15 Questions
What is the macroscopic view of adenomyosis?
Uterine enlargement with smooth surface and spongy appearance on cut surface
What is suggested to result in hyperestrogenism in patients with adenomyosis?
Increased local aromatization and decreased local estrogen metabolism
What is the proposed mechanism for the invagination of the endometrial basalis in adenomyosis?
Activation of the tissue injury and repair (TIAR) mechanism
What enzyme catalyzes aromatization of circulating androgens into E2?
Aromatase cytochrome P450
What is the characteristic location of ectopic endometrium in adenomyosis?
(nodular) deep within the myometrium
Which theory proposes metaplasia of displaced embryonic pluripotent Mullerian remnants or differentiation of adult stem cells as the pathogenesis of adenomyosis?
Metaplasia of displaced embryonic pluripotent Mullerian remnants or differentiation of adult stem cells
What is the characteristic macroscopic view of uterine enlargement in adenomyosis?
Smooth surface contour, softening, and reddish myometrial discoloration
What enzyme catalyzes aromatization of circulating androgens into E2, and is not present in the endometrium of disease-free uteri?
Aromatase cytochrome P450
What is suggested to result from increased local aromatization and decreased local estrogen metabolism in the eutopic and ectopic endometrium of patients with adenomyosis?
Hyperestrogenism
What is the proposed mechanism for the invagination of the endometrial basalis as a result of activation of the tissue injury and repair (TIAR) mechanism?
Activation of tissue injury and repair mechanism
What is the characteristic macroscopic view of uterine enlargement in adenomyosis?
Smooth surface contour, softening, and reddish myometrial discoloration
What is the proposed mechanism for the invagination of the endometrial basalis as a result of activation of the tissue injury and repair (TIAR) mechanism in adenomyosis?
Invagination of the endometrial basalis due to hyperestrogenism and TIAR mechanism activation
What is suggested to result from increased local aromatization and decreased local estrogen metabolism in the eutopic and ectopic endometrium of patients with adenomyosis?
Hyperestrogenism
What is the characteristic location of ectopic endometrium in adenomyosis?
Deep within the myometrium
What enzyme catalyzes aromatization of circulating androgens into E2, but is not present in the endometrium of disease-free uteri?
Aromatase cytochrome P450
Test your knowledge about endometriosis and adenomyosis, two gynecologic disorders characterized by the presence of endometrial tissue outside the uterus. Explore the different types, symptoms, and macroscopic features of these conditions.
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