7 Questions
Which inhibitory molecules are targeted in tumor immunotherapy?
CTLA-4 and PD-1
What is the principle behind tumor immunotherapy?
Boosting host immune responses by blocking inhibitory signals for T cells
What is the response rate to checkpoint blockade therapies?
25% to 40%
Which type of tumors are the most likely to respond to checkpoint blockade therapy?
Tumors with deficiencies in mismatch repair enzymes
What is the most common side effect associated with checkpoint blockade therapy?
Autoimmune damage to various organs
What is the first approved example of combined checkpoint blockade therapy?
Anti-CTLA-4 and anti-PD-1
What is the main role of inhibitory receptors targeted by checkpoint blockade therapy?
To maintain tolerance to self antigens
Quiz: Boosting Immune Responses Against Tumors by Blocking Inhibitory Receptors Discover the novel strategy of tumor immunotherapy by inhibiting inhibitory receptors on T cells. Test your knowledge on how blocking these receptors can stimulate antitumor immune responses and enhance host immune defenses against tumors.
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