in the distal tendon of the quadriceps femoris muscle.
- Protects the tendon as it passes over the trochlea.
- Inserts on the tibial crest.
Tibia and Fibula
- Tibia: main weight-bearing bone of the lower leg, proximally articulates with the femur to form the stifle joint.
- Fibula: thin bone that parallels the tibia, serves as a muscle attachment site.
Tarsus and Metatarsus
- Tibia and fibula articulate with the talus in the proximal tarsus.
- Distal to the talus is the central tarsal bone, and then the smaller tarsal bones.
- Tarsal bones: two rows of short bones, proximal row is named, and distal row is numbered.
Phalanges
- Similar to the metacarpal bones, but with only four digits.
- Almost exactly the same as in the thoracic limb.
The Pelvic Limb in Different Animals
- Small mammals: have specific adaptations, such as rabbits having a separate bone named os acetabuli.
- Guinea pigs: have a fibrocartilaginous suture line at the pubis and ischium, which allows separation of the pelvis prior to and during parturition.
- Birds: have separate pubis bones that do not meet in the midline, and the pelvis fuses dorsally with the synsacrum.
- Reptiles: have specific adaptations, such as chelonians having a rotated pelvis with the ilium near vertical.
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