10 Questions
In the ORBITA-2 trial, the new end point introduced was centered on what?
Contemporaneous documentation of daily angina on a smartphone application
What percentage of patients in ORBITA were found to have residual symptoms despite the use of background antianginal medications and PCI?
61%
What was the primary focus of the ORBITA-2 trial?
Testing a coronary interventional procedure without the use of background therapy that may attenuate its effect
What was the effect of PCI as monotherapy on treadmill exercise time in the blinded ORBITA-2 trial?
59.5-second difference
What was the rationale behind the use of a smartphone application in the ORBITA-2 trial?
High temporal fidelity of data and minimization of recall bias
What was the effect of PCI on angina symptom score compared to placebo in the trial?
PCI resulted in a lower angina symptom score than the placebo procedure
What was the observed effect of PCI on the daily number of angina episodes?
PCI resulted in a lower daily number of angina episodes than the placebo procedure
How did assignment to the PCI group compare to assignment to the placebo group in terms of becoming free from angina at the 12-week follow-up?
Assignment to the PCI group was associated with three times higher odds of becoming free from angina compared to the placebo group
How did the design of ORBITA-2 differ from that of ORBITA?
The trials were designed to answer different questions
What is a plausible explanation for the small effect size of PCI on treadmill exercise time in ORBITA?
The previous experience was unblinded and was therefore augmented by the placebo effect
Test your knowledge on the outcomes of percutaneous coronary intervention (PCI) in patients with stable angina in this quiz. Explore the effects of PCI on angina symptom scores and health status, and understand the impact on daily activities.
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