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What is an uncomplicated UTI infection?
What is an uncomplicated UTI infection?
An uncomplicated urinary tract infection is a bacterial infection of the bladder and associated structures. Patient with uncomplicated UTIshave no structural abnormality of the urinary tract and no comorbidities, such as diabetes, an immunocompromised state, recent neurologic, surgery, or pregnancy. 
How to treat uncomplicated UTIs
How to treat uncomplicated UTIs
Treat with PO TMR-SMX ( timethprim / sulfamethoxazole) or fluoroquinolones for 3 days or nitrofurantoin for 5 days..
Examples of fluiroquinolones used in uncomplicated UTIs with doses
Examples of fluiroquinolones used in uncomplicated UTIs with doses
Ciprofloxacin 500 mg twice daily levofloxacin 500 mg once daily Gatifloxacin 400 mg once daily. All for 3 days if uncomplicated UTI
What is the dose of nitrofurantoin in uncomplicated UTI treatment ?
What is the dose of nitrofurantoin in uncomplicated UTI treatment ?
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What is a complicated UTI infection?
What is a complicated UTI infection?
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Treatment of complicated UTI ?
Treatment of complicated UTI ?
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How to treat UTI in a pregnant woman ?
How to treat UTI in a pregnant woman ?
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What is urosepsis?
What is urosepsis?
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How to treat urosepsis?
How to treat urosepsis?
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Why methenamine is used as prophylaxis in uti?
Why methenamine is used as prophylaxis in uti?
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Mnemonic SEEKS PP
Mnemonic SEEKS PP
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What percentage of pregnant women with asymptomatic bacteriuria will develop a UTI or pyelonephritis if untreated?
What percentage of pregnant women with asymptomatic bacteriuria will develop a UTI or pyelonephritis if untreated?
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Which organism is responsible for the majority of urinary tract infections in pregnant women?
Which organism is responsible for the majority of urinary tract infections in pregnant women?
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What initial tests are best for diagnosing a urinary tract infection in pregnant women?
What initial tests are best for diagnosing a urinary tract infection in pregnant women?
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What is the recommended treatment duration for asymptomatic bacteriuria in pregnant women?
What is the recommended treatment duration for asymptomatic bacteriuria in pregnant women?
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In the case of pyelonephritis during pregnancy, what is the recommended management approach?
In the case of pyelonephritis during pregnancy, what is the recommended management approach?
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Study Notes
Urinary Tract Infections (UTIs) in Pregnancy
- Asymptomatic bacteriuria (no symptoms but bacteria in urine) affects up to 7% of pregnant women.
- Untreated asymptomatic bacteriuria increases risk of preterm labor, low birth weight, and perinatal death.
- Untreated asymptomatic bacteriuria leads to a UTI or pyelonephritis in 30-40% of cases.
- E. coli causes 70-90% of UTIs.
History and Physical Exam (H&P)
- Asymptomatic bacteriuria: Diagnosed by urine culture showing ≥103 colony-forming units (CFUs) in a first-trimester screening urine sample.
- UTI: Symptoms include dysuria (painful urination), urinary urgency (frequent need to urinate), and urinary frequency.
- Pyelonephritis: Presents similarly to UTI, but also with fever and costovertebral angle (CVA) tenderness (pain in the side or back just below the ribs where the spine and ribs meet).
Diagnosis
- Urinalysis (UA) and urine culture are the initial tests used to diagnose UTIs and pyelonephritis.
Treatment
- Asymptomatic bacteriuria and UTI: Treat with 3-7 days of nitrofurantoin, cephalexin, or amoxicillin-clavulanate (avoid nitrofurantoin in 1st trimester if possible).
- Follow up: Perform a urine culture one week after the completion of antibiotics (test of cure).
- Pyelonephritis: Requires hospitalization. Treatment includes IV fluids, IV third-generation cephalosporins, and suppressive antibiotics (antibiotics given continuously in a lower dose) that are targeted against the specific bacterial cause identified in a urine culture of the infection. Follow-up cultures throughout the rest of the pregnancy are essential, too.
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