Mice - up to slide 41
33 Questions
6 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

How much do adult mice weigh

  • Between 25 and 40g on average
  • Between 40-60g, influenced by stock or strain
  • Between 10-35g
  • Between 25-40g, influenced by stock or strain (correct)

    • Variety of colors

    Black strains = Black coat and eyes Albino strains = White coats and pink eyes Brown, agouti, grey and piebald = Irregular patches of two colors Outbred stocks = Populations of genetically variable animals that have been closed for at least four generations

    Outbred stocks are Populations of genetically variable animals that have been closed for at least four generations

    True

    Outbred stocks are Populations of genetically variable animals that have been closed for at least one generation

    <p>False</p> Signup and view all the answers

    Outbred stocks are maintained in large populations

    <p>True</p> Signup and view all the answers

    Outbred stocks are maintained in small populations

    <p>False</p> Signup and view all the answers

    Outbred stocks; do not share the same genes but overall genetic composition of population remains stable

    <p>True</p> Signup and view all the answers

    Outbred stocks; all share the same genes but overall genetic composition of population remains stable

    <p>False</p> Signup and view all the answers

    Outbred stocks; each mouse is unique and heterogenous when compared to others in the colony

    <p>True</p> Signup and view all the answers

    Outbred stocks; 20 generations of planned brother x sister or parent x offspring matings

    <p>False</p> Signup and view all the answers

    Inbred stocks; 20 generations of planned brother x sister or parent x offspring matings

    <p>True</p> Signup and view all the answers

    Outbred stocks; each mouse is unique and heterogenous when compared to others in the colony

    <p>True</p> Signup and view all the answers

    Inbred stocks; each mouse is unique and heterogenous when compared to others in the colony

    <p>False</p> Signup and view all the answers

    Outbred stocks; matings are planned to minimize unintended genetic changes like inbreeding

    <p>True</p> Signup and view all the answers

    Common outbred strains

    <p>Swiss Webster, CD-1, ICR</p> Signup and view all the answers

    Inbred strains have

    <p>99% or greater homozygosity</p> Signup and view all the answers

    Advantage of inbred strains

    <p>Produced to select for specific traits like diabetes mellitus or anemia</p> Signup and view all the answers

    Common inbred strains

    <p>C57BL/6 = Black BALB/C = Albino C3H = Agouti brown w/ some black DBA = Brown; oldest inbred strain</p> Signup and view all the answers

    Common inbred mutant strains

    <p>Nude (nu/nu), Severe combined immunodeficient (scid/scid)</p> Signup and view all the answers

    Inbred strains -mice

    <p>Nude (nu/nu) = Deficient in T-cell lymphocytes, nearly hairless Severe combine immunodeficient (scid/scid) = Deficient in both T cells and B cells</p> <ul> <li>= - . = .</li> </ul> Signup and view all the answers

    Why are nudes and SCIDS used in oncology research

    <p>Both A and B</p> Signup and view all the answers

    F1 hybrids are

    <p>All of the above</p> Signup and view all the answers

    F1 hybrids = Genetically identical at all loci if the parental sex from each strain is consistent (the female of inbred strain 1 mated to the male of inbred strain 2)

    <p>True</p> Signup and view all the answers

    F1 hybrids = Genetically identical at all loci if the parental sex from each strain is consistent (the male of inbred strain 1 mated to the female of inbred strain 2)

    <p>False</p> Signup and view all the answers

    F1 hybrids produced from the reverse mating (e.g., the male of inbred strain 1 mated to female of inbred strain are similar but not identical.

    <p>True</p> Signup and view all the answers

    F1 hybrids produced from the reverse mating (e.g., the male of inbred strain 1 mated to female of inbred strain are identical.

    <p>False</p> Signup and view all the answers

    Hybrid vigor means

    <p>The offspring is heartier than either of the parental strains</p> Signup and view all the answers

    [Trangenics] DNA orchestrates the function of an organism (foreign piece of DNA (transgene) is integrated in the genome)

    <p>True</p> Signup and view all the answers

    Which of the following is true regarding transgenics

    <p>All of the above</p> Signup and view all the answers

    Microbiologic classifications of mice

    <p>Gnotobiotic; defined = or known associated microflora Gnotobiotic; = or germ-free (free of all detectable microflora) Specific pathogen-free = Free of a defined list of pathogens Conventional = Undefined microflora</p> Signup and view all the answers

    Barber mouse has no hair loss

    <p>True</p> Signup and view all the answers

    Which of the following is true of barbering

    <p>All of the above</p> Signup and view all the answers

    Males have open inguinal canals and an os penis

    <p>True</p> Signup and view all the answers

    Study Notes

    Physical Characteristics

    • Adult mice typically weigh between 15-30 grams.
    • Mice come in a variety of colors.

    Outbred Stocks

    • Outbred stocks are populations of genetically variable animals that have been closed for at least four generations.
    • They are maintained in large populations to avoid inbreeding.
    • Each mouse in an outbred stock is unique and heterogeneous when compared to others in the colony.
    • Outbred stocks do not share the same genes, but the overall genetic composition of the population remains stable.

    Inbred Stocks

    • Inbred stocks are created through 20 generations of planned brother x sister or parent x offspring matings.
    • Inbred strains have homogeneous genetic makeup.
    • Advantage of inbred strains: reduced genetic variability, which makes them suitable for research.
    • Common inbred strains: C57BL/6, BALB/c, and C3H.

    Inbred Mutant Strains

    • Common inbred mutant strains: nude and SCID.
    • Nude and SCID mice are used in oncology research because they have impaired immune systems.

    F1 Hybrids

    • F1 hybrids are produced by crossing two inbred strains.
    • F1 hybrids are genetically identical at all loci if the parental sex from each strain is consistent.
    • F1 hybrids produced from the reverse mating are similar but not identical.

    Transgenics

    • Transgenics involve integrating a foreign piece of DNA (transgene) into the genome of an organism.
    • DNA orchestrates the function of an organism.

    Microbiologic Classifications

    • Microbiologic classifications of mice include germ-free, gnotobiotic, and specific pathogen-free.

    Barbering

    • Barbering is a behavior where mice groom each other excessively, leading to hair loss.
    • Barber mouse has no hair loss, unlike other mice.

    Anatomy

    • Males have open inguinal canals and an os penis.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser