TB

through aerosols containing M.tuberculosis

1. host entry through the lungs
2. multiplication
3. infection of macrophages
4. expansion in innate granulomas 5.granuloma maturation 6.granuloma necrosis with extracellular replication
5. transmission

exposure, latent infection, active infection, reactivation of latent infection

<p>MTB enters macrophage through receptor-mediated endocytosis and blocks maturation of the phagosome. it also blocks the phagosome from fusing with the lysosome. prevents acidification of the phagosomes. mTB produces several proteins which interfere with different antimicrobial pathways</p> Signup and view all the answers

<ol> <li>manoux test-only shows a person has been infected</li> <li>chest x-ray - shows active infection</li> <li>rapid molecular diagnostic tests</li> </ol> Signup and view all the answers

<p>isoniazid, rifampin, ethanbutol and pyrazinamide</p> Signup and view all the answers

<p>BCG vaccine</p> Signup and view all the answers

<p>early dignosis of extrapulmonary TB is hard because the symptoms can be vague</p> Signup and view all the answers