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Questions and Answers
What factors affect flowability?
What factors affect flowability?
- Material characteristics
- Equipment characteristics
- Both material and equipment characteristics (correct)
- Temperature and humidity
How can powder flowability vary?
How can powder flowability vary?
- Different powders can flow differently in the same hopper (correct)
- The same powder always flows the same way in any hopper
- Different powders always flow the same way in any hopper
- The same powder flows differently based on the weather
Is powder flowability a simple concept
Is powder flowability a simple concept
False (B)
What is the definition of powder flowability?
What is the definition of powder flowability?
What are flow properties?
What are flow properties?
What are some of the flow properties mentioned in the passage?
What are some of the flow properties mentioned in the passage?
How do flow properties arise in a powder?
How do flow properties arise in a powder?
Which of the following is NOT an example of flow properties?
Which of the following is NOT an example of flow properties?
What are some forces that affect the flow properties individual of powder?
What are some forces that affect the flow properties individual of powder?
How does uneven powder flow affect high-speed tableting conditions?
How does uneven powder flow affect high-speed tableting conditions?
Which of the following describes the purpose of reproducible filling of tablet dies and capsule dosators?
Which of the following describes the purpose of reproducible filling of tablet dies and capsule dosators?
How can excess fine particles in a powder affect its flowability?
How can excess fine particles in a powder affect its flowability?
How does excess fine particles in a powder affect its flowability?
How does excess fine particles in a powder affect its flowability?
What is the importance of flowability in the production of pharmaceutical dosage forms?
What is the importance of flowability in the production of pharmaceutical dosage forms?
Why is it important to have uniform flow from bulk storage containers or hoppers into the feed mechanisms of tableting or capsule filling equipment?
Why is it important to have uniform flow from bulk storage containers or hoppers into the feed mechanisms of tableting or capsule filling equipment?
Which of the following flow properties is of critical significance in operations such as:
Which of the following flow properties is of critical significance in operations such as:
All of the following is correct powders flow properties are measured using a number of parameters except:
All of the following is correct powders flow properties are measured using a number of parameters except:
What department is responsible for determining flow properties and other derived and intrinsic properties in the preformulation stage?
What department is responsible for determining flow properties and other derived and intrinsic properties in the preformulation stage?
What is cohesion?
What is cohesion?
What is adhesion?
What is adhesion?
What are adhesive and cohesive forces mainly composed of?
What are adhesive and cohesive forces mainly composed of?
What provides a useful method of characterizing the drag or frictional forces within a powder bed?
What provides a useful method of characterizing the drag or frictional forces within a powder bed?
Which type of forces arise from contact or frictional charging?
Which type of forces arise from contact or frictional charging?
Which of the following is NOT an attractive force contributing to interparticulate adhesion and cohesion?
Which of the following is NOT an attractive force contributing to interparticulate adhesion and cohesion?
What are flow properties used for in the formation of stable tablets?
What are flow properties used for in the formation of stable tablets?
True or False: Flow properties are employed as the flow measurements of the effect that the interparticulate forces acting at once.
True or False: Flow properties are employed as the flow measurements of the effect that the interparticulate forces acting at once.
Which of the following is flow properties powders are classified?
Which of the following is flow properties powders are classified?
Which factors can affect flow properties ?
Which factors can affect flow properties ?
Flow properties of solids have a great impact on the tableting and encapsulation process.
Flow properties of solids have a great impact on the tableting and encapsulation process.
What can be affected by the uniform & rapid flow of powders?
What can be affected by the uniform & rapid flow of powders?
All of the following is correct flow property Interparticulate forces are of several types except ?
All of the following is correct flow property Interparticulate forces are of several types except ?
What does the term hygroscopicity describe in the pharmaceutical Sciences?
What does the term hygroscopicity describe in the pharmaceutical Sciences?
How can hygroscopicity be defined?
How can hygroscopicity be defined?
What are some physicochemical properties that can affect hygroscopicity?
What are some physicochemical properties that can affect hygroscopicity?
What are some possible outcomes of water uptake by a hygroscopic material?
What are some possible outcomes of water uptake by a hygroscopic material?
What can deliquescence formation result in?
What can deliquescence formation result in?
When water exists as a hydrate, it usually results in:
When water exists as a hydrate, it usually results in:
What types of interactions can water molecules have with the components of a dosage form?
What types of interactions can water molecules have with the components of a dosage form?
Which of the following is an example of a salt with water of crystallisation?
Which of the following is an example of a salt with water of crystallisation?
Which salt has the formula CuSO4·5H2O?
Which salt has the formula CuSO4·5H2O?
Which compound has the formula Na2CO3·10H2O?
Which compound has the formula Na2CO3·10H2O?
When does water of crystallisation get lost?
When does water of crystallisation get lost?
Water of crystallisation:a certain fixed number of water molecules
Water of crystallisation:a certain fixed number of water molecules
How do efflorescent substances differ from deliquescent substances?
How do efflorescent substances differ from deliquescent substances?
What is the phenomenon called when hydrated crystals lose water molecules on exposure to air at normal temperature?
What is the phenomenon called when hydrated crystals lose water molecules on exposure to air at normal temperature?
Which of the following is an example of an efflorescent substance on exposure to air at ordinary temperature?
Which of the following is an example of an efflorescent substance on exposure to air at ordinary temperature?
What is the phenomenon called when some crystalline salts absorb moisture from the air and dissolve in it to form an aqueous solution?
What is the phenomenon called when some crystalline salts absorb moisture from the air and dissolve in it to form an aqueous solution?
True or False: Deliquescent substances always contain water of crystallization.
True or False: Deliquescent substances always contain water of crystallization.
Which of the following is an example of a deliquescent substance?
Which of the following is an example of a deliquescent substance?
What is hygroscopicity?
What is hygroscopicity?
What is a deliquescent substance?
What is a deliquescent substance?
What is an efflorescent substance?
What is an efflorescent substance?
Study Notes
Factors Affecting Flowability
- Powder flowability can be affected by various factors, including excess fine particles.
Definition of Powder Flowability
- Powder flowability refers to the ability of a powder to flow smoothly and consistently.
Flow Properties
- Flow properties are characteristics that describe the flow behavior of a powder.
- Examples of flow properties include:
- Cohesion (interparticle attraction)
- Adhesion (particle-to-particle or particle-to-surface attraction)
- Frictional forces
- Drag forces
Importance of Flowability
- Uniform flow is crucial in pharmaceutical production, as it affects the quality of tablets and capsules.
- Flowability is critical in high-speed tableting conditions to ensure consistent and accurate filling of tablet dies and capsule dosators.
Adhesion and Cohesion
- Adhesion: attraction between unlike particles or surfaces
- Cohesion: attraction between like particles
- Both adhesion and cohesion are composed of van der Waals forces, electrostatic forces, and hydrogen bonding.
Measuring Flow Properties
- Flow properties are measured using various parameters, such as angle of repose and compressibility.
Interparticulate Forces
- Interparticulate forces arise from contact or frictional charging between particles.
- Examples of interparticulate forces include van der Waals forces, electrostatic forces, and hydrogen bonding.
Hygroscopicity
- Hygroscopicity: the ability of a substance to absorb water vapor from the air.
- Physicochemical properties that can affect hygroscopicity include surface area, particle size, and surface chemistry.
- Hygroscopic materials can undergo deliquescence (dissolution in absorbed water) or efflorescence (loss of water of crystallization).
Water of Crystallization
- Water of crystallization: water molecules incorporated into a crystal lattice.
- Examples of salts with water of crystallization include CuSO4·5H2O and Na2CO3·10H2O.
- Water of crystallization can be lost on exposure to air or heat.
Deliquescent and Efflorescent Substances
- Deliquescent substances: absorb moisture from the air and dissolve in it to form a solution.
- Efflorescent substances: lose water of crystallization on exposure to air.
- Examples of deliquescent substances include NaNO3 and KNO3.
- Examples of efflorescent substances include Na2CO3 and CuSO4.
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Description
This quiz covers the importance of flowability in the production of pharmaceutical dosage forms, including reasons for producing free-flowing pharmaceutical powders and their impact on tablet weight uniformity and filling processes.
