Tyrosine Kinases and Cellular Regulation Quiz

Regulating various cellular processes, including cell growth, proliferation, differentiation, and survival.

Upon binding of specific ligands, RTKs undergo dimerization and autophosphorylation.

Mediating the transmission of signals from cell surface receptors to the nucleus.

<p>RTKs are transmembrane proteins with an extracellular ligand-binding domain, a single transmembrane domain, and an intracellular kinase domain.</p> Signup and view all the answers

<p>By phosphorylating tyrosine residues on themselves and on downstream signaling proteins.</p> Signup and view all the answers

<p>Src family kinases, Janus kinases (JAKs), and Abl kinases.</p> Signup and view all the answers

<p>Autophosphorylation leads to the activation of the kinase domain, initiating downstream signaling.</p> Signup and view all the answers

<p>Uncontrolled cell growth and proliferation, metastasis, resistance to cell death</p> Signup and view all the answers

<p>By targeting the ATP-binding site of tyrosine kinases</p> Signup and view all the answers

<p>Regulating various cellular processes with specificity and precision</p> Signup and view all the answers

<p>By autophosphorylating tyrosine residues within the kinase domain</p> Signup and view all the answers

<p>Binding to other proteins, changes in subcellular localization, post-translational modifications</p> Signup and view all the answers

<p>Ligand binding induces receptor dimerization, leading to autophosphorylation of tyrosine residues within the kinase domain</p> Signup and view all the answers

<p>Adaptor molecules (e.g., Grb2), guanine nucleotide exchange factors (GEFs)</p> Signup and view all the answers

<p>By conformational changes induced by interactions with other proteins or by phosphorylation</p> Signup and view all the answers