Understanding Cancer - Basics

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Questions and Answers

Match each term related to cancer with its correct description:

Tumor = An abnormal mass of tissue that forms when cells grow and divide more than they should or do not die when they should. Metastasis = The spread of cancer cells from the primary site to distant parts of the body. Benign = A non-cancerous growth that does not invade nearby tissues or spread to other parts of the body. Malignant = A cancerous growth capable of invading surrounding tissues and spreading to other parts of the body.

Match the following causes with their respective impact on cancer development:

Smoking = Exposure to carcinogens that damage DNA, leading to mutations and uncontrolled cell growth particularly in lung tissues. Obesity = Increased risk of several types of cancer due to chronic inflammation, hormonal changes, and altered metabolism. Viruses = Infection that can directly alter the genetic material of cells, increasing the risk of certain cancers like cervical or liver cancer. Radiation = Damage to DNA leading to genetic mutations and increased risk of cancer.

Match each cancer treatment with its primary method of action:

Chemotherapy = Use of drugs to kill cancer cells throughout the body by targeting rapidly dividing cells. Radiation Therapy = Use of high-energy rays or particles to kill cancer cells in a specific area. Immunotherapy = Therapy to boost the body's immune system to recognize and destroy cancer cells more effectively. Hormone Therapy = Blocking the effects of hormones or preventing the body from producing them, used for hormone-sensitive cancers.

Match the type of genetic abnormality with its definition:

<p>Trisomy = The presence of an extra chromosome. Monosomy = The absence of one chromosome from the normal diploid number. Nondisjunction = The failure of homologous chromosomes or sister chromatids to separate properly during cell division. Aneuploidy = The presence of an abnormal number of chromosomes in a cell.</p> Signup and view all the answers

Match the genetic syndrome to its chromosomal abnormality:

<p>Down Syndrome = Trisomy 21 Turner Syndrome = Monosomy X (XO) Klinefelter Syndrome = XXY Patau Syndrome = Trisomy 13</p> Signup and view all the answers

Match the characteristics or symptoms to the correct genetic syndrome:

<p>Down Syndrome = Intellectual disability, characteristic facial features, and often heart defects. Turner Syndrome = Females with short stature webbed neck, and infertility. Klinefelter Syndrome = Males with reduced fertility, small testes, and sometimes breast development. Patau Syndrome = Severe intellectual disability, heart defects, and multiple other physical abnormalities.</p> Signup and view all the answers

Match the condition to its description:

<p>Cancer = A condition where cells divide uncontrollably Malignant Tumor = Cancer cells that invade neighboring tissues, enter blood vessels and metastasize to different sites Benign Tumor = Tumor cells that grow only locally and cannot spread by invasion or metastasis Recurrence = When cancer comes back to a person who appeared to be free of the disease after treatment</p> Signup and view all the answers

Match the following concepts related to chromosomal abnormalities with their descriptions:

<p>Monosomy = Condition of having a diploid chromosome complement in which one chromosome lacks its homologous partner Trisomy = Condition of having an additional copy of a chromosome present in the genome Nondisjunction = Condition where homologous chromosomes or sister chromatids fail to separate Karyotyping = The process of pairing and ordering all the chromosomes of an organism</p> Signup and view all the answers

Match the treatment option for cancer with how it works:

<p>Surgery = Physically removing tumor cells from the body Hormone Therapy = Adding, blocking, or removing hormones Chemotherapy = Administering chemicals to treat a disease Radiation Therapy = Using high doses of radiation to kill cancer cells</p> Signup and view all the answers

Match the following genetic diseases to their description:

<p>Down Syndrome = An extra copy of chromosome 21 Klinefelter Syndrome = An extra X chromosome in males Turner Syndrome = Only one X chromosome present in females XYY Syndrome = An extra Y chromosome in males</p> Signup and view all the answers

Match each genetic abnormality of sex chromosomes to its typical phenotype:

<p>XO (Turner Syndrome) = Female with short stature, infertility and heart abnormalities. XXY (Klinefelter Syndrome) = Male with small testes, reduced body hair, and possible learning disabilities. XYY Syndrome = Male who is taller than average and may have learning difficulties. XXX (Triple X Syndrome) = Female who is taller than average; may have learning disabilities.</p> Signup and view all the answers

Match the cause of cancer with an example:

<p>Smoking = Lung cancer Viruses = Cervical cancer Radiation = Skin cancer Genetic Mutation = BRCA1 and BRCA2 mutations with breast cancer</p> Signup and view all the answers

Match the following genetic conditions with their likely outcomes or features:

<p>Edward’s Syndrome = Severe abnormalities likely leading to death shortly after birth. Down’s Syndrome = Physical deformities range, and mental/growth retardation. Turner’s Syndrome = Girls are missing one of their X chromosomes and intellectually normal and physical/sexual maturity problems Klinefelter's Syndrome = Boys have extra X chromosome(s)</p> Signup and view all the answers

Match each characteristic to the tumor that it most closely describes:

<p>Benign Tumor = Small and slow growing Malignant Tumor = Poorly-differentiated, involves metastasis, and destroys surrounding tissue Begin Tumor = Non-invasive, well-differentiated, and stays localized</p> Signup and view all the answers

Match the following genetic abnormality to its condition:

<p>down syndrome = Trisomy 21 Turner syndrome = Intellectually normal, but have physical/sexual maturity problems Klinefelters syndrome = Boys have extra X chromosome(s)</p> Signup and view all the answers

Match the characteristics that correspond with the correct genetic marker:

<p>Females and Trisomy X = Taller than average, with no unusual physical features Both Females and Trisomy X = May have behavioral and emotional difficulties</p> Signup and view all the answers

Match each key term related to genetics and cell division with its correct definition:

<p>Nondisjunction = The failure of homologous chromosomes to separate properly during meiosis. Monosomy = A condition in which there is only one copy of a chromosome in diploid cells. Trisomy = A condition in which there are three copies of a chromosome in diploid cells. Karyotype = A visual representation of all the chromosomes within a cell, organized by size and shape.</p> Signup and view all the answers

Relate these cancer predisposing factors with possible cancers it causes:

<p>Mouth and Throat = Smoking tobacco Voice Box = Smoking tobacco Kidney = Smoking tobacco Colon and Rectum = Smoking tobacco</p> Signup and view all the answers

Match the following genetic syndromes with their chromosomal abnormality:

<p>Down Syndrome = Trisomy 21 (an extra copy of chromosome 21) Klinefelter Syndrome = XXY (an extra X chromosome in males) Turner Syndrome = X (females only have one X chromosome) XYY Syndrome = XYY (an extra Y chromosome in males)</p> Signup and view all the answers

Match the definitions below, to their term:

<p>Tobacco use = Tobacco includes use of smoked products such as cigarettes and cigars, and smokeless products such as snuff and chewing tobacco Out-of-control growth = Characterizes the multiple forms of cancer Cancer cell = Normal cells divide and grow in orderly fashion, but these cells do not Cancer cells = Form tumors that steal resources from the body causing harm</p> Signup and view all the answers

Match the various causes and co-factors of cancer to their respective categories:

<p>Diet and Lifestyle Factors = Sedentary lifestyle contributing to oxidative stress Environmental Factors = Exposure to environmental toxins increasing toxicity Physiological Factors = Chronic inflammation disrupting normal regulatory processes</p> Signup and view all the answers

Match the potential effects of Trisomy X (XXX) with their related characteristics:

<p>Physical Traits = Absence of unusual physical features or distinct abnormalities Cognitive and Developmental Aspects = Potential for delayed development of speech and language skills</p> Signup and view all the answers

Match the genetic condition to its unique identifier:

<p>Down Syndrome = Person has three chromosome 21's, instead of two Turner's Syndrome = Intellectually normal, but may have physical/sexual maturity problems</p> Signup and view all the answers

Match the typical characteristics with these causes and co-factors of cancer:

<p>Genetics = Inherited genetic mutations making one vulnerable to cancer Occupation = Exposure to chemicals Sunlight/radiation = Exposure to UV light causing skin cancer Smoking = Damage DNA and causes lung cancer</p> Signup and view all the answers

Determine what is likely to be the end results of the following genetic diseases:

<p>Patau Syndrome = Likely leading to death in its first year Edward's Syndrome = Likely to die shortly after being born Klinefelter's Syndrome = May lead to enlargement of breast tissue in males</p> Signup and view all the answers

Match the potential symptoms of Turner Syndrome with likely age groups:

<p>Young Infants = Wide and webbed neck and likely to have a low hairline Older females = Likely to have a broad chest, and may have widely spaced nipples</p> Signup and view all the answers

Match potential cancer factors with its definition statement:

<p>Inherited genetic mutations = Increase chance of cancer Smoking = 30% Occupation = 4% Diet = 35%</p> Signup and view all the answers

Differentiate between the two different cells, both normal, and cancerous cells:

<p>Normal cell = Interphase is longest step in the cycle Cancer cell = Interphase is typically reduced</p> Signup and view all the answers

Match the different options of Chemotherapy to its correlating image:

<p>Chemotherapy = They may use an IV to receive the chemicals Surgery = Doctor uses surgical tools to cut out a tumor. Radiation Treatment = Using radiation to kill cancer cells.</p> Signup and view all the answers

Match that tumor symptoms will usually lead to, if not addressed:

<p>Tumors will form = They continue to grow and crowd out normal cells Different rates = They grow at different rates responding to different treatments. Tumor cells = Form tumors that steal resources from the body causing harm. Cancer spreads = It's still named after the part of the body where it originated.</p> Signup and view all the answers

Connect all root causes to how they relate as co-factors to cancer:

<p>Type 2 Diabetes = Chronic Inflammation Poor Diet = Nutritional Deficiencies Environmental Toxins = Environmental Factors Smoking = Pharmaceutical Drugs</p> Signup and view all the answers

Match each syndrome with their potential symptoms::

<p>Patau Syndrome = very small or poorly developed eyes (microphthalmia) Edward Syndrome = ears are malformed and low-set; mouth and jaw are small (may also have a cleft lip or cleft palate)</p> Signup and view all the answers

Match the commonalities between the different forms of syndromes listed to the likely characteristics:

<p>Edward Syndrome = unusually small head Klinefelter Syndrome = males, and it often isn't diagnosed until adulthood. Down Syndrome = Hearing loss, heart and vision disorders, physical deformity (range), and mental/growth retardation Turner's Syndrome = Girls often will be missing an X chromosome</p> Signup and view all the answers

Connect these different genetic conditions to the following identifiers listed:

<p>XYY = The signs. XXY = Smaller than normal testicles, which can lead to lower production of testosterone. XXX = may have behavioral and emotional difficulties.</p> Signup and view all the answers

Determine what outcomes relate to specific genetic mutations:

<p>Non-disjunction = Monosomy and Trisomy XYY with shorter than average height = Taller less muscular body, also might have broader hips and longer legs. Turner Syndrome affecting females = They may be sterile Inherited Genetic Diseases = Several Medical Conditions in Humans</p> Signup and view all the answers

Match the appropriate word relating to tumors, to the different tumor descriptions:

<p>Cancel cells forming tumors = Steal resource from the body causing harm Cancer cells = Crowd out normal cell functions Malignant Tumor = Invade neighboring tissues, enter blood vessels and metastasize to different sites Benign Tumor = Grow locally and cannot spread by invasion</p> Signup and view all the answers

Flashcards

Cancer

A condition where cells divide uncontrollably.

Cancer Cell Behavior

Cancer cells grow and displace normal cells.

Characterization of Cancer

Out-of-control growth of cells.

Cancer Variety

Lung and breast cancer behave differently.

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Tumor Formation

Cancer cells form tumors, stealing resources.

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Cancer Naming

Cancer retains its origin name, even if spread.

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Recurrence

Cancer's return after treatment.

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Interphase

The longest phase, often shortened in cancer cells.

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Abnormal Cells

Cancer cells will appear different in size and shape.

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Benign Tumors

Tumors grow locally and do not spread.

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Malignant Tumors

Tumors invade and metastasize to other sites.

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Cancer

Unregulated cell division.

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Causes of Cancer

Smoking, obesity, chemicals, radiation, viruses.

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Cancer Treatment Options

Surgery, radiation, Immunotherapy, Chemotherapy.

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Nondisjunction

A condition where chromosomes fail to separate properly.

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Monosomy

One copy of a chromosome.

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Trisomy

Three copies of a chromosome.

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Karyotyping

Pairing and ordering chromosomes.

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Down Syndrome

Trisomy of chromosome 21.

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Patau Syndrome

Trisomy of chromosome 13.

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Patau Syndrome Symptoms

Severe intellectual disability, physical abnormalities.

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Edward Syndrome

Trisomy of chromosome 18.

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Klinefelter Syndrome

Extra X chromosome in males (XXY).

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XYY Syndrome

Affects males with an extra Y chromosome (XYY).

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Triple X Syndrome

Females with an extra X chromosome (XXX).

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Turner Syndrome

Missing one X chromosome in females.

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Study Notes

Cancer Overview

  • Cancer involves cells dividing uncontrollably
  • Normal cells divide and grow in an orderly way, unlike cancer cells
  • Cancer cells continue to grow and crowd out normal cells
  • Many forms of cancer exist, all characterized by out-of-control cell growth
  • Different forms of cancer behave differently; lung and breast cancer are examples
  • Cancer types grow at different rates and respond to different treatments
  • Cancer cells form tumors that steal resources from the body, causing harm
  • Tumors can be benign or malignant
  • Even when cancer spreads to a new location, it retains the name of its origin
  • Prostate cancer that spreads to the bones is still called prostate cancer
  • Breast cancer that spreads to the lungs is still called breast cancer
  • Recurrence is when cancer reappears after treatment

Cancer and the Cell Cycle

  • Interphase, the longest step in the cell cycle, is reduced in cancer cells, especially G1/G2
  • Cancerous cells appear smaller and abnormal compared to normal cells

Cancerous Cells vs. Normal Cells

  • Cancer cells appear very different from normal cells
  • Cancer cells exhibit different sizes and shapes as compared to healthy cells

Tumors

  • Benign tumors grow locally and do not spread by invasion or metastasis
  • Malignant tumors invade neighboring tissues, enter blood vessels, and metastasize to different sites

Benign Tumors

  • Small
  • Slow-growing
  • Non-invasive
  • Well-differentiated
  • Stay localized, remaining where they are
  • Cannot invade or metastasize

Malignant Tumors

  • Large
  • Fast-growing
  • Invasive
  • Poorly-differentiated
  • Metastasize
  • Infiltrate, invade, and destroy surrounding tissues
  • Can metastasize to other parts of the body

Causes of Cancer

  • Smoking
  • Obesity
  • A few viruses
  • Chemicals
  • Radiation
  • Hormones
  • Immune conditions
  • Inherited genetic mutations

Cancer Treatment Options

  • Hormone therapy
  • Surgery
  • Bone marrow transplantation
  • Chemotherapy
  • Immunotherapy
  • Radiation therapy
  • Targeted therapy

Root Causes & Co-Factors of Cancer

  • Type 2 Diabetes
  • Obesity
  • Chronic Inflammation
  • Oxidative Stress
  • Toxicity/Acidity
  • Sedentary Lifestyle
  • Weakened Immunity
  • Poor Diet
  • Nutritional Deficiencies
  • Genetics
  • Environmental Toxins
  • Smoking/Alcohol
  • Stress/ Insomnia
  • Macronutrient Deficiencies
  • Vitamin Deficiencies (Vitamins A, C, D)
  • Mineral Deficiencies (Selenium, Zinc)
  • Other Deficiencies (Enzymes, Probiotics)

Nondisjunction

  • Nondisjunction involves the failure of homologous chromosomes or sister chromatids to separate
  • Can occur in meiosis 1 or 2
  • Leads to Monosomy, or 1 copy of a chromosome
  • Leads to Trisomy, or 3 copies of a chromosome

Monosomy vs Trisomy

  • Monosomy: Having a diploid chromosome complement with one chromosome lacking its homologous partner
  • Presence of a single chromosome in the homologous pair.
  • Represented as 2n-1
  • Turner syndrome is an example
  • Trisomy: Having an additional copy of a chromosome present in the genome
  • Presence of an additional chromosome
  • Represented as 2n+1
  • Down syndrome is an example
  • A number of disorders are caused by nondisjunctions
  • Down's Syndrome, Edward's Syndrome, Patau's Syndrome, Turner's Syndrome, Kleinfelter's Syndrome, Other severe abnormalities

Genetic Disease

  • Nondisjunction and polyploidy can cause several medical conditions in humans
  • Down Syndrome: trisomy of chromosome 21
  • Patau Syndrome: trisomy of chromosome 13
  • Edward Syndrome: trisomy of chromosome 18
  • Klinefelter Syndrome: an extra X chromosome in males
  • Turner Syndrome: only one X chromosome present in females
  • XYY Syndrome: an extra Y chromosome in males
  • Triple X Syndrome: an extra X chromosome in females

Karyotyping

  • Karyotyping is the process of pairing and ordering all the chromosomes
  • Karyotypes are prepared via standardized staining procedures revealing structural features for each chromosome
  • Down's Syndrome karyotype presents at pair 21: 3 copies of the chromosome, rather than the normal 2

Patau Syndrome (Trisomy 13)

  • Trisomy 13, is a chromosomal condition resulting in severe intellectual disability and physical abnormalities
  • Individuals often have heart defects, brain/spinal cord abnormalities, small/poorly developed eyes microphthalmia, extra fingers/toes, cleft lip/palate, and weak muscle tone hypotonia.
  • Most die within their first days or weeks of life
  • Only 5-10% of children with this condition live past their first year
  • Symptoms include: close-set eyes, small eyes/ no eyes, cleft lip or palate, Polydactyl

Edward's Syndrome (Trisomy 18)

  • A severe form of trisomy 18
  • Affected babies often die shortly after birth
  • Characterized by an unusually small head, a prominent back of the head, malformed/low-set ears
  • Symptoms include a small mouth and jaw, a cleft lip/palate
  • Hands are clenched into fists, and the index finger overlaps the other fingers
  • May also have clubfeet rockers, and webbed or fused toes

Klinefelter's Syndrome

  • A genetic condition in males caused by an extra copy of the X chromosome
  • Often not diagnosed until adulthood
  • May adversely affect testicular growth, smaller than normal testicles, which can lead to lower production of testosterone
  • Effects include a reduced muscle mass, reduced body and facial hair, and enlarged breast tissue
  • Most men produce little or no sperm

XYY Syndrome

  • A rare chromosomal disorder affecting males
  • There is the presence of an extra Y chromosome
  • Males normally have one X and one Y chromosome
  • However, individuals with this syndrome have one X and two Y chromosomes
  • Affected individuals are usually very tall

Triple-X Syndrome

  • Individual is female
  • Trisomy X caused by an extra X chromosome at pair 23
  • Taller than average with no unusual physical features
  • Potential increased risk of learning disabilities and delayed speech/language abilities
  • May include Weak muscle tone
  • May include behavioral and emotional difficulties

Down syndrome and Turner's syndrome

  • Trisomy 21 with 3 chromosome 21 instead of 2
  • Hearing loss, heart and vision disorders, physical deformity (range), and mental/growth retardation
  • Klinefelter's syndrome
  • Boys have extra X chromosome(s)
  • Turner's syndrome: Girls are missing one of their X chromosomes and are intellectually normal, but physical/sexual maturity problems

Down's syndrome symptoms

  • Flat nasal bridge
  • Macroglossia and protuding tongue
  • Irregularly shaped mouth
  • An almond shape to the eyes caused by an epicanthic fold of the eyelid
  • Microgenia
  • Single palmer crease, short fifth finger that curves inward
  • Upslanting palpebral fissures
  • Widely separated first and second toes and increased skin creases

Common physical signs of Down Syndrome

  • Decreased muscle tone at birth
  • Excess skin at the nape of the neck
  • Flattened nose
  • Upward slanting eyes
  • Small ears
  • Small mouth
  • Wide, short hands with short fingers
  • Separated joints between the bones of the skull
  • Single crease in the palm of the hand
  • White spots on the colored part of the eye

What causes Turner syndrome ?

  • Typically, a girl inherits one X chromosome from her mother and one X chromosome from her father
  • Those with Turner syndrome are missing one of their X chromosomes
  • Can be caused by nondisjunction
  • A pair of sex chromosomes fails to separate during the formation of a sperm or egg

Interesting facts about Turner syndrome

  • Affects 60,000 females in the United States and occurs in 1 of every 2000 to 2500 baby girls
  • About 800 new cases are diagnosed each year
  • In 75-80% of cases, the single X chromosome comes from the mother's egg
  • The father's sperm that fertilizes the egg is missing its sex chromosome
  • Named for Dr. Henry Turner, who in 1938 published a report describing the disorder

Symptoms of Turner syndrome

  • Females are shorter than average, web-like necks, poorly developed breast and immature internal sexual organs.
  • Reduced ability to interpret spatial relationships, usually infertile/sterile because they may not menstruate or ovulate
  • May present wih subnormal intelligence with many male characteristics such as heavy neck muscles and narrow hips
  • Possible symptoms in young infants: swollen hands and feet
  • wide and webbed neck and a low or indistinct hairline
  • Older females: absent or incomplete development at puberty
  • A broad chest and widely spaced nipples

Symptoms of Turner syndrome

  • Females are shorter than average and can have other noticeable physical features
  • Broad chest, swelling in hands and feet, webbed neck
  • Health issues can include heart disease, horseshoe shaped kidneys, learning disabilities

Chromosomes difference in Down and Turner syndrome

  • Down Syndrome: there is an extra copy of chromosome 21
  • Turner Syndrome: only 1 pair of sex chromosomes is present (rather than 2)

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