Understanding Digoxin's Therapeutic Index

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Questions and Answers

What does it mean to have a narrow therapeutic index for a drug like digoxin?

  • Plasma drug concentrations that produce toxicity are very close to the minimum concentration at which a beneficial effect occurs. (correct)
  • Plasma drug concentrations are extremely variable from animal to animal.
  • Plasma drug concentrations that produce toxicity are very low.
  • Plasma drug concentrations required to achieve a beneficial effect are very high.

What are early signs of digoxin toxicity in animals?

  • Decreased appetite, anorexia, diarrhea, and vomiting (correct)
  • Increased coughing and difficulty breathing
  • Increased urination and increased water consumption
  • Wobbly gait, fainting (syncope), and disorientation

Which electrolyte change greatly enhances the risk of digoxin toxicity?

  • Hypernatremia
  • Hypokalemia (correct)
  • Hyperkalemia
  • Hypochloremia

Which drug would be most effective against dermatophytes?

<p>Itraconazole (C)</p> Signup and view all the answers

What effects can be expected after receiving atropine as a preanesthetic classified as an anticholinergic drug?

<p>Increased heart rate and dilation of the pupils (C)</p> Signup and view all the answers

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