Podcast
Questions and Answers
What is the primary cause of Hemophilia A?
Which factor is associated with Hemophilia B, also known as Christmas disease?
Which of the following conditions can lead to vitamin K deficiency?
What type of hemophilia is caused by an absence of factor XI?
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In hemophilia, which pathway of clotting is considered defective?
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Study Notes
Hemophilia
- Inherited sex-linked disease
- Transmitted by females to males (infants), but females show no symptoms.
- Three types:
- Hemophilia A (85%): Deficiency of factor VIII
- Hemophilia B (10%): Deficiency of factor IX
- Hemophilia C (5%): Deficiency of factor XI
- Only the intrinsic pathway is defective in hemophilia.
Vitamin K Deficiency
- Prothrombin (factor II), factors VII, IX, and X require vitamin K for synthesis by the liver.
- Causes:
- Sterility of the intestine (no bacteria) in newborns
- Prolonged use of antibiotics
- Impaired absorption of vitamin K:
- Obstructive jaundice
- Fatty diarrhea
- Liver diseases
- Competitive inhibition with vitamin K (e.g., dicumarol)
- Both intrinsic and extrinsic pathways are defective in vitamin K deficiency.
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Description
This quiz explores the genetic aspects of hemophilia, a sex-linked inherited disease, and the role of vitamin K deficiency in coagulation disorders. Learn about the different types of hemophilia and the causes and implications of vitamin K deficiency on blood clotting pathways.
