Hypotension, Hypertension, Shock

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson
Download our mobile app to listen on the go
Get App

Questions and Answers

In most cases of shock, circulatory failure is manifested by:

  • Hyperthermia
  • Hypertension
  • Hypotension (correct)
  • Tachycardia

Which of the following best describes cardiogenic shock?

  • Shock caused by severe blood loss.
  • Shock resulting from the heart's inability to pump blood effectively. (correct)
  • Shock due to widespread vasodilation.
  • Shock due to obstruction of blood flow outside the heart.

According to the 'Perfusion Triangle', what are the three critical components necessary to maintain adequate perfusion?

  • Brain, kidneys, and liver
  • Lungs, blood, and kidneys
  • Heart, lungs, and brain
  • Heart, blood vessels, and blood (correct)

A patient presenting with a pulmonary embolism is most likely to experience which type of shock?

<p>Obstructive shock (B)</p> Signup and view all the answers

Which of the following conditions is NOT typically associated with cardiogenic shock?

<p>Severe burns (D)</p> Signup and view all the answers

In cardiogenic shock, what is the typical response of systemic vascular resistance (SVR)?

<p>SVR increases as a compensatory mechanism. (A)</p> Signup and view all the answers

Which hemodynamic parameter is typically elevated in cardiogenic shock due to back up pressure in the left atrium?

<p>Pulmonary Capillary Wedge Pressure (PCWP) (B)</p> Signup and view all the answers

A patient in shock presents with cool, clammy skin. This finding is most likely due to:

<p>Potent vasoconstrictive mechanisms (B)</p> Signup and view all the answers

Which of the following is a common laboratory finding in cardiogenic shock, especially if it is caused by acute ischemia?

<p>Elevated cardiac enzymes (A)</p> Signup and view all the answers

A patient is diagnosed with cardiogenic shock. Which of the following hemodynamic profiles is most consistent with this condition?

<p>Decreased cardiac output, increased PCWP, increased SVR (D)</p> Signup and view all the answers

A patient in cardiogenic shock is being considered for mechanical support. Which of the following devices directly assists left ventricular function?

<p>Left ventricular assist device (C)</p> Signup and view all the answers

A patient in cardiogenic shock exhibits severe metabolic acidosis with an arterial pH of 7.05. Which of the following interventions might be considered?

<p>Administration of sodium bicarbonate (C)</p> Signup and view all the answers

A patient is hypotensive with a systolic blood pressure of 80 mmHg. Which represents the threshold for hypotension in shock?

<p>&lt; 90 mmHg systolic or &lt; 65 mmHg mean arterial pressure (C)</p> Signup and view all the answers

Which of the following best explains why PCWP is elevated in cardiogenic shock?

<p>Back-up of pressure in the left atrium due to decreased left ventricular cardiac output. (A)</p> Signup and view all the answers

Which of the following is the most appropriate initial intervention for a patient in cardiogenic shock secondary to acute myocardial infarction?

<p>Reperfusion therapy via PCI or thrombolytics (A)</p> Signup and view all the answers

A patient in cardiogenic shock is receiving norepinephrine for refractory hypotension. Which of the following findings would warrant immediate discontinuation of norepinephrine?

<p>Evidence of peripheral ischemia (A)</p> Signup and view all the answers

Which of the following statements accurately describes the Frank-Starling mechanism's relevance to cardiogenic shock?

<p>It describes how increased preload, beyond a certain point, can worsen cardiac output in a failing heart. (C)</p> Signup and view all the answers

A patient with cardiogenic shock has a pulmonary artery catheter in place. Which set of hemodynamic values is MOST consistent with cardiogenic shock?

<p>Cardiac Index 1.8 L/min/m2, PCWP 22 mmHg, SVR 1800 dynes/sec/cm-5 (A)</p> Signup and view all the answers

Which intervention would be MOST appropriate to improve cardiac output in a patient with cardiogenic shock?

<p>Administer a dobutamine infusion. (A)</p> Signup and view all the answers

Which of the following best describes a potential consequence of sympathetic overactivity in cardiogenic shock?

<p>Vasoconstriction to maintain blood pressure. (C)</p> Signup and view all the answers

What is the primary purpose of inserting an intra-aortic balloon pump (IABP) in a patient with cardiogenic shock?

<p>To decrease afterload and improve coronary artery perfusion (D)</p> Signup and view all the answers

Which of the following is a typical sign or symptom of cardiogenic shock?

<p>Diffuse crackles on pulmonary auscultation. (D)</p> Signup and view all the answers

A 68-year-old male presents to the emergency department with acute dyspnea, chest pain, and a history of prior myocardial infarction. His blood pressure is 85/50 mmHg, heart rate is 110 bpm, and oxygen saturation is 88% on room air. Which of the following is the MOST likely underlying cause of this patient's presentation?

<p>Cardiogenic shock secondary to acute myocardial infarction. (C)</p> Signup and view all the answers

A physician is deciding between using dobutamine versus norepinephrine for a patient with cardiogenic shock. What is the MOST important factor that should influence this decision?

<p>The need to increase systemic vascular resistance. (B)</p> Signup and view all the answers

Which of the following is an absolute contraindication to the insertion of an intra-aortic balloon pump (IABP) in a patient with cardiogenic shock?

<p>Severe aortic insufficiency (D)</p> Signup and view all the answers

Which of the following is the MINIMUM reduction in systolic blood pressure that defines orthostatic hypotension?

<p>20 mmHg (D)</p> Signup and view all the answers

A patient experiences lightheadedness upon standing. After how many minutes of standing should blood pressure be assessed to diagnose orthostatic hypotension?

<p>After 3 minutes (D)</p> Signup and view all the answers

Which of the following is a common symptom associated with orthostatic hypotension?

<p>Syncope (C)</p> Signup and view all the answers

What is the underlying pathophysiology of orthostatic hypotension related to sympathetic response?

<p>Failure of sympathetic vasoconstrictor response (B)</p> Signup and view all the answers

Which of the following medications is LEAST likely to contribute to orthostatic hypotension?

<p>Non-steroidal anti-inflammatory drugs (NSAIDs) (D)</p> Signup and view all the answers

A patient with Postural Orthostatic Tachycardia Syndrome (POTS) and a heart rate greater than 120 bpm may benefit from which of the following medications?

<p>Ivabradine (B)</p> Signup and view all the answers

What is the primary mechanism behind vasovagal syncope?

<p>Transient increase in parasympathetic activity and sympathoinhibition (A)</p> Signup and view all the answers

Which set of circumstances is MOST likely to provoke vasovagal syncope?

<p>Prolonged standing in a warm room after donating blood (D)</p> Signup and view all the answers

Which of the following is a non-pharmacological intervention for orthostatic hypotension?

<p>Increasing sodium and fluid intake (B)</p> Signup and view all the answers

A patient with recurrent vasovagal syncope despite lifestyle modifications may benefit from which intervention?

<p>Reassurance and education on recognizing triggers (D)</p> Signup and view all the answers

Which of the following blood pressure readings is indicative of Stage 1 hypertension?

<p>130-139 mmHg systolic or 80-89 mmHg diastolic (B)</p> Signup and view all the answers

A patient is diagnosed with elevated blood pressure. Which of the following readings aligns with this diagnosis?

<p>Systolic 120-129 mmHg and Diastolic &lt; 80 mmHg (D)</p> Signup and view all the answers

What percentage of hypertensive individuals are estimated to have secondary hypertension?

<p>5-10% (A)</p> Signup and view all the answers

Which of the following is NOT typically considered a risk factor for essential hypertension?

<p>Regular vigorous exercise (B)</p> Signup and view all the answers

A 28-year-old patient is newly diagnosed with hypertension. Why is it particularly important to consider secondary causes in this patient?

<p>Secondary hypertension may have correctable causes. (B)</p> Signup and view all the answers

Which of the following best explains the impact of increased systolic or diastolic blood pressure on cardiovascular risk?

<p>Each 20 mm Hg increase in systolic or 10 mm Hg increase in diastolic BP doubles the risk of CVD. (C)</p> Signup and view all the answers

A patient's blood pressure is particularly responsive to changes in sodium intake. This is best described as:

<p>Salt sensitivity (C)</p> Signup and view all the answers

Which of the following is a potential characteristic of glucocorticoid-remediable hypertension?

<p>Increased frequency of strokes (B)</p> Signup and view all the answers

A patient presents with hypertension and hypokalemia. Further workup reveals suppressed plasma renin activity and low aldosterone levels. Which of the following conditions is most likely?

<p>Liddle's syndrome (B)</p> Signup and view all the answers

Which of the following is a known mechanism by which hyperinsulinemia can increase arterial pressure?

<p>Renal sodium retention (A)</p> Signup and view all the answers

A patient with hypertension is suspected of having renal artery stenosis. Which of the following physical exam findings would support this diagnosis?

<p>Abdominal bruit (D)</p> Signup and view all the answers

A patient presents with hypertension, suggesting coarctation of the aorta. Which physical exam findings supports this suspicion?

<p>Delayed femoral pulses (B)</p> Signup and view all the answers

A patient has recently started taking a medication and subsequently developed hypertension. Which of the following medications is LEAST likely to contribute to this new onset hypertension?

<p>Proton pump inhibitors (A)</p> Signup and view all the answers

Which of the following target organ damage is LEAST likely to be caused by chronic hypertension?

<p>Peripheral neuropathy (A)</p> Signup and view all the answers

Which of the following statements regarding symptoms of hypertension (HTN) is most accurate?

<p>Most patients with HTN are asymptomatic. (A)</p> Signup and view all the answers

Which initial laboratory tests is MOST important to perform in a patient with documented hypertension?

<p>Serum creatinine, BUN, and urinalysis (D)</p> Signup and view all the answers

A patient with hypertension has new onset atrial fibrillation. This new finding should prompt the clinician to consider which action?

<p>Evaluate for secondary causes of hypertension. (D)</p> Signup and view all the answers

Ambulatory blood pressure monitoring (ABPM) is MOST useful in which of the following scenarios?

<p>Diagnosing white coat hypertension (C)</p> Signup and view all the answers

Which of the following is the MOST appropriate initial diagnostic test for a patient suspected of having primary hyperaldosteronism?

<p>Plasma renin activity and aldosterone levels (A)</p> Signup and view all the answers

A patient with poorly controlled hypertension experiences paroxysmal episodes of headache, sweating, and tachycardia. What condition should be suspected?

<p>Pheochromocytoma (A)</p> Signup and view all the answers

Which of the following symptoms is MOST suggestive of secondary hypertension due to primary aldosteronism?

<p>Polyuria, polydipsia, and muscle weakness (C)</p> Signup and view all the answers

A young female patient is diagnosed with hypertension. A renal ultrasound reveals fibromuscular dysplasia. Which of the following is the MOST likely cause of her hypertension?

<p>Renal artery stenosis (A)</p> Signup and view all the answers

Which of the following is a typical finding in secondary hypertension due to coarctation of the aorta?

<p>Diminished and delayed femoral pulses (C)</p> Signup and view all the answers

What are the lifestyle modifications that will have the greatest SBP reduction?

<p>Weight reduction (C)</p> Signup and view all the answers

A 55-year-old patient is diagnosed with hypertension and has no other comorbidities. According to the 2017 Hypertension Guidelines, when should pharmacological treatment be initiated?

<p>Systolic BP &gt; 140 mmHg or Diastolic BP &gt; 90 mmHg (A)</p> Signup and view all the answers

According to guideline recommendations, what is the target blood pressure for most patients on antihypertensive treatment?

<p>&lt;130/80 mmHg (B)</p> Signup and view all the answers

A 62-year-old African American patient with hypertension is started on a thiazide diuretic. What is the rationale for this choice of medication?

<p>Thiazide diuretics are more effective in African Americans compared to other antihypertensive drugs. (A)</p> Signup and view all the answers

Which of the following drug classes is NOT considered as a first-line agent for the treatment of essential hypertension?

<p>Vasodilators (D)</p> Signup and view all the answers

In the treatment of hypertension, which drug class would be MOST appropriate for a male patient with concomitant benign prostatic hyperplasia (BPH)?

<p>Alpha-adrenergic receptor blockers (C)</p> Signup and view all the answers

A patient with hypertension also has a history of heart failure. Which of the following antihypertensive drug classes should be used with caution or avoided?

<p>Calcium channel antagonists (B)</p> Signup and view all the answers

A patient with hypertension develops a persistent, dry cough after starting an antihypertensive medication. Which of the following medications is most likely responsible?

<p>ACE inhibitor (C)</p> Signup and view all the answers

Which of the following antihypertensive medications is contraindicated in pregnancy?

<p>ACE inhibitors (A)</p> Signup and view all the answers

An elderly patient with hypertension is being treated with multiple antihypertensive medications. Which of the following conditions is MOST important to monitor for in this patient population?

<p>Postural hypotension (B)</p> Signup and view all the answers

Following the initiation of antihypertensive therapy, how often should serum potassium and creatinine levels be checked?

<p>1-2 times per year (C)</p> Signup and view all the answers

What is the recommended alcohol intake for patients with hypertension?

<p>Limit to 15mL daily (C)</p> Signup and view all the answers

A patient presents with a blood pressure of 220/120 mmHg, severe headache, and visual disturbances, but no evidence of end-organ damage. What is the MOST appropriate course of action?

<p>Start oral antihypertensive medications to be treated within 1-week (A)</p> Signup and view all the answers

A patient is started on hydrochlorothiazide for hypertension. Which of the following electrolyte abnormalities is MOST likely to occur?

<p>Hypokalemia (A)</p> Signup and view all the answers

The primary goal in treating a patient with hypertensive encephalopathy is to:

<p>Reduce mean arterial pressure by 20-25% within the first hours (C)</p> Signup and view all the answers

According to current hypertension guidelines, what blood pressure reading is classified as 'Elevated'?

<p>120-129/&lt;80 mmHg (D)</p> Signup and view all the answers

A patient is diagnosed with Stage 2 hypertension. According to the guidelines, which of the following blood pressure readings would confirm this diagnosis?

<p>140/90 mmHg (A)</p> Signup and view all the answers

What is the estimated prevalence of hypertension in African Americans?

<p>36% (D)</p> Signup and view all the answers

Which of the following modifiable risk factors is most closely associated with the development of hypertension?

<p>Excessive alcohol intake (A)</p> Signup and view all the answers

Which statement best summarizes the long-term impact of essential hypertension on cardiovascular health?

<p>It increases the risk of myocardial infarction, heart failure, stroke, and kidney disease. (C)</p> Signup and view all the answers

A patient's blood pressure is highly responsive to variations in their daily sodium intake. How would this patient's condition be best described?

<p>Salt sensitivity (C)</p> Signup and view all the answers

In which scenario should a clinician be MOST suspicious of secondary hypertension?

<p>A 25-year-old female with newly diagnosed hypertension and no family history. (C)</p> Signup and view all the answers

During a physical examination, which finding would be MOST suggestive of secondary hypertension due to renal artery stenosis?

<p>An abdominal bruit (C)</p> Signup and view all the answers

A patient presents with hypertension, muscle weakness, polyuria, and polydipsia. Which of the following conditions should be MOST suspected?

<p>Primary aldosteronism (C)</p> Signup and view all the answers

Which of the following physical exam findings is MOST specific for coarctation of the aorta as a cause of hypertension?

<p>Diminished or delayed femoral pulses (B)</p> Signup and view all the answers

A patient with long-standing hypertension is found to have left ventricular hypertrophy (LVH) on an ECG. What is the clinical significance of this finding?

<p>It suggests chronicity of the hypertension and increases the risk of cardiovascular events. (A)</p> Signup and view all the answers

According to the 2017 Hypertension Guidelines, what is the blood pressure target for most patients on antihypertensive treatment?

<p>&lt;130/80 mmHg (D)</p> Signup and view all the answers

Which of the following lifestyle modifications is expected to result in the GREATEST reduction in systolic blood pressure?

<p>Weight reduction (D)</p> Signup and view all the answers

A 65-year-old patient with a history of hypertension is being evaluated for suspected secondary hypertension. Which of the following historical clues would be MOST indicative of primary aldosteronism?

<p>Unexplained hypokalemia in the absence of diuretic use. (C)</p> Signup and view all the answers

In managing hypertension, a clinician is considering initiating a thiazide diuretic. In which patient would this medication be MOST appropriate as a first-line agent?

<p>A 58-year-old African American female with no comorbidities. (D)</p> Signup and view all the answers

A patient with essential hypertension develops a persistent, dry cough soon after starting treatment. Which antihypertensive medication is MOST likely responsible for this adverse effect?

<p>Lisinopril (A)</p> Signup and view all the answers

When treating hypertension in older adults, which condition is MOST important to monitor closely to avoid adverse outcomes?

<p>Orthostatic hypotension. (C)</p> Signup and view all the answers

What is the MOST appropriate initial blood pressure target in a patient presenting with hypertensive encephalopathy?

<p>Reduce mean arterial pressure (MAP) by 20-25% within the first hour (A)</p> Signup and view all the answers

After initiating antihypertensive therapy, how often should serum potassium and creatinine levels be checked?

<p>1-2 times per year (D)</p> Signup and view all the answers

According to current guidelines concerning treatment of HTN, what is the target BP for elderly (>70 years) patients?

<p>130/80 mm Hg (C)</p> Signup and view all the answers

A 26 year old female presents with hypertension on routine evaluation. Which of the following historical clues is MOST indicative of renal artery stenosis?

<p>Recent flank pain (C)</p> Signup and view all the answers

A 57 year old male presents to the clinic with hypertension. You begin to suspect Hyperaldosteronism. Which of the following symptoms is MOST suggestive of this condition?

<p>Muscle weakness (A)</p> Signup and view all the answers

An 18-year-old female is diagnosed with hypertension. A renal ultrasound reveals fibromuscular dysplasia. Which of the following is the MOST likely cause of her hypertension?

<p>Renal artery stenosis (A)</p> Signup and view all the answers

A 72 year old male presents to the clinic with hypertension. Which medication is contraindicated due to the patient also having gout?

<p>Thiazide diuretics (C)</p> Signup and view all the answers

A patient's blood pressure persistently remains above goal despite adherence to three antihypertensive medications. Which of the following should be the NEXT step in management?

<p>Refer the patient to a nephrologist for evaluation of possible renal disease. (B)</p> Signup and view all the answers

A 45-year-old man with hypertension has been experiencing erectile dysfunction since starting antihypertensive medication therapy six months ago. Which of the following medications is MOST likely contributing to this side effect?

<p>Thiazide diuretic (A)</p> Signup and view all the answers

A 60-year-old patient with a history of poorly controlled hypertension presents with a blood pressure of 220/120 mmHg and papilledema on funduscopic examination. He denies any chest pain, shortness of breath, or neurologic deficits. Which of the following is the MOST appropriate initial course of action?

<p>Admit the patient to the intensive care unit for intravenous antihypertensive therapy and continuous blood pressure monitoring. (A)</p> Signup and view all the answers

A patient in hypertensive emergency requires a continuous intravenous infusion for blood pressure control. Which of the following agents requires cyanide toxicity monitoring, especially with prolonged use or in patients with renal insufficiency?

<p>Nitroprusside (A)</p> Signup and view all the answers

A 75-year-old patient with known hypertension presents with dizziness upon standing. Blood pressure readings are 150/80 mmHg supine and 120/65 mmHg standing. What change in drug regimen is most appropriate?

<p>Review current medications and consider decreasing dosages. (D)</p> Signup and view all the answers

A 50-year-old male with a history of hypertension and benign prostatic hyperplasia (BPH) presents for a routine follow-up. Which of the following antihypertensive medications would be MOST appropriate for treating both conditions concurrently?

<p>Prazosin (C)</p> Signup and view all the answers

A 32-year-old pregnant patient is diagnosed with gestational hypertension. Which of the following antihypertensive medications is generally considered safe for use during pregnancy?

<p>Methyldopa (D)</p> Signup and view all the answers

In a patient with hypertension and known renovascular disease, initiation of which antihypertensive drug class requires careful monitoring due to the risk of acute kidney injury?

<p>ACE inhibitors or ARBs (C)</p> Signup and view all the answers

Which of the following initial diagnostic test is MOST specific for diagnosing the common causes of Cushing's syndrome?

<p>Dexamethasone suppression test (C)</p> Signup and view all the answers

Among the following antihypertensive medications, which one exhibits the LEAST versatility in managing diverse conditions?

<p>Hydralazine (B)</p> Signup and view all the answers

A patient with a history of hypertension and end-stage renal disease presents with a BP of 180/110 mmHg which diuretic is the LEAST effective in these patients?

<p>HCTZ (C)</p> Signup and view all the answers

In an elderly hypertensive patient taking diuretics, beta-blockers and ACE-inhibitors, what laboratory finding is the MOST likely precipitant of postural hypotension?

<p>Hyponatremia (B)</p> Signup and view all the answers

According to the 2017 Hypertension Guidelines, at what blood pressure level should antihypertensive drug therapy be initiated for primary prevention?

<p>Systolic BP &gt; 140 mmHg or diastolic BP &gt; 90 mmHg (A)</p> Signup and view all the answers

What is the on-treatment blood pressure goal for most patients on antihypertensive treatment?

<p>&lt; 130/80 mmHg (C)</p> Signup and view all the answers

An African American patient with hypertension is started on a thiazide diuretic. What is the rationale for this choice of medication?

<p>African American patients tend to be more salt-sensitive, and thiazide diuretics are effective in reducing sodium levels. (A)</p> Signup and view all the answers

What drug class should be used with caution or avoided in a patient with hypertension and a history of heart failure?

<p>Calcium channel blockers (A)</p> Signup and view all the answers

A patient develops a persistent, dry cough after starting an antihypertensive medication. Which medication side effect is MOST likely responsible?

<p>ACE inhibitors (A)</p> Signup and view all the answers

Which antihypertensive medications are typically contraindicated in pregnancy?

<p>ACE inhibitors (A)</p> Signup and view all the answers

An elderly patient with hypertension is being treated with multiple antihypertensive medications. What is MOST important to monitor for in this patient population?

<p>Orthostatic hypotension (D)</p> Signup and view all the answers

A patient is started on hydrochlorothiazide for hypertension. Which electrolyte abnormalities are MOST likely to occur?

<p>Hypokalemia and hyponatremia (A)</p> Signup and view all the answers

What is the primary goal in treating a patient with hypertensive encephalopathy?

<p>Gradually lower mean arterial pressure by no more than 25% within the first few hours (D)</p> Signup and view all the answers

During a physical examination for hypertension, which finding would be MOST suggestive of secondary hypertension due to renal artery stenosis?

<p>Abdominal bruit (C)</p> Signup and view all the answers

What historical clue suggests that a 65-year-old patient being evaluated for suspected secondary hypertension may have primary aldosteronism?

<p>Muscle weakness or cramps (A)</p> Signup and view all the answers

What lifestyle modification, will have the greatest impact on reducing systolic blood pressure?

<p>Weight reduction (C)</p> Signup and view all the answers

According to the provided information, which of the following best describes how essential hypertension affects cardiovascular risk?

<p>Each increase of 20 mm Hg in systolic BP or 10 mm Hg in diastolic BP doubles the risk of CVD across the entire BP range from 115/75 mm Hg to 185/115 mm Hg (A)</p> Signup and view all the answers

Which of the following signs or symptoms should prompt a high index of suspicion for secondary hypertension?

<p>Hypertension following use of oral contraceptive pills in females under the age of 30 (D)</p> Signup and view all the answers

Which of the following clinical manifestations would be anticipated in a patient with a long history of poorly controlled hypertension?

<p>Aortic Dissection (B)</p> Signup and view all the answers

A patient reports non-compliance, excess salt intake and is found to have resistant hypertension. Given this scenario, what medication class would best address the blood pressure and dietary non-compliance?

<p>Thiazide (B)</p> Signup and view all the answers

A 62-year-old African-American male is seen for his yearly PE. He has no complaints. He denies any current medications or medical problems, but the occupational medicine nurse has taken his BP several times in the past year and told him it was high. He denies any tobacco or alcohol use. His BP is 156/92 today. What is the most likely cause of his elevated BP?

<p>essential hypertension (B)</p> Signup and view all the answers

A 24-year-old male seeks medical attention for the recent onset of headaches. The headaches are described as 'pounding' and occur during the day and night. He has had minimal relief with acetaminophen. Review of symptoms is positive only for leg fatigue with exertion. PE is notable for a BP of 185/115 mmHg in the right arm, a HR of 70/min, AV nicking on fundiscopic examination, normal jugular veins and carotid arteries, a pressure-loaded PMI with an apical S4, no abdominal bruits, and reduced pulses in both lower extremities. Additional measurement of BP reveals the following: Right arm 185/115 Left arm 188/113 Right thigh 100/60 Left thigh 102/58. What is the most likely cause of this patient's hypertension?

<p>Renal artery stenosis (B)</p> Signup and view all the answers

A 12-year-old boy presents to the office with pain in his legs with activity gradually becoming worse over the past month. He is unable to ride a bicycle with his friends due to the pain in his legs. Examination of the heart reveals an ejection click and accentuation of the second heart sound. Femoral pulses are weak and delayed compared to the brachial pulses. BP obtained in both arms is elevated. Chest x-ray reveals rib notching. Which of the following is the most likely diagnosis?

<p>coarctation of the aorta (D)</p> Signup and view all the answers

A 48-year-old male presents to the emergency department with an alteration in consciousness after cocaine ingestion. On presentation, BP is 254/162, with an O2 sat of 83% on RA PE is notable for depressed consciousness. The patient does not follow commands but purposely withdraws from pain in all extremities. His pupils are equal and reactive. The cardiovascular exam is notable for a hyperdynamic precordium with a loud S4 gallop. There are no murmurs. Crackles are heard diffusely in both lung fields. The CXR is consistent with pulmonary edema. CT scan of the head reveals diffuse cerebral edema without hemorrhage. EKG shows LVH with T-wave inversions in V3 to V6. UA shows 1+ proteinuria with 25 to 50 RBC's/HPF. Creatinine is 2.6 mg/dL. What is the most appropriate management for this patient?

<p>Initiate fenoldopam by continuous infusion. (D)</p> Signup and view all the answers

A 46-year-old female is being evaluated for a new-onset HTN that was discovered on screening at her workplace. The patient had several readings revealing systolic and diastolic HTN. Patient is currently on no medications. PE is unremarkable. A complete laboratory evaluation revealed hypokalemia as the only abnormality. Which of the following is the most likely diagnosis for this patient?

<p>primary aldosteronism (A)</p> Signup and view all the answers

A 56-year-old male came to the ER with complaints of palpitations and shortness of breath for 1 week ago. He has a longstanding history of poorly controlled HTN PE reveals an elevated blood pressure of 190/98 mm Hg, elevated JVP, mild hepatomegaly, bilateral pedal edema, and rales at the lung bases. Diagnostic studies reveal concentric LVH without significant valvular abnormalities on echocardiogram. Which of the following drugs is beneficial in the treatment of the patient's condition by virtue of both afterload and preload reduction?

<p>Loop diuretics (furosemide) (D)</p> Signup and view all the answers

Which type of anti-hypertensive agent is NEVER recommended in pregnancy?

<p>ACE inhibitors (A)</p> Signup and view all the answers

A 58-year-old male presents with chest pain. VS include BP of 210/175, pulse 80, RR 20. Which of the following would you expect to find on PE?

<p>papilledema (C)</p> Signup and view all the answers

An ambulance transports a patient to your facility from the nursing home with anuria and diminished level of consciousness. Paramedics report a BP of 225/130 mm Hg. Which of the following medications is most appropriate for this patient?

<p>Nitroprusside sodium (Nipride) (B)</p> Signup and view all the answers

A 66-year-old female with a history of diabetes and hypertension presents for routine evaluation. Since beginning her ACE inhibitor and diuretic therapy her BPs have averaged 138/85 mmHg. Which of the following is the next best step in the management of this patient?

<p>Congratulate her for being &quot;at goal&quot; with a blood pressure of less than 140/90 mmHg. (D)</p> Signup and view all the answers

Which of the following antihypertensive drugs is incorrectly matched with the indication for therapy?

<p>Loop diuretic-gout (B)</p> Signup and view all the answers

While in the clinic, the nurse measures the BP of a 61-year-old male and finds that it is 183/100 mmHg sitting and 190/105 standing. He has a HR of 81/minute, with an irregularly irregular rhythm. Which of the following pathologic findings is most likely to be present:

<p>Left ventricular hypertrophy (B)</p> Signup and view all the answers

A 50-year-old construction worker continues to have an elevated BP of 160/95 even after a third agent is added to his antihypertensive regimen. PE is normal, electrolytes are normal, and the patient is taking no over-the-counter medications. The next helpful step for this patient is to:

<p>Check pill count (E)</p> Signup and view all the answers

All the following statements about severe hypertension are true EXCEPT

<p>In a hypertensive emergency, blood pressure should be lowered rapidly to normotensive levels (A)</p> Signup and view all the answers

A 68-year-old man presents with chest pain, dyspnea, hypotension (BP 78/50), elevated JVP, and crackles. Echo shows EF 20%. Swan-Ganz catheter reveals ↓ CO, ↑ PCWP, and ↑ SVR. What is the most likely diagnosis?

<p>Cardiogenic shock (B)</p> Signup and view all the answers

Which of the following hemodynamic changes is most characteristic of cardiogenic shock?

<p>Increased PCWP and increased SVR (C)</p> Signup and view all the answers

A 73-year-old woman is hypotensive (BP 88/58) and develops syncope after standing. Her HR increases from 68 to 94. Which condition does this most likely indicate?

<p>Orthostatic hypotension (C)</p> Signup and view all the answers

A 60-year-old male has episodic palpitations, sweating, and headaches. BP is 190/115 during episodes. Plasma metanephrines are elevated. What is the most likely diagnosis?

<p>Pheochromocytoma (B)</p> Signup and view all the answers

A 58-year-old man presents with blurry vision and BP of 220/130. He is confused and has papilledema on fundoscopy. What is the most appropriate immediate intervention?

<p>Start IV nitroprusside to lower MAP by 25% over 6 hours (D)</p> Signup and view all the answers

A patient presents with refractory hypertension. Exam reveals abdominal bruit. Labs show hypokalemia and elevated renin. Which of the following is the most likely diagnosis?

<p>Renal artery stenosis (C)</p> Signup and view all the answers

A 76-year-old woman has a BP of 182/78. Her PP is elevated. Which of the following is the best explanation?

<p>Increased arterial stiffness (C)</p> Signup and view all the answers

Which of the following antihypertensives is contraindicated in pregnancy?

<p>ACE inhibitors (B)</p> Signup and view all the answers

A 61-year-old male with a history of HTN presents with severe chest pain radiating to his back. BP is 210/120 in both arms. CT shows a Stanford Type B aortic dissection. Which medication should be administered first?

<p>Esmolol (D)</p> Signup and view all the answers

A 74-year-old woman presents with acute mental status changes. BP is 245/130. She has headache, visual disturbances, and confusion. What is the most appropriate next step?

<p>Start IV labetalol and admit to ICU (D)</p> Signup and view all the answers

A 66-year-old male is hypotensive after massive upper GI bleed. He is cold, clammy, and tachycardic. Which of the following is most consistent with his hemodynamic profile?

<p>↓CO, ↑ SVR, ↓PCWP (C)</p> Signup and view all the answers

A 68-year-old female presents with repeated fainting episodes. BP falls from 125/80 to 98/65 after 3 minutes of standing. HR goes from 68 → 70 bpm. Which mechanism is most likely?

<p>Autonomic failure (A)</p> Signup and view all the answers

A 26-year-old female has dizziness and palpitations upon standing. Tilt table test shows HR of 130 bpm with minimal BP drop. What is the diagnosis?

<p>POTS (C)</p> Signup and view all the answers

A 35-year-old male faints during blood donation. Witnesses report he was pale and sweating before collapse. He regains consciousness quickly. What's the best diagnosis?

<p>Vasovagal syncope (C)</p> Signup and view all the answers

Which of the following is the most appropriate initial BP reduction target in hypertensive emergency?

<p>Lower MAP by 25% over 6 hours (C)</p> Signup and view all the answers

A 59-year-old male presents with dyspnea, chest pain, and hypotension. His extremities are cold and clammy. Echo shows EF 20%. Swan-Ganz reveals ↑ PCWP, ↓ CO, ↑ SVR. Which drug is appropriate for short-term inotropic support?

<p>Dobutamine (A)</p> Signup and view all the answers

A 45-year-old woman presents with BP 185/120 and papilledema. She is admitted to ICU for hypertensive emergency. What's the maximum rate her BP should be lowered?

<p>MAP by no more than 25% in first 6 hours (C)</p> Signup and view all the answers

Which of the following findings is most consistent with distributive shock (e.g., sepsis)?

<p>↑ CO,↓ SVR, ↓PCWP (D)</p> Signup and view all the answers

Which of the following antihypertensives is most appropriate for pregnant patients with hypertensive crisis?

<p>Labetalol (A)</p> Signup and view all the answers

A 70-year-old woman presents with blurry vision and BP 240/130. Fundus exam reveals hemorrhages and papilledema. What is this condition?

<p>Malignant HTN (D)</p> Signup and view all the answers

A 75-year-old male experiences lightheadedness when standing. BP drops from 132/76 → 106/60. HR remains 72. What does this indicate?

<p>Neurogenic orthostatic hypotension (C)</p> Signup and view all the answers

A patient with cardiogenic shock has persistent hypotension despite inotropes. Which device can mechanically improve perfusion and reduce afterload?

<p>IABP (D)</p> Signup and view all the answers

Which of the following best describes the pathophysiology of vasovagal syncope?

<p>Increased parasympathetic outflow + decreased sympathetic tone (B)</p> Signup and view all the answers

Which of the following drugs is most likely to cause reflex tachycardia and flushing when used to manage severe hypertension?

<p>Hydralazine (C)</p> Signup and view all the answers

Flashcards

Shock Definition

Life-threatening condition caused by an imbalance between cellular oxygen supply and demand, leading to organ dysfunction. Often involves hypotension.

Perfusion Triangle Components

Heart (pump function), blood vessels (container function), and blood (content function).

Cardiogenic Shock

Occurs when the heart is weakened or damaged, reducing effective pumping of blood.

Cardiogenic Shock Cause

A consequence of the heart's inability to pump effectively.

Signup and view all the flashcards

Cardiogenic Shock Hemodynamics

Cardiac output decreases due to pump failure; systemic vascular resistance increases to compensate.

Signup and view all the flashcards

PCWP in Cardiogenic Shock

Increased, reflecting increased left atrial pressure due to decreased left ventricular cardiac output.

Signup and view all the flashcards

Cardiac Output in Cardiogenic Shock

Decreased, as the heart is unable to pump effectively.

Signup and view all the flashcards

SVR in Cardiogenic Shock

Increased as a compensatory mechanism to maintain perfusion to vital organs.

Signup and view all the flashcards

Signs of Shock

Hypotension, oliguria, changes in mental status, cool/clammy skin, and metabolic acidosis.

Signup and view all the flashcards

Cardiogenic Shock Symptoms

Dyspnea, chest pain, palpitations, pulmonary crackles, new murmurs/gallops, elevated JVP, diminished pulses.

Signup and view all the flashcards

CXR Findings in Cardiogenic Shock

Pulmonary congestion or edema.

Signup and view all the flashcards

Cardiogenic Shock Treatment

Optimize intravascular volume, inotropes (Epi, NE, or Dobutamine), and mechanical support.

Signup and view all the flashcards

Norepinephrine Use

Used for refractory hypotension.

Signup and view all the flashcards

Sodium Bicarbonate

May treat severe metabolic acidosis.

Signup and view all the flashcards

Ventilation Support

Supports ventilation, corrects acidosis.

Signup and view all the flashcards

Aspirin

Used in cardiogenic shock treatment.

Signup and view all the flashcards

Intravenous Heparin

Used in cardiogenic shock treatment.

Signup and view all the flashcards

Orthostatic Hypotension Definition

Reduction in systolic BP by at least 20 mmHg or diastolic BP by at least 10 mmHg within 3 minutes of standing.

Signup and view all the flashcards

Orthostatic Hypotension Pathophysiology

Failure of autonomic vasoconstriction, inadequate intravascular volume, or inability to increase cardiac output upon standing.

Signup and view all the flashcards

Common Causes of Orthostatic Hypotension

Volume depletion, vasodilator drugs, and Postural Orthostatic Tachycardia Syndrome (POTS)

Signup and view all the flashcards

Non-Pharmacological Management of Orthostatic Hypotension

Identifying and stopping BP-lowering drugs, exercise, compression stockings, high sodium/fluid intake.

Signup and view all the flashcards

Pharmacological Management of Orthostatic Hypotension

Ivabradine (for POTS with tachycardia), fludrocortisone, midodrine, or droxidopa.

Signup and view all the flashcards

Vasovagal Hypotension Definition

Sudden decreased heart rate and blood pressure, leading to fainting.

Signup and view all the flashcards

Vasovagal Hypotension Pathophysiology

Transient autonomic changes with increased parasympathetic outflow, sympathoinhibition, bradycardia & vasodilation = syncope.

Signup and view all the flashcards

Vasovagal Hypotension Management

Reassurance, avoidance of stimuli, and plasma volume expansion via fluids with salt.

Signup and view all the flashcards

Hypertension Definition

Chronic elevation in blood pressure > 140/90 mmHg.

Signup and view all the flashcards

BP Categories

Normal: <120/<80; Elevated: 120-129/<80; Stage 1: 130-139/80-89; Stage 2: >140/>90.

Signup and view all the flashcards

Essential Hypertension

90-95% has no identifiable cause. Consider secondary causes in young or resistant cases.

Signup and view all the flashcards

HTN Risk Factors

Family history, age, race, obesity, inactivity, smoking, salt, alcohol, and associated conditions.

Signup and view all the flashcards

Essential Hypertension

Chronic elevation in blood pressure (BP) >140/90 mmHg without a definable cause, representing most hypertensive persons

Signup and view all the flashcards

Glucocorticoid-remediable HTN

Early-onset HTN, strokes, hyperaldosteronism.

Signup and view all the flashcards

Liddle's Syndrome

HTN and hypokalemia; Low plasma renin and aldosterone levels.

Signup and view all the flashcards

Symptoms of Primary Hyperaldosteronism

Polyuria, polydipsia, muscle weakness due to hypokalemia.

Signup and view all the flashcards

Symptoms of Pheochromocytoma

Headaches, palpitations, diaphoresis, postural diziness.

Signup and view all the flashcards

Causes of Secondary HTN

Glomerulonephritis, diabetic nephropathy, Renal Artery Stenosis, Polycystic kidney disease.

Signup and view all the flashcards

Endocrine Causes of HTN

Hyperthyroidism, Cushing's, Adrenal and pituitary disorders, Pheochromocytoma, Primary aldosteronism.

Signup and view all the flashcards

Drugs Contributing to HTN

NSAIDs, OCPs, decongestants, steroids, stimulants, Street drugs.

Signup and view all the flashcards

Target Organ Damage (HTN)

Coronary artery disease, LVH, heart failure, stroke, kidney disease, retinopathy.

Signup and view all the flashcards

Symptoms of HTN

Most patients asymptomatic; Severe HTN: occipital headache, dizziness, epistaxis.

Signup and view all the flashcards

Signs of Hypertension

Retinal changes, LV lift, Loud A2, S4

Signup and view all the flashcards

HTN Lab Tests

Creatinine, BUN, UA, K, CXR, ECG, TSH.

Signup and view all the flashcards

Uses for ABPM

Ambulatory BP monitoring clarifies white coat HTN and circadian BP

Signup and view all the flashcards

Lifestyle Modifications (HTN)

Weight loss, DASH diet, sodium restriction, exercise, limit alcohol.

Signup and view all the flashcards

HTN Treatment Goals

Treat BP < 140/90 mmHg (< 130/80 in DM or CKD).

Signup and view all the flashcards

First Line HTN Meds

Diuretics, ACE inhibitors/ARBs, CCBs, beta blockers.

Signup and view all the flashcards

Thiazide Diuretic Side Effects

Hypokalemia, hyperglycemia, hyperuricemia.

Signup and view all the flashcards

ACE Inhibitor Side Effects

Cough, hyperkalemia, azotemia, angioedema.

Signup and view all the flashcards

CCB Side Effects

Edema, constipation, bradycardia, heart block

Signup and view all the flashcards

Beta Blocker Side Effects

Bronchospasm, bradycardia, fatigue, sexual dysfunction.

Signup and view all the flashcards

Common Treatable Cause of HTN in Elderly

Renovascular disease.

Signup and view all the flashcards

Key Assessments HTN Elderly

Screen for proteinuria, electrolytes, and end-organ damage.

Signup and view all the flashcards

Modify HTN Therapy Older Adults

Use combinations, aim lower, and consider orthostasis/polypharmacy.

Signup and view all the flashcards

Postural Hypotension

Decrease in standing SBP >10 mmHg; associated dizziness/fainting; more older people.

Signup and view all the flashcards

Consider HTN

Dementia.

Signup and view all the flashcards

Pregnancy HTN Meds:

Pregnancy: methydopa, labetalol, hydralazine, nifedipine; avoid ACEIs/ARBs.

Signup and view all the flashcards

Poor HTN

Inadequate measurement or response for BP, adherence, alcohol. Identify secondary HTN if poorly responsive.

Signup and view all the flashcards

Drugs Hypertension

Nitroprusside, Nicardipine, Labetalol, Enalaprilat, Esmolol, Nitroglycerin, Hydralazine

Signup and view all the flashcards

Hypertensive Urgency

Markedly elevated BP without acute target organ damag

Signup and view all the flashcards

HTN Prevention

Control weight, exercise, and limit sodium, alcohol, caffeine.

Signup and view all the flashcards

Coarctation of Aorta

Headaches described as pounding and occurring both day and night, elevated BP in arms compared to legs, leg fatigue with exertion.

Signup and view all the flashcards

Coarctation of the Aorta

Pain in legs with activity, ejection click, weak femoral pulses, elevated BP in arms, rib notching on chest x-ray.

Signup and view all the flashcards

Fenoldopam

Manage with continuous infusion for rapid BP control due to end-organ damage (pulmonary edema, cerebral edema).

Signup and view all the flashcards

Primary aldosteronism

New-onset hypertension with hypokalemia.

Signup and view all the flashcards

Loop Diuretics

Afterload and preload reduction

Signup and view all the flashcards

Hypertension Drug in Pregnancy

ACE inhibitors are contraindicated during pregnancy.

Signup and view all the flashcards

Rapidly lowering blood pressure

In the presence of ongoing target organ damage, blood pressure should be lowered rapidly to normotensive levels

Signup and view all the flashcards

Nitroprusside Sodium

Anuria and diminished consciousness.

Signup and view all the flashcards

ACE and Diuretic Combination

This diuretic combination has achieved BP target for diabetic and hypertensive patient

Signup and view all the flashcards

Antihypertensive Incorrectly Matched to Indication

Loop diuretic use for gout treatment

Signup and view all the flashcards

Hypertension Pathologic Finding

Left ventricular hypertrophy

Signup and view all the flashcards

Elevated BP After Agents

Poor adherence

Signup and view all the flashcards

Cardiogenic Shock Definition

Hypotension (SBP <90 or MAP <65) with evidence of inadequate tissue perfusion despite adequate fluid resuscitation.

Signup and view all the flashcards

Orthostatic Hypotension Diagnosis

Postural drop in blood pressure (≥20 mmHg systolic or ≥10 mmHg diastolic) within 3 minutes of standing.

Signup and view all the flashcards

Pheochromocytoma Symptoms

Episodic hypertension accompanied by palpitations, sweating, and headaches.

Signup and view all the flashcards

Treatment for Hypertensive Emergency

IV nitroprusside to lower mean arterial pressure (MAP) by no more than 25% within the first 6 hours.

Signup and view all the flashcards

Hypertensive Emergency Definition

Elevated blood pressure (>180/120 mmHg) accompanied by acute target organ damage.

Signup and view all the flashcards

Pathophysiology of Vasovagal Syncope

Increased parasympathetic outflow and decreased sympathetic tone leading to bradycardia and vasodilation.

Signup and view all the flashcards

Postural Orthostatic Tachycardia Syndrome (POTS)

Excessive heart rate increase (≥30 bpm) upon standing with minimal blood pressure change.

Signup and view all the flashcards

Safe Hypertension Drugs in Pregnancy

Labetalol, methyldopa, and nifedipine are safe options; ACE inhibitors and ARBs are contraindicated.

Signup and view all the flashcards

IABP Mechanism

An intra-aortic balloon pump (IABP) inflates during diastole to increase coronary perfusion and deflates before systole to reduce afterload.

Signup and view all the flashcards

Study Notes

Hypertension Review

  • A 68-year-old man presents with chest pain, dyspnea, hypotension (BP 78/50), elevated JVP, and crackles, with an echo showing EF 20%. A Swan-Ganz catheter reveals ↓ CO, ↑ PCWP, and ↑ SVR; the most likely diagnosis is cardiogenic shock.
  • Classic hemodynamic triad for cardiogenic shock: ↓ CO, ↑ PCWP, ↑ SVR.
  • PCWP reflects left atrial pressure backup in cardiogenic shock.
  • Common causes of cardiogenic shock: post-MI, myocarditis, arrhythmia.
  • Hemodynamic changes characteristic of cardiogenic shock include increased PCWP and increased SVR.
  • LV failure leads to LA pressure back-up, resulting in increased PCWP; SVR increases to compensate.
  • The sympathetic nervous system increases SVR as a compensation mechanism in cardiogenic shock.
  • Increased PCWP causes pulmonary edema.
  • Decreased CO leads to organ hypoperfusion.

Orthostatic Hypotension

  • A 73-year-old woman is hypotensive (BP 88/58) and develops syncope after standing with her HR increasing from 68 to 94; this most likely indicates orthostatic hypotension.
  • Postural BP drop ≥ 20/10 mmHg after 3 minutes of standing indicates orthostatic hypotension.
  • Symptoms of orthostatic hypotension: dizziness, syncope.
  • Causes of orthostatic hypotension: volume depletion, autonomic dysfunction, medications.
  • Tilt table can confirm orthostatic hypotension.

Pheochromocytoma and Hypertensive Crisis

  • A 60-year-old male has episodic palpitations, sweating, and headaches. BP is 190/115 during episodes. Plasma metanephrines are elevated indicating pheochromocytoma.
  • Classic triad for pheochromocytoma: paroxysmal HTN + pheo.
  • Pheochromocytoma is a catecholamine-secreting tumor.
  • Diagnosis of pheochromocytoma: elevated plasma metanephrines / 24-hr urine catecholamines.
  • Treatment for pheochromocytoma: surgery after alpha-blockade.
  • A 58-year-old man presents with blurry vision and BP of 220/130. He is confused and has papilledema on fundoscopy. The most appropriate immediate intervention is starting IV nitroprusside to lower MAP by 25% over 6 hours.
  • Hypertensive emergency = BP >180/120 + target organ damage.
  • Goal is to lower MAP by 25% in the first 6 hours, using ICU and IV medications (e.g., nitroprusside, labetalol)
  • A 74-year-old woman presents with acute mental status changes, BP is 245/130. She has headache, visual disturbances, and confusion; start IV labetalol and admit to ICU.
  • Hypertensive emergency is an elevated BP + target organ damage.
  • Signs and symptoms of hypertensive emergency: Encephalopathy, seizures, AMS.
  • Monitor the patient closely.

Renal Artery Stenosis

  • A patient presents with refractory hypertension. Exam reveals abdominal bruit. Labs show hypokalemia and elevated renin. Renal artery stenosis is the most likely diagnosis.
  • Clues to renal artery stenosis: refractory HTN + abdominal bruit + RAAS activation.
  • Older male with renal artery stenosis: atherosclerosis.
  • Younger female with renal artery stenosis: fibromuscular dysplasia.
  • Diagnosis of renal artery stenosis: renal Doppler, MRA, renal arteriogram.

Arterial Stiffness & Hypertension

  • A 76-year-old woman has a BP of 182/78. Her PP is elevated; the best explanation is increased arterial stiffness.
  • Isolated systolic HTN in elderly = + arterial compliance.
  • Pulse pressure = SBP – DBP.
  • Increased PP leads to increased CV risk.
  • Seen in aging + arteriosclerosis.

Pregnancy & Hypertension

  • ACE inhibitors are contraindicated in pregnancy.
  • ACEI/ARBs = teratogenic, so they are not indicated in pregnancy.
  • Safe anti-hypertensives in pregnancy: methyldopa, labetalol, nifedipine.
  • ACEI/ARBs = renal dysgenesis, fetal demise.

Aortic Dissection

  • A 61-year-old male with a history of HTN presents with severe chest pain radiating to his back. BP is 210/120 in both arms. CT shows a Stanford Type B aortic dissection; esmolol should be administered first.
  • Always reduce shear force first with a beta-blocker in dissection.
  • Aortic dissection: BB first (e.g., esmolol).
  • Then vasodilator if needed.
  • Never vasodilate alone, as ↑ HR = ↑ dissection risk.

Etiology of Shock

  • A 66-year-old male is hypotensive after massive upper GI bleed. He is cold, clammy, and tachycardic; his hemodynamic profile is consistent with ↓ CO, ↑ SVR, ↓ PCWP.
  • Hypovolemic shock: ↓ preload (→ ↓ PCWP), ↓ CO, ↑ SVR.
  • Trauma, bleeding, burns cause hypovolemic shock.
  • Patients with hypovolemic shock will be cold, pale, and have delayed capillary refill.
  • Treat hypovolemic shock with fluids/blood.

Neurogenic OH & POTS

  • A 68-year-old female presents with repeated fainting episodes. BP falls from 125/80 to 98/65 after 3 minutes of standing. HR goes from 68 → 70 bpm. Autonomic failure is the most likely mechanism.
  • No HR compensation = neurogenic OH.
  • Seen in Parkinson's, diabetes, aging.
  • Diagnosis of neurogenic OH: tilt test confirms.
  • Treatment of neurogenic OH: fludrocortisone, midodrine.
  • A 26-year-old female has dizziness and palpitations upon standing. Tilt table test shows HR of 130 bpm with minimal BP drop; POTS is the diagnosis.
  • Increased HR >30 bpm or >120 with minimal BP change = POTS.
  • Often young females develop POTS.
  • Possible causes of POTS: Post-viral or post-COVID.
  • Treatment of POTS: fluids, compression, sometimes BB or ivabradine.

Vasovagal Syncope

  • A 35-year-old male faints during blood donation with witnesses reporting he was pale and sweating before collapse. He regains consciousness quickly; vasovagal syncope.
  • Emotional/physical stress → parasympathetic surge → brady + vasodilation.
  • Trigger for vasovagal syncope: pain, blood, emotion.
  • Prodrome for vasovagal syncope: nausea, sweating, tunnel vision.
  • Treatment for vasovagal syncope: reassurance, avoid triggers, fluids/salt.

Hypertensive Emergency

  • The most appropriate initial BP reduction target in hypertensive emergency is lowering MAP by 25% over 6 hours.
  • Rapid drop of BP = risk of ischemia; target gradual, controlled reduction.
  • Hypertensive emergency = TOD (stroke, renal failure, etc.).
  • ICU + IV meds needed in cases of hypertensive emergency.
  • Goal is to lower MAP ~25% first 6 hrs.

Dobutamine & Cardiogenic Shock

  • A 59-year-old male presents with dyspnea, chest pain, and hypotension. His extremities are cold and clammy. Echo shows EF 20%. Swan-Ganz reveals ↑ PCWP, ↓ CO, ↑ SVR. Dobutamine is appropriate for short-term inotropic support.
  • Cardiogenic shock + low perfusion requires the use of an inotrope.
  • Dobutamine = beta-1 agonist.
  • Dobutamine increases contractility → ↑ CO.
  • Avoid negative inotropes (CCBs, BBs).
  • A 45-year-old woman presents with BP 185/120 and papilledema. She is admitted to ICU for hypertensive emergency.
  • Maximum rate that her BP should be lowered is MAP by no more than 25% in first 6 hours.
  • Too rapid BP reduction = cerebral, renal, or coronary ischemia.
  • In hypertensive emergency, there is TOD present.
  • Drug of choice in hypertensive crisis: Nitroprusside, labetalol, nicardipine.
  • Gradual reduction of blood pressure is essential.

Distributive Shock

  • Findings that are most consistent with distributive shock (e.g., sepsis): ↑ CO, ↓ SVR, ↓ PCWP.
  • Distributive shock = vasodilation, warm extremities early.
  • In early sepsis, there is "warm shock".
  • CO is increased due to inflammatory response.
  • PCWP is decreased from relative hypovolemia.

Pregnancy Hypertension

  • Labetalol is one of the most appropriate antihypertensives for pregnant patients with hypertensive crisis.
  • ACEI/ARB = contraindicated in pregnancy.
  • Safe options in pregnancy: methyldopa, labetalol, nifedipine.
  • Labetalol = fast-acting IV option.
  • Avoid RAAS blockers due to risk of fetal renal failure.

Neurogenic Orthostatic Hypotension

  • A 75-year-old male experiences lightheadedness when standing. BP drops from 132/76 → 106/60. HR remains 72 indicating neurogenic orthostatic hypotension.
  • No HR increase = think autonomic failure.
  • Seen in Parkinson's, diabetes, the elderly.
  • Treat with fludrocortisone, midodrine.
  • Tilt test diagnostic for neurogenic orthostatic hypotension.

Cardiogenic Shock Device

  • A patient with cardiogenic shock has persistent hypotension despite inotropes. An IABP can mechanically improve perfusion and reduce afterload.
  • Intra-aortic Balloon Pump (IABP) inflates during diastole (↑ coronary perfusion) and deflates before systole (↓ afterload).
  • Use IABP for temporizing support.
  • Can be used a bridge to transplant or recovery.
  • Inserted via femoral artery.

Pathophysiology of Vasovagal Syncope

  • Vasovagal syncope pathophysiologically arises from increased parasympathetic outflow + decreased sympathetic tone.
  • "Vaso" = dilation, "vagal" = bradycardia.
  • Emotional trigger → reflex.
  • ↓ HR + ↓ SVR → ↓ BP.
  • Treatment: reassurance, salt, avoid triggers.

Hydralazine

  • Hydralazine is likely to cause reflex tachycardia and flushing when used to manage severe hypertension.
  • Direct vasodilators like hydralazine cause reflex SNS activation.
  • Hydralazine is used in pregnancy or emergencies.
  • Side effects of hydralazine: headache, tachycardia, lupus-like reaction.
  • Avoid in CAD (can ↑ O2 demand).

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

More Like This

Shock States Quiz
12 questions
Introduction to Shock States
7 questions

Introduction to Shock States

LuxuriousConnemara8899 avatar
LuxuriousConnemara8899
Cardiovascular System: Shock
33 questions
Shock Definition and Circulatory Failure
5 questions
Use Quizgecko on...
Browser
Browser