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Questions and Answers
The BNP gene is activated with increased heart wall ______________ from volume or pressure.
The BNP gene is activated with increased heart wall ______________ from volume or pressure.
stress
What is the purpose of measuring BNP levels?
What is the purpose of measuring BNP levels?
Match the following symptoms with their corresponding descriptions:
Match the following symptoms with their corresponding descriptions:
Exertional Dyspnea = Shortness of breath when exercising Orthopnea = Shortness of breath when lying down Paroxysmal nocturnal dyspnea (PND) = Sudden shortness of breath at night
Heart failure is a syndrome with a single cause.
Heart failure is a syndrome with a single cause.
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One of the complications of heart failure is ______________ and thromboembolism.
One of the complications of heart failure is ______________ and thromboembolism.
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Which diagnostic test is used for both stable angina and acute coronary syndromes presentations?
Which diagnostic test is used for both stable angina and acute coronary syndromes presentations?
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Atherosclerosis is a risk factor for Coronary Artery Disease (CAD).
Atherosclerosis is a risk factor for Coronary Artery Disease (CAD).
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What is the name of the condition characterized by the narrowing or blockage of the coronary arteries?
What is the name of the condition characterized by the narrowing or blockage of the coronary arteries?
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Hypertension is a risk factor for __________________.
Hypertension is a risk factor for __________________.
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Match the following diagnostic tests with their descriptions:
Match the following diagnostic tests with their descriptions:
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What is the term for a heart attack that occurs when the blood flow to the heart is blocked?
What is the term for a heart attack that occurs when the blood flow to the heart is blocked?
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Stephen's symptoms of shortness of breath and swollen ankles are indicative of Heart Failure.
Stephen's symptoms of shortness of breath and swollen ankles are indicative of Heart Failure.
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What is the term for the condition where the heart is unable to pump enough blood to meet the body's needs?
What is the term for the condition where the heart is unable to pump enough blood to meet the body's needs?
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What is the normal blood pressure range?
What is the normal blood pressure range?
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Isolated systolic hypertension is defined as a blood pressure of ≥ 140 and ≥ 90.
Isolated systolic hypertension is defined as a blood pressure of ≥ 140 and ≥ 90.
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What is the main function of the kidney in blood pressure regulation?
What is the main function of the kidney in blood pressure regulation?
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Atherosclerosis is also known as _______________________ of the arteries.
Atherosclerosis is also known as _______________________ of the arteries.
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Match the following substances with their role in blood pressure regulation:
Match the following substances with their role in blood pressure regulation:
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What is the primary cause of mortality and morbidity in individuals 65 years or older?
What is the primary cause of mortality and morbidity in individuals 65 years or older?
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The 5-year survival rate for heart failure patients is 60%.
The 5-year survival rate for heart failure patients is 60%.
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What is the formula for cardiac output (CO)?
What is the formula for cardiac output (CO)?
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The Frank Starling Curve illustrates the relationship between __________ and stroke volume.
The Frank Starling Curve illustrates the relationship between __________ and stroke volume.
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Match the following terms with their definitions:
Match the following terms with their definitions:
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What is a harmful effect of increased myocardial oxygen demand (MVO2)?
What is a harmful effect of increased myocardial oxygen demand (MVO2)?
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Ventricular hypertrophy is always beneficial for maintaining cardiac output.
Ventricular hypertrophy is always beneficial for maintaining cardiac output.
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The renin-angiotensin-aldosterone system (RAAS) leads to __________ and Na retention.
The renin-angiotensin-aldosterone system (RAAS) leads to __________ and Na retention.
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What is the primary usage of diagnostic investigations in relation to cardiovascular disease?
What is the primary usage of diagnostic investigations in relation to cardiovascular disease?
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What is the definition of isolated systolic hypertension?
What is the definition of isolated systolic hypertension?
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Atherosclerosis is a type of cardiovascular disease that affects the blood vessels supplying the brain.
Atherosclerosis is a type of cardiovascular disease that affects the blood vessels supplying the brain.
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What is the term for disease of the coronary arteries, which can lead to angina and myocardial infarction?
What is the term for disease of the coronary arteries, which can lead to angina and myocardial infarction?
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Atherosclerosis is a risk factor for Coronary Artery Disease (CAD)
Atherosclerosis is a risk factor for Coronary Artery Disease (CAD)
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What is the term for the condition where the heart is unable to pump enough blood to meet the body's needs?
What is the term for the condition where the heart is unable to pump enough blood to meet the body's needs?
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The kidney releases ______________ when low blood pressure is detected in the afferent artery of the kidney.
The kidney releases ______________ when low blood pressure is detected in the afferent artery of the kidney.
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Hypertension is a major modifiable risk factor for cardiovascular disease, and is defined as a blood pressure of ______________ or higher.
Hypertension is a major modifiable risk factor for cardiovascular disease, and is defined as a blood pressure of ______________ or higher.
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Which of the following is a minor cardiovascular risk factor?
Which of the following is a minor cardiovascular risk factor?
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Myocardial infarction is a type of cardiovascular disease that affects the peripheral arteries.
Myocardial infarction is a type of cardiovascular disease that affects the peripheral arteries.
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What is the primary mechanism of essential hypertension?
What is the primary mechanism of essential hypertension?
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Match the following substances with their role in blood pressure regulation:
Match the following substances with their role in blood pressure regulation:
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Match the following cardiovascular conditions with their corresponding descriptions:
Match the following cardiovascular conditions with their corresponding descriptions:
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What is the term for the process of plaque buildup in the coronary arteries, leading to conditions such as angina and myocardial infarction?
What is the term for the process of plaque buildup in the coronary arteries, leading to conditions such as angina and myocardial infarction?
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Hypertension is a risk factor for Myocardial Infarction
Hypertension is a risk factor for Myocardial Infarction
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The term "hardening of the arteries" refers to ______________.
The term "hardening of the arteries" refers to ______________.
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What is the term for the condition where the heart is unable to pump enough blood to meet the body's needs?
What is the term for the condition where the heart is unable to pump enough blood to meet the body's needs?
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What is the purpose of measuring BNP levels, and what do increased levels indicate?
What is the purpose of measuring BNP levels, and what do increased levels indicate?
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What are the symptoms of heart failure, and how do they relate to Stephen's and Cynthia's cases?
What are the symptoms of heart failure, and how do they relate to Stephen's and Cynthia's cases?
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Interpret the blood pressure reading of 156/94 for someone who is concerned about their health. Should they be worried?
Interpret the blood pressure reading of 156/94 for someone who is concerned about their health. Should they be worried?
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What is the relationship between hypertension and heart failure?
What is the relationship between hypertension and heart failure?
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What is the primary mechanism of essential hypertension?
What is the primary mechanism of essential hypertension?
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What is the term for the condition characterized by the narrowing or blockage of the coronary arteries?
What is the term for the condition characterized by the narrowing or blockage of the coronary arteries?
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How do the kidney, adrenal gland, and heart regulate blood pressure?
How do the kidney, adrenal gland, and heart regulate blood pressure?
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What is the role of the renin-angiotensin-aldosterone system in blood pressure regulation?
What is the role of the renin-angiotensin-aldosterone system in blood pressure regulation?
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What are the complications of heart failure?
What are the complications of heart failure?
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What is the role of the renin-angiotensin-aldosterone system (RAAS) in blood pressure regulation?
What is the role of the renin-angiotensin-aldosterone system (RAAS) in blood pressure regulation?
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What are some causes of secondary hypertension?
What are some causes of secondary hypertension?
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What is the primary usage of diagnostic investigations in relation to cardiovascular disease?
What is the primary usage of diagnostic investigations in relation to cardiovascular disease?
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What is isolated systolic hypertension, and what is its definition?
What is isolated systolic hypertension, and what is its definition?
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What is the role of pharmacists in the care of patients with hypertension?
What is the role of pharmacists in the care of patients with hypertension?
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What is atherosclerosis, and how is it related to hypertension?
What is atherosclerosis, and how is it related to hypertension?
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How does hypertension contribute to end-organ damage?
How does hypertension contribute to end-organ damage?
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What is the significance of blood pressure regulation in the context of hypertension?
What is the significance of blood pressure regulation in the context of hypertension?
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What is the definition of hypertension, and how does it contribute to cardiovascular disease?
What is the definition of hypertension, and how does it contribute to cardiovascular disease?
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What is the primary mechanism of essential hypertension, and how does it relate to the renin-angiotensin-aldosterone system (RAAS)?
What is the primary mechanism of essential hypertension, and how does it relate to the renin-angiotensin-aldosterone system (RAAS)?
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How does hypertension increase the risk of myocardial infarction, and what are the underlying mechanisms?
How does hypertension increase the risk of myocardial infarction, and what are the underlying mechanisms?
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What is the relationship between hypertension and heart failure, and how does hypertension contribute to the development of heart failure?
What is the relationship between hypertension and heart failure, and how does hypertension contribute to the development of heart failure?
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What are the diagnostic criteria for isolated systolic hypertension, and how does it differ from diastolic hypertension?
What are the diagnostic criteria for isolated systolic hypertension, and how does it differ from diastolic hypertension?
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How does hypertension contribute to atherosclerosis, and what are the underlying mechanisms?
How does hypertension contribute to atherosclerosis, and what are the underlying mechanisms?
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What is the role of the kidney in blood pressure regulation, and how does hypertension affect kidney function?
What is the role of the kidney in blood pressure regulation, and how does hypertension affect kidney function?
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How does hypertension relate to cardiovascular mortality and morbidity, and what are the implications for public health?
How does hypertension relate to cardiovascular mortality and morbidity, and what are the implications for public health?
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What is the relationship between hypertension and cardiac output, and how does hypertension affect cardiac function?
What is the relationship between hypertension and cardiac output, and how does hypertension affect cardiac function?
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How does hypertension relate to cardiovascular risk factors, and what are the implications for cardiovascular disease prevention?
How does hypertension relate to cardiovascular risk factors, and what are the implications for cardiovascular disease prevention?
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What is the definition of hypertension?
What is the definition of hypertension?
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Which of the following is a major modifiable risk factor for cardiovascular disease?
Which of the following is a major modifiable risk factor for cardiovascular disease?
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What is the definition of normal blood pressure?
What is the definition of normal blood pressure?
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What is the relationship between hypertension and heart failure?
What is the relationship between hypertension and heart failure?
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What is the primary mechanism of essential hypertension?
What is the primary mechanism of essential hypertension?
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Which of the following is a cause of secondary hypertension?
Which of the following is a cause of secondary hypertension?
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Which of the following is a symptom of hypertension?
Which of the following is a symptom of hypertension?
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What is the primary mechanism of essential hypertension?
What is the primary mechanism of essential hypertension?
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What is the role of the kidney in blood pressure regulation?
What is the role of the kidney in blood pressure regulation?
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What is the term for isolated systolic hypertension?
What is the term for isolated systolic hypertension?
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What is the term for the condition characterized by the narrowing or blockage of the coronary arteries?
What is the term for the condition characterized by the narrowing or blockage of the coronary arteries?
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What is the primary function of the renal system in blood pressure regulation?
What is the primary function of the renal system in blood pressure regulation?
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Which of the following is a minor cardiovascular risk factor for hypertension?
Which of the following is a minor cardiovascular risk factor for hypertension?
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What is the term for 'hardening of the arteries'?
What is the term for 'hardening of the arteries'?
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What is the primary usage of diagnostic investigations in relation to hypertension?
What is the primary usage of diagnostic investigations in relation to hypertension?
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What is the relation between hypertension and atherosclerosis?
What is the relation between hypertension and atherosclerosis?
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What is the definition of isolated systolic hypertension?
What is the definition of isolated systolic hypertension?
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What is the primary role of the heart in blood pressure regulation?
What is the primary role of the heart in blood pressure regulation?
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Which of the following is a consequence of untreated hypertension?
Which of the following is a consequence of untreated hypertension?
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What is the concern with a blood pressure reading of 156/94?
What is the concern with a blood pressure reading of 156/94?
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What is the primary cause of mortality and morbidity in individuals 65 years or older?
What is the primary cause of mortality and morbidity in individuals 65 years or older?
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What is the normal range of ejection fraction in a healthy individual?
What is the normal range of ejection fraction in a healthy individual?
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What is the term for the condition where the heart is unable to pump enough blood to meet the body's needs?
What is the term for the condition where the heart is unable to pump enough blood to meet the body's needs?
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What is the result of increased heart wall stress from volume or pressure?
What is the result of increased heart wall stress from volume or pressure?
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What is a common symptom of heart failure?
What is a common symptom of heart failure?
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What is the role of BNP in the body?
What is the role of BNP in the body?
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What is the significance of increased BNP levels in the diagnosis of heart failure?
What is the significance of increased BNP levels in the diagnosis of heart failure?
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What is the relationship between hypertension and heart failure?
What is the relationship between hypertension and heart failure?
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Study Notes
Blood Pressure and Hypertension
- Normal blood pressure: < 120/80 mmHg
- Hypertension: ≥ 140/90 mmHg
- Isolated systolic hypertension: ≥ 140 and < 90 mmHg
- 25% of the adult population in Canada are hypertensive
- Blood pressure regulation involves the kidney, adrenal gland, and heart, which release substances to regulate vascular tone and sodium/fluid balance
Blood Pressure Regulation
- Renin-angiotensin-aldosterone system:
- Renin releases angiotensin I, which is converted to angiotensin II by ACE
- Angiotensin II causes smooth muscle cell contraction, increases aldosterone release, and causes sodium resorption
- Kidney:
- Releases renin when there is low blood pressure, high catecholamine levels, or low sodium levels
- Heart:
- Releases natriuretic peptides when there is increased pressure/volume sensed, which inhibits sodium resorption
Causes of Hypertension
- Essential hypertension: 90-95% of cases, due to genetic and environmental factors
- Secondary hypertension: 5-10% of cases, due to specific causes such as kidney disease, sleep apnea, and certain medications
- Mechanism of essential hypertension: reduced renal excretion of sodium, increased vascular resistance, and genetic factors
- Drug-induced hypertension: caused by drugs such as glucocorticoids, sex hormones, and NSAIDs
Cardiovascular Disease
- Cardiovascular disease is the leading cause of mortality in Canada
- Major cardiovascular risk factors: hypertension, smoking, cholesterol, diabetes, and family history
- Cardiovascular disease includes coronary artery disease, cerebrovascular disease, and vascular disease
- Heart failure: a syndrome of pulmonary and systemic congestion caused by failure of the heart to pump enough blood to meet metabolic needs
Heart Failure
- Reduced ejection fraction (systolic) dysfunction: due to reduced muscle mass or dilated cardiomyopathy
- Preserved ejection fraction (diastolic) dysfunction: due to ventricular stiffness, valve disease, or pericardial disease
- Compensatory responses to decreased cardiac output:
- Tachycardia: increases cardiac output but can be harmful
- Increased preload: increases stroke volume but can cause pulmonary and systemic congestion
- Vasoconstriction: increases blood pressure but increases myocardial oxygen demand
- Ventricular hypertrophy: maintains cardiac output but can be limited in benefit
- Neurohormonal activation:
- Renin-angiotensin-aldosterone system: causes vasoconstriction, sodium retention, and cardiac remodeling
- Sympathetic nervous system: causes vasoconstriction, increased heart rate, and cardiac remodeling
Blood Pressure and Hypertension
- Normal blood pressure is defined as < 120/80 mmHg
- Hypertension is a common condition, affecting 25% of the adult population in Canada
- Isolated systolic hypertension is defined as ≥ 140 and < 90
- Blood pressure is regulated by the kidney, adrenal gland, and myocardium/heart, which release substances to control vascular tone and sodium/fluid balance
- The renin-angiotensin-aldosterone system plays a key role in blood pressure regulation
- Causes of hypertension include:
- Essential hypertension (mechanism unknown)
- Secondary hypertension (caused by underlying conditions or medications)
- Drug-induced hypertension (e.g. glucocorticoids, sex hormones, NSAIDs)
Mechanism of Essential Hypertension
- Reduced renal excretion of sodium
- Increased vascular resistance
- Chronic changes in vascular wall
- Genetic factors (e.g. ACE gene, aldosterone gene)
- Environmental factors (e.g. excessive Na intake, stress, smoking, physical inactivity, obesity)
Role of Pharmacists
- Pharmacists play a critical role in the care of patients with hypertension
- Understanding how blood pressure is regulated is important for pharmacists to understand how drugs may impact blood pressure
- Many opportunities exist for pharmacists to impact the care of patients with hypertension
Cardiovascular System
- Cardiovascular disease is a leading cause of death in Canada
- Types of cardiovascular disease include:
- Coronary artery disease/myocardial infarction
- Stroke
- Peripheral arterial disease
- Heart failure
- Arrhythmias
- Cardiovascular risk factors include:
- Modifiable factors (e.g. hypertension, smoking, cholesterol, diabetes)
- Non-modifiable factors (e.g. age, sex, family history)
Heart Failure
- Heart failure is a syndrome with multiple causes
- Symptoms of heart failure include:
- Exertional dyspnea
- Orthopnea
- Paroxysmal nocturnal dyspnea
- Fatigue and weakness
- Nocturia
- Signs of heart failure include:
- Edema
- Pallor/cold extremities
- Sinus tachycardia
- Rales
- Elevated jugular venous pressure
- Hepatojugular reflux
- Hepatomegaly
- Brain natriuretic peptide (BNP) is a useful biomarker for heart failure
- Complications of heart failure include:
- Quality of life
- Arrhythmias
- Stroke and thromboembolism
- Hospitalizations
- Death
Blood Pressure and Hypertension
- Normal blood pressure is defined as < 120/80 mmHg
- Hypertension is a common condition, affecting 25% of the adult population in Canada
- Isolated systolic hypertension is defined as ≥ 140 and < 90
- Blood pressure is regulated by the kidney, adrenal gland, and myocardium/heart, which release substances to control vascular tone and sodium/fluid balance
- The renin-angiotensin-aldosterone system plays a key role in blood pressure regulation
- Causes of hypertension include:
- Essential hypertension (mechanism unknown)
- Secondary hypertension (caused by underlying conditions or medications)
- Drug-induced hypertension (e.g. glucocorticoids, sex hormones, NSAIDs)
Mechanism of Essential Hypertension
- Reduced renal excretion of sodium
- Increased vascular resistance
- Chronic changes in vascular wall
- Genetic factors (e.g. ACE gene, aldosterone gene)
- Environmental factors (e.g. excessive Na intake, stress, smoking, physical inactivity, obesity)
Role of Pharmacists
- Pharmacists play a critical role in the care of patients with hypertension
- Understanding how blood pressure is regulated is important for pharmacists to understand how drugs may impact blood pressure
- Many opportunities exist for pharmacists to impact the care of patients with hypertension
Cardiovascular System
- Cardiovascular disease is a leading cause of death in Canada
- Types of cardiovascular disease include:
- Coronary artery disease/myocardial infarction
- Stroke
- Peripheral arterial disease
- Heart failure
- Arrhythmias
- Cardiovascular risk factors include:
- Modifiable factors (e.g. hypertension, smoking, cholesterol, diabetes)
- Non-modifiable factors (e.g. age, sex, family history)
Heart Failure
- Heart failure is a syndrome with multiple causes
- Symptoms of heart failure include:
- Exertional dyspnea
- Orthopnea
- Paroxysmal nocturnal dyspnea
- Fatigue and weakness
- Nocturia
- Signs of heart failure include:
- Edema
- Pallor/cold extremities
- Sinus tachycardia
- Rales
- Elevated jugular venous pressure
- Hepatojugular reflux
- Hepatomegaly
- Brain natriuretic peptide (BNP) is a useful biomarker for heart failure
- Complications of heart failure include:
- Quality of life
- Arrhythmias
- Stroke and thromboembolism
- Hospitalizations
- Death
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Description
This quiz will help you understand normal blood pressure, hypertension, and their mechanisms. Learn how blood pressure is regulated and the causes of secondary hypertension.