Understanding Constipation

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Which of the following is NOT a cause of constipation?

Results of taking other medication (opioids)

Frequent bowel movements (correct)

Inappropriate diet

Lack of physical activity

Which type of laxative absorbs fluid from the lumen and increases the consistency of the stool?

Bulk-forming laxatives (correct)

Osmotic laxatives

Stimulant laxatives

All of the above

Which natural resource is commonly used as an osmotic laxative?

Manna (correct)

Linum usitatissimum (lini semen/linseed)

Plantago psyllium (psyllii semen/psyllium)

Fraxinus ornus

Which of the following is a pharmacodynamic effect of sennosides?

Increased leakiness of tight junctions Signup and view all the answers

Which of the following is a pharmacokinetic property of sennosides?

Presence in blood as glucuronides and sulphates Signup and view all the answers

Which of the following is a side effect of long-term use of stimulant laxatives?

Pseudomelanosis coli Signup and view all the answers

Which natural resource is commonly used as a stimulant laxative?

Cassia Senna Signup and view all the answers

Why is the use of Senna contraindicated during pregnancy?

It may pose a genotoxic risk Signup and view all the answers

Which type of laxative is not digested or absorbed in the GI tract?

Bulk-forming laxatives Signup and view all the answers

Which natural resource is commonly used as an osmotic laxative?

Manna Signup and view all the answers

Which of the following is the most common discoloration of urine that may occur during treatment with sennosides?

Yellow Signup and view all the answers

What is the main mechanism of action of sennosides as a laxative?

Stimulating the motility of the large intestine Signup and view all the answers

Which of the following is a potential side effect of long-term use of stimulant laxatives?

Pseudomelanosis coli Signup and view all the answers

What is the recommended duration of use for Senna as a laxative?

Up to 1 week Signup and view all the answers

Which of the following is a potential side effect of long-term use of sennosides as a laxative?

Yellow discoloration of urine Signup and view all the answers

What is the main mechanism of action of sennosides as a laxative?

Stimulation of the motility of the large intestine Signup and view all the answers

Which hydroxyanthracene derivative has been shown to be genotoxic in vitro and in vivo?

Aloe emodin Signup and view all the answers

Which of the following is a potential adverse effect of long-term use of Senna as a laxative?

Blackening of the colon Signup and view all the answers

Which of the following is a potential interaction with Senna as a laxative?

Decreased effectiveness of cardiac glycosides Signup and view all the answers

What is the recommended posology for Senna as a laxative?

Once daily at night Signup and view all the answers

Which of the following is a cause of constipation?

Inadequate physical activity Signup and view all the answers

Which chemical constituents are responsible for the effect of stimulant laxatives?

Antaquinones Signup and view all the answers

Which of the following is a natural resource commonly used as a bulk-forming laxative?

Linum usitatissimum Signup and view all the answers

Which type of laxative absorbs fluid from the lumen and increases the consistency of the stool?

Bulk-forming laxatives Signup and view all the answers

Which chemical constituents are responsible for the effect of stimulant laxatives?

Anthranols Signup and view all the answers

Which of the following is a potential adverse effect of long-term use of Senna as a laxative?

Yellow or red-brown discoloration of urine Signup and view all the answers

Which hydroxyanthracene derivative has been shown to be genotoxic in vitro and in vivo?

Danthron Signup and view all the answers

Which type of laxative is not absorbed in the upper gut and is converted into an active metabolite by bacteria in the large intestine?

Contact laxative Signup and view all the answers

Which of the following is a potential adverse effect of long-term use of Senna as a laxative?

Pseudomelanosis coli Signup and view all the answers

Which of the following is a contraindication for the use of Senna as a laxative?

Appendicitis Signup and view all the answers

What is the main mechanism of action of sennosides as a laxative?

Increasing peristalsis of the colon Signup and view all the answers

Which of the following is a potential interaction with Senna as a laxative?

Diuretics Signup and view all the answers

Which of the following is a potential adverse effect of long-term use of Senna as a laxative?

Increased risk of colon cancer Signup and view all the answers

What is the main mechanism of action of sennosides as a laxative?

Stimulation of large intestine motility Signup and view all the answers

Which hydroxyanthracene derivative has been shown to be genotoxic in vitro and in vivo?

Aloe emodin Signup and view all the answers

Which of the following is a natural resource commonly used as a bulk-forming laxative?

A) Linum usitatissimum (lini semen/linseed) Signup and view all the answers

Which type of laxative absorbs fluid from the lumen and increases the consistency of the stool?

A) Bulk-forming laxatives Signup and view all the answers

Which chemical constituents are responsible for the effect of stimulant laxatives?

D) All of the above Signup and view all the answers

Understanding Constipation

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Questions and Answers

Which of the following is NOT a cause of constipation?

Which type of laxative absorbs fluid from the lumen and increases the consistency of the stool?

Which natural resource is commonly used as an osmotic laxative?

Which of the following is a pharmacodynamic effect of sennosides?

Which of the following is a pharmacokinetic property of sennosides?

Which of the following is a side effect of long-term use of stimulant laxatives?

Which natural resource is commonly used as a stimulant laxative?

Why is the use of Senna contraindicated during pregnancy?

Which type of laxative is not digested or absorbed in the GI tract?

Which natural resource is commonly used as an osmotic laxative?

Which of the following is the most common discoloration of urine that may occur during treatment with sennosides?

What is the main mechanism of action of sennosides as a laxative?

Which of the following is a potential side effect of long-term use of stimulant laxatives?

What is the recommended duration of use for Senna as a laxative?

Which of the following is a potential side effect of long-term use of sennosides as a laxative?

What is the main mechanism of action of sennosides as a laxative?

Which hydroxyanthracene derivative has been shown to be genotoxic in vitro and in vivo?

Which of the following is a potential adverse effect of long-term use of Senna as a laxative?

Which of the following is a potential interaction with Senna as a laxative?

What is the recommended posology for Senna as a laxative?

Which of the following is a cause of constipation?

Which chemical constituents are responsible for the effect of stimulant laxatives?

Which of the following is a natural resource commonly used as a bulk-forming laxative?

Which type of laxative absorbs fluid from the lumen and increases the consistency of the stool?

Which chemical constituents are responsible for the effect of stimulant laxatives?

Which of the following is a potential adverse effect of long-term use of Senna as a laxative?

Which hydroxyanthracene derivative has been shown to be genotoxic in vitro and in vivo?

Which type of laxative is not absorbed in the upper gut and is converted into an active metabolite by bacteria in the large intestine?

Which of the following is a potential adverse effect of long-term use of Senna as a laxative?

Which of the following is a contraindication for the use of Senna as a laxative?

What is the main mechanism of action of sennosides as a laxative?

Which of the following is a potential interaction with Senna as a laxative?

Which of the following is a potential adverse effect of long-term use of Senna as a laxative?

What is the main mechanism of action of sennosides as a laxative?

Which hydroxyanthracene derivative has been shown to be genotoxic in vitro and in vivo?

Which of the following is a natural resource commonly used as a bulk-forming laxative?

Which type of laxative absorbs fluid from the lumen and increases the consistency of the stool?

Which chemical constituents are responsible for the effect of stimulant laxatives?

Which of the following is a potential adverse effect of long-term use of Senna as a laxative?

What is the recommended duration of use for Senna as a laxative?

Why is the use of Senna contraindicated during pregnancy?

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