Understanding Endometriosis and Adenomyosis
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Questions and Answers

What is the macroscopic view of adenomyosis?

  • Uterine enlargement with irregular surface and spongy appearance on cut surface
  • Uterine shrinkage with smooth surface and firm appearance on cut surface
  • Uterine shrinkage with irregular surface and firm appearance on cut surface
  • Uterine enlargement with smooth surface and spongy appearance on cut surface (correct)

    • What is suggested to result in hyperestrogenism in patients with adenomyosis?

  • Decreased systemic aromatization and increased systemic estrogen metabolism
  • Decreased local aromatization and increased local estrogen metabolism
  • Increased local aromatization and decreased local estrogen metabolism (correct)
  • Increased systemic aromatization and decreased systemic estrogen metabolism

    • What is the proposed mechanism for the invagination of the endometrial basalis in adenomyosis?

  • Activation of the tissue injury and repair (TIAR) mechanism (correct)
  • Metaplasia of displaced embryonic pluripotent Mullerian remnants
  • Activation of local paracrine activity
  • Differentiation of adult stem cells

    • What enzyme catalyzes aromatization of circulating androgens into E2?

    <p>Aromatase cytochrome P450</p> Signup and view all the answers

    What is the characteristic location of ectopic endometrium in adenomyosis?

    <p>(nodular) deep within the myometrium</p> Signup and view all the answers

    Which theory proposes metaplasia of displaced embryonic pluripotent Mullerian remnants or differentiation of adult stem cells as the pathogenesis of adenomyosis?

    <p>Metaplasia of displaced embryonic pluripotent Mullerian remnants or differentiation of adult stem cells</p> Signup and view all the answers

    What is the characteristic macroscopic view of uterine enlargement in adenomyosis?

    <p>Smooth surface contour, softening, and reddish myometrial discoloration</p> Signup and view all the answers

    What enzyme catalyzes aromatization of circulating androgens into E2, and is not present in the endometrium of disease-free uteri?

    <p>Aromatase cytochrome P450</p> Signup and view all the answers

    What is suggested to result from increased local aromatization and decreased local estrogen metabolism in the eutopic and ectopic endometrium of patients with adenomyosis?

    <p>Hyperestrogenism</p> Signup and view all the answers

    What is the proposed mechanism for the invagination of the endometrial basalis as a result of activation of the tissue injury and repair (TIAR) mechanism?

    <p>Activation of tissue injury and repair mechanism</p> Signup and view all the answers

    What is the characteristic macroscopic view of uterine enlargement in adenomyosis?

    <p>Smooth surface contour, softening, and reddish myometrial discoloration</p> Signup and view all the answers

    What is the proposed mechanism for the invagination of the endometrial basalis as a result of activation of the tissue injury and repair (TIAR) mechanism in adenomyosis?

    <p>Invagination of the endometrial basalis due to hyperestrogenism and TIAR mechanism activation</p> Signup and view all the answers

    What is suggested to result from increased local aromatization and decreased local estrogen metabolism in the eutopic and ectopic endometrium of patients with adenomyosis?

    <p>Hyperestrogenism</p> Signup and view all the answers

    What is the characteristic location of ectopic endometrium in adenomyosis?

    <p>Deep within the myometrium</p> Signup and view all the answers

    What enzyme catalyzes aromatization of circulating androgens into E2, but is not present in the endometrium of disease-free uteri?

    <p>Aromatase cytochrome P450</p> Signup and view all the answers

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