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Understanding the Outcomes of PCI in Stable Angina Patients Quiz

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Understanding the Outcomes of PCI in Stable Angina Patients Quiz

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Questions and Answers

In the ORBITA-2 trial, the new end point introduced was centered on what?

Measurement of the efficacy of PCI in patients with angina

Contemporaneous documentation of daily angina on a smartphone application (correct)

Patient and public engagement and involvement

High temporal fidelity of data

What percentage of patients in ORBITA were found to have residual symptoms despite the use of background antianginal medications and PCI?

61% (correct)

50%

75%

40%

What was the primary focus of the ORBITA-2 trial?

Testing a coronary interventional procedure without the use of background therapy that may attenuate its effect (correct)

Mandating guideline-directed antianginal medication as a precondition for PCI

Evaluation of the efficacy of PCI in patients with angina

Testing the effect of PCI on treadmill exercise time

What was the effect of PCI as monotherapy on treadmill exercise time in the blinded ORBITA-2 trial?

59.5-second difference Signup and view all the answers

What was the rationale behind the use of a smartphone application in the ORBITA-2 trial?

High temporal fidelity of data and minimization of recall bias Signup and view all the answers

What was the effect of PCI on angina symptom score compared to placebo in the trial?

PCI resulted in a lower angina symptom score than the placebo procedure Signup and view all the answers

What was the observed effect of PCI on the daily number of angina episodes?

PCI resulted in a lower daily number of angina episodes than the placebo procedure Signup and view all the answers

How did assignment to the PCI group compare to assignment to the placebo group in terms of becoming free from angina at the 12-week follow-up?

Assignment to the PCI group was associated with three times higher odds of becoming free from angina compared to the placebo group Signup and view all the answers

How did the design of ORBITA-2 differ from that of ORBITA?

The trials were designed to answer different questions Signup and view all the answers

What is a plausible explanation for the small effect size of PCI on treadmill exercise time in ORBITA?

The previous experience was unblinded and was therefore augmented by the placebo effect Signup and view all the answers