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Questions and Answers
Explain the relationship between ultrasound frequency and tissue heating.
Explain the relationship between ultrasound frequency and tissue heating.
As ultrasound frequency increases, the absorption of ultrasound energy by tissues also increases, leading to a greater rise in tissue temperature.
What are the two primary mechanisms by which ultrasound can produce biological effects?
What are the two primary mechanisms by which ultrasound can produce biological effects?
Thermal and mechanical effects.
Describe the factors that determine the extent of temperature increase in tissues exposed to ultrasound.
Describe the factors that determine the extent of temperature increase in tissues exposed to ultrasound.
The extent of temperature increase is influenced by intensity, frequency, exposure duration, and tissue properties like absorption and attenuation.
What is the relationship between tissue type and its tolerance to temperature increases due to ultrasound exposure?
What is the relationship between tissue type and its tolerance to temperature increases due to ultrasound exposure?
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What is the purpose of calculating the Thermal Index (TI)?
What is the purpose of calculating the Thermal Index (TI)?
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Describe the three subdivisions of the Thermal Index (TI).
Describe the three subdivisions of the Thermal Index (TI).
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Explain the difference between stable and transient cavitation.
Explain the difference between stable and transient cavitation.
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What is the primary mechanism associated with mechanical effects of ultrasound?
What is the primary mechanism associated with mechanical effects of ultrasound?
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In obstetric ultrasound, when is it recommended to use TIS, and when to use TIB?
In obstetric ultrasound, when is it recommended to use TIS, and when to use TIB?
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If TIS=2, what is the estimated maximum temperature increase (∆Tmax) in the tissue?
If TIS=2, what is the estimated maximum temperature increase (∆Tmax) in the tissue?
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What is the primary reason for using contrast agents in ultrasound imaging?
What is the primary reason for using contrast agents in ultrasound imaging?
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What is the relationship between the mechanical index (MI) and the likelihood of cavitation?
What is the relationship between the mechanical index (MI) and the likelihood of cavitation?
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Explain how the focal zone of an ultrasound beam affects tissue heating.
Explain how the focal zone of an ultrasound beam affects tissue heating.
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Why is the depth of penetration a relevant consideration for safety in ultrasound imaging?
Why is the depth of penetration a relevant consideration for safety in ultrasound imaging?
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What are the two main ultrasound parameters that influence the intensity of the mechanical effects?
What are the two main ultrasound parameters that influence the intensity of the mechanical effects?
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How does frequency impact the absorption of ultrasound energy by tissues?
How does frequency impact the absorption of ultrasound energy by tissues?
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What is the primary contributing factor to the high intensity output of spectral Doppler ultrasound?
What is the primary contributing factor to the high intensity output of spectral Doppler ultrasound?
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Describe one way in which the FOV of an ultrasound image can influence the potential for cavitation.
Describe one way in which the FOV of an ultrasound image can influence the potential for cavitation.
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Explain how cavitation can lead to potentially destructive effects.
Explain how cavitation can lead to potentially destructive effects.
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What is the principle of ALARA and how does it apply to ultrasound use?
What is the principle of ALARA and how does it apply to ultrasound use?
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What is the primary mechanism by which contrast agents enhance echogenicity?
What is the primary mechanism by which contrast agents enhance echogenicity?
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What is sister-chromatid exchange (SCE) and how is it related to ultrasound exposure in cell studies?
What is sister-chromatid exchange (SCE) and how is it related to ultrasound exposure in cell studies?
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Why are plant studies considered useful for studying cavitation effects of ultrasound?
Why are plant studies considered useful for studying cavitation effects of ultrasound?
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List two in vivo (in living organisms) effects observed in animal studies related to ultrasound exposure.
List two in vivo (in living organisms) effects observed in animal studies related to ultrasound exposure.
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Describe the main objective of the epidemiological study mentioned in the text on 806 children exposed to diagnostic ultrasound in utero.
Describe the main objective of the epidemiological study mentioned in the text on 806 children exposed to diagnostic ultrasound in utero.
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What is a major limitation of cell studies in relation to their applicability to clinical settings?
What is a major limitation of cell studies in relation to their applicability to clinical settings?
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What is the role of the 'phases' (A, B, C, D) in the process of cavitation as described in the text?
What is the role of the 'phases' (A, B, C, D) in the process of cavitation as described in the text?
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Explain the relationship between SCE formation and chromosomal instability.
Explain the relationship between SCE formation and chromosomal instability.
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How do plant studies contribute to our understanding of ultrasound bioeffects?
How do plant studies contribute to our understanding of ultrasound bioeffects?
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What is the main reason for concluding that the cause of statistically significant effects in cell studies is unknown?
What is the main reason for concluding that the cause of statistically significant effects in cell studies is unknown?
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Flashcards
Ultrasound
Ultrasound
A mechanical form of energy that propagates through tissues.
Thermal Effect
Thermal Effect
Conversion of ultrasound to heat in tissue through absorption.
Intensity and Frequency
Intensity and Frequency
Increased intensity or frequency leads to greater tissue heating.
Bioeffects
Bioeffects
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ALARA principle
ALARA principle
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Thermal Index (TI)
Thermal Index (TI)
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Absorption Variation
Absorption Variation
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Sister Chromatid Exchange (SCE)
Sister Chromatid Exchange (SCE)
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Cavitations
Cavitations
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Exposure Duration
Exposure Duration
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Stable Cavitation
Stable Cavitation
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Plant studies
Plant studies
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Animal studies
Animal studies
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Transient Cavitation
Transient Cavitation
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Epidemiological studies
Epidemiological studies
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Tissue Tolerance
Tissue Tolerance
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Thermal Indices Types
Thermal Indices Types
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Exposure effects
Exposure effects
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Thermal/non-thermal effects
Thermal/non-thermal effects
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Max Temperature Increase (∆Tmax)
Max Temperature Increase (∆Tmax)
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Mechanical Index (MI)
Mechanical Index (MI)
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Peak Rarefactional Pressure (Pr)
Peak Rarefactional Pressure (Pr)
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Transmitted Frequency (f)
Transmitted Frequency (f)
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Focal Zone
Focal Zone
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TI Value (Thermal Index)
TI Value (Thermal Index)
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Depth of Penetration
Depth of Penetration
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Contrast Agent
Contrast Agent
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Echogenicity
Echogenicity
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Safety of Diagnostic Ultrasound
Safety of Diagnostic Ultrasound
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Study Notes
Ultrasound Physics and Instrumentation - MRD535
- Course focuses on ultrasound physics and instrumentation, particularly bioeffects and safety.
- Learning objectives include describing the principles, physics, instrumentation, accessories, and image recording of ultrasonography.
- Another objective is analysing numerical and visual data related to the physics and instrumentation within ultrasonography.
Bioeffects
- Ultrasound is a mechanical energy form interacting with biological tissue.
- Ultrasound has the potential to cause biological effects, posing risks.
- Minimising risk while achieving diagnostic benefit is a crucial consideration (ALARA).
Contents
- Bioeffects are categorized into thermal and non-thermal effects on tissue.
- Contrast agents, used to improve sonography, are also covered.
Cells
- Sister chromatid exchange (SCE) is an endpoint study examining cell response to ultrasound exposure.
- SCE occurs during DNA synthesis, potentially due to replication errors or DNA replication inhibition.
- SCE is an indicator of chromosome instability.
- Comparing cells in suspension/culture vs intact patient is necessary.
- Cell studies are useful for understanding interaction mechanisms and informing animal and epidemiological studies.
Plants and Animal Studies
- Plant tissue, with its gas-filled channels, is useful in studying cavitation effects.
- Animal studies examine in vivo effects like fetal weight reduction, postpartum mortality, fetal abnormalities, and tumour regression.
Mechanisms
- Ultrasound bioeffects mechanisms are categorized into thermal and non-thermal.
- The thermal (heating) effect is due to ultrasound absorption converting energy to heat.
- The extent of tissue heating relates to intensity and frequency (higher intensity and frequency mean greater heating).
- Bone absorbs more ultrasound than soft tissue.
- The thermal index is calculated and includes soft tissue, bone, and adult cranial exposure subdivisions and is helpful in obstetrics applications
- Non-thermal effects are related to cavitation. Cavitation is categorized into stable and transient types.
Cavitation
- Stable cavitation: bubbles oscillate in size with sound waves.
- Transient cavitation: bubbles oscillate drastically and collapse, resulting in a potentially harmful destructive effect.
Mechanical Index (MI)
- MI is a parameter that aids in evaluating the potential for cavitation.
- MI calculation depends on peak rarefactional pressure and frequency of ultrasound. The mechanical effects, cavitation, affect tissues dependent on their characterization and ultrasound parameters (pressure amplitude, pulse duration and frequency).
Epidemiological Studies
- A study involving 806 children exposed to in utero diagnostic ultrasound demonstrated no significant biological differences compared to unexposed children.
Safety
- Currently, there's no known risk associated with diagnostic ultrasound use.
- Subtle, low incidence, or delayed bioeffects are recognized as a potential possibility.
- Factors influencing the effects of ultrasound include focal zones (where the beam is concentrated), field-of-view (FOV), frequency (higher frequency leads to greater absorption), intensity (higher intensity may cause greater tissue heating), and mode of operation.
Ultrasound Output
- Intensity is the most common measurement to quantify ultrasound output.
- Spectral Doppler outputs are highest, and gray-scale imaging outputs are lowest; other modalities fall in-between.
AIUM Statements
- The AIUM (American Institute of Ultrasound in Medicine) released a 2011 statement cautioning against using high thermal index (TI) spectral Doppler in first trimesters, emphasizing the need for careful assessment of benefit versus risk and examination duration minimization.
- A separate AIUM statement on fetal heart rate measurement (2011) recommends using M-mode ultrasound first and spectral Doppler only when necessary, emphasizing keeping TI as low as possible.
Contrast Agent
- Contrast agents are liquid suspensions introduced into circulation to enhance tissue echogenicity.
- Microbubbles of gas, stabilized by a shell, allow the agent to pass through capillaries, exhibiting strong echoes due to impedance differences.
- The enhancement pattern is similar to CT and MRI but recorded in real time.
Advantages
- Real-time imaging with high temporal resolution.
- Ability to study dynamic enhancement patterns without predefined scan points or bolus tracking.
- Excellent patient tolerance and lack of nephrotoxicity.
Safety Considerations
- There are no known cardio-, hepato-, or nephrotoxic effects from contrast agents.
- The incidence of serious sensitivity is lower than with current X-ray contrast agents and comparable to MRI contrast agents.
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Description
This quiz explores the intricate relationship between ultrasound frequency and tissue heating, including biological effects and the mechanisms involved. It delves into factors influencing temperature increase, tissue tolerance to heating, and the significance of the Thermal Index. Additionally, it covers cavitation types and their implications in ultrasound imaging.