Urinary tract infection
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Questions and Answers

What is an uncomplicated UTI infection?

An uncomplicated urinary tract infection is a bacterial infection of the bladder and associated structures. Patient with uncomplicated UTIshave no structural abnormality of the urinary tract and no comorbidities, such as diabetes, an immunocompromised state, recent neurologic, surgery, or pregnancy. 

How to treat uncomplicated UTIs

Treat with PO TMR-SMX ( timethprim / sulfamethoxazole) or fluoroquinolones for 3 days or nitrofurantoin for 5 days..

Examples of fluiroquinolones used in uncomplicated UTIs with doses

Ciprofloxacin 500 mg twice daily levofloxacin 500 mg once daily Gatifloxacin 400 mg once daily. All for 3 days if uncomplicated UTI

What is the dose of nitrofurantoin in uncomplicated UTI treatment ?

<p>Adults and children 12 years old of age and older : 100 mg every 12 hours for 5 days</p> Signup and view all the answers

What is a complicated UTI infection?

<p>Any UTI in immunocompromised patients , males , pregnant patients , and those with urinary obstruction, renal transplant patient and catheter instrumentation are considered complicated UTI</p> Signup and view all the answers

Treatment of complicated UTI ?

<p>The same antibiotics as uncomplicated UTI but for 7-14 days</p> Signup and view all the answers

How to treat UTI in a pregnant woman ?

<p>Treat a symptomatic bacteria or symptomatic UTI with NITROFURANTOIN, oral cephalosporin, or amoxicillin for 3 to 7 days point avoid fluoroquinolone, TMP – SMX, and tetracyclines. Confirm clearance with a post treatment urine culture.</p> Signup and view all the answers

What is urosepsis?

<p>Urosepsis is a severe and potentially life-threatening condition caused by a urinary tract infection that spreads into the bloodstream, leading to systemic infection and sepsis.</p> Signup and view all the answers

How to treat urosepsis?

<p>Patients with urosepsis should be hospitalized for urgent care, starting with intravenous antibiotics to combat the infection. Initial treatment often includes broad-spectrum antibiotics to cover resistant Gram-negative rods (GNRs) and enterococcus, ensuring effective management of potential resistant pathogens until specific cultures guide therapy adjustments.</p> Signup and view all the answers

Why methenamine is used as prophylaxis in uti?

<p>Methenamine is used as a urinary antiseptic to help prevent recurrent urinary tract infections (UTIs). It works by being converted to formaldehyde in the acidic environment of the urine, which then acts to suppress bacterial growth. Methenamine is typically used for prophylaxis rather than acute treatment of UTIs and is most effective when the urine is consistently acidic.</p> Signup and view all the answers

Mnemonic SEEKS PP

<p>The mnemonic SEEKS PP is a helpful way to remember the common organisms that cause urinary tract infections (UTIs):</p> <ul> <li> <strong>S</strong>: Serratia</li> <li> <strong>E</strong>: Escherichia coli (E. coli)</li> <li> <strong>E</strong>: Enterococcus</li> <li> <strong>K</strong>: Klebsiella</li> <li> <strong>S</strong>: Staphylococcus saprophyticus</li> <li> <strong>P</strong>: Proteus</li> <li> <strong>P</strong>: Pseudomonas These pathogens are frequently involved in UTIs, with Escherichia coli being the most common culprit.</li> </ul> Signup and view all the answers

What percentage of pregnant women with asymptomatic bacteriuria will develop a UTI or pyelonephritis if untreated?

<p>30-40% (D)</p> Signup and view all the answers

Which organism is responsible for the majority of urinary tract infections in pregnant women?

<p>Escherichia coli (D)</p> Signup and view all the answers

What initial tests are best for diagnosing a urinary tract infection in pregnant women?

<p>Urinalysis and urine culture (C)</p> Signup and view all the answers

What is the recommended treatment duration for asymptomatic bacteriuria in pregnant women?

<p>3-7 days (A)</p> Signup and view all the answers

In the case of pyelonephritis during pregnancy, what is the recommended management approach?

<p>Admit to hospital for IV treatment and fluids (A)</p> Signup and view all the answers

Study Notes

Urinary Tract Infections (UTIs) in Pregnancy

  • Asymptomatic bacteriuria (no symptoms but bacteria in urine) affects up to 7% of pregnant women.
  • Untreated asymptomatic bacteriuria increases risk of preterm labor, low birth weight, and perinatal death.
  • Untreated asymptomatic bacteriuria leads to a UTI or pyelonephritis in 30-40% of cases.
  • E. coli causes 70-90% of UTIs.

History and Physical Exam (H&P)

  • Asymptomatic bacteriuria: Diagnosed by urine culture showing ≥103 colony-forming units (CFUs) in a first-trimester screening urine sample.
  • UTI: Symptoms include dysuria (painful urination), urinary urgency (frequent need to urinate), and urinary frequency.
  • Pyelonephritis: Presents similarly to UTI, but also with fever and costovertebral angle (CVA) tenderness (pain in the side or back just below the ribs where the spine and ribs meet).

Diagnosis

  • Urinalysis (UA) and urine culture are the initial tests used to diagnose UTIs and pyelonephritis.

Treatment

  • Asymptomatic bacteriuria and UTI: Treat with 3-7 days of nitrofurantoin, cephalexin, or amoxicillin-clavulanate (avoid nitrofurantoin in 1st trimester if possible).
  • Follow up: Perform a urine culture one week after the completion of antibiotics (test of cure).
  • Pyelonephritis: Requires hospitalization. Treatment includes IV fluids, IV third-generation cephalosporins, and suppressive antibiotics (antibiotics given continuously in a lower dose) that are targeted against the specific bacterial cause identified in a urine culture of the infection. Follow-up cultures throughout the rest of the pregnancy are essential, too.

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