Podcast
Questions and Answers
What is the primary cause of Hemophilia A?
What is the primary cause of Hemophilia A?
- Deficiency of factor IX
- Deficiency of factor VII
- Deficiency of factor XI
- Deficiency of factor VIII (correct)
Which factor is associated with Hemophilia B, also known as Christmas disease?
Which factor is associated with Hemophilia B, also known as Christmas disease?
- Factor IX (correct)
- Factor X
- Factor II
- Factor VII
Which of the following conditions can lead to vitamin K deficiency?
Which of the following conditions can lead to vitamin K deficiency?
- Sterility of the intestine (correct)
- Excess intake of vitamin K
- High-fat diet
- Excessive liver function
What type of hemophilia is caused by an absence of factor XI?
What type of hemophilia is caused by an absence of factor XI?
In hemophilia, which pathway of clotting is considered defective?
In hemophilia, which pathway of clotting is considered defective?
Flashcards
Hemophilia A
Hemophilia A
A type of hemophilia caused by a deficiency of factor VIII, a clotting protein.
Vitamin K Deficiency
Vitamin K Deficiency
A condition where a lack of vitamin K affects clotting factors, impacting both pathways.
Hemophilia Transmission
Hemophilia Transmission
Hemophilia is inherited from mothers to sons, as it's linked to the X chromosome, but mothers usually don't have hemophilia symptoms.
Intrinsic Pathway Defect (Hemophilia)
Intrinsic Pathway Defect (Hemophilia)
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Vitamin K Deficiency Causes
Vitamin K Deficiency Causes
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Study Notes
Hemophilia
- Inherited sex-linked disease
- Transmitted by females to males (infants), but females show no symptoms.
- Three types:
- Hemophilia A (85%): Deficiency of factor VIII
- Hemophilia B (10%): Deficiency of factor IX
- Hemophilia C (5%): Deficiency of factor XI
- Only the intrinsic pathway is defective in hemophilia.
Vitamin K Deficiency
- Prothrombin (factor II), factors VII, IX, and X require vitamin K for synthesis by the liver.
- Causes:
- Sterility of the intestine (no bacteria) in newborns
- Prolonged use of antibiotics
- Impaired absorption of vitamin K:
- Obstructive jaundice
- Fatty diarrhea
- Liver diseases
- Competitive inhibition with vitamin K (e.g., dicumarol)
- Both intrinsic and extrinsic pathways are defective in vitamin K deficiency.
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Description
This quiz explores the genetic aspects of hemophilia, a sex-linked inherited disease, and the role of vitamin K deficiency in coagulation disorders. Learn about the different types of hemophilia and the causes and implications of vitamin K deficiency on blood clotting pathways.
