Unraveling Human Genetic Diversity

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Variants in the human genome are from population genetics over about 0.5 million years. Mutations over animal and human evolution. Interbreeding with extinct hominins. Human migrations (gene flow). Bottleneck and Founder effects on population size lead to genetic drift. Environmental selection for specific alleles

explanations

1000 Genomes ______ consortium analyzed genomic data to develop ethnic haplotypes for use as reference genomes. Sequenced genomes from regions across the globe to generate haplotypes (a) Haplotype: genotype inherited from one of the parents (b) Haplotype mostly algorithmically determined but imputed (predicted) in some cases via parent-offspring analysis (c) Homologous recombination is not random on a chromosome/have specific locations. Compared haplotypes to determine variants within and between different human populations. Typical variation

project

Variants in the human ______ are from population genetics over about 0.5 million years. Mutations over animal and human evolution. Interbreeding with extinct hominins. Human migrations (gene flow). Bottleneck and Founder effects on population size lead to genetic drift. Environmental selection for specific alleles

genome

1000 Genomes project consortium analyzed genomic data to develop ethnic for use as reference genomes. Sequenced genomes from regions across the globe to generate (a) Haplotype: genotype inherited from one of the parents (b) Haplotype mostly algorithmically determined but imputed (predicted) in some cases via parent-offspring analysis (c) Homologous recombination is not random on a chromosome/have specific locations. Compared __ to determine variants within and between different human populations. Typical variation

haplotypes Signup and view all the answers

Variants in the human genome are from population genetics over about 0.5 million years. Mutations over animal and human evolution. Interbreeding with extinct hominins. Human migrations (gene flow). Bottleneck and Founder effects on population size lead to genetic drift. Environmental selection for specific alleles

humans Signup and view all the answers

Match the following factors to the correct descriptions:

Variants in the human genome = Are from population genetics over about 0.5 million years Mutations = Occurred over animal and human evolution Interbreeding with extinct hominins = Has contributed to variants in the human genome Human migrations (gene flow) = Has influenced the genetic variation in different populations Signup and view all the answers

Match the following terms to their definitions:

Haplotype = Genotype inherited from one of the parents Genetic drift = Bottleneck and Founder effects on population size lead to this Environmental selection = Leads to specific alleles being favored in a given environment Homologous recombination = Not random on a chromosome and has specific locations Signup and view all the answers

Match the following actions to their descriptions in the 1000 Genomes project:

Sequencing genomes from regions across the globe = To generate haplotypes Comparing haplotypes = To determine variants within and between different human populations Algorithmically determining haplotypes = In most cases, but not all Using parent-offspring analysis = To predict haplotypes in some cases Signup and view all the answers

Match the following effects to their causes in population genetics:

Genetic drift = Caused by Bottleneck and Founder effects on population size Variation in the human genome = Caused by mutations over animal and human evolution Specific alleles favored = Caused by environmental selection Different variants between human populations = Caused by human migrations (gene flow) Signup and view all the answers

Match the following terms to their definitions in the context of population genetics:

Bottleneck effect = Occurs when a population's size is reduced for at least one generation, leading to a loss of genetic variation Founder effect = Occurs when a new colony is started by a few members of the original population, leading to a loss of genetic variation Gene flow = The transfer of genetic variation from one population to another Environmental selection = The process by which certain genotypes are favored in a particular environment Signup and view all the answers