Understanding Descriptive Statistics

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Questions and Answers

Which genetic amplification is associated with Glioblastoma?

  • GFAP
  • EGFR (correct)
  • 1q/19q
  • S100

Which of the following is a typical location for Glioblastoma?

  • 4th ventricle
  • Frontal Lobe
  • Cerebellopontine angle
  • Cerebral Hemisphere (correct)

What imaging finding is characteristic of Glioblastoma?

  • Chicken-wire capillary system
  • Psammoma bodies
  • Butterfly glioma (correct)
  • Perivascular pseudo-rosettes

What genetic codeletion is associated with Oligodendroglioma?

<p>1q/19q (D)</p> Signup and view all the answers

Cells with round nuclei and a clear cytoplasm are seen in which tumor?

<p>Oligodendroglioma (B)</p> Signup and view all the answers

Which of the following is a common location for Oligodendroglioma?

<p>Frontal Lobe (C)</p> Signup and view all the answers

What is the most common symptom associated with Meningioma?

<p>Asymptomatic (B)</p> Signup and view all the answers

Which of the following is the most common risk factor for Meningioma?

<p>Females (A)</p> Signup and view all the answers

Which of the following is the location of Meningioma?

<p>Surface of brain and spinal cord (C)</p> Signup and view all the answers

Which of the following is the common location for Hemangioblastoma?

<p>Cerebellum (C)</p> Signup and view all the answers

What syndrome is associated with Hemangioblastoma?

<p>Hippel-Lindau Syndrome (C)</p> Signup and view all the answers

What do Hemangioblastomas produce following polycythemia?

<p>Erythropoietin (D)</p> Signup and view all the answers

Which of the following is a common result of pituitary adenoma?

<p>Bitemporal hemianopia (B)</p> Signup and view all the answers

Which hormone is secreted by Lactotrophs?

<p>Prolactin (A)</p> Signup and view all the answers

Which is the cranial nerve most commonly damaged in Schwannoma?

<p>CN8 (D)</p> Signup and view all the answers

A tumor in which location is most likely to be a Schwannoma?

<p>Internal acoustic meatus (A)</p> Signup and view all the answers

What type of cells are found in Pilocytic Astrocytoma?

<p>Bipolar neoplastic cells with hairlike projections (A)</p> Signup and view all the answers

Compression of which ventricle causes Hydrocephalus?

<p>4th ventricle (C)</p> Signup and view all the answers

What type of structure is seen in damaged regions of the cerebellar vermis?

<p>Truncal Ataxia (B)</p> Signup and view all the answers

What distinctive structure are seen in Medulloblastoma?

<p>Homer-Wright rosettes (A)</p> Signup and view all the answers

What anatomical location is the Ependymoma found?

<p>4th ventricle (D)</p> Signup and view all the answers

What is the most common childhood location of Craniopharyngioma?

<p>Sellar or suprasellar region (C)</p> Signup and view all the answers

What is the visual field defect from Craniopharyngioma?

<p>Bitemporal hemianopia (A)</p> Signup and view all the answers

What triad is the result of Pineal Gland Tumors?

<p>Parinaud Syndrome (B)</p> Signup and view all the answers

Where is Pilocytic Astrocytoma typically located?

<p>Cerebellum (B)</p> Signup and view all the answers

Which of the following is a characteristic histological feature of Meningioma?

<p>Psammoma bodies (C)</p> Signup and view all the answers

Which of the following causes Hydrocephalus in Medulloblastoma?

<p>Compression of the 4th ventricle (C)</p> Signup and view all the answers

What type of cells secrete Prolactin?

<p>Lactotrophs (C)</p> Signup and view all the answers

Which cranial nerve is most commonly affected by Schwannoma?

<p>CN8 (B)</p> Signup and view all the answers

What is the most common symptom for Meningioma?

<p>Asymptomatic (A)</p> Signup and view all the answers

Which of the following conditions can Hemangioblastoma cause?

<p>Polycythemia (D)</p> Signup and view all the answers

Which of the following is a typical presentation of Prolactinoma in women?

<p>Galactorrhea (C)</p> Signup and view all the answers

What condition results from the suppression of estrogen in females and decreased libido?

<p>Osteoporosis (A)</p> Signup and view all the answers

Which of the following tumors is most likely to be located in the frontal lobe?

<p>Oligodendroglioma (C)</p> Signup and view all the answers

What kind of tumor is derived from remnants of Rathke's pouch?

<p>Craniopharyngioma (A)</p> Signup and view all the answers

What is the origin cell of Somatotrophs?

<p>GH (C)</p> Signup and view all the answers

GFAP positivity is associated with which tumor?

<p>Pilocytic Astrocytoma (A)</p> Signup and view all the answers

What does the compression of the cerebral aqueduct result in?

<p>Obstructive Hydrocephalus (C)</p> Signup and view all the answers

Which of the following locations is most likely to harbor a Hemangioblastoma?

<p>Cerebellum (C)</p> Signup and view all the answers

Which of the following tumors is more common in children?

<p>Medulloblastoma (C)</p> Signup and view all the answers

Which of the following is a type of germ cell tumor?

<p>Pineal Gland Tumor (B)</p> Signup and view all the answers

Which tumor presentation gives rise to hearing loss?

<p>Schwannoma (B)</p> Signup and view all the answers

Which tumor is known to compress the dorsal midbrain?

<p>Pineal Gland Tumor (C)</p> Signup and view all the answers

Which of the following describes Ependymoma?

<p>Compresses 4th ventricle (B)</p> Signup and view all the answers

Which of the following tumors is commonly located in the cerebellopontine angle?

<p>Schwannoma (D)</p> Signup and view all the answers

What is the histology marker for Schwannoma?

<p>S-100 (A)</p> Signup and view all the answers

What imaging does Glioblastoma show?

<p>Butterfly Glioma (A)</p> Signup and view all the answers

Which of the following can cause bitemporal hemianopia?

<p>Craniopharyngioma (B)</p> Signup and view all the answers

True or False: Glioblastoma is highly malignant?

<p>True (A)</p> Signup and view all the answers

Flashcards

Glioblastoma

A highly malignant primary brain tumor commonly found in the cerebral hemisphere.

Glioblastoma Imaging

GFAP positive and often presents as a butterfly glioma on CT, crossing the corpus callosum.

Glioblastoma Histology

"Pseudo-palisading" pleomorphic tumor cells with border central areas of necrosis, hemorrhage and/or microvascular proliferation.

Oligodendroglioma

A rare, slow-growing brain tumor often located in the frontal lobe.

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Oligodendroglioma Histology

"Fried egg" cells with round nuclei with clear cytoplasm and a "chicken-wire" capillary system.

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Meningioma

A common brain tumor more frequently seen in females, located on the surface of the brain and spinal cord.

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Meningioma Histology

Spindle cells concentrically arranged in a whorled pattern with psammoma bodies (laminated calcifications).

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Pilocytic Astrocytoma

A benign primary brain tumor that's the most common in children, usually in posterior fossa.

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Pilocytic Astrocytoma Histology

GFAP positive with bipolar neoplastic cells with hairlike projections and Rosenthal fibers.

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Medulloblastoma

The most common malignant primary brain tumor in children, typically found in the cerebellum.

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Medulloblastoma Histology

Small blue cells surrounding central areas of neuropil forming Homer-Wright rosettes, with tumor cells being synaptophysin positive.

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Ependymoma

Compresses the 4th ventricle causing non-communicating hydrocephalus and is located in the 4th ventricle.

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Ependymoma Histology

Perivascular pseudo-rosettes, basal ciliary bodies, and rod-shaped blepharoplasts found near the nucleus.

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Craniopharyngioma

Most common childhood supratentorial tumors located in sellar or suprasellar region.

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Craniopharyngioma Histology

Derived from remnants of Rathke pouch (ectoderm), with cholesterol crystals found in motor oil like fluid within the tumor.

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Schwannoma

A benign tumor found in the cerebellopontine angle or internal acoustic meatus.

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Schwannoma Histology

S100 positive with biphasic, dense and hypercellular spindle cells, altering with hypocellular, myxoid areas.

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Hemangioblastoma

A tumor associated with Hippel-Lindau syndrome and found in the cerebellum.

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Hemangioblastoma Histology

Characterized by closely arranged, thin-walled capillaries with minimal intervening parenchyma.

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Craniopharyngioma symptoms

Tumors causing mass effect on optic chiasm leading to bitemporal hemianopia with possible hypopituitarism in children or with abducens nerve palsy.

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Pineal Gland Tumors

Compresses cerebral aqueduct leading to obstructive hydrocephalus and causes Parinaud syndrome with compression of dorsal midbrain.

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Hemangioblastoma and Polycythemia

Can produce erythropoietin, leading to polycythemia.

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Pituitary Adenoma Types

Can be nonfunctioning (silent) and cause bitemporal hemianopia pressing on optic chiasm, hypopituitarism, or hyperpituitarism.

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Prolactinoma in women

Galactorrhea, amenorrhea, and osteoporosis (due to suppression of estrogen).

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Prolactinoma in men

Infertility, gynecomastia, and decreased libido.

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Meningioma Treatment

Resection or stereotactic radiosurgery.

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Hemangioblastoma Treatment

Dopamine agonists(bromocriptine, cabergoline).

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Schwannoma treatment

Resection or stereotactic radiosurgery.

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Pituitary adenoma cell types

Somatotrophs (Secrete GH), Corticotropes (Secrete ACTH), Lactotrophs (Secrete Prolactin), Thyrotrophs (Secrete TSH), Gonadotrophs (Secrete FSH and LH).

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Medulloblastoma effect

The tumor compresses the fourth ventricle leading to hydrocephalus.

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Pituitary Adenoma Treatment

Dopamine agonists (bromocriptine, cabergoline) or Transsphenoidal resection.

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Ependymoma effect

Homonymous hemianopsia.

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Oligodendroglioma Imaging

Calcification.

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Glioblastoma treatment

Resection or stereotactic radiosurgery.

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Schwannoma damage

Damage to cranial nerves V, VI, VII, and VIII.

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Pineal Gland Tumors impact

Parinaud Syndrome Triad

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Study Notes

  • Descriptive statistics is a branch of mathematics focused on summarizing, organizing and presenting data in a meaningful way.
  • Its main goal is to describe the main characteristics of a data set, without making inferences or generalizations to a larger population.

Methods of Descriptive Statistics

  • Measures of Central Tendency: Mean, median, and mode are used.
  • Measures of Dispersion: Range, variance, and standard deviation are utilized.
  • Frequency Tables: Data distribution across categories is shown.
  • Graphics: Includes histograms, bar charts, pie charts.

Applications

  • Business: Used for sales analysis and market studies.
  • Social Sciences: Applied in public opinion surveys and demographic analysis.
  • Health Sciences: Used in epidemiological studies and clinical results analysis.
  • Engineering: Useful for quality control and experimental data analysis.

Measures of Central Tendency

  • Measures that represent the center of a data set.
  • Common measures include mean, median, and mode.

Mean

  • The sum of all values divided by the total number of values.
  • Formula: $\qquad \mu = \frac{\sum_{i=1}^{N} X_i}{N}$

Median

  • The value in the center of the data set when the values are ordered from least to greatest.

Mode

  • The value that appears most frequently in the data set.

Example

  • In the data set 3, 5, 7, 2, 8:
    • Mean = (3 + 5 + 7 + 2 + 8) / 5 = 5
    • Median = 2, 3, 5, 7, 8 (5 is the median)
    • This data set has no mode because no value repeats.

Measures of Dispersion

  • Indicate how spread out the data is in a data set.
  • Includes range, variance and standard deviation.

Range

  • Difference between the maximum and minimum values.

Variance

  • The average of the squared differences between each value and the mean.
  • Formula: $\qquad \sigma^2 = \frac{\sum_{i=1}^{N} (X_i - \mu)^2}{N}$

Standard Deviation

  • The square root of the variance.
  • Formula: $\qquad \sigma = \sqrt{\frac{\sum_{i=1}^{N} (X_i - \mu)^2}{N}}$

Example

  • In the data set 3, 5, 7, 2, 8:
    • Range = 8 - 2 = 6
    • Variance = $\qquad \sigma^2 = \frac{(3-5)^2 + (5-5)^2 + (7-5)^2 + (2-5)^2 + (8-5)^2}{5} = 6.8$
    • Standard Deviation = $\sigma = \sqrt{6.8} \approx 2.61$

Frequency Tables

  • A way to organize data into categories and show the frequency each category appears.

Example

  • Eye color data for a group: Azul, Marrón, Verde, Azul, Marrón, Azul, Marrón, Negro, Azul, Verde
  • Frequency table:
    • Azul: 4
    • Marrón: 3
    • Verde: 2
    • Negro: 1

Graphics

  • Visual ways to represent data.
  • Common types include histograms, bar charts, pie charts and scatter plots.

Histograms

  • Bar charts showing the frequency distribution of continuous data.

Bar Charts

  • Compare the frequencies of different categories.

Pie Charts

  • Show the proportion of each category in relation to the total.

Scatter Plots

  • Show the relationship between two variables.

Conclusion

  • Descriptive statistics is a tool for analyzing and understanding data.
  • Summarizes and presents information clearly, facilitating decision-making in various fields.

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