Sellar tumor

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Questions and Answers

Activating mutations in the CTNNB1 gene, encoding beta-catenin, are characteristically associated with which type of sellar tumor?

  • Spindle cell oncocytoma
  • Papillary craniopharyngioma (correct)
  • Pituitary adenoma
  • Adamantinomatous craniopharyngioma

The majority of sellar tumors are located in the suprasellar compartment. Which of the following clinical manifestations would most directly indicate tumor extension into the anterior cranial fossa?

  • Bitemporal hemianopsia
  • Trigeminal neuralgia
  • Hypopituitarism
  • Olfactory dysfunction (correct)

A patient presents with visual impairment and endocrine deficits. An incidental sellar mass is discovered on imaging, but is asymptomatic. Given the incidental nature, what percentage of sellar tumors are estimated to be truly incidental findings?

  • Around 25%
  • Approximately 10%
  • Greater than 50%
  • Less than 2% (correct)

Pituitary adenomas are characterized by monomorphic neuroendocrine cells. Which of the following cellular features is most helpful in differentiating pituitary adenoma cells from normal anterior pituitary cells?

<p>Lack of reticulin staining (C)</p> Signup and view all the answers

Crooke cell adenomas are a subtype of pituitary adenomas characterized by specific cytoplasmic features. What is the primary component accumulating in the cytoplasm of Crooke cells, leading to their hyalinized appearance?

<p>Keratin intermediate filaments (B)</p> Signup and view all the answers

Which immunohistochemical marker is most consistently utilized and diagnostically relevant for somatotroph pituitary adenomas?

<p>Growth Hormone (GH) (B)</p> Signup and view all the answers

Silent corticotroph adenomas are a subtype of pituitary adenomas that pose a diagnostic challenge. What is the primary reason they are termed 'silent' clinically?

<p>They produce ACTH but do not secrete clinically significant levels into circulation (B)</p> Signup and view all the answers

Prolactinomas, the most common type of pituitary adenoma, can cause hyperprolactinemia. In the context of sellar masses, what other mechanism, besides tumor secretion, can lead to elevated prolactin levels, particularly in the presence of a large sellar lesion?

<p>&quot;Stalk effect&quot; - disruption of dopamine inhibition (A)</p> Signup and view all the answers

Pituitary apoplexy is a critical complication of pituitary adenomas. What is the most common underlying pathological event leading to pituitary apoplexy?

<p>Acute hemorrhagic necrosis within the adenoma (A)</p> Signup and view all the answers

On MRI, pituitary adenomas often present with characteristic signal intensities. How do pituitary adenomas typically appear on T1-weighted images compared to normal pituitary tissue?

<p>Hypointense (B)</p> Signup and view all the answers

Somatic mutations in the GNAS gene are implicated in the pathogenesis of a specific subtype of pituitary adenoma. Which type of pituitary adenoma is most strongly associated with GNAS mutations?

<p>Somatotroph adenoma (C)</p> Signup and view all the answers

Transcription factor expression profiling is crucial in classifying pituitary adenomas. Which transcription factor is most specifically associated with lactotroph, somatotroph, and thyrotroph lineage pituitary adenomas?

<p>PIT1 (D)</p> Signup and view all the answers

Gonadotroph adenomas, while often clinically silent, can present with hormonal disturbances. In females, what is the most typical clinical manifestation associated with gonadotroph adenomas?

<p>Menstrual irregularities or dysfunction (D)</p> Signup and view all the answers

Plurihormonal pituitary adenomas are characterized by the production of multiple hormones. Which of the following is a typical characteristic distinguishing plurihormonal adenomas from null cell adenomas?

<p>Expression of multiple pituitary hormones (D)</p> Signup and view all the answers

Granular cell tumors of the sellar region are distinct from pituitary adenomas. Which of the following is a key morphological characteristic that helps differentiate granular cell tumors from pituitary adenomas?

<p>Abundant granular eosinophilic cytoplasm with lysosomes (B)</p> Signup and view all the answers

Immunohistochemistry plays a role in distinguishing granular cell tumors. Which of the following is typically positive in granular cell tumors and negative in pituitary adenomas, aiding in their differentiation?

<p>CD68 (D)</p> Signup and view all the answers

Papillary craniopharyngiomas are a subtype of craniopharyngiomas with distinct morphological and molecular features. What is the typical architectural pattern observed in papillary craniopharyngiomas?

<p>Papillary architecture with fibrovascular cores (B)</p> Signup and view all the answers

Unlike adamantinomatous craniopharyngiomas, papillary craniopharyngiomas are thought to arise from a specific cellular origin. Which of the following is considered the likely cell of origin for papillary craniopharyngiomas?

<p>Remnants of Rathke's pouch (B)</p> Signup and view all the answers

Adamantinomatous craniopharyngiomas are known for their mixed solid and cystic components. What is the characteristic nature of the cystic fluid typically found in adamantinomatous craniopharyngioma cysts?

<p>&quot;Machine oil&quot; cyst fluid (C)</p> Signup and view all the answers

A key morphological feature of adamantinomatous craniopharyngiomas is the basal layer of cells with palisading. What cellular pattern is typically observed in the central portion of the tumor lobules, away from the basal palisading layer?

<p>Stellate reticulum (A)</p> Signup and view all the answers

Calcifications are a common finding in adamantinomatous craniopharyngiomas. What type of calcification is most frequently observed within these tumors?

<p>&quot;Wet&quot; keratin-related calcifications (D)</p> Signup and view all the answers

BRAF V600E mutations are molecularly significant in craniopharyngiomas, but show differential prevalence between subtypes. In which subtype of craniopharyngioma are BRAF V600E mutations characteristically found?

<p>Papillary craniopharyngioma (A)</p> Signup and view all the answers

Adamantinomatous craniopharyngiomas exhibit a bimodal age distribution. During which decades of life are the two peaks in incidence typically observed?

<p>1st and 5th decades (C)</p> Signup and view all the answers

In children, adamantinomatous craniopharyngiomas represent a significant proportion of all craniopharyngiomas. Approximately what percentage of craniopharyngiomas in children are of the adamantinomatous variant?

<p>80% (B)</p> Signup and view all the answers

Pituitary blastoma is a rare and aggressive tumor of the sellar region, primarily affecting a specific patient demographic. In which age group is pituitary blastoma most commonly observed?

<p>Neonates and infants (B)</p> Signup and view all the answers

Pituitary blastomas are associated with germline and somatic mutations in a specific gene. Mutations in which gene are characteristically linked to the development of pituitary blastoma?

<p>DICER1 (D)</p> Signup and view all the answers

Clinically, pituitary blastomas often present with a characteristic endocrine syndrome. Which hormonal syndrome is most commonly associated with pituitary blastoma in infants?

<p>Cushing syndrome (B)</p> Signup and view all the answers

Spindle cell oncocytoma is a tumor of the posterior pituitary with distinct morphology. What is the predominant cell type characterizing spindle cell oncocytomas?

<p>Spindled to epithelioid oncocytes (A)</p> Signup and view all the answers

Spindle cell oncocytomas are considered non-neuroendocrine neoplasms. Which of the following immunohistochemical markers is typically negative in spindle cell oncocytomas, supporting their non-neuroendocrine nature?

<p>Synaptophysin (D)</p> Signup and view all the answers

Compared to pituitary adenomas and granular cell tumors of the sellar region, spindle cell oncocytomas are associated with a different clinical behavior regarding recurrence. What is the relative recurrence rate of spindle cell oncocytomas?

<p>Higher recurrence rate (D)</p> Signup and view all the answers

Variable nuclear pleomorphism is a morphological feature described in spindle cell oncocytomas. What does 'nuclear pleomorphism' refer to in the context of tumor cell morphology?

<p>Variability in nuclear size and shape within the tumor cell population (D)</p> Signup and view all the answers

Intersecting fascicles is a specific architectural pattern seen in spindle cell oncocytomas. How are the tumor cells arranged in this fascicular pattern?

<p>In parallel bundles or tracts that intersect with each other (A)</p> Signup and view all the answers

Which of the following is NOT considered a typical location for sellar tumors to extend?

<p>Middle cranial fossa (D)</p> Signup and view all the answers

Malignant progression of sellar tumors is described as extremely rare. Which of the following features is most suggestive of malignant transformation in a sellar tumor?

<p>Systemic metastasis (B)</p> Signup and view all the answers

Which of the following pituitary adenoma subtypes is most likely to present with mass effect symptoms due to its larger size at diagnosis?

<p>Macroadenoma (A)</p> Signup and view all the answers

Increased propensity for early recurrence and resistance to therapy is noted for a specific subtype of pituitary adenoma. Which subtype exhibits this more aggressive clinical behavior?

<p>Sparsely granulated somatotroph adenoma (C)</p> Signup and view all the answers

In the classification of pituitary adenomas based on transcription factor expression, TPIT lineage adenomas are associated with which functional subtype?

<p>Corticotroph adenoma (C)</p> Signup and view all the answers

TBX19 is another transcription factor involved in pituitary adenoma classification. Which functional subtype is associated with TBX19 lineage?

<p>Melanotroph adenoma (C)</p> Signup and view all the answers

SF1 (Steroidogenic Factor 1) lineage in pituitary adenoma classification is linked to which functional subtype?

<p>Gonadotroph adenoma (D)</p> Signup and view all the answers

Which imaging modality is most useful in visualizing sellar and suprasellar masses and assessing for compression of the optic chiasm?

<p>MRI (B)</p> Signup and view all the answers

Cavernous sinus or sphenoid sinus invasion by a pituitary adenoma is a significant factor in surgical planning and prognosis. How is sinus invasion best assessed radiologically?

<p>MRI with contrast (C)</p> Signup and view all the answers

Genetic predisposition is generally considered to play a minor role in the development of pituitary adenomas. What is the predominant genetic factor in the etiology of most pituitary adenomas?

<p>Sporadic somatic mutations (A)</p> Signup and view all the answers

A 45-year-old patient presents with progressive bitemporal hemianopsia and is subsequently diagnosed with a large sellar mass. Immunohistochemical analysis of the tumor reveals positive staining for synaptophysin and chromogranin, but is negative for all pituitary hormones. Which of the following is the MOST likely subtype of pituitary adenoma, considering the immunohistochemical profile and clinical presentation?

<p>Null cell adenoma (B)</p> Signup and view all the answers

In the classification of pituitary tumors, transcription factor expression plays a crucial role in lineage assignment. Considering the functional subtypes of pituitary adenomas, which of the following transcription factor and associated lineage pairings is MOST accurate?

<p>TBX19 lineage: Thyrotroph adenoma (C)</p> Signup and view all the answers

A pediatric patient is diagnosed with a sellar tumor presenting with Cushing syndrome. Histopathological examination reveals an embryonal neoplasm composed of primitive blastemal cells. Genetic testing is MOST likely to reveal mutations in which of the following genes?

<p><em>DICER1</em> (B)</p> Signup and view all the answers

Adamantinomatous craniopharyngiomas and papillary craniopharyngiomas are distinct subtypes with differing molecular profiles and histogenesis. Which of the following features BEST differentiates papillary craniopharyngioma from adamantinomatous craniopharyngioma?

<p><em>BRAF</em> V600E mutation (A)</p> Signup and view all the answers

A 60-year-old patient is diagnosed with a spindle cell oncocytoma of the posterior pituitary. Considering its unique characteristics compared to other sellar tumors, which of the following statements is MOST accurate regarding spindle cell oncocytoma?

<p>It typically exhibits a lower recurrence rate compared to pituitary adenomas and granular cell tumors. (D)</p> Signup and view all the answers

Flashcards

Location of Sellar Tumors

Majority of sellar tumors have suprasellar component and can extend to the anterior, middle, or posterior cranial fossa.

Sellar Tumors: Molecular Characteristics

Rare tumors molecularly defined by activating CTNNB1 mutations (encodes beta catenin). Malignant progression is extremely rare.

Pituicytoma Morphology

Low-grade glial tumor composed of bland bipolar spindle cells arranged in a fascicular or storiform pattern.

Pituicytoma: Key Absence

Loss of Rosenthal fibers, eosinophilic granular bodies, hyalinized blood vessels.

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Granular Cell Tumor Morphology

Densely packed polygonal cells with abundant granular eosinophilic cytoplasm (lysosomes: positive for PAS, diastase resistant).

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Papillary Craniopharyngioma Morphology

Resembles a squamous papilloma: non-keratinizing epithelium with fibrovascular cores.

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Adamantinomatous Craniopharyngioma Morphology

Mixed solid and cystic squamous epithelial tumor, Stellate reticulum (loose background), "Wet" keratin, calcifications, cholesterol clefts, xanthogranulomatous reaction.

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Pituitary Blastoma Morphology

Embryonal neoplasm of sellar region, Primitive blastemal cells, small, chromophobic, and undifferentiated. Neuroendocrine cells - round nuclei and abundant cytoplasm arranged in lobules or sheets

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Spindle Cell Oncocytoma Morphology

Spindled to epithelioid oncocytic non-neuroendocrine neoplasm. Intersecting fascicles and poorly defined nodules.

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Pituitary Adenoma Location

Sellar region with/without suprasellar extension. Ectopic: Sphenoid sinus > clival, suprasellar. Rarely arises in teratoma.

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Pituitary Adenoma Hormone Secretion

Hormone secretion - cytoplasmic staining; may have high background. Functioning adenomas secrete hormones and cause symptoms related to hormone secretion.

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Pituitary Adenoma: Prevalence

Common tumor of the sellar region. Benign but can invade adjacent structures.

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Pituitary Adenoma Imaging

MRI shows a sellar/suprasellar mass with or without compression of optic chiasm.

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Pituitary Adenoma Classification

Transcription factor expression (PIT1, TPIT/TBX19, SF1) – nuclear staining Lactotroph (PIT1-lineage): Most common (~50% of adenomas); prolactin → galactorrhea and amenorrhea (females) or sexual dysfunction (males)

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Study Notes

Understanding Slope

  • Slope measures the steepness of a line.
  • It is calculated as "rise over run".
  • Rise over run is the change in the vertical (y) direction divided by the change in the horizontal (x) direction.

Calculating Slope

Using Coordinates

  • Given two points $(x_1, y_1)$ and $(x_2, y_2)$, the slope ((m)) is: $m = \frac{y_2 - y_1}{x_2 - x_1}$
  • For points (1, 2) and (4, 6): $m = \frac{6 - 2}{4 - 1} = \frac{4}{3}$

Using Slope-Intercept Form

  • Slope-intercept form of a linear equation is: $y = mx + b$
  • (m) is the slope
  • (b) is the y-intercept
  • In the equation $y = 3x - 2$, the slope ((m)) is 3, and the y-intercept ((b)) is -2.

Types of Slopes

Positive Slope

  • Positive slope lines go upwards from left to right.
  • Slope of 2 means the line goes up 2 units for every 1 unit to the right.

Negative Slope

  • Negative slope lines go downwards from left to right.
  • Slope of -1 means the line goes down 1 unit for every 1 unit to the right.

Zero Slope

  • Horizontal lines have a slope of 0.
  • This is because the y-value doesn't change.

Undefined Slope

  • Vertical lines have an undefined slope.
  • This is because the x-value doesn't change, resulting in division by zero.

Examples

  • Positive Slope: A line that rises from left to right.
  • Negative Slope: A line that falls from left to right.
  • Zero Slope: A horizontal line.
  • Undefined Slope: A vertical line.

Funciones Vectoriales de Variable Real

Introducción

  • A vector function of a real variable assigns a vector to each real number in its domain.
  • These functions are of the form:$\qquad \vec{r}(t) = (f(t), g(t), h(t))$
  • $f(t)$, $g(t)$ and $h(t)$ are real functions of the real variable $t$.
  • They represent the components of the vector $\vec{r}(t)$ in a three-dimensional coordinate system.

Dominio

  • The domain of a vector function $\vec{r}(t)$ is the set of all values of $t$ for which the function is defined.
  • The interception of the domains of the component functions are: $\qquad Dom(\vec{r}(t)) = Dom(f(t)) \cap Dom(g(t)) \cap Dom(h(t))$

Límite

  • The limit of a vector function $\vec{r}(t)$ as $t$ tends to $a$ is the vector whose components are the limits of the component functions: $\qquad \lim_{t \to a} \vec{r}(t) = (\lim_{t \to a} f(t), \lim_{t \to a} g(t), \lim_{t \to a} h(t))$
  • Only when the limits of the component functions exist.

Continuidad

  • A vector function $\vec{r}(t)$ is continuous at $t = a$ if the following conditions are met:
  • $\vec{r}(a)$ is defined.
  • $\lim_{t \to a} \vec{r}(t)$ exists.
  • $\lim_{t \to a} \vec{r}(t) = \vec{r}(a)$
  • A vector function is continuous if each of its component functions is continuous.

Derivada

  • The derivative of a vector function $\vec{r}(t)$ is defined as: $\qquad \vec{r}'(t) = \lim_{h \to 0} \frac{\vec{r}(t + h) - \vec{r}(t)}{h}$
  • If the derivatives of the component functions exist, then the derivative of $\vec{r}(t)$ can be calculated component by component: $\qquad \vec{r}'(t) = (f'(t), g'(t), h'(t))$

Interpretación geométrica de la derivada

  • The derivative $\vec{r}'(t)$ represents a vector tangent to the curve described by $\vec{r}(t)$ at the point $\vec{r}(t)$.
  • The direction of this vector indicates the direction in which a point moving along the curve moves at time $t$.

Integrales

  • The integral of a vector function $\vec{r}(t)$ is defined as: $\qquad \int \vec{r}(t) dt = (\int f(t) dt, \int g(t) dt, \int h(t) dt) + \vec{C}$
  • $\vec{C}$ is a vector constant of integration.

Longitud de arco

  • The arc length of a curve described by a vector function $\vec{r}(t)$ from $t = a$ to $t = b$ is calculated as: $\qquad L = \int_{a}^{b} |\vec{r}'(t)| dt = \int_{a}^{b} \sqrt{(f'(t))^2 + (g'(t))^2 + (h'(t))^2} dt$

Curvatura

  • The curvature $K$ of a curve at a given point measures how quickly the curve changes direction at that point.
  • It is defined as: $\qquad K = \frac{|\vec{T}'(t)|}{|\vec{r}'(t)|}$
  • $\vec{T}(t) = \frac{\vec{r}'(t)}{|\vec{r}'(t)|}$ is the unit tangent vector.
  • It can also be calculated as: $\qquad K = \frac{|\vec{r}'(t) \times \vec{r}''(t)|}{|\vec{r}'(t)|^3}$

Regulární výrazy

Co jsou regulární výrazy?

  • Regulární výraz, zkráceně regexp nebo regex, je textový řetězec, který slouží jako vzor pro vyhledávání a manipulaci s textem.
  • Regulární výrazy se skládají z:
  • Literálů: Přesné znaky, které se mají shodovat.
  • Metaznaků: Speciální znaky, které mají zvláštní význam.

Metaznaky

Metaznak Význam
. Libovolný znak (kromě nového řádku).
* Opakování předchozího výrazu 0x nebo vícekrát.
+ Opakování předchozího výrazu 1x nebo vícekrát.
? Opakování předchozího výrazu 0x nebo 1x.
[] Množina znaků. Např. [abc] se shoduje s a, b nebo c.
() Skupina. Umožňuje seskupit výrazy a aplikovat na ně operátory.
\ Escape sekvence. Umožňuje zrušit speciální význam metaznaku. Např. \. se shoduje s tečkou.
` `
^ Začátek řetězce (nebo řádku v multiline módu).
$ Konec řetězce (nebo řádku v multiline módu).
\d Číslice (ekvivalentní [0-9]).
\w Alfanumerický znak nebo podtržítko (ekvivalentní [a-zA-Z0-9_]).
\s Bílý znak (mezera, tabulátor, nový řádek).
{n} Přesně n opakování předchozího výrazu.
{n,} Nejméně n opakování předchozího výrazu.
{n,m} Nejméně n a nejvýše m opakování předchozího výrazu.
[^...] Negace množiny znaků. Např. [^abc] se shoduje s libovolným znakem kromě a, b a c.
\b Hranice slova.
\B Non-word boundary.
\A Začátek řetězce.
\Z Konec řetězce (před případným novým řádkem na konci).
\z Konec řetězce.
\t Tabulátor.
\r Carriage return.
\n Nový řádek.
\v Vertikální tabulátor.
\f Form feed.
\e Escape character.
\NNN Znak s oktalovým kódem NNN.
\xXX Znak s hexadecimálním kódem XX.
\uXXXX Znak s Unicode kódem XXXX.
\cX Control-X charakter.
(?:...) Non-capturing group.
(?=...) Positive lookahead assertion.
(?!...) Negative lookahead assertion.
(?...) Named group.
(?P=name) Backreference to a named group.
(?#...) Comment.

Příklady

  • [a-z]+ - Shoduje se s jedním nebo více malými písmeny.
  • \d{3}-\d{2}-\d{3} - Shoduje se s formátem rodného čísla.
  • [A-Za-z0-9._%+-]+@[A-Za-z0-9.-]+\.[A-Za-z]{2,} - Shoduje se s e-mailovou adresou.
  • ^\s*$ - Shoduje se s prázdným řádkem.
  • `` - Shoduje se s HTML tagem.

Použití

  • Regulární výrazy se používají v mnoha programovacích jazycích a nástrojích, např.:
  • Programovací jazyky: Python, JavaScript, Java, C#, PHP, atd.
  • Textové editory: Notepad++, Sublime Text, VS Code, atd.
  • Příkazová řádka: grep, sed, awk, atd.
  • Databáze: MySQL, PostgreSQL, atd.

Guía breve de Markdown

¿Qué es Markdown?

  • Markdown is a lightweight markup language with plain text formatting syntax.
  • Created by John Gruber in 2004, Markdown is now one of the most popular markup languages in the world.

¿Por qué usar Markdown?

  • It is ligero: Markdown files are text files.
  • They are very easy to open and edit with any text editor.
  • It is fácil de leer: The syntax of Markdown is very simple.
  • Making it easy to read even in plain text format.
  • It is fácil de convertir: Markdown files can be easily converted to other formats.
  • Such as HTML, PDF, etc.
  • It is portable: Markdown files can be opened on any operating system.
  • It is versátil: Markdown can be used to write anything.
  • From quick notes to complete books.

Sintaxis de Markdown

Encabezados
  • The Markdown syntax for headers is very simple.
  • Simply use one or more # symbols at the beginning of the line
  • Followed by a space and the header text.
  • The number of # symbols determines the level of the header.
## Encabezado 1
## Encabezado 2
### Encabezado 3
#### Encabezado 4
##### Encabezado 5
###### Encabezado 6
Énfasis
  • The Markdown syntax for emphasis is very simple.
  • Simply use asterisks * or underscores _ to indicate the text.
- Texto en cursiva* o _Texto en cursiva_
- *Texto en negrita** o __Texto en negrita__
- **Texto en negrita y cursiva*** o ___Texto en negrita y cursiva___
Listas
  • The Markdown syntax for lists is very simple.
  • Simply use asterisks *, hyphens - or numbers 1. at the beginning of the line.
  • Followed by a space and the text of the list item.
- Elemento 1
- Elemento 2
- Elemento 3

- Elemento 1
- Elemento 2
- Elemento 3

1. Elemento 1
2. Elemento 2
3. Elemento 3
Enlaces
  • The Markdown syntax for links is very simple.
  • Simply use square brackets [] to indicate the link text.
  • Followed by parentheses () to indicate the link URL.
[Texto del enlace](URL del enlace)
  • Titles can also be added to links.
  • To be displayed when the user hovers over the link.
[Texto del enlace](URL del enlace "Título del enlace")
Imágenes
  • The Markdown syntax for images is very similar to that of links.
  • Simply use an exclamation mark ! at the beginning of the line.
  • Followed by square brackets [] to indicate the alternative text of the image.
  • Followed by parentheses () to indicate the image URL.
![Texto alternativo](URL de la imagen)
  • Titles can also be added to the image.
  • To be displayed when the user hovers over the image.
![Texto alternativo](URL de la imagen "Título de la imagen")
Código
  • The Markdown syntax for code is very simple.
  • Simply use backticks ` to indicate the code.
`Código en línea`
  • To display a code block, use three backticks ``` at the beginning and end.

Bloque de código

  • The language of the code block can be indicated after the first three backticks.
```python
Bloque de código en Python

##### Tablas
- The Markdown syntax for tables is a bit more complicated, but still simple.
- Simply use hyphens `-` and vertical bars `|` to indicate the table cells.
```markdown
| Encabezado 1 | Encabezado 2 | Encabezado 3 |
| ------------ | ------------ | ------------ |
| Celda 1     | Celda 2     | Celda 3     |
| Celda 4     | Celda 5     | Celda 6     |
  • The cell text can also be aligned using colons :.
| Encabezado 1 | Encabezado 2 | Encabezado 3 |
| :----------- | :----------: | -----------: |
| Celda 1      |   Celda 2    |      Celda 3 |
| Celda 4      |   Celda 5    |      Celda 6 |
Citas
  • The Markdown syntax for quotes is very simple.
  • Simply use the > symbol at the beginning of the line.
  • Followed by a space and the text of the quote.
> Esto es una cita.
Saltos de línea
  • To create a line break in Markdown, simply leave two spaces at the end of the line.
Esto es una línea.
Esto es otra línea.
Reglas horizontales
  • To create a horizontal rule in Markdown, simply use three or more asterisks *, hyphens - or underscores _ in a line.
- **
- --
___

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