33 Questions
How much do adult mice weigh
Between 25-40g, influenced by stock or strain
Variety of colors
Black strains = Black coat and eyes Albino strains = White coats and pink eyes Brown, agouti, grey and piebald = Irregular patches of two colors Outbred stocks = Populations of genetically variable animals that have been closed for at least four generations
Outbred stocks are Populations of genetically variable animals that have been closed for at least four generations
True
Outbred stocks are Populations of genetically variable animals that have been closed for at least one generation
False
Outbred stocks are maintained in large populations
True
Outbred stocks are maintained in small populations
False
Outbred stocks; do not share the same genes but overall genetic composition of population remains stable
True
Outbred stocks; all share the same genes but overall genetic composition of population remains stable
False
Outbred stocks; each mouse is unique and heterogenous when compared to others in the colony
True
Outbred stocks; 20 generations of planned brother x sister or parent x offspring matings
False
Inbred stocks; 20 generations of planned brother x sister or parent x offspring matings
True
Outbred stocks; each mouse is unique and heterogenous when compared to others in the colony
True
Inbred stocks; each mouse is unique and heterogenous when compared to others in the colony
False
Outbred stocks; matings are planned to minimize unintended genetic changes like inbreeding
True
Common outbred strains
Swiss Webster, CD-1, ICR
Inbred strains have
99% or greater homozygosity
Advantage of inbred strains
Produced to select for specific traits like diabetes mellitus or anemia
Common inbred strains
C57BL/6 = Black BALB/C = Albino C3H = Agouti brown w/ some black DBA = Brown; oldest inbred strain
Common inbred mutant strains
Nude (nu/nu), Severe combined immunodeficient (scid/scid)
Inbred strains -mice
Nude (nu/nu) = Deficient in T-cell lymphocytes, nearly hairless Severe combine immunodeficient (scid/scid) = Deficient in both T cells and B cells
- = - . = .
Why are nudes and SCIDS used in oncology research
Both A and B
F1 hybrids are
All of the above
F1 hybrids = Genetically identical at all loci if the parental sex from each strain is consistent (the female of inbred strain 1 mated to the male of inbred strain 2)
True
F1 hybrids = Genetically identical at all loci if the parental sex from each strain is consistent (the male of inbred strain 1 mated to the female of inbred strain 2)
False
F1 hybrids produced from the reverse mating (e.g., the male of inbred strain 1 mated to female of inbred strain are similar but not identical.
True
F1 hybrids produced from the reverse mating (e.g., the male of inbred strain 1 mated to female of inbred strain are identical.
False
Hybrid vigor means
The offspring is heartier than either of the parental strains
[Trangenics] DNA orchestrates the function of an organism (foreign piece of DNA (transgene) is integrated in the genome)
True
Which of the following is true regarding transgenics
All of the above
Microbiologic classifications of mice
Gnotobiotic; defined = or known associated microflora Gnotobiotic; = or germ-free (free of all detectable microflora) Specific pathogen-free = Free of a defined list of pathogens Conventional = Undefined microflora
Barber mouse has no hair loss
True
Which of the following is true of barbering
All of the above
Males have open inguinal canals and an os penis
True
Study Notes
Physical Characteristics
- Adult mice typically weigh between 15-30 grams.
- Mice come in a variety of colors.
Outbred Stocks
- Outbred stocks are populations of genetically variable animals that have been closed for at least four generations.
- They are maintained in large populations to avoid inbreeding.
- Each mouse in an outbred stock is unique and heterogeneous when compared to others in the colony.
- Outbred stocks do not share the same genes, but the overall genetic composition of the population remains stable.
Inbred Stocks
- Inbred stocks are created through 20 generations of planned brother x sister or parent x offspring matings.
- Inbred strains have homogeneous genetic makeup.
- Advantage of inbred strains: reduced genetic variability, which makes them suitable for research.
- Common inbred strains: C57BL/6, BALB/c, and C3H.
Inbred Mutant Strains
- Common inbred mutant strains: nude and SCID.
- Nude and SCID mice are used in oncology research because they have impaired immune systems.
F1 Hybrids
- F1 hybrids are produced by crossing two inbred strains.
- F1 hybrids are genetically identical at all loci if the parental sex from each strain is consistent.
- F1 hybrids produced from the reverse mating are similar but not identical.
Transgenics
- Transgenics involve integrating a foreign piece of DNA (transgene) into the genome of an organism.
- DNA orchestrates the function of an organism.
Microbiologic Classifications
- Microbiologic classifications of mice include germ-free, gnotobiotic, and specific pathogen-free.
Barbering
- Barbering is a behavior where mice groom each other excessively, leading to hair loss.
- Barber mouse has no hair loss, unlike other mice.
Anatomy
- Males have open inguinal canals and an os penis.
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