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Understanding Parkinson's Disease

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Questions and Answers

What is the primary cause of neuronal death in the Substantia Niagra leading to Parkinson's Disease?

Industrial age

Mutation of the Parkin gene (correct)

Oxidative stress

High exposure to pesticides and toxins

How is Parkinson's Disease treated?

Antioxidant therapy to reduce oxidative stress

Surgical intervention in the Basal Ganglia

Toxin removal therapy

Dopaminergic drugs to compensate for deficient dopamine secretion (correct)

What effect do dopaminergic drugs used in Parkinson's treatment have?

Localized with temporary side effects

Generalized with a lot of side effects and tolerance (correct)

Specific to the Basal Ganglia with no side effects

Targeted with minimal side effects and no tolerance

What coincides with the relatively new emergence of Parkinson's Disease, suggesting a possible cause?

The industrial age and high exposure to pesticides and toxins Signup and view all the answers

What is the function of the sub-thalamic nucleus post-gene replacement in Parkinson's disease?

Inhibits the Globus Pallidus, leading to stimulation of movement Signup and view all the answers

What is a concern associated with gene replacement for Parkinson's disease?

Use of viral vectors can be unpredictable Signup and view all the answers

What is a potential long-term cure for Parkinson's disease involving pluripotent cells?

Stem cell treatment Signup and view all the answers

What is a characteristic of Huntington's disease?

Associated with constant movement and brain degeneration Signup and view all the answers

What is a characteristic of stem cells derived from adults for treatment?

Can be reverted into pluripotent state and converted into any cell type Signup and view all the answers

What is a characteristic of deep-brain stimulation for Parkinson's disease?

Involves implantation of electrodes to alter circuit functions Signup and view all the answers

What is a key difference between Huntington's disease and Parkinson's disease?

Parkinson's is stuck in the OFF mode, while Huntington's is stuck in the ON mode. Signup and view all the answers

What is a concern associated with surgical ablation for Parkinson's disease?

It involves surgically-induced brain damage with high risk. Signup and view all the answers