10 Questions
True or false: Class B G-protein-coupled receptors (GPCRs) are not important drug targets
False
True or false: Injectable peptide drugs targeting GLP1R and PTH1R have been developed
True
True or false: Orally available small-molecule drugs targeting GLP1R and PTH1R are currently available
False
True or false: The high-resolution structure of human PTH1R in complex with Gs and a small-molecule agonist, PCO371, was reported in the article
True
True or false: The binding site of PCO371 on PTH1R is located at the extracellular interface
False
What is the main focus of the article?
The main focus of the article is the activation of class B G-protein-coupled receptors (GPCRs) by a biased intracellular agonist.
Which receptors are mentioned as important drug targets?
Glucagon-like peptide 1 receptor (GLP1R) and parathyroid hormone 1 receptor (PTH1R) are mentioned as important drug targets.
What is the binding site of PCO371 on PTH1R?
The binding site of PCO371 on PTH1R is located at the cytoplasmic interface.
What is the current status of orally available small-molecule drugs targeting GLP1R and PTH1R?
Orally available small-molecule drugs targeting GLP1R and PTH1R remain under development.
What is the purpose of the reported high-resolution structure?
The purpose of the reported high-resolution structure is to reveal the unexpected binding mode of PCO371 on PTH1R with Gs.
Quiz: Understanding the Activation of Class B GPCRs by Biased Intracellular Agonists Test your knowledge on the conserved activation mechanism of Class B G protein-coupled receptors (GPCRs) by biased intracellular agonists. This quiz covers the latest research findings and insights from the article "Conserved class B GPCR activation by a biased intracellular agonist." Challenge yourself and enhance your understanding of GPCR signaling pathways.
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