Unlocking Tumor Immunity
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Questions and Answers

Which inhibitory molecules are targeted in tumor immunotherapy?

  • CTLA-4 and PD-1 (correct)
  • PD-L1 and CTLA-4
  • PD-1 and TIM-3
  • LAG-3 and TIM-3

    • What is the principle behind tumor immunotherapy?

  • Engaging regulatory mechanisms to evade immune attack
  • Suppressing immune responses to tumors
  • Boosting host immune responses by blocking inhibitory signals for T cells (correct)
  • Enhancing the efficacy of checkpoint blockade therapies

    • What is the response rate to checkpoint blockade therapies?

  • Less than 10%
  • 50% to 75%
  • 25% to 40% (correct)
  • More than 90%

    • Which type of tumors are the most likely to respond to checkpoint blockade therapy?

    <p>Tumors with deficiencies in mismatch repair enzymes</p> Signup and view all the answers

    What is the most common side effect associated with checkpoint blockade therapy?

    <p>Autoimmune damage to various organs</p> Signup and view all the answers

    What is the first approved example of combined checkpoint blockade therapy?

    <p>Anti-CTLA-4 and anti-PD-1</p> Signup and view all the answers

    What is the main role of inhibitory receptors targeted by checkpoint blockade therapy?

    <p>To maintain tolerance to self antigens</p> Signup and view all the answers

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