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Questions and Answers
What is the main focus of methods for assessing druggability mentioned in the text?
What is the main focus of methods for assessing druggability mentioned in the text?
- Identifying drug-like ligands
- Assessing the likelihood of proteins binding drug-like molecules (correct)
- Prioritizing proteins in the human genome
- Predicting protein crystal structures
Which algorithm is specifically mentioned as being trained on a set of binding sites from the Protein Data Bank?
Which algorithm is specifically mentioned as being trained on a set of binding sites from the Protein Data Bank?
- DogSiteScorer
- Homology-based method
- DailyMed.gov
- PocketFinder (correct)
What does the text suggest as an issue with ligand/structure-based druggability assessment methods?
What does the text suggest as an issue with ligand/structure-based druggability assessment methods?
- They provide the highest degree of confidence
- They are useful for all novel targets
- They rely on protein sequences
- They are not applicable when crystal structures are unavailable (correct)
Which database is NOT mentioned as a source for high affinity drug-like compounds in the text?
Which database is NOT mentioned as a source for high affinity drug-like compounds in the text?
What is a key property used in structure-based prediction methods to assess druggability?
What is a key property used in structure-based prediction methods to assess druggability?
Why are methods needed to prioritize proteins in the human genome according to the text?
Why are methods needed to prioritize proteins in the human genome according to the text?
What are the key properties a protein's binding site should have to bind drug-like compounds?
What are the key properties a protein's binding site should have to bind drug-like compounds?
Why is it important to assess druggability when identifying potential drug targets?
Why is it important to assess druggability when identifying potential drug targets?
How can protein druggability be assessed based on structural analysis?
How can protein druggability be assessed based on structural analysis?
What is one reason choosing a target that doesn't bind small molecules can lead to failure?
What is one reason choosing a target that doesn't bind small molecules can lead to failure?
What percentage of human genome is estimated to be druggable with a small molecule approach?
What percentage of human genome is estimated to be druggable with a small molecule approach?
In assessing druggability, what type of studies are used to relate genes/proteins to disease?
In assessing druggability, what type of studies are used to relate genes/proteins to disease?
What is another term sometimes used instead of 'druggability'?
What is another term sometimes used instead of 'druggability'?
Which of the following is NOT one of Lipinski's Rule of Five for drug-likeness?
Which of the following is NOT one of Lipinski's Rule of Five for drug-likeness?
What do the Lipinski's Rule of Five suggest may lead to poor absorption and permeability?
What do the Lipinski's Rule of Five suggest may lead to poor absorption and permeability?
Which term describes the likelihood of finding orally bioavailable small molecules that bind to a particular target in a disease-modifying way?
Which term describes the likelihood of finding orally bioavailable small molecules that bind to a particular target in a disease-modifying way?
What is important in assessing ligand-based druggability?
What is important in assessing ligand-based druggability?
Which parameter is crucial in determining the ability of a protein target to bind small molecules with high affinity?
Which parameter is crucial in determining the ability of a protein target to bind small molecules with high affinity?
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