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Understanding Programmed Cell Death
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Understanding Programmed Cell Death

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Questions and Answers

What process triggers entosis?

  • Integrin-ECM attachment (correct)
  • E-cadherin and α-catenin interaction
  • Phagocytosis
  • RhoA and ROCK activation

    • Which proteins are downstream targets of the small GTPases RhoA, RhoB, and RhoC?

  • LC3 and RhoA
  • E-cadherin and α-catenin
  • ROCK1 and ROCK2 (correct)
  • Actin and myosin complex

    • What cellular activities are ROCKs involved in?

  • Autophagy and lysosome-mediated degradation
  • Actin cytoskeleton organization and cell adhesion (correct)
  • Smooth muscle cell contraction and autophagic cell death
  • Phagocytosis and proliferation

    • What is the term used to describe accidental cell death?

    <p>Non-PCD</p> Signup and view all the answers

    How does apoptosis differ from non-apoptotic cell death?

    <p>Apoptosis occurs in a caspase-dependent manner, while non-apoptotic cell death is caspase-independent</p> Signup and view all the answers

    What stimulates non-programmed necrosis?

    <p>Infection, toxins, and physical injury</p> Signup and view all the answers

    What are the defining features of paraptosis?

    <p>Cytoplasmic vacuolation and caspase activation</p> Signup and view all the answers

    How is methuosis typically assessed in research?

    <p>By electron microscopy</p> Signup and view all the answers

    What is the main cause of methuosis?

    <p>Ras hyper-activation and apoptosis impairment</p> Signup and view all the answers

    What is the specific characteristic of the vacuoles formed in methuosis?

    <p>Massive accumulation of large fluid-filled single membrane vacuoles</p> Signup and view all the answers

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