Podcast
Questions and Answers
Match each term related to cancer with its correct description:
Match each term related to cancer with its correct description:
Tumor = An abnormal mass of tissue that forms when cells grow and divide more than they should or do not die when they should. Metastasis = The spread of cancer cells from the primary site to distant parts of the body. Benign = A non-cancerous growth that does not invade nearby tissues or spread to other parts of the body. Malignant = A cancerous growth capable of invading surrounding tissues and spreading to other parts of the body.
Match the following causes with their respective impact on cancer development:
Match the following causes with their respective impact on cancer development:
Smoking = Exposure to carcinogens that damage DNA, leading to mutations and uncontrolled cell growth particularly in lung tissues. Obesity = Increased risk of several types of cancer due to chronic inflammation, hormonal changes, and altered metabolism. Viruses = Infection that can directly alter the genetic material of cells, increasing the risk of certain cancers like cervical or liver cancer. Radiation = Damage to DNA leading to genetic mutations and increased risk of cancer.
Match each cancer treatment with its primary method of action:
Match each cancer treatment with its primary method of action:
Chemotherapy = Use of drugs to kill cancer cells throughout the body by targeting rapidly dividing cells. Radiation Therapy = Use of high-energy rays or particles to kill cancer cells in a specific area. Immunotherapy = Therapy to boost the body's immune system to recognize and destroy cancer cells more effectively. Hormone Therapy = Blocking the effects of hormones or preventing the body from producing them, used for hormone-sensitive cancers.
Match the type of genetic abnormality with its definition:
Match the type of genetic abnormality with its definition:
Match the genetic syndrome to its chromosomal abnormality:
Match the genetic syndrome to its chromosomal abnormality:
Match the characteristics or symptoms to the correct genetic syndrome:
Match the characteristics or symptoms to the correct genetic syndrome:
Match the condition to its description:
Match the condition to its description:
Match the following concepts related to chromosomal abnormalities with their descriptions:
Match the following concepts related to chromosomal abnormalities with their descriptions:
Match the treatment option for cancer with how it works:
Match the treatment option for cancer with how it works:
Match the following genetic diseases to their description:
Match the following genetic diseases to their description:
Match each genetic abnormality of sex chromosomes to its typical phenotype:
Match each genetic abnormality of sex chromosomes to its typical phenotype:
Match the cause of cancer with an example:
Match the cause of cancer with an example:
Match the following genetic conditions with their likely outcomes or features:
Match the following genetic conditions with their likely outcomes or features:
Match each characteristic to the tumor that it most closely describes:
Match each characteristic to the tumor that it most closely describes:
Match the following genetic abnormality to its condition:
Match the following genetic abnormality to its condition:
Match the characteristics that correspond with the correct genetic marker:
Match the characteristics that correspond with the correct genetic marker:
Match each key term related to genetics and cell division with its correct definition:
Match each key term related to genetics and cell division with its correct definition:
Relate these cancer predisposing factors with possible cancers it causes:
Relate these cancer predisposing factors with possible cancers it causes:
Match the following genetic syndromes with their chromosomal abnormality:
Match the following genetic syndromes with their chromosomal abnormality:
Match the definitions below, to their term:
Match the definitions below, to their term:
Match the various causes and co-factors of cancer to their respective categories:
Match the various causes and co-factors of cancer to their respective categories:
Match the potential effects of Trisomy X (XXX) with their related characteristics:
Match the potential effects of Trisomy X (XXX) with their related characteristics:
Match the genetic condition to its unique identifier:
Match the genetic condition to its unique identifier:
Match the typical characteristics with these causes and co-factors of cancer:
Match the typical characteristics with these causes and co-factors of cancer:
Determine what is likely to be the end results of the following genetic diseases:
Determine what is likely to be the end results of the following genetic diseases:
Match the potential symptoms of Turner Syndrome with likely age groups:
Match the potential symptoms of Turner Syndrome with likely age groups:
Match potential cancer factors with its definition statement:
Match potential cancer factors with its definition statement:
Differentiate between the two different cells, both normal, and cancerous cells:
Differentiate between the two different cells, both normal, and cancerous cells:
Match the different options of Chemotherapy to its correlating image:
Match the different options of Chemotherapy to its correlating image:
Match that tumor symptoms will usually lead to, if not addressed:
Match that tumor symptoms will usually lead to, if not addressed:
Connect all root causes to how they relate as co-factors to cancer:
Connect all root causes to how they relate as co-factors to cancer:
Match each syndrome with their potential symptoms::
Match each syndrome with their potential symptoms::
Match the commonalities between the different forms of syndromes listed to the likely characteristics:
Match the commonalities between the different forms of syndromes listed to the likely characteristics:
Connect these different genetic conditions to the following identifiers listed:
Connect these different genetic conditions to the following identifiers listed:
Determine what outcomes relate to specific genetic mutations:
Determine what outcomes relate to specific genetic mutations:
Match the appropriate word relating to tumors, to the different tumor descriptions:
Match the appropriate word relating to tumors, to the different tumor descriptions:
Flashcards
Cancer
Cancer
A condition where cells divide uncontrollably.
Cancer Cell Behavior
Cancer Cell Behavior
Cancer cells grow and displace normal cells.
Characterization of Cancer
Characterization of Cancer
Out-of-control growth of cells.
Cancer Variety
Cancer Variety
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Tumor Formation
Tumor Formation
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Cancer Naming
Cancer Naming
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Recurrence
Recurrence
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Interphase
Interphase
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Abnormal Cells
Abnormal Cells
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Benign Tumors
Benign Tumors
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Malignant Tumors
Malignant Tumors
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Cancer
Cancer
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Causes of Cancer
Causes of Cancer
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Cancer Treatment Options
Cancer Treatment Options
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Nondisjunction
Nondisjunction
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Monosomy
Monosomy
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Trisomy
Trisomy
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Karyotyping
Karyotyping
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Down Syndrome
Down Syndrome
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Patau Syndrome
Patau Syndrome
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Patau Syndrome Symptoms
Patau Syndrome Symptoms
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Edward Syndrome
Edward Syndrome
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Klinefelter Syndrome
Klinefelter Syndrome
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XYY Syndrome
XYY Syndrome
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Triple X Syndrome
Triple X Syndrome
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Turner Syndrome
Turner Syndrome
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Study Notes
Cancer Overview
- Cancer involves cells dividing uncontrollably
- Normal cells divide and grow in an orderly way, unlike cancer cells
- Cancer cells continue to grow and crowd out normal cells
- Many forms of cancer exist, all characterized by out-of-control cell growth
- Different forms of cancer behave differently; lung and breast cancer are examples
- Cancer types grow at different rates and respond to different treatments
- Cancer cells form tumors that steal resources from the body, causing harm
- Tumors can be benign or malignant
- Even when cancer spreads to a new location, it retains the name of its origin
- Prostate cancer that spreads to the bones is still called prostate cancer
- Breast cancer that spreads to the lungs is still called breast cancer
- Recurrence is when cancer reappears after treatment
Cancer and the Cell Cycle
- Interphase, the longest step in the cell cycle, is reduced in cancer cells, especially G1/G2
- Cancerous cells appear smaller and abnormal compared to normal cells
Cancerous Cells vs. Normal Cells
- Cancer cells appear very different from normal cells
- Cancer cells exhibit different sizes and shapes as compared to healthy cells
Tumors
- Benign tumors grow locally and do not spread by invasion or metastasis
- Malignant tumors invade neighboring tissues, enter blood vessels, and metastasize to different sites
Benign Tumors
- Small
- Slow-growing
- Non-invasive
- Well-differentiated
- Stay localized, remaining where they are
- Cannot invade or metastasize
Malignant Tumors
- Large
- Fast-growing
- Invasive
- Poorly-differentiated
- Metastasize
- Infiltrate, invade, and destroy surrounding tissues
- Can metastasize to other parts of the body
Causes of Cancer
- Smoking
- Obesity
- A few viruses
- Chemicals
- Radiation
- Hormones
- Immune conditions
- Inherited genetic mutations
Cancer Treatment Options
- Hormone therapy
- Surgery
- Bone marrow transplantation
- Chemotherapy
- Immunotherapy
- Radiation therapy
- Targeted therapy
Root Causes & Co-Factors of Cancer
- Type 2 Diabetes
- Obesity
- Chronic Inflammation
- Oxidative Stress
- Toxicity/Acidity
- Sedentary Lifestyle
- Weakened Immunity
- Poor Diet
- Nutritional Deficiencies
- Genetics
- Environmental Toxins
- Smoking/Alcohol
- Stress/ Insomnia
- Macronutrient Deficiencies
- Vitamin Deficiencies (Vitamins A, C, D)
- Mineral Deficiencies (Selenium, Zinc)
- Other Deficiencies (Enzymes, Probiotics)
Nondisjunction
- Nondisjunction involves the failure of homologous chromosomes or sister chromatids to separate
- Can occur in meiosis 1 or 2
- Leads to Monosomy, or 1 copy of a chromosome
- Leads to Trisomy, or 3 copies of a chromosome
Monosomy vs Trisomy
- Monosomy: Having a diploid chromosome complement with one chromosome lacking its homologous partner
- Presence of a single chromosome in the homologous pair.
- Represented as 2n-1
- Turner syndrome is an example
- Trisomy: Having an additional copy of a chromosome present in the genome
- Presence of an additional chromosome
- Represented as 2n+1
- Down syndrome is an example
- A number of disorders are caused by nondisjunctions
- Down's Syndrome, Edward's Syndrome, Patau's Syndrome, Turner's Syndrome, Kleinfelter's Syndrome, Other severe abnormalities
Genetic Disease
- Nondisjunction and polyploidy can cause several medical conditions in humans
- Down Syndrome: trisomy of chromosome 21
- Patau Syndrome: trisomy of chromosome 13
- Edward Syndrome: trisomy of chromosome 18
- Klinefelter Syndrome: an extra X chromosome in males
- Turner Syndrome: only one X chromosome present in females
- XYY Syndrome: an extra Y chromosome in males
- Triple X Syndrome: an extra X chromosome in females
Karyotyping
- Karyotyping is the process of pairing and ordering all the chromosomes
- Karyotypes are prepared via standardized staining procedures revealing structural features for each chromosome
- Down's Syndrome karyotype presents at pair 21: 3 copies of the chromosome, rather than the normal 2
Patau Syndrome (Trisomy 13)
- Trisomy 13, is a chromosomal condition resulting in severe intellectual disability and physical abnormalities
- Individuals often have heart defects, brain/spinal cord abnormalities, small/poorly developed eyes microphthalmia, extra fingers/toes, cleft lip/palate, and weak muscle tone hypotonia.
- Most die within their first days or weeks of life
- Only 5-10% of children with this condition live past their first year
- Symptoms include: close-set eyes, small eyes/ no eyes, cleft lip or palate, Polydactyl
Edward's Syndrome (Trisomy 18)
- A severe form of trisomy 18
- Affected babies often die shortly after birth
- Characterized by an unusually small head, a prominent back of the head, malformed/low-set ears
- Symptoms include a small mouth and jaw, a cleft lip/palate
- Hands are clenched into fists, and the index finger overlaps the other fingers
- May also have clubfeet rockers, and webbed or fused toes
Klinefelter's Syndrome
- A genetic condition in males caused by an extra copy of the X chromosome
- Often not diagnosed until adulthood
- May adversely affect testicular growth, smaller than normal testicles, which can lead to lower production of testosterone
- Effects include a reduced muscle mass, reduced body and facial hair, and enlarged breast tissue
- Most men produce little or no sperm
XYY Syndrome
- A rare chromosomal disorder affecting males
- There is the presence of an extra Y chromosome
- Males normally have one X and one Y chromosome
- However, individuals with this syndrome have one X and two Y chromosomes
- Affected individuals are usually very tall
Triple-X Syndrome
- Individual is female
- Trisomy X caused by an extra X chromosome at pair 23
- Taller than average with no unusual physical features
- Potential increased risk of learning disabilities and delayed speech/language abilities
- May include Weak muscle tone
- May include behavioral and emotional difficulties
Down syndrome and Turner's syndrome
- Trisomy 21 with 3 chromosome 21 instead of 2
- Hearing loss, heart and vision disorders, physical deformity (range), and mental/growth retardation
- Klinefelter's syndrome
- Boys have extra X chromosome(s)
- Turner's syndrome: Girls are missing one of their X chromosomes and are intellectually normal, but physical/sexual maturity problems
Down's syndrome symptoms
- Flat nasal bridge
- Macroglossia and protuding tongue
- Irregularly shaped mouth
- An almond shape to the eyes caused by an epicanthic fold of the eyelid
- Microgenia
- Single palmer crease, short fifth finger that curves inward
- Upslanting palpebral fissures
- Widely separated first and second toes and increased skin creases
Common physical signs of Down Syndrome
- Decreased muscle tone at birth
- Excess skin at the nape of the neck
- Flattened nose
- Upward slanting eyes
- Small ears
- Small mouth
- Wide, short hands with short fingers
- Separated joints between the bones of the skull
- Single crease in the palm of the hand
- White spots on the colored part of the eye
What causes Turner syndrome ?
- Typically, a girl inherits one X chromosome from her mother and one X chromosome from her father
- Those with Turner syndrome are missing one of their X chromosomes
- Can be caused by nondisjunction
- A pair of sex chromosomes fails to separate during the formation of a sperm or egg
Interesting facts about Turner syndrome
- Affects 60,000 females in the United States and occurs in 1 of every 2000 to 2500 baby girls
- About 800 new cases are diagnosed each year
- In 75-80% of cases, the single X chromosome comes from the mother's egg
- The father's sperm that fertilizes the egg is missing its sex chromosome
- Named for Dr. Henry Turner, who in 1938 published a report describing the disorder
Symptoms of Turner syndrome
- Females are shorter than average, web-like necks, poorly developed breast and immature internal sexual organs.
- Reduced ability to interpret spatial relationships, usually infertile/sterile because they may not menstruate or ovulate
- May present wih subnormal intelligence with many male characteristics such as heavy neck muscles and narrow hips
- Possible symptoms in young infants: swollen hands and feet
- wide and webbed neck and a low or indistinct hairline
- Older females: absent or incomplete development at puberty
- A broad chest and widely spaced nipples
Symptoms of Turner syndrome
- Females are shorter than average and can have other noticeable physical features
- Broad chest, swelling in hands and feet, webbed neck
- Health issues can include heart disease, horseshoe shaped kidneys, learning disabilities
Chromosomes difference in Down and Turner syndrome
- Down Syndrome: there is an extra copy of chromosome 21
- Turner Syndrome: only 1 pair of sex chromosomes is present (rather than 2)
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