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Questions and Answers

What is the mechanism of digoxin action?

  • Enzymatic
  • Receptor
  • Direct chemical
  • Action on ion channels of membrane (correct)
  • What is the phenomenon responsible for intoxication in a patient with chronic cardiac insufficiency prescribed digoxin?

  • Material cumulation
  • Idiosyncrasy
  • Functional cumulation (correct)
  • Tachyphilaxis
  • What is the cause of a patient's condition worsening when using digitoxin for heart failure?

  • Cumulation (correct)
  • Potentiation
  • Tachyphylaxis
  • Functional cumulation
  • What is the phenomenon responsible for the difference in action of methamizole and Piraminal in dental pain?

    <p>Potentiation</p> Signup and view all the answers

    What is the phenomenon responsible for the weakening effect of buckthorn in an elderly patient with senile atonic constipation?

    <p>Tolerance</p> Signup and view all the answers

    What is the phenomenon responsible for the curative effect of bemegride in a patient with respiratory depression during barbituric anesthesia?

    <p>Direct antagonism</p> Signup and view all the answers

    What is the mechanism of action of digoxin in the treatment of heart failure?

    <p>Action on ion channels of membrane</p> Signup and view all the answers

    What is the effect of long-term treatment with digoxin on the heart rate?

    <p>Decreased heart rate</p> Signup and view all the answers

    What is the process of abnormal development of an embryo due to exposure to a toxic substance?

    <p>Teratogenesis</p> Signup and view all the answers

    What is the phenomenon that occurred in the patient who took nitroglycerin several times and then experienced no relief from pain?

    <p>Tolerance</p> Signup and view all the answers

    What is the term for a drug that has no pharmacological activity but is converted to an active form in the body?

    <p>Pro-drug</p> Signup and view all the answers

    What is the phenomenon where a patient requires a lower dose of an analgetic due to the presence of another drug?

    <p>Potentiation</p> Signup and view all the answers

    What is the term for a rapid decrease in the response to a drug, requiring higher doses to achieve the same effect?

    <p>Tachyphylaxis</p> Signup and view all the answers

    What is the syndrome characterized by impairment of psychic, somatic, and vegetative functions caused by drug discontinuation?

    <p>Abstinence</p> Signup and view all the answers

    What is the mechanism of absorption of a lipophilic and unionized drug?

    <p>Passive transport</p> Signup and view all the answers

    What is the term for the development of a new organism from embryo to adult?

    <p>Ontogenesis</p> Signup and view all the answers

    What is the primary purpose of adding adrenaline to a novocaine solution in dentistry?

    <p>To induce local vasoconstriction</p> Signup and view all the answers

    Which drug is most likely to be prescribed to a patient with a tachyarrhythmia?

    <p>Propranolol (Anaprilin)</p> Signup and view all the answers

    What is the mechanism of action of novocaine as an anaesthetic?

    <p>Sodium ion-selective channels blockade</p> Signup and view all the answers

    Which of the following drugs can be used as an alternative to novocaine for anaesthetization in a patient with a positive sensitivity test?

    <p>Lidocaine</p> Signup and view all the answers

    What is the primary concern when choosing an antiarrhythmic drug for a patient with paroxysmal ventricular tachycardia?

    <p>Avoiding lowering cardiac output</p> Signup and view all the answers

    What is the primary mechanism of action of beta-adrenoblockers in the treatment of angina?

    <p>Reducing heart rate and contractility</p> Signup and view all the answers

    What is the likely cause of central nervous system excitation followed by paralysis and acute cardiovascular insufficiency (collapse) in a patient administered a drug for conduction anesthesia?

    <p>Overdose of novocaine</p> Signup and view all the answers

    What is the primary effect of adrenaline on blood vessels?

    <p>Vasoconstriction</p> Signup and view all the answers

    What is the clinical application of diazepam in a patient with nervous tension and poor sleep?

    <p>Anxiolytic effect</p> Signup and view all the answers

    What is a characteristic of zolpidem, a medication prescribed for insomnia?

    <p>It has the ability to cause quick onset of sleep</p> Signup and view all the answers

    Which medication is commonly used to arrest convulsions in a patient with status epilepticus?

    <p>Diazepam</p> Signup and view all the answers

    How does intravenously administered sodium bicarbonate promote kidney excretion of barbiturate in a patient with phenobarbital poisoning?

    <p>Increases the polarity of barbiturate</p> Signup and view all the answers

    Which medication is used as replacement therapy in Parkinson's disease?

    <p>Levodopa</p> Signup and view all the answers

    What is the mechanism of action of zolpidem in promoting sleep in a patient with insomnia?

    <p>It binds to benzodiazepine receptors</p> Signup and view all the answers

    What is a side effect of long-term use of bromizoval, a medication prescribed for insomnia?

    <p>Dependence and withdrawal symptoms</p> Signup and view all the answers

    What type of adrenoceptor stimulation is most likely to increase noradrenaline release from sympathetic nerve endings?

    <p>Alpha2– adrenoceptors</p> Signup and view all the answers

    What is the mechanism of action of the drug used to treat a patient with moderate hypertension?

    <p>Decrease in noradrenaline release from sympathetic nerve endings</p> Signup and view all the answers

    Which of the following drugs is most likely to be used for pharmacotherapy of benign tumor of prostate?

    <p>Prazosin</p> Signup and view all the answers

    What is the most likely cause of the patient's condition after the injection of 1% procaine for conduction anesthesia?

    <p>Anaphylactic shock</p> Signup and view all the answers

    Which of the following drugs is a beta1– adrenoceptor agonist with inotropic action?

    <p>Dobutamine</p> Signup and view all the answers

    What type of drug is most likely to be used to provide first aid in an asthma attack?

    <p>Beta– adrenomimetics</p> Signup and view all the answers

    What is the mechanism of action of the drug used to treat a patient with heart failure resistant to cardiac glycosides?

    <p>Increase in beta1– adrenoceptors stimulation</p> Signup and view all the answers

    Which of the following drugs is most likely to be used to treat anaphylactic shock?

    <p>Adrenaline</p> Signup and view all the answers

    Study Notes

    Teratogenesis, Carcinogenesis, and Mutagenesis

    • Teratogenesis is not mentioned in the provided text.
    • Carcinogenesis is not mentioned in the provided text.
    • Mutagenesis is not mentioned in the provided text.

    Pharmacology

    • Nitroglycerin is a medication that can cause tolerance, which means that the patient may need to take higher doses to achieve the same effect.
    • The doctor advised the patient to withdraw nitroglycerin for 8 hours and prescribed another drug to restore the effect of nitroglycerin.
    • Enalapril is a pro-drug used to treat hypertension.
    • Diazepam can cause tolerance, which means that the patient may need to take higher doses to achieve the same effect.
    • The doctor took into account the phenomenon of potentiation when prescribing an analgetic to the patient.
    • Sustak-forte is a medication that can cause tachyphylaxis, which means that the patient may experience a decrease in response to the drug over time.
    • Dependence is a syndrome characterized by impairment of psychic, somatic, and vegetative functions when the drug is discontinued.
    • Digoxin is a medication that can cause material cumulation, which means that the concentration of the drug in the body increases over time.
    • Digitoxin is a medication that can cause cumulation, which means that the concentration of the drug in the body increases over time.
    • Methamizole (analgin) is an analgesic that has a faster and shorter duration of action compared to Piraminal.
    • Buckthorn is a medication that can cause tolerance, which means that the patient may need to take higher doses to achieve the same effect.
    • Bemegride is a medication that can reverse the effects of barbituric anesthesia.
    • Reserpine is a medication that can cause drowsiness as a side effect.
    • Prazosin is a medication that can decrease noradrenaline release from sympathetic nerve endings.
    • Adrenaline is a medication that can be used to treat severe allergic reactions.
    • Dobutamine is a medication that has inotropic (cardiotonic) action.
    • Fenoterol is a beta-adrenomimetic that can be used to provide first aid in severe allergic reactions.
    • Propranolol (Anaprilin) is a beta-adrenoblocker that can be used to treat tachyarrhythmia.
    • Metoprolol is a selective beta-adrenoblocker that can be used to treat angina.
    • Atropine is a medication that can cause local vasoconstriction when added to novocaine solution.
    • Novocaine is a local anesthetic that can cause sodium ion-selective channels blockade.
    • Lidocaine is a medication that can be used for anaesthetization in patients who are sensitive to novocaine.
    • Verapamil is a medication that can be used to treat paroxysmal ventricular tachycardia.
    • Diazepam is a medication that has anxiolytic (tranquilizing) effects and can be used to treat nervous tension and insomnia.
    • Zolpidem is a medication that can cause quick onset of sleep and is used to treat insomnia.
    • Sodium valproate is a medication that can be used to treat epilepsy (grand mal).
    • Phenytoin is an antiepileptic drug that can prevent metabolism of GABA.
    • Carbamazepine is an antiepileptic drug that can be used to treat epilepsy (grand mal).
    • Levodopa is a medication that can be used to treat Parkinson's disease.

    Mechanisms of Action

    • Physicochemical mechanism of action: not mentioned in the provided text.
    • Enzymatic mechanism of action: not mentioned in the provided text.
    • Receptor mechanism of action: not mentioned in the provided text.
    • Action on ion channels of membrane: not mentioned in the provided text.

    Drug Interactions

    • Potentiation: the phenomenon of two or more drugs increasing each other's effects.
    • Cumulation: the phenomenon of a drug accumulating in the body over time, leading to increased effects.
    • Tolerance: the phenomenon of the body adapting to the presence of a drug, leading to decreased effects.
    • Dependence: the phenomenon of the body becoming physically dependent on a drug, leading to withdrawal symptoms when the drug is discontinued.
    • Sensitization: the phenomenon of the body becoming more sensitive to the effects of a drug over time.
    • Idiosyncrasy: the phenomenon of an individual's unusual response to a drug.
    • Desensitization: the phenomenon of the body becoming less sensitive to the effects of a drug over time.
    • Synergism: the phenomenon of two or more drugs working together to produce a greater effect.
    • Antagonism: the phenomenon of two or more drugs opposing each other's effects.

    Pharmacokinetics

    • Absorption: the process of a drug entering the body.
    • Distribution: the process of a drug spreading throughout the body.
    • Metabolism: the process of a drug being broken down by the body.
    • Excretion: the process of a drug being eliminated from the body.

    Pharmacodynamics

    • Mechanism of action: the way in which a drug produces its effects.
    • Effects: the changes produced by a drug in the body.
    • Side effects: the unwanted effects produced by a drug in the body.
    • Interactions: the effects of a drug on other drugs or substances in the body.

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