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Questions and Answers
What is the main characteristic of Polyomavirus JC and BK?
What is the main characteristic of Polyomavirus JC and BK?
- They have a linear DNA genome
- They are enveloped viruses
- They have a circular dsDNA genome (correct)
- They are RNA viruses
What is the primary cause of progressive multifocal leukoencephalopathy (PML)?
What is the primary cause of progressive multifocal leukoencephalopathy (PML)?
- JC virus (correct)
- BK virus
- Human immunodeficiency virus (HIV)
- Cytomegalovirus (CMV)
What is the CD4 count associated with an increased risk of developing PML?
What is the CD4 count associated with an increased risk of developing PML?
- Less than 1000
- Less than 100
- Less than 200 (correct)
- Less than 500
What is the characteristic of PML in terms of brain lesions?
What is the characteristic of PML in terms of brain lesions?
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What is the primary complication associated with BK virus?
What is the primary complication associated with BK virus?
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What is the common complication observed in transplant patients infected with Polyomavirus?
What is the common complication observed in transplant patients infected with Polyomavirus?
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What is the unique feature of Polyomavirus JC and BK among viruses?
What is the unique feature of Polyomavirus JC and BK among viruses?
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Study Notes
Polyomavirus JC and BK
- Polyomavirus JC is a circular double-stranded DNA virus that causes progressive multifocal leukoencephalopathy (PML).
- PML is a demyelination disease that occurs in immunocompromised individuals, typically with CD4 counts less than 200 in AIDS patients.
- PML is a multifocal disease, characterized by non-enhancing multifocal brain lesions in white matter, and has a high mortality rate (1/2 of patients die within a few months).
- Polyomavirus JC is associated with motor neuropathy in AIDS patients.
BK Virus
- BK Virus is a polyomavirus that causes nephropathy, particularly in kidney transplant patients.
- The virus can cause hemorrhagic cystitis, characterized by red-colored urine.
- BK Virus is commonly found in renal patients on immunosuppressants who experience hematuria (blood in the urine).
- Polyomavirus BK has a unique circular double-stranded DNA structure, similar to Polyomavirus JC.
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