Podcast
Questions and Answers
In the ORBITA-2 trial, the new end point introduced was centered on what?
In the ORBITA-2 trial, the new end point introduced was centered on what?
- Measurement of the efficacy of PCI in patients with angina
- Contemporaneous documentation of daily angina on a smartphone application (correct)
- Patient and public engagement and involvement
- High temporal fidelity of data
What percentage of patients in ORBITA were found to have residual symptoms despite the use of background antianginal medications and PCI?
What percentage of patients in ORBITA were found to have residual symptoms despite the use of background antianginal medications and PCI?
- 61% (correct)
- 50%
- 75%
- 40%
What was the primary focus of the ORBITA-2 trial?
What was the primary focus of the ORBITA-2 trial?
- Testing a coronary interventional procedure without the use of background therapy that may attenuate its effect (correct)
- Mandating guideline-directed antianginal medication as a precondition for PCI
- Evaluation of the efficacy of PCI in patients with angina
- Testing the effect of PCI on treadmill exercise time
What was the effect of PCI as monotherapy on treadmill exercise time in the blinded ORBITA-2 trial?
What was the effect of PCI as monotherapy on treadmill exercise time in the blinded ORBITA-2 trial?
What was the rationale behind the use of a smartphone application in the ORBITA-2 trial?
What was the rationale behind the use of a smartphone application in the ORBITA-2 trial?
What was the effect of PCI on angina symptom score compared to placebo in the trial?
What was the effect of PCI on angina symptom score compared to placebo in the trial?
What was the observed effect of PCI on the daily number of angina episodes?
What was the observed effect of PCI on the daily number of angina episodes?
How did assignment to the PCI group compare to assignment to the placebo group in terms of becoming free from angina at the 12-week follow-up?
How did assignment to the PCI group compare to assignment to the placebo group in terms of becoming free from angina at the 12-week follow-up?
How did the design of ORBITA-2 differ from that of ORBITA?
How did the design of ORBITA-2 differ from that of ORBITA?
What is a plausible explanation for the small effect size of PCI on treadmill exercise time in ORBITA?
What is a plausible explanation for the small effect size of PCI on treadmill exercise time in ORBITA?
