Podcast
Questions and Answers
In most cases of shock, circulatory failure is manifested by:
In most cases of shock, circulatory failure is manifested by:
- Hyperthermia
- Hypertension
- Hypotension (correct)
- Tachycardia
Which of the following best describes cardiogenic shock?
Which of the following best describes cardiogenic shock?
- Shock caused by severe blood loss.
- Shock resulting from the heart's inability to pump blood effectively. (correct)
- Shock due to widespread vasodilation.
- Shock due to obstruction of blood flow outside the heart.
According to the 'Perfusion Triangle', what are the three critical components necessary to maintain adequate perfusion?
According to the 'Perfusion Triangle', what are the three critical components necessary to maintain adequate perfusion?
- Brain, kidneys, and liver
- Lungs, blood, and kidneys
- Heart, lungs, and brain
- Heart, blood vessels, and blood (correct)
A patient presenting with a pulmonary embolism is most likely to experience which type of shock?
A patient presenting with a pulmonary embolism is most likely to experience which type of shock?
Which of the following conditions is NOT typically associated with cardiogenic shock?
Which of the following conditions is NOT typically associated with cardiogenic shock?
In cardiogenic shock, what is the typical response of systemic vascular resistance (SVR)?
In cardiogenic shock, what is the typical response of systemic vascular resistance (SVR)?
Which hemodynamic parameter is typically elevated in cardiogenic shock due to back up pressure in the left atrium?
Which hemodynamic parameter is typically elevated in cardiogenic shock due to back up pressure in the left atrium?
A patient in shock presents with cool, clammy skin. This finding is most likely due to:
A patient in shock presents with cool, clammy skin. This finding is most likely due to:
Which of the following is a common laboratory finding in cardiogenic shock, especially if it is caused by acute ischemia?
Which of the following is a common laboratory finding in cardiogenic shock, especially if it is caused by acute ischemia?
A patient is diagnosed with cardiogenic shock. Which of the following hemodynamic profiles is most consistent with this condition?
A patient is diagnosed with cardiogenic shock. Which of the following hemodynamic profiles is most consistent with this condition?
A patient in cardiogenic shock is being considered for mechanical support. Which of the following devices directly assists left ventricular function?
A patient in cardiogenic shock is being considered for mechanical support. Which of the following devices directly assists left ventricular function?
A patient in cardiogenic shock exhibits severe metabolic acidosis with an arterial pH of 7.05. Which of the following interventions might be considered?
A patient in cardiogenic shock exhibits severe metabolic acidosis with an arterial pH of 7.05. Which of the following interventions might be considered?
A patient is hypotensive with a systolic blood pressure of 80 mmHg. Which represents the threshold for hypotension in shock?
A patient is hypotensive with a systolic blood pressure of 80 mmHg. Which represents the threshold for hypotension in shock?
Which of the following best explains why PCWP is elevated in cardiogenic shock?
Which of the following best explains why PCWP is elevated in cardiogenic shock?
Which of the following is the most appropriate initial intervention for a patient in cardiogenic shock secondary to acute myocardial infarction?
Which of the following is the most appropriate initial intervention for a patient in cardiogenic shock secondary to acute myocardial infarction?
A patient in cardiogenic shock is receiving norepinephrine for refractory hypotension. Which of the following findings would warrant immediate discontinuation of norepinephrine?
A patient in cardiogenic shock is receiving norepinephrine for refractory hypotension. Which of the following findings would warrant immediate discontinuation of norepinephrine?
Which of the following statements accurately describes the Frank-Starling mechanism's relevance to cardiogenic shock?
Which of the following statements accurately describes the Frank-Starling mechanism's relevance to cardiogenic shock?
A patient with cardiogenic shock has a pulmonary artery catheter in place. Which set of hemodynamic values is MOST consistent with cardiogenic shock?
A patient with cardiogenic shock has a pulmonary artery catheter in place. Which set of hemodynamic values is MOST consistent with cardiogenic shock?
Which intervention would be MOST appropriate to improve cardiac output in a patient with cardiogenic shock?
Which intervention would be MOST appropriate to improve cardiac output in a patient with cardiogenic shock?
Which of the following best describes a potential consequence of sympathetic overactivity in cardiogenic shock?
Which of the following best describes a potential consequence of sympathetic overactivity in cardiogenic shock?
What is the primary purpose of inserting an intra-aortic balloon pump (IABP) in a patient with cardiogenic shock?
What is the primary purpose of inserting an intra-aortic balloon pump (IABP) in a patient with cardiogenic shock?
Which of the following is a typical sign or symptom of cardiogenic shock?
Which of the following is a typical sign or symptom of cardiogenic shock?
A 68-year-old male presents to the emergency department with acute dyspnea, chest pain, and a history of prior myocardial infarction. His blood pressure is 85/50 mmHg, heart rate is 110 bpm, and oxygen saturation is 88% on room air. Which of the following is the MOST likely underlying cause of this patient's presentation?
A 68-year-old male presents to the emergency department with acute dyspnea, chest pain, and a history of prior myocardial infarction. His blood pressure is 85/50 mmHg, heart rate is 110 bpm, and oxygen saturation is 88% on room air. Which of the following is the MOST likely underlying cause of this patient's presentation?
A physician is deciding between using dobutamine versus norepinephrine for a patient with cardiogenic shock. What is the MOST important factor that should influence this decision?
A physician is deciding between using dobutamine versus norepinephrine for a patient with cardiogenic shock. What is the MOST important factor that should influence this decision?
Which of the following is an absolute contraindication to the insertion of an intra-aortic balloon pump (IABP) in a patient with cardiogenic shock?
Which of the following is an absolute contraindication to the insertion of an intra-aortic balloon pump (IABP) in a patient with cardiogenic shock?
Which of the following is the MINIMUM reduction in systolic blood pressure that defines orthostatic hypotension?
Which of the following is the MINIMUM reduction in systolic blood pressure that defines orthostatic hypotension?
A patient experiences lightheadedness upon standing. After how many minutes of standing should blood pressure be assessed to diagnose orthostatic hypotension?
A patient experiences lightheadedness upon standing. After how many minutes of standing should blood pressure be assessed to diagnose orthostatic hypotension?
Which of the following is a common symptom associated with orthostatic hypotension?
Which of the following is a common symptom associated with orthostatic hypotension?
What is the underlying pathophysiology of orthostatic hypotension related to sympathetic response?
What is the underlying pathophysiology of orthostatic hypotension related to sympathetic response?
Which of the following medications is LEAST likely to contribute to orthostatic hypotension?
Which of the following medications is LEAST likely to contribute to orthostatic hypotension?
A patient with Postural Orthostatic Tachycardia Syndrome (POTS) and a heart rate greater than 120 bpm may benefit from which of the following medications?
A patient with Postural Orthostatic Tachycardia Syndrome (POTS) and a heart rate greater than 120 bpm may benefit from which of the following medications?
What is the primary mechanism behind vasovagal syncope?
What is the primary mechanism behind vasovagal syncope?
Which set of circumstances is MOST likely to provoke vasovagal syncope?
Which set of circumstances is MOST likely to provoke vasovagal syncope?
Which of the following is a non-pharmacological intervention for orthostatic hypotension?
Which of the following is a non-pharmacological intervention for orthostatic hypotension?
A patient with recurrent vasovagal syncope despite lifestyle modifications may benefit from which intervention?
A patient with recurrent vasovagal syncope despite lifestyle modifications may benefit from which intervention?
Which of the following blood pressure readings is indicative of Stage 1 hypertension?
Which of the following blood pressure readings is indicative of Stage 1 hypertension?
A patient is diagnosed with elevated blood pressure. Which of the following readings aligns with this diagnosis?
A patient is diagnosed with elevated blood pressure. Which of the following readings aligns with this diagnosis?
What percentage of hypertensive individuals are estimated to have secondary hypertension?
What percentage of hypertensive individuals are estimated to have secondary hypertension?
Which of the following is NOT typically considered a risk factor for essential hypertension?
Which of the following is NOT typically considered a risk factor for essential hypertension?
A 28-year-old patient is newly diagnosed with hypertension. Why is it particularly important to consider secondary causes in this patient?
A 28-year-old patient is newly diagnosed with hypertension. Why is it particularly important to consider secondary causes in this patient?
Which of the following best explains the impact of increased systolic or diastolic blood pressure on cardiovascular risk?
Which of the following best explains the impact of increased systolic or diastolic blood pressure on cardiovascular risk?
A patient's blood pressure is particularly responsive to changes in sodium intake. This is best described as:
A patient's blood pressure is particularly responsive to changes in sodium intake. This is best described as:
Which of the following is a potential characteristic of glucocorticoid-remediable hypertension?
Which of the following is a potential characteristic of glucocorticoid-remediable hypertension?
A patient presents with hypertension and hypokalemia. Further workup reveals suppressed plasma renin activity and low aldosterone levels. Which of the following conditions is most likely?
A patient presents with hypertension and hypokalemia. Further workup reveals suppressed plasma renin activity and low aldosterone levels. Which of the following conditions is most likely?
Which of the following is a known mechanism by which hyperinsulinemia can increase arterial pressure?
Which of the following is a known mechanism by which hyperinsulinemia can increase arterial pressure?
A patient with hypertension is suspected of having renal artery stenosis. Which of the following physical exam findings would support this diagnosis?
A patient with hypertension is suspected of having renal artery stenosis. Which of the following physical exam findings would support this diagnosis?
A patient presents with hypertension, suggesting coarctation of the aorta. Which physical exam findings supports this suspicion?
A patient presents with hypertension, suggesting coarctation of the aorta. Which physical exam findings supports this suspicion?
A patient has recently started taking a medication and subsequently developed hypertension. Which of the following medications is LEAST likely to contribute to this new onset hypertension?
A patient has recently started taking a medication and subsequently developed hypertension. Which of the following medications is LEAST likely to contribute to this new onset hypertension?
Which of the following target organ damage is LEAST likely to be caused by chronic hypertension?
Which of the following target organ damage is LEAST likely to be caused by chronic hypertension?
Which of the following statements regarding symptoms of hypertension (HTN) is most accurate?
Which of the following statements regarding symptoms of hypertension (HTN) is most accurate?
Which initial laboratory tests is MOST important to perform in a patient with documented hypertension?
Which initial laboratory tests is MOST important to perform in a patient with documented hypertension?
A patient with hypertension has new onset atrial fibrillation. This new finding should prompt the clinician to consider which action?
A patient with hypertension has new onset atrial fibrillation. This new finding should prompt the clinician to consider which action?
Ambulatory blood pressure monitoring (ABPM) is MOST useful in which of the following scenarios?
Ambulatory blood pressure monitoring (ABPM) is MOST useful in which of the following scenarios?
Which of the following is the MOST appropriate initial diagnostic test for a patient suspected of having primary hyperaldosteronism?
Which of the following is the MOST appropriate initial diagnostic test for a patient suspected of having primary hyperaldosteronism?
A patient with poorly controlled hypertension experiences paroxysmal episodes of headache, sweating, and tachycardia. What condition should be suspected?
A patient with poorly controlled hypertension experiences paroxysmal episodes of headache, sweating, and tachycardia. What condition should be suspected?
Which of the following symptoms is MOST suggestive of secondary hypertension due to primary aldosteronism?
Which of the following symptoms is MOST suggestive of secondary hypertension due to primary aldosteronism?
A young female patient is diagnosed with hypertension. A renal ultrasound reveals fibromuscular dysplasia. Which of the following is the MOST likely cause of her hypertension?
A young female patient is diagnosed with hypertension. A renal ultrasound reveals fibromuscular dysplasia. Which of the following is the MOST likely cause of her hypertension?
Which of the following is a typical finding in secondary hypertension due to coarctation of the aorta?
Which of the following is a typical finding in secondary hypertension due to coarctation of the aorta?
What are the lifestyle modifications that will have the greatest SBP reduction?
What are the lifestyle modifications that will have the greatest SBP reduction?
A 55-year-old patient is diagnosed with hypertension and has no other comorbidities. According to the 2017 Hypertension Guidelines, when should pharmacological treatment be initiated?
A 55-year-old patient is diagnosed with hypertension and has no other comorbidities. According to the 2017 Hypertension Guidelines, when should pharmacological treatment be initiated?
According to guideline recommendations, what is the target blood pressure for most patients on antihypertensive treatment?
According to guideline recommendations, what is the target blood pressure for most patients on antihypertensive treatment?
A 62-year-old African American patient with hypertension is started on a thiazide diuretic. What is the rationale for this choice of medication?
A 62-year-old African American patient with hypertension is started on a thiazide diuretic. What is the rationale for this choice of medication?
Which of the following drug classes is NOT considered as a first-line agent for the treatment of essential hypertension?
Which of the following drug classes is NOT considered as a first-line agent for the treatment of essential hypertension?
In the treatment of hypertension, which drug class would be MOST appropriate for a male patient with concomitant benign prostatic hyperplasia (BPH)?
In the treatment of hypertension, which drug class would be MOST appropriate for a male patient with concomitant benign prostatic hyperplasia (BPH)?
A patient with hypertension also has a history of heart failure. Which of the following antihypertensive drug classes should be used with caution or avoided?
A patient with hypertension also has a history of heart failure. Which of the following antihypertensive drug classes should be used with caution or avoided?
A patient with hypertension develops a persistent, dry cough after starting an antihypertensive medication. Which of the following medications is most likely responsible?
A patient with hypertension develops a persistent, dry cough after starting an antihypertensive medication. Which of the following medications is most likely responsible?
Which of the following antihypertensive medications is contraindicated in pregnancy?
Which of the following antihypertensive medications is contraindicated in pregnancy?
An elderly patient with hypertension is being treated with multiple antihypertensive medications. Which of the following conditions is MOST important to monitor for in this patient population?
An elderly patient with hypertension is being treated with multiple antihypertensive medications. Which of the following conditions is MOST important to monitor for in this patient population?
Following the initiation of antihypertensive therapy, how often should serum potassium and creatinine levels be checked?
Following the initiation of antihypertensive therapy, how often should serum potassium and creatinine levels be checked?
What is the recommended alcohol intake for patients with hypertension?
What is the recommended alcohol intake for patients with hypertension?
A patient presents with a blood pressure of 220/120 mmHg, severe headache, and visual disturbances, but no evidence of end-organ damage. What is the MOST appropriate course of action?
A patient presents with a blood pressure of 220/120 mmHg, severe headache, and visual disturbances, but no evidence of end-organ damage. What is the MOST appropriate course of action?
A patient is started on hydrochlorothiazide for hypertension. Which of the following electrolyte abnormalities is MOST likely to occur?
A patient is started on hydrochlorothiazide for hypertension. Which of the following electrolyte abnormalities is MOST likely to occur?
The primary goal in treating a patient with hypertensive encephalopathy is to:
The primary goal in treating a patient with hypertensive encephalopathy is to:
According to current hypertension guidelines, what blood pressure reading is classified as 'Elevated'?
According to current hypertension guidelines, what blood pressure reading is classified as 'Elevated'?
A patient is diagnosed with Stage 2 hypertension. According to the guidelines, which of the following blood pressure readings would confirm this diagnosis?
A patient is diagnosed with Stage 2 hypertension. According to the guidelines, which of the following blood pressure readings would confirm this diagnosis?
What is the estimated prevalence of hypertension in African Americans?
What is the estimated prevalence of hypertension in African Americans?
Which of the following modifiable risk factors is most closely associated with the development of hypertension?
Which of the following modifiable risk factors is most closely associated with the development of hypertension?
Which statement best summarizes the long-term impact of essential hypertension on cardiovascular health?
Which statement best summarizes the long-term impact of essential hypertension on cardiovascular health?
A patient's blood pressure is highly responsive to variations in their daily sodium intake. How would this patient's condition be best described?
A patient's blood pressure is highly responsive to variations in their daily sodium intake. How would this patient's condition be best described?
In which scenario should a clinician be MOST suspicious of secondary hypertension?
In which scenario should a clinician be MOST suspicious of secondary hypertension?
During a physical examination, which finding would be MOST suggestive of secondary hypertension due to renal artery stenosis?
During a physical examination, which finding would be MOST suggestive of secondary hypertension due to renal artery stenosis?
A patient presents with hypertension, muscle weakness, polyuria, and polydipsia. Which of the following conditions should be MOST suspected?
A patient presents with hypertension, muscle weakness, polyuria, and polydipsia. Which of the following conditions should be MOST suspected?
Which of the following physical exam findings is MOST specific for coarctation of the aorta as a cause of hypertension?
Which of the following physical exam findings is MOST specific for coarctation of the aorta as a cause of hypertension?
A patient with long-standing hypertension is found to have left ventricular hypertrophy (LVH) on an ECG. What is the clinical significance of this finding?
A patient with long-standing hypertension is found to have left ventricular hypertrophy (LVH) on an ECG. What is the clinical significance of this finding?
According to the 2017 Hypertension Guidelines, what is the blood pressure target for most patients on antihypertensive treatment?
According to the 2017 Hypertension Guidelines, what is the blood pressure target for most patients on antihypertensive treatment?
Which of the following lifestyle modifications is expected to result in the GREATEST reduction in systolic blood pressure?
Which of the following lifestyle modifications is expected to result in the GREATEST reduction in systolic blood pressure?
A 65-year-old patient with a history of hypertension is being evaluated for suspected secondary hypertension. Which of the following historical clues would be MOST indicative of primary aldosteronism?
A 65-year-old patient with a history of hypertension is being evaluated for suspected secondary hypertension. Which of the following historical clues would be MOST indicative of primary aldosteronism?
In managing hypertension, a clinician is considering initiating a thiazide diuretic. In which patient would this medication be MOST appropriate as a first-line agent?
In managing hypertension, a clinician is considering initiating a thiazide diuretic. In which patient would this medication be MOST appropriate as a first-line agent?
A patient with essential hypertension develops a persistent, dry cough soon after starting treatment. Which antihypertensive medication is MOST likely responsible for this adverse effect?
A patient with essential hypertension develops a persistent, dry cough soon after starting treatment. Which antihypertensive medication is MOST likely responsible for this adverse effect?
When treating hypertension in older adults, which condition is MOST important to monitor closely to avoid adverse outcomes?
When treating hypertension in older adults, which condition is MOST important to monitor closely to avoid adverse outcomes?
What is the MOST appropriate initial blood pressure target in a patient presenting with hypertensive encephalopathy?
What is the MOST appropriate initial blood pressure target in a patient presenting with hypertensive encephalopathy?
After initiating antihypertensive therapy, how often should serum potassium and creatinine levels be checked?
After initiating antihypertensive therapy, how often should serum potassium and creatinine levels be checked?
According to current guidelines concerning treatment of HTN, what is the target BP for elderly (>70 years) patients?
According to current guidelines concerning treatment of HTN, what is the target BP for elderly (>70 years) patients?
A 26 year old female presents with hypertension on routine evaluation. Which of the following historical clues is MOST indicative of renal artery stenosis?
A 26 year old female presents with hypertension on routine evaluation. Which of the following historical clues is MOST indicative of renal artery stenosis?
A 57 year old male presents to the clinic with hypertension. You begin to suspect Hyperaldosteronism. Which of the following symptoms is MOST suggestive of this condition?
A 57 year old male presents to the clinic with hypertension. You begin to suspect Hyperaldosteronism. Which of the following symptoms is MOST suggestive of this condition?
An 18-year-old female is diagnosed with hypertension. A renal ultrasound reveals fibromuscular dysplasia. Which of the following is the MOST likely cause of her hypertension?
An 18-year-old female is diagnosed with hypertension. A renal ultrasound reveals fibromuscular dysplasia. Which of the following is the MOST likely cause of her hypertension?
A 72 year old male presents to the clinic with hypertension. Which medication is contraindicated due to the patient also having gout?
A 72 year old male presents to the clinic with hypertension. Which medication is contraindicated due to the patient also having gout?
A patient's blood pressure persistently remains above goal despite adherence to three antihypertensive medications. Which of the following should be the NEXT step in management?
A patient's blood pressure persistently remains above goal despite adherence to three antihypertensive medications. Which of the following should be the NEXT step in management?
A 45-year-old man with hypertension has been experiencing erectile dysfunction since starting antihypertensive medication therapy six months ago. Which of the following medications is MOST likely contributing to this side effect?
A 45-year-old man with hypertension has been experiencing erectile dysfunction since starting antihypertensive medication therapy six months ago. Which of the following medications is MOST likely contributing to this side effect?
A 60-year-old patient with a history of poorly controlled hypertension presents with a blood pressure of 220/120 mmHg and papilledema on funduscopic examination. He denies any chest pain, shortness of breath, or neurologic deficits. Which of the following is the MOST appropriate initial course of action?
A 60-year-old patient with a history of poorly controlled hypertension presents with a blood pressure of 220/120 mmHg and papilledema on funduscopic examination. He denies any chest pain, shortness of breath, or neurologic deficits. Which of the following is the MOST appropriate initial course of action?
A patient in hypertensive emergency requires a continuous intravenous infusion for blood pressure control. Which of the following agents requires cyanide toxicity monitoring, especially with prolonged use or in patients with renal insufficiency?
A patient in hypertensive emergency requires a continuous intravenous infusion for blood pressure control. Which of the following agents requires cyanide toxicity monitoring, especially with prolonged use or in patients with renal insufficiency?
A 75-year-old patient with known hypertension presents with dizziness upon standing. Blood pressure readings are 150/80 mmHg supine and 120/65 mmHg standing. What change in drug regimen is most appropriate?
A 75-year-old patient with known hypertension presents with dizziness upon standing. Blood pressure readings are 150/80 mmHg supine and 120/65 mmHg standing. What change in drug regimen is most appropriate?
A 50-year-old male with a history of hypertension and benign prostatic hyperplasia (BPH) presents for a routine follow-up. Which of the following antihypertensive medications would be MOST appropriate for treating both conditions concurrently?
A 50-year-old male with a history of hypertension and benign prostatic hyperplasia (BPH) presents for a routine follow-up. Which of the following antihypertensive medications would be MOST appropriate for treating both conditions concurrently?
A 32-year-old pregnant patient is diagnosed with gestational hypertension. Which of the following antihypertensive medications is generally considered safe for use during pregnancy?
A 32-year-old pregnant patient is diagnosed with gestational hypertension. Which of the following antihypertensive medications is generally considered safe for use during pregnancy?
In a patient with hypertension and known renovascular disease, initiation of which antihypertensive drug class requires careful monitoring due to the risk of acute kidney injury?
In a patient with hypertension and known renovascular disease, initiation of which antihypertensive drug class requires careful monitoring due to the risk of acute kidney injury?
Which of the following initial diagnostic test is MOST specific for diagnosing the common causes of Cushing's syndrome?
Which of the following initial diagnostic test is MOST specific for diagnosing the common causes of Cushing's syndrome?
Among the following antihypertensive medications, which one exhibits the LEAST versatility in managing diverse conditions?
Among the following antihypertensive medications, which one exhibits the LEAST versatility in managing diverse conditions?
A patient with a history of hypertension and end-stage renal disease presents with a BP of 180/110 mmHg which diuretic is the LEAST effective in these patients?
A patient with a history of hypertension and end-stage renal disease presents with a BP of 180/110 mmHg which diuretic is the LEAST effective in these patients?
In an elderly hypertensive patient taking diuretics, beta-blockers and ACE-inhibitors, what laboratory finding is the MOST likely precipitant of postural hypotension?
In an elderly hypertensive patient taking diuretics, beta-blockers and ACE-inhibitors, what laboratory finding is the MOST likely precipitant of postural hypotension?
According to the 2017 Hypertension Guidelines, at what blood pressure level should antihypertensive drug therapy be initiated for primary prevention?
According to the 2017 Hypertension Guidelines, at what blood pressure level should antihypertensive drug therapy be initiated for primary prevention?
What is the on-treatment blood pressure goal for most patients on antihypertensive treatment?
What is the on-treatment blood pressure goal for most patients on antihypertensive treatment?
An African American patient with hypertension is started on a thiazide diuretic. What is the rationale for this choice of medication?
An African American patient with hypertension is started on a thiazide diuretic. What is the rationale for this choice of medication?
What drug class should be used with caution or avoided in a patient with hypertension and a history of heart failure?
What drug class should be used with caution or avoided in a patient with hypertension and a history of heart failure?
A patient develops a persistent, dry cough after starting an antihypertensive medication. Which medication side effect is MOST likely responsible?
A patient develops a persistent, dry cough after starting an antihypertensive medication. Which medication side effect is MOST likely responsible?
Which antihypertensive medications are typically contraindicated in pregnancy?
Which antihypertensive medications are typically contraindicated in pregnancy?
An elderly patient with hypertension is being treated with multiple antihypertensive medications. What is MOST important to monitor for in this patient population?
An elderly patient with hypertension is being treated with multiple antihypertensive medications. What is MOST important to monitor for in this patient population?
A patient is started on hydrochlorothiazide for hypertension. Which electrolyte abnormalities are MOST likely to occur?
A patient is started on hydrochlorothiazide for hypertension. Which electrolyte abnormalities are MOST likely to occur?
What is the primary goal in treating a patient with hypertensive encephalopathy?
What is the primary goal in treating a patient with hypertensive encephalopathy?
During a physical examination for hypertension, which finding would be MOST suggestive of secondary hypertension due to renal artery stenosis?
During a physical examination for hypertension, which finding would be MOST suggestive of secondary hypertension due to renal artery stenosis?
What historical clue suggests that a 65-year-old patient being evaluated for suspected secondary hypertension may have primary aldosteronism?
What historical clue suggests that a 65-year-old patient being evaluated for suspected secondary hypertension may have primary aldosteronism?
What lifestyle modification, will have the greatest impact on reducing systolic blood pressure?
What lifestyle modification, will have the greatest impact on reducing systolic blood pressure?
According to the provided information, which of the following best describes how essential hypertension affects cardiovascular risk?
According to the provided information, which of the following best describes how essential hypertension affects cardiovascular risk?
Which of the following signs or symptoms should prompt a high index of suspicion for secondary hypertension?
Which of the following signs or symptoms should prompt a high index of suspicion for secondary hypertension?
Which of the following clinical manifestations would be anticipated in a patient with a long history of poorly controlled hypertension?
Which of the following clinical manifestations would be anticipated in a patient with a long history of poorly controlled hypertension?
A patient reports non-compliance, excess salt intake and is found to have resistant hypertension. Given this scenario, what medication class would best address the blood pressure and dietary non-compliance?
A patient reports non-compliance, excess salt intake and is found to have resistant hypertension. Given this scenario, what medication class would best address the blood pressure and dietary non-compliance?
A 62-year-old African-American male is seen for his yearly PE. He has no complaints. He denies any current medications or medical problems, but the occupational medicine nurse has taken his BP several times in the past year and told him it was high. He denies any tobacco or alcohol use. His BP is 156/92 today. What is the most likely cause of his elevated BP?
A 62-year-old African-American male is seen for his yearly PE. He has no complaints. He denies any current medications or medical problems, but the occupational medicine nurse has taken his BP several times in the past year and told him it was high. He denies any tobacco or alcohol use. His BP is 156/92 today. What is the most likely cause of his elevated BP?
A 24-year-old male seeks medical attention for the recent onset of headaches. The headaches are described as 'pounding' and occur during the day and night. He has had minimal relief with acetaminophen. Review of symptoms is positive only for leg fatigue with exertion.
PE is notable for a BP of 185/115 mmHg in the right arm, a HR of 70/min, AV nicking on fundiscopic examination, normal jugular veins and carotid arteries, a pressure-loaded PMI with an apical S4, no abdominal bruits, and reduced pulses in both lower extremities. Additional measurement of BP reveals the following:
Right arm 185/115
Left arm 188/113
Right thigh 100/60
Left thigh 102/58. What is the most likely cause of this patient's hypertension?
A 24-year-old male seeks medical attention for the recent onset of headaches. The headaches are described as 'pounding' and occur during the day and night. He has had minimal relief with acetaminophen. Review of symptoms is positive only for leg fatigue with exertion. PE is notable for a BP of 185/115 mmHg in the right arm, a HR of 70/min, AV nicking on fundiscopic examination, normal jugular veins and carotid arteries, a pressure-loaded PMI with an apical S4, no abdominal bruits, and reduced pulses in both lower extremities. Additional measurement of BP reveals the following: Right arm 185/115 Left arm 188/113 Right thigh 100/60 Left thigh 102/58. What is the most likely cause of this patient's hypertension?
A 12-year-old boy presents to the office with pain in his legs with activity gradually becoming worse over the past month. He is unable to ride a bicycle with his friends due to the pain in his legs. Examination of the heart reveals an ejection click and accentuation of the second heart sound. Femoral pulses are weak and delayed compared to the brachial pulses. BP obtained in both arms is elevated. Chest x-ray reveals rib notching. Which of the following is the most likely diagnosis?
A 12-year-old boy presents to the office with pain in his legs with activity gradually becoming worse over the past month. He is unable to ride a bicycle with his friends due to the pain in his legs. Examination of the heart reveals an ejection click and accentuation of the second heart sound. Femoral pulses are weak and delayed compared to the brachial pulses. BP obtained in both arms is elevated. Chest x-ray reveals rib notching. Which of the following is the most likely diagnosis?
A 48-year-old male presents to the emergency department with an alteration in consciousness after cocaine ingestion. On presentation, BP is 254/162, with an O2 sat of 83% on RA
PE is notable for depressed consciousness. The patient does not follow commands but purposely withdraws from pain in all extremities. His pupils are equal and reactive. The cardiovascular exam is notable for a hyperdynamic precordium with a loud S4 gallop. There are no murmurs. Crackles are heard diffusely in both lung fields. The CXR is consistent with pulmonary edema. CT scan of the head reveals diffuse cerebral edema without hemorrhage.
EKG shows LVH with T-wave inversions in V3 to V6. UA shows 1+ proteinuria with 25 to 50 RBC's/HPF. Creatinine is 2.6 mg/dL. What is the most appropriate management for this patient?
A 48-year-old male presents to the emergency department with an alteration in consciousness after cocaine ingestion. On presentation, BP is 254/162, with an O2 sat of 83% on RA PE is notable for depressed consciousness. The patient does not follow commands but purposely withdraws from pain in all extremities. His pupils are equal and reactive. The cardiovascular exam is notable for a hyperdynamic precordium with a loud S4 gallop. There are no murmurs. Crackles are heard diffusely in both lung fields. The CXR is consistent with pulmonary edema. CT scan of the head reveals diffuse cerebral edema without hemorrhage. EKG shows LVH with T-wave inversions in V3 to V6. UA shows 1+ proteinuria with 25 to 50 RBC's/HPF. Creatinine is 2.6 mg/dL. What is the most appropriate management for this patient?
A 46-year-old female is being evaluated for a new-onset HTN that was discovered on screening at her workplace. The patient had several readings revealing systolic and diastolic HTN. Patient is currently on no medications. PE is unremarkable. A complete laboratory evaluation revealed hypokalemia as the only abnormality. Which of the following is the most likely diagnosis for this patient?
A 46-year-old female is being evaluated for a new-onset HTN that was discovered on screening at her workplace. The patient had several readings revealing systolic and diastolic HTN. Patient is currently on no medications. PE is unremarkable. A complete laboratory evaluation revealed hypokalemia as the only abnormality. Which of the following is the most likely diagnosis for this patient?
A 56-year-old male came to the ER with complaints of palpitations and shortness of breath for 1 week ago.
He has a longstanding history of poorly controlled HTN
PE reveals an elevated blood pressure of 190/98 mm Hg, elevated JVP, mild hepatomegaly, bilateral pedal edema, and rales at the lung bases.
Diagnostic studies reveal concentric LVH without significant valvular abnormalities on echocardiogram. Which of the following drugs is beneficial in the treatment of the patient's condition by virtue of both afterload and preload reduction?
A 56-year-old male came to the ER with complaints of palpitations and shortness of breath for 1 week ago. He has a longstanding history of poorly controlled HTN PE reveals an elevated blood pressure of 190/98 mm Hg, elevated JVP, mild hepatomegaly, bilateral pedal edema, and rales at the lung bases. Diagnostic studies reveal concentric LVH without significant valvular abnormalities on echocardiogram. Which of the following drugs is beneficial in the treatment of the patient's condition by virtue of both afterload and preload reduction?
Which type of anti-hypertensive agent is NEVER recommended in pregnancy?
Which type of anti-hypertensive agent is NEVER recommended in pregnancy?
A 58-year-old male presents with chest pain. VS include BP of 210/175, pulse 80, RR 20. Which of the following would you expect to find on PE?
A 58-year-old male presents with chest pain. VS include BP of 210/175, pulse 80, RR 20. Which of the following would you expect to find on PE?
An ambulance transports a patient to your facility from the nursing home with anuria and diminished level of consciousness.
Paramedics report a BP of 225/130 mm Hg. Which of the following medications is most appropriate for this patient?
An ambulance transports a patient to your facility from the nursing home with anuria and diminished level of consciousness. Paramedics report a BP of 225/130 mm Hg. Which of the following medications is most appropriate for this patient?
A 66-year-old female with a history of diabetes and hypertension presents for routine evaluation. Since beginning her ACE inhibitor and diuretic therapy her BPs have averaged 138/85 mmHg. Which of the following is the next best step in the management of this patient?
A 66-year-old female with a history of diabetes and hypertension presents for routine evaluation. Since beginning her ACE inhibitor and diuretic therapy her BPs have averaged 138/85 mmHg. Which of the following is the next best step in the management of this patient?
Which of the following antihypertensive drugs is incorrectly matched with the indication for therapy?
Which of the following antihypertensive drugs is incorrectly matched with the indication for therapy?
While in the clinic, the nurse measures the BP of a 61-year-old male and finds that it is 183/100 mmHg sitting and 190/105 standing. He has a HR of 81/minute, with an irregularly irregular rhythm.
Which of the following pathologic findings is most likely to be present:
While in the clinic, the nurse measures the BP of a 61-year-old male and finds that it is 183/100 mmHg sitting and 190/105 standing. He has a HR of 81/minute, with an irregularly irregular rhythm. Which of the following pathologic findings is most likely to be present:
A 50-year-old construction worker continues to have an elevated BP of 160/95 even after a third agent is added to his antihypertensive regimen. PE is normal, electrolytes are normal, and the patient is taking no over-the-counter medications. The next helpful step for this patient is to:
A 50-year-old construction worker continues to have an elevated BP of 160/95 even after a third agent is added to his antihypertensive regimen. PE is normal, electrolytes are normal, and the patient is taking no over-the-counter medications. The next helpful step for this patient is to:
All the following statements about severe hypertension are true EXCEPT
All the following statements about severe hypertension are true EXCEPT
A 68-year-old man presents with chest pain, dyspnea, hypotension (BP 78/50), elevated JVP, and crackles. Echo shows EF 20%. Swan-Ganz catheter reveals ↓ CO, ↑ PCWP, and ↑ SVR. What is the most likely diagnosis?
A 68-year-old man presents with chest pain, dyspnea, hypotension (BP 78/50), elevated JVP, and crackles. Echo shows EF 20%. Swan-Ganz catheter reveals ↓ CO, ↑ PCWP, and ↑ SVR. What is the most likely diagnosis?
Which of the following hemodynamic changes is most characteristic of cardiogenic shock?
Which of the following hemodynamic changes is most characteristic of cardiogenic shock?
A 73-year-old woman is hypotensive (BP 88/58) and develops syncope after standing. Her HR increases from 68 to 94. Which condition does this most likely indicate?
A 73-year-old woman is hypotensive (BP 88/58) and develops syncope after standing. Her HR increases from 68 to 94. Which condition does this most likely indicate?
A 60-year-old male has episodic palpitations, sweating, and headaches. BP is 190/115 during episodes. Plasma metanephrines are elevated. What is the most likely diagnosis?
A 60-year-old male has episodic palpitations, sweating, and headaches. BP is 190/115 during episodes. Plasma metanephrines are elevated. What is the most likely diagnosis?
A 58-year-old man presents with blurry vision and BP of 220/130. He is confused and has papilledema on fundoscopy. What is the most appropriate immediate intervention?
A 58-year-old man presents with blurry vision and BP of 220/130. He is confused and has papilledema on fundoscopy. What is the most appropriate immediate intervention?
A patient presents with refractory hypertension. Exam reveals abdominal bruit. Labs show hypokalemia and elevated renin. Which of the following is the most likely diagnosis?
A patient presents with refractory hypertension. Exam reveals abdominal bruit. Labs show hypokalemia and elevated renin. Which of the following is the most likely diagnosis?
A 76-year-old woman has a BP of 182/78. Her PP is elevated. Which of the following is the best explanation?
A 76-year-old woman has a BP of 182/78. Her PP is elevated. Which of the following is the best explanation?
Which of the following antihypertensives is contraindicated in pregnancy?
Which of the following antihypertensives is contraindicated in pregnancy?
A 61-year-old male with a history of HTN presents with severe chest pain radiating to his back. BP is 210/120 in both arms. CT shows a Stanford Type B aortic dissection. Which medication should be administered first?
A 61-year-old male with a history of HTN presents with severe chest pain radiating to his back. BP is 210/120 in both arms. CT shows a Stanford Type B aortic dissection. Which medication should be administered first?
A 74-year-old woman presents with acute mental status changes. BP is 245/130. She has headache, visual disturbances, and confusion. What is the most appropriate next step?
A 74-year-old woman presents with acute mental status changes. BP is 245/130. She has headache, visual disturbances, and confusion. What is the most appropriate next step?
A 66-year-old male is hypotensive after massive upper GI bleed. He is cold, clammy, and tachycardic. Which of the following is most consistent with his hemodynamic profile?
A 66-year-old male is hypotensive after massive upper GI bleed. He is cold, clammy, and tachycardic. Which of the following is most consistent with his hemodynamic profile?
A 68-year-old female presents with repeated fainting episodes. BP falls from 125/80 to 98/65 after 3 minutes of standing. HR goes from 68 → 70 bpm. Which mechanism is most likely?
A 68-year-old female presents with repeated fainting episodes. BP falls from 125/80 to 98/65 after 3 minutes of standing. HR goes from 68 → 70 bpm. Which mechanism is most likely?
A 26-year-old female has dizziness and palpitations upon standing. Tilt table test shows HR of 130 bpm with minimal BP drop. What is the diagnosis?
A 26-year-old female has dizziness and palpitations upon standing. Tilt table test shows HR of 130 bpm with minimal BP drop. What is the diagnosis?
A 35-year-old male faints during blood donation. Witnesses report he was pale and sweating before collapse. He regains consciousness quickly. What's the best diagnosis?
A 35-year-old male faints during blood donation. Witnesses report he was pale and sweating before collapse. He regains consciousness quickly. What's the best diagnosis?
Which of the following is the most appropriate initial BP reduction target in hypertensive emergency?
Which of the following is the most appropriate initial BP reduction target in hypertensive emergency?
A 59-year-old male presents with dyspnea, chest pain, and hypotension. His extremities are cold and clammy. Echo shows EF 20%. Swan-Ganz reveals ↑ PCWP, ↓ CO, ↑ SVR. Which drug is appropriate for short-term inotropic support?
A 59-year-old male presents with dyspnea, chest pain, and hypotension. His extremities are cold and clammy. Echo shows EF 20%. Swan-Ganz reveals ↑ PCWP, ↓ CO, ↑ SVR. Which drug is appropriate for short-term inotropic support?
A 45-year-old woman presents with BP 185/120 and papilledema. She is admitted to ICU for hypertensive emergency. What's the maximum rate her BP should be lowered?
A 45-year-old woman presents with BP 185/120 and papilledema. She is admitted to ICU for hypertensive emergency. What's the maximum rate her BP should be lowered?
Which of the following findings is most consistent with distributive shock (e.g., sepsis)?
Which of the following findings is most consistent with distributive shock (e.g., sepsis)?
Which of the following antihypertensives is most appropriate for pregnant patients with hypertensive crisis?
Which of the following antihypertensives is most appropriate for pregnant patients with hypertensive crisis?
A 70-year-old woman presents with blurry vision and BP 240/130. Fundus exam reveals hemorrhages and papilledema. What is this condition?
A 70-year-old woman presents with blurry vision and BP 240/130. Fundus exam reveals hemorrhages and papilledema. What is this condition?
A 75-year-old male experiences lightheadedness when standing. BP drops from 132/76 → 106/60. HR remains 72. What does this indicate?
A 75-year-old male experiences lightheadedness when standing. BP drops from 132/76 → 106/60. HR remains 72. What does this indicate?
A patient with cardiogenic shock has persistent hypotension despite inotropes. Which device can mechanically improve perfusion and reduce afterload?
A patient with cardiogenic shock has persistent hypotension despite inotropes. Which device can mechanically improve perfusion and reduce afterload?
Which of the following best describes the pathophysiology of vasovagal syncope?
Which of the following best describes the pathophysiology of vasovagal syncope?
Which of the following drugs is most likely to cause reflex tachycardia and flushing when used to manage severe hypertension?
Which of the following drugs is most likely to cause reflex tachycardia and flushing when used to manage severe hypertension?
Flashcards
Shock Definition
Shock Definition
Life-threatening condition caused by an imbalance between cellular oxygen supply and demand, leading to organ dysfunction. Often involves hypotension.
Perfusion Triangle Components
Perfusion Triangle Components
Heart (pump function), blood vessels (container function), and blood (content function).
Cardiogenic Shock
Cardiogenic Shock
Occurs when the heart is weakened or damaged, reducing effective pumping of blood.
Cardiogenic Shock Cause
Cardiogenic Shock Cause
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Cardiogenic Shock Hemodynamics
Cardiogenic Shock Hemodynamics
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PCWP in Cardiogenic Shock
PCWP in Cardiogenic Shock
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Cardiac Output in Cardiogenic Shock
Cardiac Output in Cardiogenic Shock
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SVR in Cardiogenic Shock
SVR in Cardiogenic Shock
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Signs of Shock
Signs of Shock
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Cardiogenic Shock Symptoms
Cardiogenic Shock Symptoms
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CXR Findings in Cardiogenic Shock
CXR Findings in Cardiogenic Shock
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Cardiogenic Shock Treatment
Cardiogenic Shock Treatment
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Norepinephrine Use
Norepinephrine Use
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Sodium Bicarbonate
Sodium Bicarbonate
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Ventilation Support
Ventilation Support
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Aspirin
Aspirin
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Intravenous Heparin
Intravenous Heparin
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Orthostatic Hypotension Definition
Orthostatic Hypotension Definition
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Orthostatic Hypotension Pathophysiology
Orthostatic Hypotension Pathophysiology
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Common Causes of Orthostatic Hypotension
Common Causes of Orthostatic Hypotension
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Non-Pharmacological Management of Orthostatic Hypotension
Non-Pharmacological Management of Orthostatic Hypotension
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Pharmacological Management of Orthostatic Hypotension
Pharmacological Management of Orthostatic Hypotension
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Vasovagal Hypotension Definition
Vasovagal Hypotension Definition
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Vasovagal Hypotension Pathophysiology
Vasovagal Hypotension Pathophysiology
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Vasovagal Hypotension Management
Vasovagal Hypotension Management
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Hypertension Definition
Hypertension Definition
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BP Categories
BP Categories
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Essential Hypertension
Essential Hypertension
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HTN Risk Factors
HTN Risk Factors
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Essential Hypertension
Essential Hypertension
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Glucocorticoid-remediable HTN
Glucocorticoid-remediable HTN
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Liddle's Syndrome
Liddle's Syndrome
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Symptoms of Primary Hyperaldosteronism
Symptoms of Primary Hyperaldosteronism
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Symptoms of Pheochromocytoma
Symptoms of Pheochromocytoma
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Causes of Secondary HTN
Causes of Secondary HTN
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Endocrine Causes of HTN
Endocrine Causes of HTN
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Drugs Contributing to HTN
Drugs Contributing to HTN
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Target Organ Damage (HTN)
Target Organ Damage (HTN)
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Symptoms of HTN
Symptoms of HTN
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Signs of Hypertension
Signs of Hypertension
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HTN Lab Tests
HTN Lab Tests
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Uses for ABPM
Uses for ABPM
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Lifestyle Modifications (HTN)
Lifestyle Modifications (HTN)
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HTN Treatment Goals
HTN Treatment Goals
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First Line HTN Meds
First Line HTN Meds
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Thiazide Diuretic Side Effects
Thiazide Diuretic Side Effects
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ACE Inhibitor Side Effects
ACE Inhibitor Side Effects
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CCB Side Effects
CCB Side Effects
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Beta Blocker Side Effects
Beta Blocker Side Effects
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Common Treatable Cause of HTN in Elderly
Common Treatable Cause of HTN in Elderly
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Key Assessments HTN Elderly
Key Assessments HTN Elderly
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Modify HTN Therapy Older Adults
Modify HTN Therapy Older Adults
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Postural Hypotension
Postural Hypotension
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Consider HTN
Consider HTN
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Pregnancy HTN Meds:
Pregnancy HTN Meds:
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Poor HTN
Poor HTN
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Drugs Hypertension
Drugs Hypertension
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Hypertensive Urgency
Hypertensive Urgency
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HTN Prevention
HTN Prevention
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Coarctation of Aorta
Coarctation of Aorta
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Coarctation of the Aorta
Coarctation of the Aorta
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Fenoldopam
Fenoldopam
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Primary aldosteronism
Primary aldosteronism
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Loop Diuretics
Loop Diuretics
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Hypertension Drug in Pregnancy
Hypertension Drug in Pregnancy
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Rapidly lowering blood pressure
Rapidly lowering blood pressure
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Nitroprusside Sodium
Nitroprusside Sodium
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ACE and Diuretic Combination
ACE and Diuretic Combination
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Antihypertensive Incorrectly Matched to Indication
Antihypertensive Incorrectly Matched to Indication
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Hypertension Pathologic Finding
Hypertension Pathologic Finding
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Elevated BP After Agents
Elevated BP After Agents
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Cardiogenic Shock Definition
Cardiogenic Shock Definition
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Orthostatic Hypotension Diagnosis
Orthostatic Hypotension Diagnosis
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Pheochromocytoma Symptoms
Pheochromocytoma Symptoms
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Treatment for Hypertensive Emergency
Treatment for Hypertensive Emergency
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Hypertensive Emergency Definition
Hypertensive Emergency Definition
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Pathophysiology of Vasovagal Syncope
Pathophysiology of Vasovagal Syncope
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Postural Orthostatic Tachycardia Syndrome (POTS)
Postural Orthostatic Tachycardia Syndrome (POTS)
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Safe Hypertension Drugs in Pregnancy
Safe Hypertension Drugs in Pregnancy
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IABP Mechanism
IABP Mechanism
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Study Notes
Hypertension Review
- A 68-year-old man presents with chest pain, dyspnea, hypotension (BP 78/50), elevated JVP, and crackles, with an echo showing EF 20%. A Swan-Ganz catheter reveals ↓ CO, ↑ PCWP, and ↑ SVR; the most likely diagnosis is cardiogenic shock.
- Classic hemodynamic triad for cardiogenic shock: ↓ CO, ↑ PCWP, ↑ SVR.
- PCWP reflects left atrial pressure backup in cardiogenic shock.
- Common causes of cardiogenic shock: post-MI, myocarditis, arrhythmia.
- Hemodynamic changes characteristic of cardiogenic shock include increased PCWP and increased SVR.
- LV failure leads to LA pressure back-up, resulting in increased PCWP; SVR increases to compensate.
- The sympathetic nervous system increases SVR as a compensation mechanism in cardiogenic shock.
- Increased PCWP causes pulmonary edema.
- Decreased CO leads to organ hypoperfusion.
Orthostatic Hypotension
- A 73-year-old woman is hypotensive (BP 88/58) and develops syncope after standing with her HR increasing from 68 to 94; this most likely indicates orthostatic hypotension.
- Postural BP drop ≥ 20/10 mmHg after 3 minutes of standing indicates orthostatic hypotension.
- Symptoms of orthostatic hypotension: dizziness, syncope.
- Causes of orthostatic hypotension: volume depletion, autonomic dysfunction, medications.
- Tilt table can confirm orthostatic hypotension.
Pheochromocytoma and Hypertensive Crisis
- A 60-year-old male has episodic palpitations, sweating, and headaches. BP is 190/115 during episodes. Plasma metanephrines are elevated indicating pheochromocytoma.
- Classic triad for pheochromocytoma: paroxysmal HTN + pheo.
- Pheochromocytoma is a catecholamine-secreting tumor.
- Diagnosis of pheochromocytoma: elevated plasma metanephrines / 24-hr urine catecholamines.
- Treatment for pheochromocytoma: surgery after alpha-blockade.
- A 58-year-old man presents with blurry vision and BP of 220/130. He is confused and has papilledema on fundoscopy. The most appropriate immediate intervention is starting IV nitroprusside to lower MAP by 25% over 6 hours.
- Hypertensive emergency = BP >180/120 + target organ damage.
- Goal is to lower MAP by 25% in the first 6 hours, using ICU and IV medications (e.g., nitroprusside, labetalol)
- A 74-year-old woman presents with acute mental status changes, BP is 245/130. She has headache, visual disturbances, and confusion; start IV labetalol and admit to ICU.
- Hypertensive emergency is an elevated BP + target organ damage.
- Signs and symptoms of hypertensive emergency: Encephalopathy, seizures, AMS.
- Monitor the patient closely.
Renal Artery Stenosis
- A patient presents with refractory hypertension. Exam reveals abdominal bruit. Labs show hypokalemia and elevated renin. Renal artery stenosis is the most likely diagnosis.
- Clues to renal artery stenosis: refractory HTN + abdominal bruit + RAAS activation.
- Older male with renal artery stenosis: atherosclerosis.
- Younger female with renal artery stenosis: fibromuscular dysplasia.
- Diagnosis of renal artery stenosis: renal Doppler, MRA, renal arteriogram.
Arterial Stiffness & Hypertension
- A 76-year-old woman has a BP of 182/78. Her PP is elevated; the best explanation is increased arterial stiffness.
- Isolated systolic HTN in elderly = + arterial compliance.
- Pulse pressure = SBP – DBP.
- Increased PP leads to increased CV risk.
- Seen in aging + arteriosclerosis.
Pregnancy & Hypertension
- ACE inhibitors are contraindicated in pregnancy.
- ACEI/ARBs = teratogenic, so they are not indicated in pregnancy.
- Safe anti-hypertensives in pregnancy: methyldopa, labetalol, nifedipine.
- ACEI/ARBs = renal dysgenesis, fetal demise.
Aortic Dissection
- A 61-year-old male with a history of HTN presents with severe chest pain radiating to his back. BP is 210/120 in both arms. CT shows a Stanford Type B aortic dissection; esmolol should be administered first.
- Always reduce shear force first with a beta-blocker in dissection.
- Aortic dissection: BB first (e.g., esmolol).
- Then vasodilator if needed.
- Never vasodilate alone, as ↑ HR = ↑ dissection risk.
Etiology of Shock
- A 66-year-old male is hypotensive after massive upper GI bleed. He is cold, clammy, and tachycardic; his hemodynamic profile is consistent with ↓ CO, ↑ SVR, ↓ PCWP.
- Hypovolemic shock: ↓ preload (→ ↓ PCWP), ↓ CO, ↑ SVR.
- Trauma, bleeding, burns cause hypovolemic shock.
- Patients with hypovolemic shock will be cold, pale, and have delayed capillary refill.
- Treat hypovolemic shock with fluids/blood.
Neurogenic OH & POTS
- A 68-year-old female presents with repeated fainting episodes. BP falls from 125/80 to 98/65 after 3 minutes of standing. HR goes from 68 → 70 bpm. Autonomic failure is the most likely mechanism.
- No HR compensation = neurogenic OH.
- Seen in Parkinson's, diabetes, aging.
- Diagnosis of neurogenic OH: tilt test confirms.
- Treatment of neurogenic OH: fludrocortisone, midodrine.
- A 26-year-old female has dizziness and palpitations upon standing. Tilt table test shows HR of 130 bpm with minimal BP drop; POTS is the diagnosis.
- Increased HR >30 bpm or >120 with minimal BP change = POTS.
- Often young females develop POTS.
- Possible causes of POTS: Post-viral or post-COVID.
- Treatment of POTS: fluids, compression, sometimes BB or ivabradine.
Vasovagal Syncope
- A 35-year-old male faints during blood donation with witnesses reporting he was pale and sweating before collapse. He regains consciousness quickly; vasovagal syncope.
- Emotional/physical stress → parasympathetic surge → brady + vasodilation.
- Trigger for vasovagal syncope: pain, blood, emotion.
- Prodrome for vasovagal syncope: nausea, sweating, tunnel vision.
- Treatment for vasovagal syncope: reassurance, avoid triggers, fluids/salt.
Hypertensive Emergency
- The most appropriate initial BP reduction target in hypertensive emergency is lowering MAP by 25% over 6 hours.
- Rapid drop of BP = risk of ischemia; target gradual, controlled reduction.
- Hypertensive emergency = TOD (stroke, renal failure, etc.).
- ICU + IV meds needed in cases of hypertensive emergency.
- Goal is to lower MAP ~25% first 6 hrs.
Dobutamine & Cardiogenic Shock
- A 59-year-old male presents with dyspnea, chest pain, and hypotension. His extremities are cold and clammy. Echo shows EF 20%. Swan-Ganz reveals ↑ PCWP, ↓ CO, ↑ SVR. Dobutamine is appropriate for short-term inotropic support.
- Cardiogenic shock + low perfusion requires the use of an inotrope.
- Dobutamine = beta-1 agonist.
- Dobutamine increases contractility → ↑ CO.
- Avoid negative inotropes (CCBs, BBs).
- A 45-year-old woman presents with BP 185/120 and papilledema. She is admitted to ICU for hypertensive emergency.
- Maximum rate that her BP should be lowered is MAP by no more than 25% in first 6 hours.
- Too rapid BP reduction = cerebral, renal, or coronary ischemia.
- In hypertensive emergency, there is TOD present.
- Drug of choice in hypertensive crisis: Nitroprusside, labetalol, nicardipine.
- Gradual reduction of blood pressure is essential.
Distributive Shock
- Findings that are most consistent with distributive shock (e.g., sepsis): ↑ CO, ↓ SVR, ↓ PCWP.
- Distributive shock = vasodilation, warm extremities early.
- In early sepsis, there is "warm shock".
- CO is increased due to inflammatory response.
- PCWP is decreased from relative hypovolemia.
Pregnancy Hypertension
- Labetalol is one of the most appropriate antihypertensives for pregnant patients with hypertensive crisis.
- ACEI/ARB = contraindicated in pregnancy.
- Safe options in pregnancy: methyldopa, labetalol, nifedipine.
- Labetalol = fast-acting IV option.
- Avoid RAAS blockers due to risk of fetal renal failure.
Neurogenic Orthostatic Hypotension
- A 75-year-old male experiences lightheadedness when standing. BP drops from 132/76 → 106/60. HR remains 72 indicating neurogenic orthostatic hypotension.
- No HR increase = think autonomic failure.
- Seen in Parkinson's, diabetes, the elderly.
- Treat with fludrocortisone, midodrine.
- Tilt test diagnostic for neurogenic orthostatic hypotension.
Cardiogenic Shock Device
- A patient with cardiogenic shock has persistent hypotension despite inotropes. An IABP can mechanically improve perfusion and reduce afterload.
- Intra-aortic Balloon Pump (IABP) inflates during diastole (↑ coronary perfusion) and deflates before systole (↓ afterload).
- Use IABP for temporizing support.
- Can be used a bridge to transplant or recovery.
- Inserted via femoral artery.
Pathophysiology of Vasovagal Syncope
- Vasovagal syncope pathophysiologically arises from increased parasympathetic outflow + decreased sympathetic tone.
- "Vaso" = dilation, "vagal" = bradycardia.
- Emotional trigger → reflex.
- ↓ HR + ↓ SVR → ↓ BP.
- Treatment: reassurance, salt, avoid triggers.
Hydralazine
- Hydralazine is likely to cause reflex tachycardia and flushing when used to manage severe hypertension.
- Direct vasodilators like hydralazine cause reflex SNS activation.
- Hydralazine is used in pregnancy or emergencies.
- Side effects of hydralazine: headache, tachycardia, lupus-like reaction.
- Avoid in CAD (can ↑ O2 demand).
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