Unraveling the Intricacies of Functional Dyspepsia
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Questions and Answers

Which pathways are proposed to contribute to dyspeptic symptoms in FD?

  • Central signalling only
  • Intestinal immune dysfunction and the microbiome only
  • Inflammatory mediators and cytokines released by activated intestinal eosinophils and mast cells only
  • All of the above (correct)

What can alter peripheral gastrointestinal function in FD?

  • Acute infections and food antigens
  • The gastrointestinal immune system and the microbiome
  • Bile acid metabolism and corticotropin-releasing hormone
  • All of the above (correct)

What might lead to dysfunction of the intestinal epithelial barrier in FD?

  • Low-grade inflammatory response
  • Recognition of antigens by immune cells
  • Alterations in steady state (correct)
  • All of the above

How can intestinal immune dysfunction and the microbiome modulate CNS function in FD?

<p>By releasing inflammatory mediators and cytokines (A)</p> Signup and view all the answers

What are potential environmental factors that can impact gastrointestinal function in FD?

<p>Acid and capsaicin (A)</p> Signup and view all the answers

What is the role of central signaling in the pathophysiology of FD?

<p>It can alter peripheral gastrointestinal function (A)</p> Signup and view all the answers

How can alterations in the steady state of the gastrointestinal tract and gut microbiome impact FD?

<p>They can increase mucosal permeability (C)</p> Signup and view all the answers

What can lead to a low-grade inflammatory response in FD?

<p>All of the above (D)</p> Signup and view all the answers

Which cells release inflammatory mediators and cytokines in FD?

<p>All of the above (D)</p> Signup and view all the answers

How can intestinal immune dysfunction and the microbiome impact CNS function in FD?

<p>They can modulate CNS function (B)</p> Signup and view all the answers

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