Podcast
Questions and Answers
What is the primary focus of epigenetics?
What is the primary focus of epigenetics?
- Changes in the DNA sequence
- Inhibiting gene transcription
- Interactions between genes and their products (correct)
- Altering chromatin structure
How does DNA methylation inhibit gene transcription?
How does DNA methylation inhibit gene transcription?
- By adding methyl groups to bases (correct)
- By changing the DNA sequence
- By copying the methylation pattern from the parent strand
- By altering chromatin structure
According to Lamarck's theory of evolution, what can an organism pass on to its offspring?
According to Lamarck's theory of evolution, what can an organism pass on to its offspring?
- Molecular attachments to histone tails
- Physical characteristics acquired during its lifetime (correct)
- Epigenetic patterns inherited during meiosis
- Changes in the DNA sequence
Which epigenetic mechanism involves different molecules attaching to the tails of histones?
Which epigenetic mechanism involves different molecules attaching to the tails of histones?
What is the outcome of lifestyle and epigenetics according to the statement 'You are what your grandparents ate'?
What is the outcome of lifestyle and epigenetics according to the statement 'You are what your grandparents ate'?
What is the main difference between DNA methylation and histone modification?
What is the main difference between DNA methylation and histone modification?
What is the function of CpG islands in the human genome?
What is the function of CpG islands in the human genome?
Which type of DNA sequences can move from one region of the genome to another?
Which type of DNA sequences can move from one region of the genome to another?
What is the role of DNA methylation at enhancers in affecting transcription?
What is the role of DNA methylation at enhancers in affecting transcription?
Which activity does DNA methylation not couple to according to Moore et al. (2013)?
Which activity does DNA methylation not couple to according to Moore et al. (2013)?
What is the mechanism through which DNA methylation can silence gene expression at promoter regions?
What is the mechanism through which DNA methylation can silence gene expression at promoter regions?
Which is a characteristic of CpG islands in the human genome?
Which is a characteristic of CpG islands in the human genome?
2.2
2.2
Which genomic distribution is hypomethylated in cancer according to Tubio, Science 2014?
Which genomic distribution is hypomethylated in cancer according to Tubio, Science 2014?
How does DNA methylation affect the expression of perturbed genes indirectly?
How does DNA methylation affect the expression of perturbed genes indirectly?
What is the purpose of X-chromosome inactivation?
What is the purpose of X-chromosome inactivation?
Which of the following is true about Xist?
Which of the following is true about Xist?
What is the main function of DNMT1?
What is the main function of DNMT1?
What is the result of deficiency in DNMT3B?
What is the result of deficiency in DNMT3B?
In which type of cancer can CpG Island Methylator Phenotype (CIMP) be observed?
In which type of cancer can CpG Island Methylator Phenotype (CIMP) be observed?
What is the distinctive prognosis associated with MI+ CRC tumors?
What is the distinctive prognosis associated with MI+ CRC tumors?
Which gene is hypermethylated in colorectal cancer?
Which gene is hypermethylated in colorectal cancer?
What is the mutation type found in approximately 60% of DNMT3A mutations in AML patients?
What is the mutation type found in approximately 60% of DNMT3A mutations in AML patients?
In which type of cancer has global hypomethylation been observed in early stages?
In which type of cancer has global hypomethylation been observed in early stages?
What is the main function of DNMT3A?
What is the main function of DNMT3A?
What is the genetic model for colorectal tumorigenesis?
What is the genetic model for colorectal tumorigenesis?
What does CTCF binding to the insulator lead to?
What does CTCF binding to the insulator lead to?
What are the types of DNA methylation changes that occur in cancer?
What are the types of DNA methylation changes that occur in cancer?
