Understanding Hemophilia and Vitamin K Deficiency
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Questions and Answers

What is the primary cause of Hemophilia A?

  • Deficiency of factor IX
  • Deficiency of factor VII
  • Deficiency of factor XI
  • Deficiency of factor VIII (correct)
  • Which factor is associated with Hemophilia B, also known as Christmas disease?

  • Factor IX (correct)
  • Factor X
  • Factor II
  • Factor VII
  • Which of the following conditions can lead to vitamin K deficiency?

  • Sterility of the intestine (correct)
  • Excess intake of vitamin K
  • High-fat diet
  • Excessive liver function
  • What type of hemophilia is caused by an absence of factor XI?

    <p>Hemophilia C</p> Signup and view all the answers

    In hemophilia, which pathway of clotting is considered defective?

    <p>Only the intrinsic pathway</p> Signup and view all the answers

    Study Notes

    Hemophilia

    • Inherited sex-linked disease
    • Transmitted by females to males (infants), but females show no symptoms.
    • Three types:
      • Hemophilia A (85%): Deficiency of factor VIII
      • Hemophilia B (10%): Deficiency of factor IX
      • Hemophilia C (5%): Deficiency of factor XI
    • Only the intrinsic pathway is defective in hemophilia.

    Vitamin K Deficiency

    • Prothrombin (factor II), factors VII, IX, and X require vitamin K for synthesis by the liver.
    • Causes:
      • Sterility of the intestine (no bacteria) in newborns
      • Prolonged use of antibiotics
      • Impaired absorption of vitamin K:
        • Obstructive jaundice
        • Fatty diarrhea
      • Liver diseases
      • Competitive inhibition with vitamin K (e.g., dicumarol)
    • Both intrinsic and extrinsic pathways are defective in vitamin K deficiency.

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    Description

    This quiz explores the genetic aspects of hemophilia, a sex-linked inherited disease, and the role of vitamin K deficiency in coagulation disorders. Learn about the different types of hemophilia and the causes and implications of vitamin K deficiency on blood clotting pathways.

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