11 Questions
Which group of individuals is more susceptible to developing TB disease?
Individuals with diabetes
What is the primary cause of tuberculosis?
Mycobacterium tuberculosis bacteria
Which genetic factor may be associated with increased susceptibility to TB?
Variations in HLA-DRB1 gene
How is tuberculosis predominantly spread?
Through the air by infected individuals
Why is prevention and early detection crucial for controlling tuberculosis?
Because those with weakened immune systems are more vulnerable to developing active TB disease
What is the bacterium responsible for causing tuberculosis?
Mycobacterium tuberculosis
Which part of the body does tuberculosis primarily affect?
Lungs
What makes it difficult for antibiotics to penetrate the cell membrane of Mycobacterium tuberculosis?
Presence of arabinogalactan
How does tuberculosis primarily spread from person to person?
Airborne droplets
Which of the following conditions makes a person more susceptible to developing TB after exposure to the bacteria?
Malnutrition
What characteristic of Mycobacterium tuberculosis contributes to its survival within the host?
Unique cell wall structure
Study Notes
Understanding Tuberculosis and Its Causes
Tuberculosis, commonly referred to as TB, is a disease caused by mycobacteria, specifically Mycobacterium tuberculosis. It primarily affects the lungs, although it can also affect other parts of the body like the brain, kidneys, or spine. In this article, we will discuss the causes of tuberculosis and how it spreads.
Bacterial Structure and Resistance
The bacterium responsible for tuberculosis is Mycobacterium tuberculosis, which is a gram-positive aerobe. It has a unique cell wall structure that allows it to resist phagocytic digestion by immune cells, contributing to its ability to survive within the host. The cell wall of Mycobacterium tuberculosis contains a high content of mycolic acids, peptidoglycan, arabinogalactan, and lipoproteins. This complex composition makes it difficult for antibiotics to penetrate the cell membrane of the bacteria, leading to drug resistance.
Mode of Transmission
Tuberculosis spreads through tiny droplets released into the air when an infected person coughs, sneezes, or talks. People can also get infected by being around others who have active TB disease, mainly if they spend many hours with them in poorly ventilated spaces. While most people exposed to the bacteria do not develop TB, those with weakened immune systems are more likely to get sick.
Risks and Vulnerabilities
People with weakened immune systems, such as children, older adults, individuals living with HIV, and those with medical conditions like diabetes, malnutrition, or substance abuse disorders, are more susceptible to developing TB disease. Additionally, certain genetic factors may increase the risk of getting infected with Mycobacterium tuberculosis. Some studies suggest that variations in genes like HLA-DRB1 may be associated with increased susceptibility to TB.
In conclusion, tuberculosis is primarily caused by infection with Mycobacterium tuberculosis and is predominantly spread through the air by infected individuals. Those with weakened immune systems are more vulnerable to developing active TB disease, making prevention and early detection crucial for controlling this global health concern.
Test your knowledge on the causes and transmission of tuberculosis with this quiz. Explore topics like bacterial structures, drug resistance, modes of transmission, and vulnerable populations at risk of developing TB.
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