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Understanding Programmed Cell Death

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Questions and Answers

What process triggers entosis?

Integrin-ECM attachment (correct)

E-cadherin and α-catenin interaction

Phagocytosis

RhoA and ROCK activation

Which proteins are downstream targets of the small GTPases RhoA, RhoB, and RhoC?

LC3 and RhoA

E-cadherin and α-catenin

ROCK1 and ROCK2 (correct)

Actin and myosin complex

What cellular activities are ROCKs involved in?

Autophagy and lysosome-mediated degradation

Actin cytoskeleton organization and cell adhesion (correct)

Smooth muscle cell contraction and autophagic cell death

Phagocytosis and proliferation

What is the term used to describe accidental cell death?

Non-PCD Signup and view all the answers

How does apoptosis differ from non-apoptotic cell death?

Apoptosis occurs in a caspase-dependent manner, while non-apoptotic cell death is caspase-independent Signup and view all the answers

What stimulates non-programmed necrosis?

Infection, toxins, and physical injury Signup and view all the answers

What are the defining features of paraptosis?

Cytoplasmic vacuolation and caspase activation Signup and view all the answers

How is methuosis typically assessed in research?

By electron microscopy Signup and view all the answers

What is the main cause of methuosis?

Ras hyper-activation and apoptosis impairment Signup and view all the answers

What is the specific characteristic of the vacuoles formed in methuosis?

Massive accumulation of large fluid-filled single membrane vacuoles Signup and view all the answers