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Questions and Answers
What is the main characteristic of Polyomavirus JC and BK?
What is the primary cause of progressive multifocal leukoencephalopathy (PML)?
What is the CD4 count associated with an increased risk of developing PML?
What is the characteristic of PML in terms of brain lesions?
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What is the primary complication associated with BK virus?
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What is the common complication observed in transplant patients infected with Polyomavirus?
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What is the unique feature of Polyomavirus JC and BK among viruses?
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Study Notes
Polyomavirus JC and BK
- Polyomavirus JC is a circular double-stranded DNA virus that causes progressive multifocal leukoencephalopathy (PML).
- PML is a demyelination disease that occurs in immunocompromised individuals, typically with CD4 counts less than 200 in AIDS patients.
- PML is a multifocal disease, characterized by non-enhancing multifocal brain lesions in white matter, and has a high mortality rate (1/2 of patients die within a few months).
- Polyomavirus JC is associated with motor neuropathy in AIDS patients.
BK Virus
- BK Virus is a polyomavirus that causes nephropathy, particularly in kidney transplant patients.
- The virus can cause hemorrhagic cystitis, characterized by red-colored urine.
- BK Virus is commonly found in renal patients on immunosuppressants who experience hematuria (blood in the urine).
- Polyomavirus BK has a unique circular double-stranded DNA structure, similar to Polyomavirus JC.
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Description
Test your knowledge of Polyomavirus JC and BK, including their characteristics, effects on immunocompromised individuals, and relationship to progressive multifocal leukoencephalopathy (PML).
