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What is the main finding about the CD4+ T cell response to SARS-CoV-2 in previously infected individuals?
What is the main finding about the CD4+ T cell response to SARS-CoV-2 in previously infected individuals?
The CD4+ T cell response in every individual targeted several viral epitopes.
What is the significance of the broad CD4+ T cell response to SARS-CoV-2?
What is the significance of the broad CD4+ T cell response to SARS-CoV-2?
The broad CD4+ T cell response limits the impact of mutations in current VOCs on overall CD4+ T cell surveillance.
What does the lack of cross-reactivity with β-HCoVs indicate about the origin of SARS-CoV-2 S-specific CD4+ T cell clones?
What does the lack of cross-reactivity with β-HCoVs indicate about the origin of SARS-CoV-2 S-specific CD4+ T cell clones?
The SARS-CoV-2 S-specific CD4+ T cell clones originated from the naïve repertoire rather than pre-existing β-HCoV-specific CD4+ TM cells.
How do mutations in SARS-CoV-2 VOCs affect CD4+ T cell recognition of S epitopes?
How do mutations in SARS-CoV-2 VOCs affect CD4+ T cell recognition of S epitopes?
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What is the potential role of T cells elicited by previous infection with endemic β-HCoVs?
What is the potential role of T cells elicited by previous infection with endemic β-HCoVs?
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