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Types of Non-competitive Antagonism

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Questions and Answers

Which type of non-competitive antagonism involves covalent binding with the receptors?

Reversible antagonism

Competitive antagonism

Irreversible antagonism (correct)

Functional antagonism

Which type of non-competitive antagonism is usually of short duration?

Reversible antagonism (correct)

Irreversible antagonism

Competitive antagonism

Functional antagonism

What is an example of functional antagonism mentioned in the text?

Phenoxybenzamine on α-adrenergic receptors

Epinephrine to histamine (correct)

Nicotine in large dose

Cocaine on dopamine receptors

What is an example of a drug causing reversible non-competitive antagonism?

Nicotine in large dose Signup and view all the answers

What is potentiation in pharmacology?

One drug with no effect increases the action of another drug by interfering with its biotransformation Signup and view all the answers

What is the additive effect (summation) of two drugs with the same effect?

The combined effect is the sum of the individual action Signup and view all the answers

What characterizes synergism in pharmacology?

The effect of two drugs with the same effect is greater than the additive effect Signup and view all the answers

What is the characteristic of a drug designated as cumulative?

Slow elimination and/or detoxification Signup and view all the answers

How can toxicity from a cumulative drug be avoided?

By decreasing the dose Signup and view all the answers

What is tolerance to a drug?

Decrease or failed response to the usual therapeutic dose Signup and view all the answers

What characterizes congenital tolerance?

Existing from birth Signup and view all the answers

What may contribute to individual tolerance within any population?

"Biological variation i.e. individual tolerance within any population" Signup and view all the answers