Unlocking the Secrets of mtDNA Mutations

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Questions and Answers

Which of the following is true about the mitochondrial theory of ageing?

  • There is no evidence to support the mitochondrial theory of ageing.
  • Somatic mutations in mtDNA result in the accumulation of reactive oxygen species. (correct)
  • Somatic mutations in mtDNA do not affect cellular and tissue functions.
  • Somatic mutations in mtDNA lead to an increase in mitochondrial function.

What did Vogelstein and colleagues find in their study on colorectal cancer cell lines?

  • All of the cell lines studied had mtDNA mutations.
  • Only a few of the cell lines studied had mtDNA mutations. (correct)
  • The study did not find any evidence of mtDNA mutations in colorectal cancer.
  • No mtDNA mutations were present in any of the cell lines studied.

What is the relationship between mtDNA mutations and the development of tumours?

  • mtDNA mutations only contribute to the detection of tumour recurrence.
  • There is a direct link between the presence of mtDNA mutations and the development of tumours.
  • There is no evidence to suggest that mtDNA mutations contribute to the development of tumours. (correct)
  • mtDNA mutations only contribute to the detection of genotoxic damage.

What is the main consequence of the reactive oxygen species vicious cycle during ageing?

<p>Exponential increase in oxidative damage. (A)</p> Signup and view all the answers

What is the potential significance of mtDNA mutations in the detection of tumour recurrence?

<p>mtDNA mutations can be used to detect the presence of tumours. (D)</p> Signup and view all the answers

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