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Sickle cell disease

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what does hg s do

The presence of Haemoglobin S causes red blood cells to be sickle-shaped and rigid, making it more difficult for them to flow through blood vessels in the body to deliver oxygen.

There was substitution of lysin for Glutamic acid at position 6 on the beta polypeptide chain of the haemoglobin.

False

correct answer for the previous

valine

effect of substitution of valine for glutamate for position 6

Effect is polymerization of haemoglobin S@ low O2 tension with formation of sickle cell shape, haemolysis, aggregation & blockage of blood vessels.

Sickle cell disease

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